DEAF-1, a novel protein that binds an essential region in a Deformed response element

EMBO Journal

Volumn 15, Issue 8, 1996, Pages 1961-1970

  Gross, Cornelius T ^a   McGinnis, William ^a,b  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DEAF 1; Deformed; DNA binding protein; Drosophila; Homeotic; HOXD4

Indexed keywords

CYSTEINE; DNA BINDING PROTEIN; MUTANT PROTEIN; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN ISOLATION;

EID: 0029986957     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00547.x     Document Type: Article

References (48)

1. Affolter, M., Percival-Smith, A., Müller, M., Leupin, W. and Gehring, W.J. (1990) DNA binding properties of the purified antennapedia homeodomain. Proc. Natl Acad. Sci. USA, 87, 4093-4097.
2. Biggin, M.D. and Tjian, R. (1988) Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts. Cell, 53, 699-711.
3. Brown, N.H. and Kafatos, F.C (1988) Functional cDNA libraries from Drosophila embryos. J. Mol. Biol., 203, 425-437.
4. Chadwick, R. and McGinnis, W. (1987) Temporal and spatial distribution of transcripts from the Deformed gene of Drosophila. EMBO J., 6, 779-789
5. Chan, S.-K., Jaffe, L., Capovilia, M., Botas, J. and Mann, R. (1994) The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell, 78, 603-615.
6. Chang, C.-P., Shen, W.-F., Rozenfeld, S., Lawrence, H.J., Largman, C. and Cleary, M.L. (1995) Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev., 9, 663-674.
7. Desplan, C., Theis, J. and O'Farrell, P.H. (1988) The sequence specificity of homeodomain-DNA interaction. Cell, 54, 1081-1090.
8. Dessain, S., Gross, C.T., Kuziora, M. and McGinnis, W. (1992) Antp-type homeodomains have distinct DNA binding specificities that correlate with their target specificities in the embryo. EMBO J., 11, 991-1002.
9. Ekker, S., Jackson, D., Kessler, D., Sun, B., Young, K. and Beachy, P. (1994) The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J., 13, 3551-3560.
10. Elfring, L., Deuring, R., McCallum, C., Peterson, C. and Tamkun, J.W. (1994) Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SW12. Mol. Cell. Biol., 14, 2225-2234.
11. Erickson, P.F., Robinson, M., Owens, G. and Drabkin, H A. (1994) The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor. Cancer Res., 54, 1782-1786.
12. Feinstein, PG., Kornfeld, K , Hogness, D.S. and Mann, R.S. (1995) Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue. Genetics, 140, 573-586.
13. Florence, B., Handrow, R. and Laughon, A (1991) DNA-binding specificity of the fushi tarazu homeodomain. Mol Cell. Biol , 11, 3613-3623.
14. Hanes, S.D., Riddihough, G., Ish-Horowicz, D. and Brent, R. (1994) Specific DNA recognition and intersite spacing are critical for action of the bicoid morphogen. Mol. Cell. Biol., 14, 3364-3375.
15. Hatfull, G. and Grindley, N. (1986) Analysis of γδ resolvase mutants in vitro: evidence for an interaction between serine-10 of resolvase and site 1 of res Proc. Natl Acad Sci USA, 83, 5429-5433.
16. Herr, W. (1992) Oct-1 and Oct-2: differential transcriptional regulation by proteins that bind to the same DNA sequence. In McKnight, S. and Yamamoto, K. (eds), Transcriptional Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 1103-1135.
17. Hoey, T. and Levine, M. (1988) Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature, 332, 858-861.
18. Johnson, A. (1992) A combinatorial regulatory circuit in budding yeast. In McKnight, S. and Yamamoto, K. (eds). Transcriptional Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. pp. 975-1006.
19. Johnson, F.B., Parker, E and Krasnow, M. (1995) Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction Proc. Natl Acad. Sci. USA, 92, 739-743.
20. Kadereit, S., Gewert, D.R., Galabru, J., Hovanessian, A.G. and Meurs, E.F. (1993) Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. J. Biol. Chem., 268, 24432-24441.
21. Kadonaga, J.T. and Tjian, R. (1986) Affinity purification of sequence-specific DNA binding proteins Proc. Natl Acad. Sci USA, 83, 5889-5893.
