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Volumn 26, Issue , 1997, Pages 567-596

Optical detection of single molecules

Author keywords

Confocal microscopy; DNA; Fluorescence; Molecular motors; Near field optics

Indexed keywords

CONFOCAL MICROSCOPY; FLUORESCENCE; LASER; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; OPTICS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REVIEW;

EID: 0030957271     PISSN: 10568700     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biophys.26.1.567     Document Type: Review
Times cited : (422)

References (154)
  • 1
    • 8244242321 scopus 로고
    • Imaging biological molecules with single molecule sensitivity using near-field scanning optical microscopy
    • Ambrose WP, Affleck RL, Goodwin PM, Keller RA, Martin JC, et al. 1995. Imaging biological molecules with single molecule sensitivity using near-field scanning optical microscopy. Exp. Tech. Phys. 41:1-12
    • (1995) Exp. Tech. Phys. , vol.41 , pp. 1-12
    • Ambrose, W.P.1    Affleck, R.L.2    Goodwin, P.M.3    Keller, R.A.4    Martin, J.C.5
  • 3
    • 0028137086 scopus 로고
    • Alterations of single molecule fluorescence lifetimes in near-field optical microscopy
    • Ambrose WP, Goodwin PM, Martin JC, Keller, RA. 1994. Alterations of single molecule fluorescence lifetimes in near-field optical microscopy. Science 265:364-67
    • (1994) Science , vol.265 , pp. 364-367
    • Ambrose, W.P.1    Goodwin, P.M.2    Martin, J.C.3    Keller, R.A.4
  • 4
    • 0025920682 scopus 로고
    • Fluorescence spectroscopy and spectral diffusion of single impurity molecules in a crystal
    • Ambrose WP, Moerner WE. 1991. Fluorescence spectroscopy and spectral diffusion of single impurity molecules in a crystal. Nature 349:225-27
    • (1991) Nature , vol.349 , pp. 225-227
    • Ambrose, W.P.1    Moerner, W.E.2
  • 5
    • 0029973119 scopus 로고    scopus 로고
    • Direct observation of fast protein folding: The initial collapse of apomyoglobin
    • Ballew RM, Sabelko J, Gruebele M. 1996. Direct observation of fast protein folding: The initial collapse of apomyoglobin. Proc. Natl. Acad. Sci. USA 93:5759-64
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5759-5764
    • Ballew, R.M.1    Sabelko, J.2    Gruebele, M.3
  • 6
    • 0019848925 scopus 로고
    • Fluorescent low-density lipoprotein for observation of dynamics of individual receptor complexes on cultured human-fibroblasts
    • Barak LS, Webb WW. 1981. Fluorescent low-density lipoprotein for observation of dynamics of individual receptor complexes on cultured human-fibroblasts. J. Cell Biol. 90:595-604
    • (1981) J. Cell Biol. , vol.90 , pp. 595-604
    • Barak, L.S.1    Webb, W.W.2
  • 7
    • 0020459573 scopus 로고
    • Diffusion of low-density lipoprotein-receptor complex on human-fibroblasts
    • Barak LS, Webb WW. 1982. Diffusion of low-density lipoprotein-receptor complex on human-fibroblasts J. Cell Biol. 95:846-52
    • (1982) J. Cell Biol. , vol.95 , pp. 846-852
    • Barak, L.S.1    Webb, W.W.2
  • 9
    • 0000185750 scopus 로고
    • Detection of single rhodamine 6G molecules in levitated microdroplets
    • Barnes MD, Ng KC, Whitten WB, Ramsey JM. 1993. Detection of single rhodamine 6G molecules in levitated microdroplets. Anal. Chem. 65:2360-65
    • (1993) Anal. Chem. , vol.65 , pp. 2360-2365
    • Barnes, M.D.1    Ng, K.C.2    Whitten, W.B.3    Ramsey, J.M.4
  • 10
    • 84975646310 scopus 로고
    • Enhanced fluorescence yields through cavity quantum-electrodynamic effects in microdroplets
    • Barnes MD, Whitten WB, Ramsey JM. 1994. Enhanced fluorescence yields through cavity quantum-electrodynamic effects in microdroplets. J. Opt. Soc. Am. B 11:1297-1304
    • (1994) J. Opt. Soc. Am. B , vol.11 , pp. 1297-1304
    • Barnes, M.D.1    Whitten, W.B.2    Ramsey, J.M.3
  • 12
    • 0001660191 scopus 로고
    • Optical modification of a single impurity molecule in a solid
    • Basche T, Moerner WE. 1992. Optical modification of a single impurity molecule in a solid. Nature 355:335-37
    • (1992) Nature , vol.355 , pp. 335-337
    • Basche, T.1    Moerner, W.E.2
  • 13
    • 11944252657 scopus 로고
    • Photon antibunching in the fluorescence of a single dye molecule trapped in a solid
    • Basche T, Moerner WE, Orrit M, Talon H. 1992. Photon antibunching in the fluorescence of a single dye molecule trapped in a solid. Phys. Rev. Lett. 69:1516-19
    • (1992) Phys. Rev. Lett. , vol.69 , pp. 1516-1519
    • Basche, T.1    Moerner, W.E.2    Orrit, M.3    Talon, H.4
  • 14
    • 0030113706 scopus 로고    scopus 로고
    • Spectroscopy commissions of the international union of pure and applied chemistry
    • Bertie JE, Vo-Dinh T. 1996. Spectroscopy commissions of the international union of pure and applied chemistry. Appl. Spectrosc. 50:A12-A20
    • (1996) Appl. Spectrosc. , vol.50
    • Bertie, J.E.1    Vo-Dinh, T.2
  • 15
    • 36149016205 scopus 로고
    • Theory of diffraction by small holes
    • Bethe HA. 1944. Theory of diffraction by small holes. Phys. Rev. 66:163-82
    • (1944) Phys. Rev. , vol.66 , pp. 163-182
    • Bethe, H.A.1
  • 16
    • 0027698450 scopus 로고
    • Single molecules observed by near-field scanning optical microscopy
    • Betzig E, Chichester RJ. 1993. Single molecules observed by near-field scanning optical microscopy. Science 262:1422-25
    • (1993) Science , vol.262 , pp. 1422-1425
    • Betzig, E.1    Chichester, R.J.2
  • 18
    • 21544436741 scopus 로고
    • Combined shear force and near-field scanning optical microscopy
    • Betzig E, Finn PL, Weiner JS. 1992. Combined shear force and near-field scanning optical microscopy. Appl. Phys. Lett. 60:2484-6
    • (1992) Appl. Phys. Lett. , vol.60 , pp. 2484-2486
    • Betzig, E.1    Finn, P.L.2    Weiner, J.S.3
  • 19
    • 3743151120 scopus 로고
