Synthesis and biological evaluation of 4-alkoxysubstituted trinems. Part II

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 16, 1996, Pages 2025-2030

  Di Fabio, Romano ^a   Andreotti, Daniele ^a   Biondi, Stefano ^a   Gaviraghi, Giovanni ^a   Rossi, Tino ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; IMIPENEM; SANFETRINEM; TRINEM DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; PSEUDOMONAS; STRUCTURE ACTIVITY RELATION;

PSEUDOMONAS;

EID: 0030594998     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00358-7     Document Type: Article

References (37)

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2. 1. Di Modugno, E; Erbetti, I.; Ferrari. L; Galassi, G; Hammond, S.H.; Xerri, L. Antimicrob. Agents Chemother. 1994, 38, 10, 2362; Tamburini, B.; Perboni, A.; Rossi, T.; Donati, D.; Andreotti, D.; Gaviraghi, G.; Carlesso, R.; Bismara, C. Eur. Pat. Appl. 416,953 (C07D477/00), March 13, 1991; Tamburini, B; Perboni, A; Donati, D; Andreotti, D.; Biondi, S.; Bismara, C. Eur. Pat. Appl. 416,952 (C07F7/18) 1991; Roberts, S.N.; Donati, D.; Perboni, A.; Rossi, T.; Padova, A. J. Chem. Soc. Chem. Commun. 1994, 441. For the synthesis of 4-heterosubstituted tribactams see: Di Fabio, R.; Feriani, A.; Gaviraghi, G.; Rossi, T. Biorg. Med. Chem. Lett. 1995, 5 ,12, 1235.
3. 1. Di Modugno, E; Erbetti, I.; Ferrari. L; Galassi, G; Hammond, S.H.; Xerri, L. Antimicrob. Agents Chemother. 1994, 38, 10, 2362; Tamburini, B.; Perboni, A.; Rossi, T.; Donati, D.; Andreotti, D.; Gaviraghi, G.; Carlesso, R.; Bismara, C. Eur. Pat. Appl. 416,953 (C07D477/00), March 13, 1991; Tamburini, B; Perboni, A; Donati, D; Andreotti, D.; Biondi, S.; Bismara, C. Eur. Pat. Appl. 416,952 (C07F7/18) 1991; Roberts, S.N.; Donati, D.; Perboni, A.; Rossi, T.; Padova, A. J. Chem. Soc. Chem. Commun. 1994, 441. For the synthesis of 4-heterosubstituted tribactams see: Di Fabio, R.; Feriani, A.; Gaviraghi, G.; Rossi, T. Biorg. Med. Chem. Lett. 1995, 5 ,12, 1235.
4. 1. Di Modugno, E; Erbetti, I.; Ferrari. L; Galassi, G; Hammond, S.H.; Xerri, L. Antimicrob. Agents Chemother. 1994, 38, 10, 2362; Tamburini, B.; Perboni, A.; Rossi, T.; Donati, D.; Andreotti, D.; Gaviraghi, G.; Carlesso, R.; Bismara, C. Eur. Pat. Appl. 416,953 (C07D477/00), March 13, 1991; Tamburini, B; Perboni, A; Donati, D; Andreotti, D.; Biondi, S.; Bismara, C. Eur. Pat. Appl. 416,952 (C07F7/18) 1991; Roberts, S.N.; Donati, D.; Perboni, A.; Rossi, T.; Padova, A. J. Chem. Soc. Chem. Commun. 1994, 441. For the synthesis of 4-heterosubstituted tribactams see: Di Fabio, R.; Feriani, A.; Gaviraghi, G.; Rossi, T. Biorg. Med. Chem. Lett. 1995, 5 ,12, 1235.
5. 1. Di Modugno, E; Erbetti, I.; Ferrari. L; Galassi, G; Hammond, S.H.; Xerri, L. Antimicrob. Agents Chemother. 1994, 38, 10, 2362; Tamburini, B.; Perboni, A.; Rossi, T.; Donati, D.; Andreotti, D.; Gaviraghi, G.; Carlesso, R.; Bismara, C. Eur. Pat. Appl. 416,953 (C07D477/00), March 13, 1991; Tamburini, B; Perboni, A; Donati, D; Andreotti, D.; Biondi, S.; Bismara, C. Eur. Pat. Appl. 416,952 (C07F7/18) 1991; Roberts, S.N.; Donati, D.; Perboni, A.; Rossi, T.; Padova, A. J. Chem. Soc. Chem. Commun. 1994, 441. For the synthesis of 4-heterosubstituted tribactams see: Di Fabio, R.; Feriani, A.; Gaviraghi, G.; Rossi, T. Biorg. Med. Chem. Lett. 1995, 5 ,12, 1235.
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14. 3. For recent reviews on β-lactam antibiotics see: Neuhaus, F.C.; Georgopapadakou, N.H. in Emerging Targets in Antibacterial and Antifungal Chemotherapy, Sutcliffe, J.; Georgopapadakou, N.H. Ed.; Chapman and Hall, New York, 1992; Georgopapadakou, N.H. Antimicrobial Agents Ann. 1988, 3, 409; Southgate, R.; Elson, S. in Progress in the Chemistry of Organic Natural Products; Herz, W.; Grisebach, H.; Kirby, G.W.; Tamm, Ch. Sringer Vergal: New York, 1985, 1; Durckheimer, W.; Blumbach, J.; Lattrell, R.; Scheunemann, K. H. Angew. Chem. Int. Ed. Engl. 1985, 24, 180; Recent Advances in the Chemistry of β-Lactam Antibiotics; Brown, A. G.; Roberts, S. M.; The Royal Society of Chemistry: Burlington House, Cambridge, U.K. 1984; Georgopapadakou, N.H. Ann. Rep. Med. Chem. 1983, 18, 119.
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36. 15. All new compounds were characterized by routine analytical and spectroscopic methods.
37. 16. See note 10 of the previous paper of this issue.