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Volumn 43, Issue 5, 1997, Pages 708-714

Telomeres and telomerase: Biological and clinical importance

Author keywords

aging; cell regulation; chromosomes; tumorigenesis

Indexed keywords

ANTINEOPLASTIC AGENT; DIAGNOSTIC AGENT; DNA; ENZYME INHIBITOR; RNA; TELOMERASE; TUMOR MARKER;

EID: 0030990276     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/43.5.708     Document Type: Review
Times cited : (99)

References (55)
  • 1
    • 33847453816 scopus 로고
    • Blackburn EH, Greider CW, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Blackburn EH, Greider CW, eds. Telomeres. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1995:1-396.
    • (1995) Telomeres , pp. 1-396
  • 2
    • 0026541384 scopus 로고
    • Human telomeres are attached to the nuclear matrix
    • de Lange T. Human telomeres are attached to the nuclear matrix. EMBO J 1992;11:717-24.
    • (1992) EMBO J , vol.11 , pp. 717-724
    • De Lange, T.1
  • 3
    • 0029894237 scopus 로고    scopus 로고
    • Telomere length regulation
    • Greider CW. Telomere length regulation. Annu Rev Biochem 1996; 65:337-65.
    • (1996) Annu Rev Biochem , vol.65 , pp. 337-365
    • Greider, C.W.1
  • 4
    • 0026599251 scopus 로고
    • Interstitial telomeres are hotspots for illegitimate recombination with DNA molecules injected into the macronucleus of Paramecium primaurelia
    • Katinka M, Bourgain F. Interstitial telomeres are hotspots for illegitimate recombination with DNA molecules injected into the macronucleus of Paramecium primaurelia. EMBO J 1992;11:725-32.
    • (1992) EMBO J , vol.11 , pp. 725-732
    • Katinka, M.1    Bourgain, F.2
  • 5
    • 0030120559 scopus 로고    scopus 로고
    • Telomere (telomerase) hypothesis of aging and immortalization
    • Kalluri R. Telomere (telomerase) hypothesis of aging and immortalization. Indian J Biochem Biophys 1996;33:88-92.
    • (1996) Indian J Biochem Biophys , vol.33 , pp. 88-92
    • Kalluri, R.1
  • 7
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est1-senescence
    • Lundblad V, Blackburn E. An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell 1993;73:347-60.
    • (1993) Cell , vol.73 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.2
  • 8
    • 0026619175 scopus 로고
    • Genetics and molecular biology of telomeres
    • Biessmann H, Mason J. Genetics and molecular biology of telomeres [Review]. Adv Genet 1992;30:185-249.
    • (1992) Adv Genet , vol.30 , pp. 185-249
    • Biessmann, H.1    Mason, J.2
  • 9
    • 0021234973 scopus 로고
    • DNA sequences of telomeres maintained in yeast
    • Shampay J, Szostak J, Blackburn E. DNA sequences of telomeres maintained in yeast. Nature 1984;310:154-7.
    • (1984) Nature , vol.310 , pp. 154-157
    • Shampay, J.1    Szostak, J.2    Blackburn, E.3
  • 10
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider C, Blackburn E. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985; 43:405-13.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.1    Blackburn, E.2
  • 11
    • 0023663881 scopus 로고
    • The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
    • Greider C, Blackburn E. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987;51:887-98.
    • (1987) Cell , vol.51 , pp. 887-898
    • Greider, C.1    Blackburn, E.2
  • 12
    • 0027944347 scopus 로고
    • TLCI, template RNA component of Saccharomyces cerevisiae telomerase
    • Singer M, Gottschling D. TLCI, template RNA component of Saccharomyces cerevisiae telomerase. Science 1994;266:404-9.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.1    Gottschling, D.2
  • 14
    • 0010585575 scopus 로고    scopus 로고
    • The structure and properties of mammalian telomerase and their potential impact on human disease
    • Morin GB. The structure and properties of mammalian telomerase and their potential impact on human disease. Sem Cell Dev Biol 1996;7:5-13.
    • (1996) Sem Cell Dev Biol , vol.7 , pp. 5-13
    • Morin, G.B.1
  • 15
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim N, Piatyszek M, Prowse K, Harley C, West M, Ho P, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-4.
    • (1994) Science , vol.266 , pp. 2011-2014
    • Kim, N.1    Piatyszek, M.2    Prowse, K.3    Harley, C.4    West, M.5    Ho, P.6
  • 16
    • 0015844590 scopus 로고