22. Kennison, J.A. (1993) Transcriptional activation of Drosophila homeotic genes from distant regulatory elements Trends Genet., 9, 75-79
23. Kennison, J.A. and Tamkun, J.W. (1988) Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. Proc Natl Acad. Sci. USA, 85, 8136-8140.
24. Kenyon, C. (1994) If birds fly, why can't we? Homeotic genes and evolution. Cell, 78, 175-180.
25. Mahaffey, J.W., Jones, D.F., Hickel, J. and Grisewold, C.M (1993) Identification and characterization of a gene activated by the deformed homeoprotein. Development, 118, 203-214.
26. Malicki, J., Cianetti, L C., Peschle, C. and McGinnis, W. (1992) A human HOX4B regulatory element provides head-specific expression in Drosophila embryos. Nature, 358, 345-347
27. Mazo, A.M., Huang, D., Mozer, B.A. and David, I B (1990) The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc. Natl. Acad. Sci. USA, 87, 2112-2116.
28. McGinnis, W. and Kiumlauf, R (1992) Homeobox genes and axial patterning. Cell, 68, 283-302.
29. Merrill, V.K.L., Turner, F.R. and Kaufman, T.C. (1987) A genetic and developmental analysis of mutations in the Deformed locus in Drosophila melanogaster Dev. Biol., 122, 379-395.
30. Miyoshi, H., Kozu, T., Shimizu, K., Enomoto, K., Maseki, N., Kaneko, Y., Kamada, N. and Ohki, M. (1993) The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J., 12, 2715-2721
31. Mohler, J., Mahaffey, J W., Deutsch, E. and Vani, K. (1995) Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development, 121, 237-247.
32. Nelson, H. and Laughon, A. (1993) Drosophila glial architecture and development: analysis using a collection of new cell-specific markers. Devel. Biol, 202, 341-354.
33. Owens, G.P., Hahn, W.E. and Cohen, J.J. (1991) Identification of mRNAs associated with programmed cell death in immature thymocytes Mol. Cell. Biol., 11, 4177-4188.
34. Peifer, M., and Weischaus, E. (1990) Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity. Genes Dev., 4, 1209-1223.
35. Popperl, H., Bienz, M., Studer, M., Chan, S., Aparicio, S, Brenner, S., Mann, R.S. and Krumlauf, R. (1995) Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent on exd/ pbx, Cell, 81, 1031-1042.
36. Regulski, M, McGinnis, N. Chadwick, R. and McGinnis, W. (1987) Developmental and molecular analysis of Deformed: a homeotic gene controlling Drosophila head development. EMBO J., 6, 767-777.
37. Schier, A.F. and Gehring, W.J. (1993) Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity. EMBO J., 12, 1111-1119.
38. Schwabe, J.W.R. and Klug, A. (1994) Zinc mining for protein domains. Struct. Biol., 1, 345-349.
39. Sedkov, Y., Tillib, S., Mizrokhi, L. and Mazo, A. (1994) The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of early trithorax transcripts. Development, 120, 1907-1917.
40. Smith, D.L. and Johnson, A.D. (1992) A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer. Cell, 68, 133-142
41. Stassen, M.J., Bailey, D., Fox, S., Chinwalla, V. and Harte, P.J. (1995) The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech. Dev., 52, 1-15.
42. Tautz, D. and Pfeifle, C. (1989) A non-radioactive in situ hybridization method for localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback Chromosoma, 98, 81-85.
43. Tripoulas, N.A., Hersperger, E., La Jeunesse, D. and Shearn, A. (1994) Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs1 (ashl). Genetic, 137, 1027-1038.
44. van Dijk, M. and Murre, C. (1994) Extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell, 78, 617-624.
45. Vincent J.P, Kassis, J.A. and O'Farrell, P H (1990) A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. EMBO J., 9, 2573-2578.
46. Walker, S., Hayes, S. and O'Hare, P. (1994) Site-specific conformational alteration of the Oct-1 POU domain-DNA complex as the basis for differential recognition by Vmw65(VP16) Cell, 79, 841-852.
47. Walter, J. and Biggin, M D. (1994) Two homeodomain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos. Genes Dev., 8, 1678-1692.
48. Zeng, C., Pinsonneault, J., Gellon, G. McGinnis, N. and McGinnis, W. (1994) Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos. EMBO J., 13, 2362-2377.