The role of cytogenetics in the classification of soft tissue tumours

Virchows Archiv

Volumn 431, Issue 2, 1997, Pages 83-94

  Dei Tos, Angelo P ^a   Dal Cin, Paola ^b  

^a City Hospital   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Classification; Cytogenetics; Soft tissue tumours

Indexed keywords

ADIPOSE TISSUE; CANCER CLASSIFICATION; CHROMOSOME 11Q; CHROMOSOME 16Q; CHROMOSOME 18; CHROMOSOME 20; CHROMOSOME 8Q; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 1; CHROMOSOME TRANSLOCATION 13; CHROMOSOME TRANSLOCATION 17; CHROMOSOME TRANSLOCATION 2; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 9; CYTOGENETICS; DERMATOFIBROSARCOMA PROTUBERANS; EWING SARCOMA; FIBROSARCOMA; GIANT CELL TUMOR; HUMAN; LIPOSARCOMA; MESENCHYMOMA; NEUROECTODERM TUMOR; PRIORITY JOURNAL; REVIEW; RHABDOMYOSARCOMA; RING CHROMOSOME; SOFT TISSUE TUMOR; TRISOMY 8; UTERUS MYOMA; X CHROMOSOME;

CHROMOSOMES, HUMAN; HUMANS; KARYOTYPING; MOLECULAR BIOLOGY; SOFT TISSUE NEOPLASMS;

EID: 0030823151     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050073     Document Type: Review

References (110)