    • A theory of marginotomy. the incomplete copying of template margin in enzymatic synthesis of polynucleotides, and biological significance of the phenomenon
    • Olovnikov A. A theory of marginotomy. The incomplete copying of template margin in enzymatic synthesis of polynucleotides, and biological significance of the phenomenon. J Theor Biol 1973;41: 181-90.
    • (1973) J Theor Biol , vol.41 , pp. 181-190
    • Olovnikov, A.1
  • 17
    • 0025787643 scopus 로고
    • Telomere loss, mitotic clock or genetic bomb?
    • Harley CB. Telomere loss, mitotic clock or genetic bomb? Mutat Res 1991;256:271-82.
    • (1991) Mutat Res , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 18
    • 0001934324 scopus 로고
    • Telomeres and aging
    • Blackburn EH, Greider CW, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Harley CB. Telomeres and aging. In: Blackburn EH, Greider CW, eds. Telomeres. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1995:247-63.
    • (1995) Telomeres , pp. 247-263
    • Harley, C.B.1
  • 20
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter C, Avilion A, LeFeuvre C, Stewart N, Greider C, Harley C, Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992;11:1921-9.
    • (1992) EMBO J , vol.11 , pp. 1921-1929
    • Counter, C.1    Avilion, A.2    LeFeuvre, C.3    Stewart, N.4    Greider, C.5    Harley, C.6    Bacchetti, S.7
  • 21
    • 0028981143 scopus 로고
    • Time, telomeres and tumours. Is cellular senescence more than an anticancer mechanism?
    • Wright W, Shay J. Time, telomeres and tumours. Is cellular senescence more than an anticancer mechanism? Trends Cell Biol 1995;5:293-7.
    • (1995) Trends Cell Biol , vol.5 , pp. 293-297
    • Wright, W.1    Shay, J.2
  • 22
    • 0028007237 scopus 로고
    • Telomere dynamics in an immortal cell line
    • Murnane J, Sabatier L, Marder B. Telomere dynamics in an immortal cell line. EMBO J 1994;13:4953-62.
    • (1994) EMBO J , vol.13 , pp. 4953-4962
    • Murnane, J.1    Sabatier, L.2    Marder, B.3
  • 23
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan T, Englezou A, Gupta J, Bacchetti S, Reddel R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240-8.
    • (1995) EMBO J , vol.14 , pp. 4240-4248
    • Bryan, T.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.5
  • 25
    • 0028329431 scopus 로고
    • Hutchinson-Gilford syndrome
    • Stables G, Morley W. Hutchinson-Gilford syndrome. J R Soc Med 1994;87:243-4.
    • (1994) J R Soc Med , vol.87 , pp. 243-244
    • Stables, G.1    Morley, W.2
  • 26
    • 0029933242 scopus 로고    scopus 로고
    • Premature aging gene discovered
    • Pennisi E. Premature aging gene discovered. Science 1996;272: 193-4.
    • (1996) Science , vol.272 , pp. 193-194
    • Pennisi, E.1
  • 27
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
    • Schulz V, Zakian V, Ogburn C, McKay J, Jarzebowicz A, Edland S, Martin G. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet 1996;97:750-4.
    • (1996) Hum Genet , vol.97 , pp. 750-754
    • Schulz, V.1    Zakian, V.2    Ogburn, C.3    McKay, J.4    Jarzebowicz, A.5    Edland, S.6    Martin, G.7
  • 28
    • 0028909019 scopus 로고
    • DNA damage and repair in telomeres. Relation to aging
    • Kruk P, Rampino N, Bohr V. DNA damage and repair in telomeres. Relation to aging. Proc Natl Acad Sci U S A 1995;92:258-62.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 258-262
    • Kruk, P.1    Rampino, N.2    Bohr, V.3
  • 29
    • 0028991396 scopus 로고
    • Mutation of cell cycle regulators. Biological and clinical implications for human neoplasia
    • Cordon-Cardo C. Mutation of cell cycle regulators. Biological and clinical implications for human neoplasia [Review]. Am J Pathol 1995;147:545-60.
    • (1995) Am J Pathol , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 30
    • 0029114679 scopus 로고
    • Telomeres and telomerase in human cancer
    • Bacchetti S, Counter C. Telomeres and telomerase in human cancer [Review]. Int J Oncol 1995;7:423-32.
    • (1995) Int J Oncol , vol.7 , pp. 423-432
    • Bacchetti, S.1    Counter, C.2
  • 31
    • 0026541358 scopus 로고
    • Length of telomeric repeats in neuroblastoma; correlation with prognosis and other biological characteristics