    • Near-field optics: Microscopy, spectroscopy, and surface modification beyond the diffraction limit
    • Betzig E, Trautman JK. 1992. Near-field optics: microscopy, spectroscopy, and surface modification beyond the diffraction limit. Science 257:189-95
    • (1992) Science , vol.257 , pp. 189-195
    • Betzig, E.1    Trautman, J.K.2
  • 21
    • 35949012856 scopus 로고
    • Scanning tunneling microscopy: From birth to adolescence
    • Binnig G, Rohrer H. 1987. Scanning tunneling microscopy: from birth to adolescence. Rev. Mod. Phys. 59:615-25
    • (1987) Rev. Mod. Phys. , vol.59 , pp. 615-625
    • Binnig, G.1    Rohrer, H.2
  • 22
    • 0028945734 scopus 로고
    • Nanometres and piconewtons: The macromolecular mechanics of kinesin
    • Block SM. 1995. Nanometres and piconewtons: The macromolecular mechanics of kinesin. Trends Cell Biol. 5:169-75
    • (1995) Trends Cell Biol. , vol.5 , pp. 169-175
    • Block, S.M.1
  • 25
    • 0029970157 scopus 로고    scopus 로고
    • Visualizing protein-nucleic acid interactions on a large scale with the scanning force microscope
    • 24a. Bustamente C, Rivetti C. 1996. Visualizing protein-nucleic acid interactions on a large scale with the scanning force microscope. Annu. Rev. Biophys. Biomol. Struct. 25:395-429
    • (1996) Annu. Rev. Biophys. Biomol. Struct. , vol.25 , pp. 395-429
    • Bustamente, C.1    Rivetti, C.2
  • 26
    • 0000686482 scopus 로고
    • Fluorescence detection and size measurement of single DNA molecules
    • Castro A, Fairfield FR, Shera EB. 1993. Fluorescence detection and size measurement of single DNA molecules. Anal. Chem. 65:849-52
    • (1993) Anal. Chem. , vol.65 , pp. 849-852
    • Castro, A.1    Fairfield, F.R.2    Shera, E.B.3
  • 27
    • 0029369442 scopus 로고
    • Single-molecule electrophoresis
    • Castro A, Shera EB. 1995. Single-molecule electrophoresis. Anal. Chem. 67:3181-86
    • (1995) Anal. Chem. , vol.67 , pp. 3181-3186
    • Castro, A.1    Shera, E.B.2
  • 28
    • 0000259568 scopus 로고    scopus 로고
    • Single-molecule detection in capillary electrophoresis: Molecular shot noise as a fundamental limit to chemical analysis
    • Chen D, Dovichi NJ. 1996. Single-molecule detection in capillary electrophoresis: molecular shot noise as a fundamental limit to chemical analysis. Anal. Chem. 68:690-96
    • (1996) Anal. Chem. , vol.68 , pp. 690-696
    • Chen, D.1    Dovichi, N.J.2
  • 29
    • 0029886063 scopus 로고    scopus 로고
    • Biased diffusion, optical trapping, and manipulation of single molecules in solution
    • Chiu DT, Zare RN. 1996. Biased diffusion, optical trapping, and manipulation of single molecules in solution. J. Am. Chem. Soc. 118:6512-13
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 6512-6513
    • Chiu, D.T.1    Zare, R.N.2
  • 30
    • 0029239703 scopus 로고
    • Analysis of near field tip patterns including object interaction using finite-difference time-domain calculations
    • Christensen DA. 1995. Analysis of near field tip patterns including object interaction using finite-difference time-domain calculations. Ultramicroscopy 57:189-95
    • (1995) Ultramicroscopy , vol.57 , pp. 189-195
    • Christensen, D.A.1
  • 31
    • 0028223378 scopus 로고
    • In vitro selection from protein and peptide libraries
    • Clackson T, Wells JA. 1994. In vitro selection from protein and peptide libraries. Trends Biotechnol. 12:173-84
    • (1994) Trends Biotechnol. , vol.12 , pp. 173-184
    • Clackson, T.1    Wells, J.A.2
  • 33
    • 0001625480 scopus 로고
    • Observation of individual chemical reactions in solution
    • Collinson MM, Wightman RM. 1995. Observation of individual chemical reactions in solution. Science 268:1883-85
    • (1995) Science , vol.268 , pp. 1883-1885
    • Collinson, M.M.1    Wightman, R.M.2
  • 34
    • 0030003076 scopus 로고    scopus 로고
    • Studies on single alkaline phosphatase molecules: Reaction rate and activation energy of a reaction catalyzed by a single molecule and the effect of thermal denaturation - The death of an enzyme
    • Craig DB, Arriaga EA, Wong JCY, Lu H, Dovichi NJ. 1996. Studies on single alkaline phosphatase molecules: reaction rate and activation energy of a reaction catalyzed by a single molecule and the effect of thermal denaturation - the death of an enzyme. J. Am. Chem. Soc. 118:5245-53
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 5245-5253
    • Craig, D.B.1    Arriaga, E.A.2    Wong, J.C.Y.3    Lu, H.4    Dovichi, N.J.5
  • 35
    • 8244234303 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 36
    • 0030575902 scopus 로고    scopus 로고
    • Three-dimensional imaging of single molecules solvated in pores of polyacrylamide gels
    • Dickson RM, Norris DJ, Tzeng Y-L, Moerner WE. 1996. Three-dimensional imaging of single molecules solvated in pores of polyacrylamide gels. Science 274:966-69
    • (1996) Science , vol.274 , pp. 966-969
    • Dickson, R.M.1    Norris, D.J.2    Tzeng, Y.-L.3    Moerner, W.E.4
  • 37
    • 0020658579 scopus 로고
    • Attogram detection limit for aqueous dye samples by laser-induced fluorescence
    • Dovichi NJ, Martin JC, Jett JH, Keller RA. 1983. Attogram detection limit for aqueous dye samples by laser-induced fluorescence. Science 219:845-47
    • (1983) Science , vol.219 , pp. 845-847
    • Dovichi, N.J.1    Martin, J.C.2    Jett, J.H.3    Keller, R.A.4
  • 38
    • 0027182063 scopus 로고
    • DNA sequence determination by hybridization: A strategy for efficient large-scale sequencing
    • Drmanac R, Drmanac S, Strezoska Z, Paunesku T, Labat I, et al. 1993. DNA sequence determination by hybridization: A strategy for efficient large-scale sequencing. Science 260:1649-52
    • (1993) Science , vol.260 , pp. 1649-1652
    • Drmanac, R.1    Drmanac, S.2    Strezoska, Z.3    Paunesku, T.4    Labat, I.5