1. Alava E de, Ladanyi M, Rosai J, Gerald WL (1995) Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. Am J Pathol 147:1584-1591
2. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82:57-65
3. Aurias A, Rimbaut C, Buffe D, Zucker J-M, Mazabraud A (1984) Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cytogenet 12:21-25
4. Beham A, Fletcher CDM (1990) Dermatofibrosarcoma protuberans with areas resembling giant cell fibroblastoma: report of two cases. Histopathology 17:165-167
5. Biegel JA, Rorke LB, Packer RJ, Emanuel BS (1992) Monosomy 22 in rhabdoid or atypical tumors of the brain. J Neurosurg 37:710-714
6. Boghosian L, Dal Cin P, Turc-Carel C, Karakousis C, Rao U, Sait S, Sandberg AA (1989) Three possible cytogenetic subgroups of leiomyosarcomas. Cancer Genet Cytogenet 43: 39-49
7. Bonnici AV, Birjandi F, Spencer JD, Fox SP, Berry AC (1992) Chromosomal abnormalities in Dupuytren's contracture and carpal tunnel syndrome. J Hand Surg [Br] 17: 349-355
8. Crew AJ, Clark J, Fisher C, Gill S, Grimer R, Chand A, Shipley J, Gusterson BA, Cooper CS (1995) Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 14:2333-2340
9. Crozat A, Aman P, Mandahl N, Ron D (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363:640-644
10. Cummings O, Ulbright TM, Young RH, Dei Tos AP, Fletcher CDM, Hull TM (1997) Desmoplastic small round cell tumors of the paratesticular region: a report of six cases. Am J Surg Pathol 21:219-225
11. Dal Cin P, Van de Berghe H (1997) Ten years of the cytogenetics of soft tissue tumors. Cancer Genet Cytogenet (in press)
12. Dal Cin P, Kools, P, Sciot R, De Wever I, Van Damme B, Van de Ven W, Van Den Berghe H (1993) Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet 68:85-90
13. Dal Cin P, Sciot R, De Wever I, Van Damme B, Van den Berghe H (1994) New discriminative chromosomal marker in adipose tissue tumors. The chromosome 8q11-q13 region in lipoblastoma. Cancer Genet Cytogenet 78:232-235
14. Dal Cin P, Sciot, R, Samson I, De Smet L, De Wever I, Van Damme B, Van den Berghe H (1994) Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). Cancer Res 54:3986-3987
15. Dal Cin P, Moerman P, Deprest J, Brosens I, Van den Berghe H (1995) A new Cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3. Genes Chromosom Cancer 13:219-220
16. Dal Cin P, Pauwels P, Sciot R, Van den Berghe H (1996) Multiple chromosome rearrangements in a fibrosarcoma. Cancer Genet Cytogenet 87:176-178
17. Dal Cin P, Sciot R, De Wever I, Brock P, Casteels-Van Daele M, Van Damme B, Van den Berghe H (1996) Cytogenetic and immunohistochemical evidence that giant cell fibroblas toma is related to dermatofibrosarcoma protuberans. Genes Chromosom Cancer 15:73-75
18. Dal Cin P, Qi H, Sciot R, Van den Berghe H (1997) Involvement of chromosomes 6 and 11 in a soft tissue chondroma. Cancer Genet Cytogenet (in press)
19. Dal Cin P, Sciot R, Panagopoulos I, Aman P, Smason I, Mandhal N, Mitelman F, Van de Berghe H, Fletcher CDM (1997) Additional evidence of a variant translocation t(12;22) with EWS/CHOP usion in myxoid liposarcoma: clinicopathologic features. J Pathol (Lond) (in press)
20. Dangel A, Meloni AM, Lunch HT, Sandberg AA (1994) Deletion (5q) in a desmoid tumor of a patient with Gardner's syndrome. Cancer Genet Cytogenet 78:94-98.39
21. Davis RJ, D'Cruz CM, Lovell MA, Biegel JA. Barr FG (1994) Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res 54: 2869-2872
22. Dei Tos AP, Doglioni C, Laurino L, Barbareschi M, Fletcher CDM (1993) p53 protein expression in non neoplastic lesions and benign and malignant neoplasms of soft tissue. Histopathology 22:45-50
23. Dei Tos AP, Mentzel T, Newman PL, Fletcher CDM (1994) Spindle cell liposarcoma: a hitherto unrecognized variant of well-differentiated liposarcoma: analysis of six cases. Am J Surg Pathol 18:913-921
24. MIC2 (CD99) in synovial sarcoma. A potential cause of diagnostic confusion. Appl Immunohistochem 3:168-173
25. Dei Tos AP, Maestro R, Doglioni C, Piccinin S, Della Libera D, Boiocchi M, Fletcher CDM (1996) Tumor suppressor genes and related molecules in leiomyosarcoma. Am J Pathol 148:1037-1045
26. Dei Tos AP, Doglioni C, Piccinin S, Maestro R, Mentzel T, Barbareschi M, Boiocchi M, Fletcher CDM (1997) Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. J Pathol (Lond) 181:8-13
27. Dei Tos AP, Wadden C, Fletcher CDM (1997) Extraskeletal myxoid chondrosarcoma: an immunohistochemical reappraisal of 39 cases. Appl Immunohistochem (in press)
28. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, Jong P de, Rouleau G, Aurias A. Thomas G (1992) Gene fusion with an KTS DNA-binding domain eaused by chromosome translocation in human tumours. Nature 359:162-165
29. Delattre O, Zucman J, Melot T, Garau XS, Zucker J-M, Lenoir GM, Ambros PF, Sheer D, Turc-Carel C, Triche TJ, Aurisa A, Thomas G (1994) The Ewing family of tumors. A subgroup of small-round-cell tumours defined by specific chimeric transcripts. N Engl J Med 331:294-299
30. Dijkhuizen T, Berg E van den. Molenaar WM, Meuzelaar JJ. Jong B de (1995) Rearrangements involving 12p12 in two cases of cardiac myxoma. Cancer Genet Cytogenet 82: 161-162
31. Donner LR (1994) Cytogenetics of tumors of soft tissue and bone. Implications for pathology. Cancer Genet Cytogenet 78:115-126
32. Douglass EC, Valentine M, Etcubanas E, Parham D, Webber BL, Houghton PJ, Green AA (1987) A specific chromosomal abnormality in rhabdomyosarcoma. Cytogenet Cell Genet 45: 148-155
33. Douglass EC, Valentine M, Rowe ST, Parham DM, Wilimas JA, Sanders JM, Houghton PJ (1990) Malignant rhabdoid tumor: a highly malignant childhood tumor with minimal karyotypic changes. Genes Chromosom Cancer 2:210-216
34. Downing JR, Khandekar A, Shurtleff SA, Head DR, Parham DM, Webber BL, Pappo AS, Hulshof MG, Conn WP, Shapiro DN (1995) Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Am J Pathol 146:626-634
35. Enzinger RM, Weiss SW (eds) (1995) Soft tissue tumors, 3rd edn. Mosby, St. Louis
36. Evans HL (1979) Liposarcoma. A study of 55 cases with a reassessment of its classification. Am J Surg Pathol 3:507-523
37. Fletcher CDM (1991) Angiomatoid "malignant fibrous histiocytoma". An immunohistochemical study indicative of myoid differentiation. Hum Pathol 22:563-568
38. Fletcher CDM (1992) Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 16:213-228
39. Fletcher CDM (1995) Soft tissue tumors. In: Fletcher CDM (ed) Diagnostic histopathology of tumors. Churchill-Livingstone, Edinburgh, pp 1043-1096
40. Fletcher CDM, McKee PH (1990) Pathobiology of soft tissue tumours. Churchill-Livingstone, Edinburgh
41. Fletcher CDM, Akerman M, Dal Cin P, De Wever I, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, Van den Berghe H, Van de Ven W, Vanni R, Willen H (1996) Correlation between clinicopathological features and karyotype in lipomatous tumors. Am J Pathol 148: 623-630
42. Fletcher JA (1995) Cytogenetic analysis of soft tissue tumors. In: Enzinger RM, Weiss SW (eds) Soft tissue tumors, 3rd edn. Mosby, St Louis, pp 105-118
43. Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (1995) Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. Am J Pathol 147:1592-1599
44. Foschini MP, Eusebi V (1994) Alveolar soft part sarcoma: a new type of rhabdomyosarcoma? Semin Diagn Pathol 11: 58-68
45. Galili N, Davis RJ, Frederickx WJ, Mukhopadhyay S, Rauscher FJ III, Emanuel BJ, Rovera G, Barr FG (1993) Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet 5:230-235
46. Gerald WL, Miller HK, Battifora H, Miettinen M, Silva EG, Rosai J (1991) Intra-abdominal desmoplastic small roundcell tumor. Report of 19 cases of a distinctive type of high grade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol 15:499-513
47. Gerald WL, Ladunyi M, de Alava E, Rosai J (1995) Desmoplastic small round-cell tumor: a recently recognized tumor type associated with a unique gene fusion. Adv Anat Pathol 2:341-345
48. Giannini C, Scheithauer BW, Jenkins RB, Erlandson RA, Borell TJ, Hoda RS, Woodruff JM (1997) Soft tissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 21:164-173
49. Grosschedl R, Giese K, Pagel J (1994) HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet 10:94-100
50. Guillou L, Wadden C, Kraus MD, Dei Tos AP, Fletcher CDM (1996) S-100 protein reactivity in synovial sarcomas: a potentially frequent diagnostic pitfall. Immunohistochemical analysis of 100 cases. Appl Immunohistochem 4:167-175
51. Hindkjaer J, Hammoudah SAFM, Hansen KB, Jensen PD, Koch J, Pedersen B (1995) Translocation (1;16) identified by chromosome painting and PRimed IN Situ-labeling (PRINS). Cancer Genet Cytogenet 79:15-20
52. Jeon I, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN (1995) A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 10:1229-1234
