The stereoselective synthesis of 4-formyltrinem, a key intermediate for novel trinems

Tetrahedron Letters

Volumn 38, Issue 20, 1997, Pages 3569-3572

  Ghiron, Chiara ^a   Rossi, Tino ^a   Thomas, Russell J ^a  

^a GSK   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; TRINEM DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030958478     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00665-5     Document Type: Article

References (20)

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18. Rodriguez, L.; Lu, N.; Yang, N.-L., Synlett, 1990, 227. Poly(oxymethylene) is sold by the Aldrich Chemical Co. Inc. Milwaukee, US.
19. The phosphoranes 10c and 10d were made according to; Carsky, P.; Huenig, S.; Stemmler, I.; Scheutzow, D., Liebigs Ann. Chem., 1980, 2, 291. All other non - commercial phosphoranes were made from their corresponding chloro-derivatives and triphenylphosphine. All phosphonates were made under standard Arbuzov conditions.
20. In these cases the reactions were decidedly slower than the others studied, and significant amounts of the α,β - unsaturated aldehyde 14 were isolated, presumably formed through a competitive deprotonation - rearrangement.