  • 40
    • 33751159033 scopus 로고
    • Near-field fluorescence imaging and fluorescence lifetime measurement of light harvesting complexes in intact photosynthetic
    • Dunn RC, Holtom GR, Mets L, Xie XS. 1994. Near-field fluorescence imaging and fluorescence lifetime measurement of light harvesting complexes in intact photosynthetic. J. Phys. Chem. 98:3094-98
    • (1994) J. Phys. Chem. , vol.98 , pp. 3094-3098
    • Dunn, R.C.1    Holtom, G.R.2    Mets, L.3    Xie, X.S.4
  • 41
    • 0029900789 scopus 로고    scopus 로고
    • Conformational transitions monitored for single molecules in solution
    • Edman L, Mets U, Rigler R. 1996. Conformational transitions monitored for single molecules in solution. Proc. Natl. Acad. Sci. USA 193:6710-15
    • (1996) Proc. Natl. Acad. Sci. USA , vol.193 , pp. 6710-6715
    • Edman, L.1    Mets, U.2    Rigler, R.3
  • 42
    • 0028229903 scopus 로고
    • Sorting single molecules: Application to diagnostics and evolutionary biotechnology
    • Eigen M, Rigler R. 1994. Sorting single molecules: application to diagnostics and evolutionary biotechnology. Proc. Natl. Acad. Sci. USA 91:5740-47
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5740-5747
    • Eigen, M.1    Rigler, R.2
  • 43
    • 0031037501 scopus 로고    scopus 로고
    • Probing single molecules and single nanoparticles by surface-enhanced Raman scattering
    • In press
    • Emory SR, Nie S. 1997. Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science. In press
    • (1997) Science
    • Emory, S.R.1    Nie, S.2
  • 44
    • 0028927479 scopus 로고
    • Electrochemical detection of single molecules
    • Fan F-R F, Bard AJ. 1995. Electrochemical detection of single molecules. Science 267:871-74
    • (1995) Science , vol.267 , pp. 871-874
    • Fan, F.-R.F.1    Bard, A.J.2
  • 46
    • 0002760785 scopus 로고
    • Fluorescence spectra of single pentacene molecules in p-terphenyl at 1.7 K
    • Fleury L, Tamarat Ph, Lounis B, Bernard J, Orrit M. 1995. Fluorescence spectra of single pentacene molecules in p-terphenyl at 1.7 K. Chem. Phys. Lett. 236:87-95
    • (1995) Chem. Phys. Lett. , vol.236 , pp. 87-95
    • Fleury, L.1    Tamarat, Ph.2    Lounis, B.3    Bernard, J.4    Orrit, M.5
  • 47
    • 0028945654 scopus 로고
    • Imaging of single fluorescent molecules and individual ATP turnovers by single myosin molecules in aqueous solution
    • Funatsu T, Harada Y, Tokunaga M, Saito K, Yanagida T. 1995. Imaging of single fluorescent molecules and individual ATP turnovers by single myosin molecules in aqueous solution. Nature 374:555-59
    • (1995) Nature , vol.374 , pp. 555-559
    • Funatsu, T.1    Harada, Y.2    Tokunaga, M.3    Saito, K.4    Yanagida, T.5
  • 48
    • 0024395540 scopus 로고
    • Digital fluorescence imaging of fusion of influenza virus with erythrocytes
    • Georgiou GN, Morrison IEG, Cherry RJ. 1989. Digital fluorescence imaging of fusion of influenza virus with erythrocytes. FEBS Lett. 250:487-92
    • (1989) FEBS Lett. , vol.250 , pp. 487-492
    • Georgiou, G.N.1    Morrison, I.E.G.2    Cherry, R.J.3
  • 49
    • 0028281482 scopus 로고
    • Automated detection and tracking of individual and clustered cell surface low density lipoprotein receptor molecules
    • Ghosh RN, Webb WW. 1994. Automated detection and tracking of individual and clustered cell surface low density lipoprotein receptor molecules. Biophys. J. 66:1301-18
    • (1994) Biophys. J. , vol.66 , pp. 1301-1318
    • Ghosh, R.N.1    Webb, W.W.2
  • 50
    • 0029269777 scopus 로고
    • Micrometer- And nanometer-sized polymeric light-emitting diodes
    • Granstrom M, Berggren M, Inganas O. 1995. Micrometer- and nanometer-sized polymeric light-emitting diodes. Science 267:1479-81
    • (1995) Science , vol.267 , pp. 1479-1481
    • Granstrom, M.1    Berggren, M.2    Inganas, O.3
  • 52
    • 0029987587 scopus 로고    scopus 로고
    • Probing the interaction between two single molecules: Fluorescence resonance energy transfer between a single donor and a single acceptor
    • Ha T, Enderle Th, Ogletree DF, Chemla DS, Selvin PR, Weiss S. 1996. Probing the interaction between two single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor. Proc. Natl. Acad. Sci. USA 93:6264-68
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6264-6268
    • Ha, T.1    Enderle, Th.2    Ogletree, D.F.3    Chemla, D.S.4    Selvin, P.R.5    Weiss, S.6
  • 53
    • 0029645417 scopus 로고
    • Single molecule fluorescence burst detection of DNA fragments separated by capillary electrophoresis
    • Haab BB, Mathies RA. 1995. Single molecule fluorescence burst detection of DNA fragments separated by capillary electrophoresis. Anal. Chem. 67:3253-60
    • (1995) Anal. Chem. , vol.67 , pp. 3253-3260
    • Haab, B.B.1    Mathies, R.A.2
  • 54
    • 0004098672 scopus 로고
    • How does EcoR1 cleave its recognition site on DNA
    • Halford SE. 1983. How does EcoR1 cleave its recognition site on DNA. Trends Biochem. Sci. 8:455-60
    • (1983) Trends Biochem. Sci. , vol.8 , pp. 455-460
    • Halford, S.E.1
  • 55
    • 0024286273 scopus 로고
    • Scanning tunneling microscopy and atomic force microscopy: Application to biology and technology
    • Hansma PK, Elings VB, Marti O, Bracker CE. 1988. Scanning tunneling microscopy and atomic force microscopy: application to biology and technology. Science 242:209-16
    • (1988) Science , vol.242 , pp. 209-216
    • Hansma, P.K.1    Elings, V.B.2    Marti, O.3    Bracker, C.E.4
  • 57
    • 0025104145 scopus 로고
    • Mechanochemical coupling in actomyosin energy transduction studied by in vitro movement assay
    • Harada Y, Sakurada K, Aoki T, Thomas DD, Yanagida T. 1990. Mechanochemical coupling in actomyosin energy transduction studied by in vitro movement assay. J. Mol. Biol. 216:49-68