53. Jhanwar SC, Chen Q, Li FP, Brennan MF, Woodruff JM (1994) Cytogenetic analysis of soft tissue sarcomas. Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). Cancer Genet Cytogenet 78: 138-144
54. Kazmierczak B, Wanschura S, Meyer-Bolte K, Caselitz J, Meister P, Bartnitzke S, Van de Ven W, Bullerdiek J (1995) Cytogenetic and molecular analysis of an aggressive angiomyxoma. Am J Pathol 147:580-585
55. Kazmierczak B, Rosigkeit J, Wanschura S, Meyer-Bolte K, Van de Ven WJM, Kayser K, Krieghoff B, Kastendiek HK, Bartnitzke S, Bullerdiek J (1996) HMGI-C rearrangements at the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene 12:515-521
56. Kazmierczak B, Wanschura S, Rommel B, Bartnitzke S, Bullerdiek J (1996) Ten pulmonary chondroid hamartomas with chromosome 6p21 breakpoints within the HMG-I(Y) gene or its immediate surroundings. J Natl Cancer Inst 17:1234-1236
57. Kazmierczak B, Bol S, Wanschura S, Bartnitzke S, Bullerdiek J (1996) A PAC clone containing the HMGI-(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line. Genes Chromosom Cancer 17:191-193
58. Kilpatrick SE, Hitchcock MG, Kraus MD, Calonje E, Fletcher CDM (1997) Mixed tumor and myoepithelioma of soft tissue: a clinicopathologic study of 19 cases with a unifying concept. Am J Surg Pathol 21:13-22
59. Knight JC, Renwick PJ, Dal Cin P, Van den Berghe H, Fletcher CDM (1995) Translocation t(12;16)(q13:p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 55:24-27
60. Kuroda M, Ishida T, Horiuchi H, Kida N, Uozaki H, Takeuchi H, Tsuji K, Mori S, Machinami R, Watanabe T (1995) ChimericTLS/FUS-CHOP gene expression and heterogeneity of its junction in human myxoid and round cell liposarcoma. Am J Pathol 147:1221-1227
61. Labelle YK, Zucman J, Stenman G, Kindblom L-G, Knight J, Turc-Carel C, Dockhkorn-Dworniczak B, Mandahl N, Dezmase C, Peter M, Aurias A, Delattre O, Thomas G (1995) Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. Hum Mol Genet 4:2219-2226
62. Ladanyi M (1995) The emerging molecular genetics of sarcoma translocations. Diagn Mol Pathol 4:162-173
63. Mandahl N, Heim S, Willén H, Rydholm A, Eneroth M, Nilbert M, Kreicbergs A, Mitelman F (1989) Characteristic karyotypic anomalies identify subtypes of malignant fibrous histiocytoma. Genes Chromosom Cancer 1:9-14
64. Mandahl N, Akerman M, Aman P, Dal Cin P, De Wever I, Fletcher CDM, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, Van Den Berghe H, Van de Ven W, Vanni R, Willén H (1996) Duplication of chromosome segment 12q 15-24 is associated with atypical lipomatous tumors: a report of the CHAMP collaborative study group. Int J Cancer 67:632-635
65. Martuza RL, Elridge R (1983) Neurofibromatosis 2 (bilateral acoustic neurofibromatosis). N Engl J Med 318:684-688
66. McCormick D, Mentzel T, Beham A, Fletcher CDM (1994) Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol 18:1213-1223
67. Meltzer PS (1995) Molecular biology of soft tissue tumors. In: Enzinger RM, Weiss SW (eds) Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 89-104
68. Mentzel T, Fletcher CDM (1995) Lipomatous tumours of the soft tissues: an update. Virchows Arch 427:353-363
69. Mentzel T, Fletcher CDM (1997) The emerging role of myofibroblasts in soft tissue neoplasia. Am J Clin Pathol (in press)
70. Mentzel T, Calonje E, Fletcher CDM (1993) Lipoblastoma and lipoblastomatosis: a clinicopathologic sudy of 14 cases. Histopathology 23:527-533
71. Mentzel T, Calonje E, Fletcher CDM (1994) Leiomyosarcoma with prominent osteoclast-like giant cell. Analysis of eight cases closely mimicking the so-called giant cell variant of malignant fibrous histiocytoma. Am J Surg Pathol 18: 258-265
72. Mentzel T, Dei Tos AP, Fletcher CDM (1994) Perineurioma (storiform perineurial fibroma): clinicopathologic analysis of four cases. Histopathology 25:261-267
73. Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, Fletcher CDM (1996) Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low grade variant. Am J Surg Pathol 20:391-405
74. Mertens F, Rydholm A, Brosjo O, Willen H, Mitelman F, Mandahl N (1994) Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer 58: 503-505
75. Mitelman F (1994) Catalog of chromosome aberrations in cancer, 5th edn. Wiley-Liss, New York
76. Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Tanaka K, Takahashi H, Muraoka M, Mori T, Konishi F, Iwama T (1993) Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis. Cancer Res 53:5079-5082
