The use of zinc enolates in the synthesis of a key intermediate for the preparation of trinem antibiotics

Tetrahedron Letters

Volumn 37, Issue 41, 1996, Pages 7441-7444

  Kennedy, Gordon ^a   Rossi, Tino ^a   Tamburini, Bruno ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM DERIVATIVE; SANFETRINEM;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030573982     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01606-1     Document Type: Article

References (13)

1. 1. Di Modugno, E., et al., Antimicrob. Agents Chemother., 1994, 38, 2362. Padova, A., Roberts, S. M., Donati, D., Perboni, A., and Rossi, T., J. Chem. Soc. Chem. Commun., 1994, 441.
2. 1. Di Modugno, E., et al., Antimicrob. Agents Chemother., 1994, 38, 2362. Padova, A., Roberts, S. M., Donati, D., Perboni, A., and Rossi, T., J. Chem. Soc. Chem. Commun., 1994, 441.
3. 2. Perboni, A., et al, in "Recent Advances in the Chemistry of Anti-infective Agents" -ed. Bentley, P.H., Ponsford, R., RSC Cambridge, pp 21-35, 1992; Andreotti, D., et al., Bioorg. Med. Chem. Lett., 1996, 6, 491
4. 2. Perboni, A., et al, in "Recent Advances in the Chemistry of Anti-infective Agents" -ed. Bentley, P.H., Ponsford, R., RSC Cambridge, pp 21-35, 1992; Andreotti, D., et al., Bioorg. Med. Chem. Lett., 1996, 6, 491
5. 3. Rossi, L., Pecunioso, A., Tetrahedron Lett., 1994, 35, 5285
6. 4. Pecunioso, A., Ghiron, C., Piga, E., GB 2 287 709 A1
7. 5. House, H. O., et al., J. Am. Chem. Soc., 1973, 95, 3310
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9. 7. Stolle, A., Ollivier, J., Piras, P.P., Salaun, J., De Meijere, A., J. Am. Chem. Soc., 1992, 114, 4051
10. 8. Rossi, T., Zarantonello, P., Thomas, R.J., WO 95/26333 A1; Stead, P., et al., manuscript in preparation.
11. 8. Rossi, T., Zarantonello, P., Thomas, R.J., WO 95/26333 A1; Stead, P., et al., manuscript in preparation.
12. 9. Juaresti, E., Beck, A. K., Hansen, J., Matt., Mukhopadhyay, T., Malgorzata, S., Seebach, D., Synthesis, 1993, 1271
13. -1 /UV detection 205nm) (external standard); 55% and for the ratio of 2a:2c by NMR (6:1). NMR data: Marchioro, C., et al., Mag. Chem. Res., submitted.