    • (1990) J. Mol. Biol. , vol.216 , pp. 49-68
    • Harada, Y.1    Sakurada, K.2    Aoki, T.3    Thomas, D.D.4    Yanagida, T.5
  • 59
    • 0342507903 scopus 로고
    • Micromachining a miniaturized capillary electrophoresis-based chemicalanalysis system on a chip
    • Harrison DJ, Fluri K, Seiler K, Fan ZH, Effenhauser CS, Manz A. 1993. Micromachining a miniaturized capillary electrophoresis-based chemicalanalysis system on a chip. Science 261:895-97
    • (1993) Science , vol.261 , pp. 895-897
    • Harrison, D.J.1    Fluri, K.2    Seiler, K.3    Fan, Z.H.4    Effenhauser, C.S.5    Manz, A.6
  • 60
    • 0029934337 scopus 로고    scopus 로고
    • A molecular yarn: Near-field optical studies of self-assembled, flexible, fluorescent fibers
    • Higgins DA, Kerimo J, Bout DA, Vanden B, Paul F. 1996. A molecular yarn: near-field optical studies of self-assembled, flexible, fluorescent fibers. J. Am. Chem. Soc. 118:4049-58
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 4049-4058
    • Higgins, D.A.1    Kerimo, J.2    Bout, D.A.3    Vanden, B.4    Paul, F.5
  • 61
    • 84975568363 scopus 로고
    • Optical microscopic observation of single small molecules
    • Hirschfeld T. 1976. Optical microscopic observation of single small molecules. Appl. Opt. 15:2965-66
    • (1976) Appl. Opt. , vol.15 , pp. 2965-2966
    • Hirschfeld, T.1
  • 62
    • 0029057460 scopus 로고
    • Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle
    • Irving M, Allen TSC, Sabido DC, Craik JS, Brandmeier B, et al. 1995. Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle. Nature 375:688-91
    • (1995) Nature , vol.375 , pp. 688-691
    • Irving, M.1    Allen, T.S.C.2    Sabido, D.C.3    Craik, J.S.4    Brandmeier, B.5
  • 63
    • 0025822885 scopus 로고
    • Sub-piconewton force fluctuations of actomyosin in vitro
    • Ishijima A, Doi T, Sakurada K, Yanagida T. 1991 Sub-piconewton force fluctuations of actomyosin in vitro. Nature 352:301-6
    • (1991) Nature , vol.352 , pp. 301-306
    • Ishijima, A.1    Doi, T.2    Sakurada, K.3    Yanagida, T.4
  • 64
    • 0028404256 scopus 로고
    • Single-molecule detection by laser-induced fluorescence technique with a position-sensitive photon-counting apparatus
    • Ishikawa M, Hirano K, Hayakawa T, Hosoi S, Brenner S. 1994. Single-molecule detection by laser-induced fluorescence technique with a position-sensitive photon-counting apparatus. Jpn. J. Appl. Phys. 33:1571-76
    • (1994) Jpn. J. Appl. Phys. , vol.33 , pp. 1571-1576
    • Ishikawa, M.1    Hirano, K.2    Hayakawa, T.3    Hosoi, S.4    Brenner, S.5
  • 65
    • 2842550379 scopus 로고    scopus 로고
    • Integrated microdevice for DNA restriction fragment analysis
    • Jacobson SC, Ramsey JM. 1996. Integrated microdevice for DNA restriction fragment analysis. Anal. Chem. 68:720-23
    • (1996) Anal. Chem. , vol.68 , pp. 720-723
    • Jacobson, S.C.1    Ramsey, J.M.2
  • 66
    • 0024461333 scopus 로고
    • High-speed DNA sequencing: An approach based upon fluorescence detection of single molecules
    • Jett J, Keller RA, Martin JC, Marrone BL, Moyzis RK, et al. 1989. High-speed DNA sequencing: An approach based upon fluorescence detection of single molecules. J. Biomol. Struct. Dyn. 7:301-10
    • (1989) J. Biomol. Struct. Dyn. , vol.7 , pp. 301-310
    • Jett, J.1    Keller, R.A.2    Martin, J.C.3    Marrone, B.L.4    Moyzis, R.K.5
  • 67
    • 33751554832 scopus 로고
    • Optical detection and probing of single dopant molecules of pentacene in a p-terphenyl host crystal by means of absorption spectroscopy
    • Kador L, Horne DE, Moerner WE. 1990. Optical detection and probing of single dopant molecules of pentacene in a p-terphenyl host crystal by means of absorption spectroscopy. J. Phys. Chem. 94:1237-48
    • (1990) J. Phys. Chem. , vol.94 , pp. 1237-1248
    • Kador, L.1    Horne, D.E.2    Moerner, W.E.3
  • 70
    • 0029021710 scopus 로고
    • Ultrasensitive hybridization analysis using fluorescence correlation spectroscopy
    • Kinjo M, Rigler R. 1995. Ultrasensitive hybridization analysis using fluorescence correlation spectroscopy. Nucleic Acids Res. 23:1795-99
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1795-1799
    • Kinjo, M.1    Rigler, R.2
  • 71
    • 0002573484 scopus 로고
    • Fluorescence detection of single molecule magnetic resonance for pentacene in p-terphenyl
    • Köhler J, Brouwer ACJ, Groenen EJJ, Schmidt J. 1994. Fluorescence detection of single molecule magnetic resonance for pentacene in p-terphenyl. Chem. Phys. Lett. 228:47-52
    • (1994) Chem. Phys. Lett. , vol.228 , pp. 47-52
    • Köhler, J.1    Acj, B.2    Ejj, G.3    Schmidt, J.4
  • 72
    • 0042254385 scopus 로고
    • Single molecule electron paramagnetic resonance spectroscopy: Hyperfine splitting
    • Köhler J, Brouwer ACJ, Groenen EJJ, Schmidt J. 1995. Single molecule electron paramagnetic resonance spectroscopy: hyperfine splitting. Science 268:1457-60
    • (1995) Science , vol.268 , pp. 1457-1460
    • Köhler, J.1    Brouwer, A.C.J.2    Groenen, E.J.J.3    Schmidt, J.4
  • 74
    • 0028262742 scopus 로고
    • Subwavelength spectroscopy, exciton supertips and mesoscopic light-matter interactions
    • Kopelman R, Weihong T, Birnbaum D. 1994. Subwavelength spectroscopy, exciton supertips and mesoscopic light-matter interactions. J. Lumin. 58:380-87
    • (1994) J. Lumin. , vol.58 , pp. 380-387
    • Kopelman, R.1    Weihong, T.2    Birnbaum, D.3
  • 75
    • 0028988416 scopus 로고
    • 2+ binding to the active site of EcoRV endonuclease: A crystallographic study of complexes with substrate and product DNA at 2 Å resolution
    • 2+ binding to the active site of EcoRV endonuclease: A crystallographic study of complexes with substrate and product DNA at 2 Å resolution. Biochemistry 34:683-96.