    • Hiyama E, Hiyama K, Yokoyama T, Ichikawa T, Matsuura Y. Length of telomeric repeats in neuroblastoma; correlation with prognosis and other biological characteristics. Jpn J Cancer Res 1992;83: 159-64.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 159-164
    • Hiyama, E.1    Hiyama, K.2    Yokoyama, T.3    Ichikawa, T.4    Matsuura, Y.5
  • 32
    • 0026676643 scopus 로고
    • Telomere reduction in endometrial adenocarcinoma
    • Smith J, Yeh G. Telomere reduction in endometrial adenocarcinoma. Am J Obstet Gynecol 1992;167:1883-7.
    • (1992) Am J Obstet Gynecol , vol.167 , pp. 1883-1887
    • Smith, J.1    Yeh, G.2
  • 33
    • 0028303112 scopus 로고
    • Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma and gynecomastia
    • Odagiri E, Kanda N, Jibiki K, Demura R, Aikawa E, Demura H. Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma and gynecomastia. Cancer 1994;73:2978-84.
    • (1994) Cancer , vol.73 , pp. 2978-2984
    • Odagiri, E.1    Kanda, N.2    Jibiki, K.3    Demura, R.4    Aikawa, E.5    Demura, H.6
  • 36
  • 37
    • 0027298979 scopus 로고
    • Changes of telomere lengths in human intracranial tumors
    • Nürnberg P, Thiel G. Weber F, Epplen J. Changes of telomere lengths in human intracranial tumors. Hum Genet 1993;91: 190-2.
    • (1993) Hum Genet , vol.91 , pp. 190-192
    • Nürnberg, P.1    Thiel, G.2    Weber, F.3    Epplen, J.4
  • 38
    • 0028838096 scopus 로고
    • Changes in mean telomere length in basal cell carcinomas of the skin
    • Wainwright J, Middleton PG, Rees JL. Changes in mean telomere length in basal cell carcinomas of the skin. Genes Chromosom Cancer 1995;12:45-9.
    • (1995) Genes Chromosom Cancer , vol.12 , pp. 45-49
    • Wainwright, J.1    Middleton, P.G.2    Rees, J.L.3
  • 40
    • 0029075066 scopus 로고
    • Telomeres, telomerase, immortality
    • Rhyu M. Telomeres, telomerase, immortality [Review]. J Natl Cancer Inst 1995;87:885-94.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 885-894
    • Rhyu, M.1
  • 41
    • 0029091386 scopus 로고
    • Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
    • Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek M, et al. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 1995;155:3711-5.
    • (1995) J Immunol , vol.155 , pp. 3711-3715
    • Hiyama, K.1    Hirai, Y.2    Kyoizumi, S.3    Akiyama, M.4    Hiyama, E.5    Piatyszek, M.6
  • 42
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright W, Piatyszek M, Rainey W, Byrd W, Shay J. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 1996;18:173-9.
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.1    Piatyszek, M.2    Rainey, W.3    Byrd, W.4    Shay, J.5
  • 47
    • 0029013631 scopus 로고
    • Telomerase activity associated with acquisition of malignancy in human colorectal cancer
    • Chadeneau C, Hay K, Hirte H, Gallinger S, Bacchetti S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 1995;55:2533-6.
    • (1995) Cancer Res , vol.55 , pp. 2533-2536
    • Chadeneau, C.1    Hay, K.2    Hirte, H.3    Gallinger, S.4    Bacchetti, S.5
  • 48
    • 0028987052 scopus 로고
    • Telomerase activity and oncogenesis in giant cell tumors of bone
    • Schwarte H, Juliao S, Sciadini M, Miller L, Butler M. Telomerase activity and oncogenesis in giant cell tumors of bone. Cancer 1995;75:1094-9.
    • (1995) Cancer , vol.75 , pp. 1094-1099
    • Schwarte, H.1    Juliao, S.2    Sciadini, M.3    Miller, L.4    Butler, M.5
  • 51
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    • Blasco M, Rizen M, Greider C, Hanahan D. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nature Genet 1996;12:200-4.
    • (1996) Nature Genet , vol.12 , pp. 200-204
    • Blasco, M.1    Rizen, M.2    Greider, C.3    Hanahan, D.4
  • 52
    • 0030067487 scopus 로고    scopus 로고
    • Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
    • Avilion A, Piatyszek A, Gupta J, Shay J, Bacchetti S, Greider C. Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 1996;56:645-50.
    • (1996) Cancer Res , vol.56 , pp. 645-650
    • Avilion, A.1    Piatyszek, A.2    Gupta, J.3    Shay, J.4    Bacchetti, S.5    Greider, C.6
  • 53
    • 0028901802 scopus 로고
    • Therapeutic antisense and ribozymes
    • Rossi J. Therapeutic antisense and ribozymes. Br Med Bull 1995;51:217-25.
    • (1995) Br Med Bull , vol.51 , pp. 217-225
    • Rossi, J.1


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