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Volumn 9, Issue 2, 1997, Pages 239-244

B cell development and differentiation

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 0030887833     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80142-2     Document Type: Article
Times cited : (78)

References (62)
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    • Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition
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    • of special interest Papavasiliou F, Jankovic M, Nussenzweig MC. Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition. J Exp Med. 184:1996;2025-2030 In RAG-1/ 5 double-knockout mice, membrane μ HC transgenes were unable to promote pre-B cell progression, but either λ5 or λLC transgenes could complement this deficiency thus providing direct support for the dual pathways of early B cell development.
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    • of special interest Lffert D, Ehlich A, Mller W, Rajewsky K. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:1996;133-144 This study employed single cell polymerase chain reaction analysis of VDJ rearrangements on both alleles to demonstrate allelic inclusion in early pre-B cells and allelic exclusion in B cells of λ5 knockout mice. The data indicate that pre-BCR expression can terminate the VDJ rearrangement process. Cells that pursue the alternate pathway with early LC VJ rearrangements presumably become B cells to account for the limited numbers of these cells that are generated in these mice. This paper also provides evidence for the mediation of allelic exclusion at the IgH locus by a Dμ pre-BCR.
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    • Interleukin 7 independent development of human B cells
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.