    • (1995) Biochemistry , vol.34 , pp. 683-696
    • Kostrewa, D.1    Winkler, F.K.2
  • 76
    • 0000511219 scopus 로고
    • Laser-induced fluorescence detection of a single molecule in a capillary
    • Lee Y, Maus RG, Smith BW, Winefordner JD. 1994. Laser-induced fluorescence detection of a single molecule in a capillary. Anal. Chem. 66:4142-49
    • (1994) Anal. Chem. , vol.66 , pp. 4142-4149
    • Lee, Y.1    Maus, R.G.2    Smith, B.W.3    Winefordner, J.D.4
  • 77
    • 0028908039 scopus 로고
    • Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex
    • Liu B, Alberts BM. 1995. Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Science 267:1131-37
    • (1995) Science , vol.267 , pp. 1131-1137
    • Liu, B.1    Alberts, B.M.2
  • 78
    • 0027443441 scopus 로고
    • The DNA replication fork can pass RNA polymerase without displacing the nascent transcript
    • Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM. 1993. The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Nature 366:33-39.
    • (1993) Nature , vol.366 , pp. 33-39
    • Liu, B.1    Wong, M.L.2    Tinker, R.L.3    Geiduschek, E.P.4    Alberts, B.M.5
  • 79
    • 0031032395 scopus 로고    scopus 로고
    • Understanding single-molecule dynamics at room temperature
    • Lu HP, Xie XS. 1996. Understanding single-molecule dynamics at room temperature. Nature. 385:143-46
    • (1996) Nature , vol.385 , pp. 143-146
    • Lu, H.P.1    Xie, X.S.2
  • 80
    • 8244243027 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 81
    • 8244234302 scopus 로고    scopus 로고
    • Manuscripts in preparation
    • Lyon WA, Nie S. Manuscripts in preparation
    • Lyon, W.A.1    Nie, S.2
  • 82
    • 0000793711 scopus 로고    scopus 로고
    • Imaging and time-resolved spectroscopy of single molecules at an interface
    • Macklin JJ, Trantman JK, Harris TD, Brus LE. 1996. Imaging and time-resolved spectroscopy of single molecules at an interface. Science 272:255-58
    • (1996) Science , vol.272 , pp. 255-258
    • Macklin, J.J.1    Trantman, J.K.2    Harris, T.D.3    Brus, L.E.4
  • 83
    • 0029350755 scopus 로고
    • Super-resolution imaging and detection of fluorescence from single molecules by scanning near-field optical microscopy
    • Meixner AJ, Zeisel D, Bopp MA, Tarrach G. 1995. Super-resolution imaging and detection of fluorescence from single molecules by scanning near-field optical microscopy. Opt. Eng. 34:2324-32
    • (1995) Opt. Eng. , vol.34 , pp. 2324-2332
    • Meixner, A.J.1    Zeisel, D.2    Bopp, M.A.3    Tarrach, G.4
  • 84
    • 0028950997 scopus 로고
    • Optical mapping of lambda bacteriophage clones using restriction endonucleases
    • Meng X, Benson K, Chada K, Huff EJ, Schwartz DC. 1995. Optical mapping of lambda bacteriophage clones using restriction endonucleases. Nat. Genet. 9:432-38
    • (1995) Nat. Genet. , vol.9 , pp. 432-438
    • Meng, X.1    Benson, K.2    Chada, K.3    Huff, E.J.4    Schwartz, D.C.5
  • 85
    • 0010649138 scopus 로고
    • Single-molecule detection by two-photon-excited fluorescence
    • Mertz J, Xu C, Webb WW. 1995. Single-molecule detection by two-photon-excited fluorescence. Opt. Lett. 20:2532-34
    • (1995) Opt. Lett. , vol.20 , pp. 2532-2534
    • Mertz, J.1    Xu, C.2    Webb, W.W.3
  • 86
    • 0000761369 scopus 로고
    • Submillisecond detection of single rhodamine molecules in water
    • Mets U, Rigler R. 1994. Submillisecond detection of single rhodamine molecules in water. J. Fluoresc. 4:259-64
    • (1994) J. Fluoresc. , vol.4 , pp. 259-264
    • Mets, U.1    Rigler, R.2
  • 88
    • 0028467727 scopus 로고
    • Examining nanoenvironments in solids on the scale of a single, isolated impurity molecule
    • Moerner WE. 1994. Examining nanoenvironments in solids on the scale of a single, isolated impurity molecule. Science 265:46-53
    • (1994) Science , vol.265 , pp. 46-53
    • Moerner, W.E.1
  • 89
    • 0000795267 scopus 로고
    • Optical spectroscopy of individual dopant molecules in solids
    • Moerner WE, Basche T. 1993. Optical spectroscopy of individual dopant molecules in solids. Angew. Chem. 105:537-57
    • (1993) Angew. Chem. , vol.105 , pp. 537-557
    • Moerner, W.E.1    Basche, T.2
  • 90
    • 4244084400 scopus 로고
    • Optical detection and spectroscopy of single molecule solids
    • Moerner WE, Kador L. 1989. Optical detection and spectroscopy of single molecule solids. Phys. Rev. Lett. 62:2535-38
    • (1989) Phys. Rev. Lett. , vol.62 , pp. 2535-2538
    • Moerner, W.E.1    Kador, L.2
  • 91
    • 0141673857 scopus 로고
    • Optical probing of single molecules of terrylene in a shpol'kii matrix: A two-state single-molecule switch
    • Moerner WE, Plakhotnik T, Irngartinger T, Croci M, Palm V, Wild UPJ. 1994. Optical probing of single molecules of terrylene in a shpol'kii matrix: A two-state single-molecule switch. J. Phys. Chem. 98:7382-89
    • (1994) J. Phys. Chem. , vol.98 , pp. 7382-7389
    • Moerner, W.E.1    Plakhotnik, T.2    Irngartinger, T.3    Croci, M.4    Palm, V.5    Wild, U.P.J.6
  • 95
    • 0017258698 scopus 로고
    • Single-channel currents recorded from membrane of denervated frog muscle fibres
    • Neher E, Sakmann B. 1976. Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 260:799-802
    • (1976) Nature , vol.260 , pp. 799-802
    • Neher, E.1    Sakmann, B.2
  • 96
    • 0023421854 scopus 로고
    • Detection of single molecules of phycoerythrin in hydrodynamically focused flows by laser-induced fluorescence
    • Nguyen DC, Keller RA, Jett H, Martin JC. 1987. Detection of single molecules of phycoerythrin in hydrodynamically focused flows by laser-induced fluorescence Anal. Chem. 59:2158-61
    • (1987) Anal. Chem. , vol.59 , pp. 2158-2161
    • Nguyen, D.C.1    Keller, R.A.2    Jett, H.3    Martin, J.C.4
  • 97
    • 0028104148 scopus 로고
    • Probing individual molecules with confocal fluorescence microscopy
    • Nie S, Chiu, DT, Zare RN. 1994. Probing individual molecules with confocal fluorescence microscopy. Science 266:1018-21
    • (1994) Science , vol.266 , pp. 1018-1021
    • Nie, S.1    Chiu, D.T.2    Zare, R.N.3
  • 98
    • 11744333526 scopus 로고
    • Real-time detection of single molecules in solution by confocal fluorescence microscopy
    • Nie S, Chiu, DT, Zare RN. 1995. Real-time detection of single molecules in solution by confocal fluorescence microscopy. Anal. Chem. 67:2849-57
    • (1995) Anal. Chem. , vol.67 , pp. 2849-2857
    • Nie, S.1    Chiu, D.T.2    Zare, R.N.3
  • 99
    • 0028459866 scopus 로고
    • Light propagation through nanometer-sized structures: The two-dimensional-aperture scanning near-field optical microscope
    • Novotny L, Pohl DW, Regli P. 1994. Light propagation through nanometer-sized structures: the two-dimensional-aperture scanning near-field optical microscope. J. Opt. Soc. Am. A 11:1768-79
    • (1994) J. Opt. Soc. Am. A , vol.11 , pp. 1768-1779
    • Novotny, L.1    Pohl, D.W.2    Regli, P.3
  • 100
    • 0028066790 scopus 로고
    • Discontinuous mechanism of transcription elongation
    • Nudler E, Goldfarb A, Kashlev M. 1994. Discontinuous mechanism of transcription elongation. Science 265:793-96
    • (1994) Science , vol.265 , pp. 793-796
    • Nudler, E.1    Goldfarb, A.2    Kashlev, M.3
  • 101
    • 0040391480 scopus 로고
    • Single pentacene molecules detected by fluorescence excitation in a p-terphenyl crystal
    • Orrit M, Bernard J. 1990. Single pentacene molecules detected by fluorescence excitation in a p-terphenyl crystal. Phys. Rev. Lett. 65:2716-19
    • (1990) Phys. Rev. Lett. , vol.65 , pp. 2716-2719
    • Orrit, M.1    Bernard, J.2
  • 102
    • 4143105528 scopus 로고
    • High-resolution spectroscopy of organic molecules in solids: From fluorescence line narrowing and hole burning to single molecule spectroscopy
    • Orrit M, Bernard J, Personov RI. 1993. High-resolution spectroscopy of organic molecules in solids: from fluorescence line narrowing and hole burning to single molecule spectroscopy. J. Phys. Chem. 97:10256-68
    • (1993) J. Phys. Chem. , vol.97 , pp. 10256-10268
    • Orrit, M.1    Bernard, J.2    Personov, R.I.3
  • 104
    • 0030056547 scopus 로고    scopus 로고
    • Patch-clamp detection of neurotransmitters in capillary electrophoresis
    • Orwar O, Jardemark K, Jacobson I, Moscho A, Fishman HA, et al. 1996. Patch-clamp detection of neurotransmitters in capillary electrophoresis. Science 272:1779-82
    • (1996) Science , vol.272 , pp. 1779-1782
    • Orwar, O.1    Jardemark, K.2    Jacobson, I.3    Moscho, A.4    Fishman, H.A.5
  • 108
    • 0024689006 scopus 로고
    • Single-molecule fluorescence detection: Autocorrelation criterion and experimental realization with phycoerythrin
    • Peck K, Stryer L, Glazer AN, Mathies RA. 1989. Single-molecule fluorescence detection: Autocorrelation criterion and experimental realization with phycoerythrin. Proc. Natl. Acad. Sci. USA 86:4087-91
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 4087-4091
    • Peck, K.1    Stryer, L.2    Glazer, A.N.3    Mathies, R.A.4
  • 109
    • 0028766432 scopus 로고
    • Direct observation of tube-like motion of a single polymer chain
    • Perkins TT, Smith DE, Chu S. 1994. Direct observation of tube-like motion of a single polymer chain. Science 264:819-22.
    • (1994) Science , vol.264 , pp. 819-822
    • Perkins, T.T.1    Smith, D.E.2    Chu, S.3
  • 110
    • 0026917533 scopus 로고
    • From molecules to cells: Imaging soft samples with the atomic force microscope
    • Radmacher M, Tillmann RW, Fritz M, Gaub HE. 1992. From molecules to cells: imaging soft samples with the atomic force microscope. Science 257:1900-5
    • (1992) Science , vol.257 , pp. 1900-1905
    • Radmacher, M.1    Tillmann, R.W.2    Fritz, M.3    Gaub, H.E.4
  • 111
    • 0030024020 scopus 로고    scopus 로고
    • Fluorescence correlation spectrometry of the interaction kinetics of tetramethylrhodamine alpha-bungarotoxin with Torpedo californica acetylcholine receptor Biophys
    • Rauer B, Neumann E, Widengren J, Rigler R. 1996. Fluorescence correlation spectrometry of the interaction kinetics of tetramethylrhodamine alpha-bungarotoxin with Torpedo californica acetylcholine receptor Biophys. Chem. 58:3-12
    • (1996) Chem. , vol.58 , pp. 3-12
    • Rauer, B.1    Neumann, E.2    Widengren, J.3    Rigler, R.4
  • 112
    • 0029091561 scopus 로고
    • Fluorescence correlations, single molecule detection and large number screening. Applications in biotechnology
    • Rigler R. 1995. Fluorescence correlations, single molecule detection and large number screening. Applications in biotechnology. J. Biotechnol. 41:177-86
    • (1995) J. Biotechnol. , vol.41 , pp. 177-186
    • Rigler, R.1
  • 113
    • 0027317178 scopus 로고
    • Fluorescence correlation spectroscopy with high count rate and low background: Analysis of translational diffusion
    • Rigler R, Mets U, Widengren J, Kask P. 1993. Fluorescence correlation spectroscopy with high count rate and low background: analysis of translational diffusion. Eur. Biophys. J. 22:169-75
    • (1993) Eur. Biophys. J. , vol.22 , pp. 169-175
    • Rigler, R.1    Mets, U.2    Widengren, J.3    Kask, P.4
  • 115
    • 78651119908 scopus 로고
    • Measurement of activity of single molecules of β-D-galactosidase
    • 112a. Rothman B. 1961. Measurement of activity of single molecules of β-D-galactosidase. Proc. Natl. Acad. Sci. USA 47:1981-91
    • (1961) Proc. Natl. Acad. Sci. USA , vol.47 , pp. 1981-1991
    • Rothman, B.1
  • 117
    • 0029654971 scopus 로고
    • Mapping the genome one molecule at a time: Optical mapping
    • Samad AH, Cai WW, Hu XH, Irvin B, Jing JP, et al. 1995. Mapping the genome one molecule at a time: Optical mapping. Nature 378:516
    • (1995) Nature , vol.378 , pp. 516
    • Samad, A.H.1    Cai, W.W.2    Hu, X.H.3    Irvin, B.4    Jing, J.P.5
  • 118
    • 0029129917 scopus 로고
    • Real time imaging of single fluorophores on moving actin with an epifluorescence microscope
    • Sase I, Miyata H, Corrie JET, Craik JS, Kinosita K Jr. 1995. Real time imaging of single fluorophores on moving actin with an epifluorescence microscope. Biophys. J. 69:323-28
    • (1995) Biophys. J. , vol.69 , pp. 323-328
    • Sase, I.1    Miyata, H.2    Corrie, J.E.T.3    Craik, J.S.4    Kinosita Jr., K.5
  • 119
    • 0030599990 scopus 로고    scopus 로고
    • Diode laser based detection of single molecules in solutions
    • Sauer M, Drexhage KH, Zander C, Wolfrum J. 1996. Diode laser based detection of single molecules in solutions. Chem. Phys. Lett. 254:223-28
    • (1996) Chem. Phys. Lett. , vol.254 , pp. 223-228
    • Sauer, M.1    Drexhage, K.H.2    Zander, C.3    Wolfrum, J.4
  • 120
    • 0029463142 scopus 로고
    • Flow-based continuous DNA sequencing via single molecule detection of enzymatically cleaved fluorescent nucleotides
    • Schecker JA, Goodwin PM, Affleck RL, Wu M, Martin JC, et al. 1995. Flow-based continuous DNA sequencing via single molecule detection of enzymatically cleaved fluorescent nucleotides. Proc. SPIE - Int. Soc. Opt. Eng. 2386:4-12
    • (1995) Proc. SPIE - Int. Soc. Opt. Eng. , vol.2386 , pp. 4-12
    • Schecker, J.A.1    Goodwin, P.M.2    Affleck, R.L.3    Wu, M.4    Martin, J.C.5
  • 121
    • 33750626346 scopus 로고
    • Characterization of photophysics and mobility of single molecules in a fluid lipid-membrane
    • Schmidt T, Schutz GJ, Baumgartner W, Gruber HJ, Schindler H. 1995. Characterization of photophysics and mobility of single molecules in a fluid lipid-membrane. J. Phys. Chem. 99:17662-68
    • (1995) J. Phys. Chem. , vol.99 , pp. 17662-17668
    • Schmidt, T.1    Schutz, G.J.2    Baumgartner, W.3    Gruber, H.J.4    Schindler, H.5
  • 123
    • 21544480371 scopus 로고
    • A micropipette force probe suitable for near-field scanning optical microscopy
    • Shalom S, Lieberman K, Lewis A. 1992. A micropipette force probe suitable for near-field scanning optical microscopy. Rev. Sci. Instrum. 63:4061-65
    • (1992) Rev. Sci. Instrum. , vol.63 , pp. 4061-4065
    • Shalom, S.1    Lieberman, K.2    Lewis, A.3
  • 125
    • 0030024985 scopus 로고    scopus 로고
    • Overstretching b-DNA: The elastic response of individual double-stranded and single-stranded DNA molecules
    • Smith SB, Cui Y, Bustamante C. 1996. Overstretching b-DNA: The elastic response of individual double-stranded and single-stranded DNA molecules. Science 271:795-99
    • (1996) Science , vol.271 , pp. 795-799
    • Smith, S.B.1    Cui, Y.2    Bustamante, C.3
  • 126
    • 21144474938 scopus 로고
    • Detection and identification of single molecules in solution
    • Soper SA, Davis LM, Shera EB. 1992. Detection and identification of single molecules in solution. J. Opt. Soc. Am. B 9:1761-69
    • (1992) J. Opt. Soc. Am. B , vol.9 , pp. 1761-1769
    • Soper, S.A.1    Davis, L.M.2    Shera, E.B.3
  • 127
    • 0001120071 scopus 로고
    • Photon burst detection of single near-infrared fluorescent molecules
    • Soper SA, Mattingly QL, Vegunta P. 1993. Photon burst detection of single near-infrared fluorescent molecules. Anal. Chem. 65:740-47
    • (1993) Anal. Chem. , vol.65 , pp. 740-747
    • Soper, S.A.1    Mattingly, Q.L.2    Vegunta, P.3
  • 128
    • 0001469758 scopus 로고
    • Single-molecule detection of rhodamine 6G in ethanolic solutions using continuous wave laser excitation
    • Soper SA, Shera EB, Martin JC, Jett JH, Hahn JH, et al. 1991. Single-molecule detection of rhodamine 6G in ethanolic solutions using continuous wave laser excitation. Anal. Chem. 63:432-37
    • (1991) Anal. Chem. , vol.63 , pp. 432-437
    • Soper, S.A.1    Shera, E.B.2    Martin, J.C.3    Jett, J.H.4    Hahn, J.H.5
  • 129
    • 0029962816 scopus 로고    scopus 로고
    • DNA chips: Analysing sequence by hybridization to oligonucleotides on a large scale
    • Southern EM. 1996. DNA chips: Analysing sequence by hybridization to oligonucleotides on a large scale. Trends Genet. 12:110-15
    • (1996) Trends Genet. , vol.12 , pp. 110-115
    • Southern, E.M.1
  • 130
    • 0028075752 scopus 로고
    • How molecular motors work
    • Spudich JA. 1994. How molecular motors work. Nature 372:515-18
    • (1994) Nature , vol.372 , pp. 515-518
    • Spudich, J.A.1
  • 132
    • 0028320267 scopus 로고
    • Analysis of fluorescence lifetime data for single rhodamine molecules in flowing sample streams
    • Tellinghuisen J, Goodwin PM, Ambrose WP, Martin JC, Keller RA. 1994. Analysis of fluorescence lifetime data for single rhodamine molecules in flowing sample streams. Anal. Chem. 66:64-72
    • (1994) Anal. Chem. , vol.66 , pp. 64-72
    • Tellinghuisen, J.1    Goodwin, P.M.2    Ambrose, W.P.3    Martin, J.C.4    Keller, R.A.5
  • 133
    • 0028269587 scopus 로고
    • Near-field spectroscopy of single molecules at room temperature
    • Trautman JK, Macklin JJ, Brus LE, Betzig E. 1994. Near-field spectroscopy of single molecules at room temperature. Nature 369:40-42
    • (1994) Nature , vol.369 , pp. 40-42
    • Trautman, J.K.1    Macklin, J.J.2    Brus, L.E.3    Betzig, E.4
  • 134
    • 0025900542 scopus 로고
    • Quantized velocities at low myosin densities in an in vitro motility assay
    • Uyeda TQP, Warrick HM, Kron SJ, Spudich JA. 1991. Quantized velocities at low myosin densities in an in vitro motility assay. Nature 352:307-11
    • (1991) Nature , vol.352 , pp. 307-311
    • Uyeda, T.Q.P.1    Warrick, H.M.2    Kron, S.J.3    Spudich, J.A.4
  • 135
    • 0029267575 scopus 로고
    • Parameter control, characterization, and optimization in the fabrication of optical fiber near-field probes
    • Valaskovic GA, Holton M, Morrison GH. 1995. Parameter control, characterization, and optimization in the fabrication of optical fiber near-field probes. Appl. Opt. 34:1215-28
    • (1995) Appl. Opt. , vol.34 , pp. 1215-1228
    • Valaskovic, G.A.1    Holton, M.2    Morrison, G.H.3
  • 137
    • 0028938496 scopus 로고
    • Divalent metal ions at the active sites of the EcoRV and EcoRI restriction endonucleases
    • Vipond IB, Baldwin GS, Halford SE. 1995. Divalent metal ions at the active sites of the EcoRV and EcoRI restriction endonucleases. Biochemistry 34:697-704
    • (1995) Biochemistry , vol.34 , pp. 697-704
    • Vipond, I.B.1    Baldwin, G.S.2    Halford, S.E.3
  • 138
    • 0029029468 scopus 로고
    • Discontinuous movements of DNA and RNA in RNA polymerase accompany formation of a paused transcription complex
    • Wang D, Meier TI, Chan CL, Feng G, Lee DN, Landick R. 1995. Discontinuous movements of DNA and RNA in RNA polymerase accompany formation of a paused transcription complex. Cell 81:341-50
    • (1995) Cell , vol.81 , pp. 341-350
    • Wang, D.1    Meier, T.I.2    Chan, C.L.3    Feng, G.4    Lee, D.N.5    Landick, R.6
  • 139
    • 9644263074 scopus 로고
    • Intermittency of single molecule reaction dynamics in fluctuating environments
    • Wang J, Wolynes P. 1995. Intermittency of single molecule reaction dynamics in fluctuating environments. Phys. Rev. Lett. 74:4317-20
    • (1995) Phys. Rev. Lett. , vol.74 , pp. 4317-4320
    • Wang, J.1    Wolynes, P.2
  • 140
    • 0028919171 scopus 로고
    • Optical mapping of site-directed cleavages on single DNA by the RecA-assisted restriction endonuclease technique
    • Wang, Y-K, Huff EJ, Schwartz DC. 1995. Optical mapping of site-directed cleavages on single DNA by the RecA-assisted restriction endonuclease technique. Proc. Natl. Acad. Sci. USA 92:165-69
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 165-169
    • Wang, Y.-K.1    Huff, E.J.2    Schwartz, D.C.3
  • 142
    • 0039025943 scopus 로고
    • Fluorescence correlation spectroscopy of triplet states in solution: A theoretical and experimental study
    • Widengren J. 1995. Fluorescence correlation spectroscopy of triplet states in solution: a theoretical and experimental study. J. Phys. Chem. 99:13368-79
    • (1995) J. Phys. Chem. , vol.99 , pp. 13368-13379
    • Widengren, J.1
  • 143
    • 0000934691 scopus 로고
    • Triplet-state monitoring by fluorescence correlation spectroscopy
    • Widengren J, Rigler R, Mets U. 1994. Triplet-state monitoring by fluorescence correlation spectroscopy. J. Fluoresc. 4:255-58
    • (1994) J. Fluoresc. , vol.4 , pp. 255-258
    • Widengren, J.1    Rigler, R.2    Mets, U.3
  • 144
    • 36448999220 scopus 로고
    • Detection and lifetime measurement of single molecules in flowing sample streams by laser-induced fluorescence
    • Wilkerson CW Jr, Goodwin PM, Ambrose WP, Martin JC, Keller RA. 1993. Detection and lifetime measurement of single molecules in flowing sample streams by laser-induced fluorescence Appl. Phys. Lett. 62:2030-32
    • (1993) Appl. Phys. Lett. , vol.62 , pp. 2030-2032
    • Wilkerson Jr., C.W.1    Goodwin, P.M.2    Ambrose, W.P.3    Martin, J.C.4    Keller, R.A.5
  • 145
    • 0029645606 scopus 로고
    • Ultra-high-speed DNA sequencing using capillary electrophoresis chips
    • Woolley AT. 1995. Ultra-high-speed DNA sequencing using capillary electrophoresis chips. Anal. Chem. 67:3676-80
    • (1995) Anal. Chem. , vol.67 , pp. 3676-3680
    • Woolley, A.T.1
  • 147
    • 0042660688 scopus 로고    scopus 로고
    • Near-field microscopy and spectroscopy of single molecules, single proteins, and biological membranes
    • River Edge, NJ: World Science
    • Xie XS, Bian RX, Dunn RC, Wu JL, Chen PC, eds. 1996. Near-field microscopy and spectroscopy of single molecules, single proteins, and biological membranes. In Focus of Modern Microscopy. River Edge, NJ: World Science
    • (1996) Focus of Modern Microscopy
    • Xie, X.S.1    Bian, R.X.2    Dunn, R.C.3    Wu, J.L.4    Chen, P.C.5
  • 148
    • 0028137085 scopus 로고
    • Probing single molecule dynamics
    • Xie XS, Dunn RC. 1994. Probing single molecule dynamics. Science 265:361-64
    • (1994) Science , vol.265 , pp. 361-364
    • Xie, X.S.1    Dunn, R.C.2
  • 149
    • 0028934277 scopus 로고
    • Differences in the chemical reactivity of individual molecules of an enzyme
    • Xue Q, Yeung ES. 1995. Differences in the chemical reactivity of individual molecules of an enzyme. Nature 373:681-83
    • (1995) Nature , vol.373 , pp. 681-683
    • Xue, Q.1    Yeung, E.S.2
  • 150
    • 0027296257 scopus 로고
    • Nano-manipulation of actomyosin molecular motors in vitro, a new working principle
    • Yanagida T, Harada Y, Ishijima A. 1993. Nano-manipulation of actomyosin molecular motors in vitro, a new working principle. Trends Biochem. Sci. 18:319-24
    • (1993) Trends Biochem. Sci. , vol.18 , pp. 319-324
    • Yanagida, T.1    Harada, Y.2    Ishijima, A.3
  • 154
    • 0030023197 scopus 로고    scopus 로고
    • Progress in the application of scanning probe microscopy to biology
    • You H X, Lowe CR. 1996. Progress in the application of scanning probe microscopy to biology. Curr. Opin. Biotechnol. 7:78-84
    • (1996) Curr. Opin. Biotechnol. , vol.7 , pp. 78-84
    • You, H.X.1    Lowe, C.R.2


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