77. Mugneret F, Lizard S, Aurias A, Turc-Carel C (1988) Chromosomes in Ewing's sarcoma II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16). Cancer Genet Cytogenet 32:239-245
78. Naeem R, Lux ML, Huang S-F, Naber SP, Corson JM, Fletcher JA (1995) Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. Am J Pathol 147:1553-1558
79. Nakayama T, Toguchida, Wadayama B, Kanobe H, Kotoura Y, Sasaki MS (1995) mdm2 amplification in soft tissue tumours: association with tumour progression in differentiated adipose tissue tumours. Int J Cancer 64:342-346
80. Nowell PC, Hungerford DA (1960) A minute chromosome in human chronic granulocytic leukemia. Science 132:1497
81. Ouchida M, Ohno T, Fujimura Y, Rao VN, Reddy ESP (1995) Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts. Oncogene 11:1049-1054
82. Panagopoulos I, Höglund M, Mertens F, Mandahl N, Mitelman F, Åman P (1996) Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene 12: 489-494
83. Parham DM, Shapiro DN, Downing JR, Webber BL, Douglass EC (1994) Solid alveolar rhabdomyosarcomas with the t(2;13). Am J Surg Pathol 18:474-478
84. Parham DM, Weeks DA, Beckwith JB (1994) The clinicopathologic spectrum of putative extrarenal rhabdoid tumors. An analysis of 42 cases studied with immunohistochemistry and/or electron microscopy. Am J Surg Pathol 18: 1010-1029
85. Parkash V, Gerald WL, Parma A, Miettinen M, Rosai J (1995) Desmoplastic small round cell tumor of the pleura. Am J Surg Pathol 19:659-665
86. Petit MR, Mois R, Schoenmakers EFPM, Mandhal N, Van de Ven WJM (1996) LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 86:118-129
87. Qi H, Dal Cin P, Hernández JM, Garcia JL, Sciot R, Fletcher C, Van Eyken P, De Wever I, Van den Berghe H (1996) Trisomies 8 and 20 in desmoid tumors. Cancer Genet Cylogenet 92:147-149
88. Rabbitts TH (1994) Chromosomal translocations in human cancer. Nature 372:143-149
89. Rosai J, Akerman M, Dal Cin P, De Wever I, Fletcher CDM, Mandahl N, Mertens F, Mitelman F, Rydholm A, Sciot R, Tallini G, Van den Berghe H, Van de Ven W, Vanni R, Willén H (1996) Combined morphologic and karyotypic study of 59 atypical lipomatous tumors: evaluation of their relationship and differential diagnosis with other adipose tissue tumors. Am J Surg Pathol 20:1182-1189
90. Sandberg AA (1990) The chromosomes in human cancer and leukemia. 2nd edn. Elsevier, New York
91. Sandberg AA, Bridge JA (1994) The cytogenetics of bone and soft tissue tumors. Landes, Austin, pp 75-124
92. Schoenmakers EFPM, Wanchura S, Mols R. Bullerdiek J, Van den Berghe H, Van de Ven W (1995) Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 10:436-144
93. Schofield DE, Fletcher JA, Grier HE, Yunis EJ (1994) Fibrosarcoma in infants and children. Am J Surg Pathol 18:14-24
94. Shmookler BM: Enzinger FM, Weiss SW (1989) Giant cell fibroblastoma. A juvenile form of dermatofibrosarcoma protuberans. Cancer 17:165-167
95. Sciot R, Dal Cin P, De Vos R, Van Damme B, De Wever I, Van den Berghe H, Desmet V (1993) Alveolar soft part sarcoma: evidence for its myogenic origin and for the involvement of 17q25. Histopathology 23:439-444
96. Sciot R, Dal Cin P, Fletcher CDM, Samson I, Smith M, De Vos R, Van Damme B, Van den Berghe H (1995) t(9;22)(q22-31;q11-12) is a consistent marker of extraskeletal myxoid chondrosarcoma: evaluation of 3 cases. Mod Pathol 8: 765-768
97. Sciot R, Akerman M, Dal Cin P, De Wever I, Fletcher CDM, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Tallini G, Van den Berghe H, Vanni R, Willén H (1997) Cytogenetic analysis of angiolipoma: further evidence against its neoplastic lipogenic nature. A report of the CHAMP study group. Am J Surg Pathol (in press)
98. Simon M-P, Pedeutour F, Sirvent N, Grosgeorge J, Minoletti F, Coindre J-M, Terrier-Lacombe M-J, Mandhal N, Craver RD, Blin N, Sozzi G, Turc-Carel C, O'Brien KP, Kedra D, Fransson I, Guibaud C, Dumanski JP (1997) Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COLIA1 in dermatofibrosarcoma protuberans and giant cell fibroblastoma. Nat Genet 15:95-98
99. Sorensen PHB, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT (1994) A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 6:141-151
100. Squire J, Zielenska M, Thorner P, Tennyson S, Weitzman S, Pai Mohan K, Yeger H, Ng Y-K, Weksberg R (1993) Variant translocation of chromosome 22 in Ewing's sarcoma. Genes Chromosom Cancer 8:190-194
101. Sreekantaiah C, Karakousis CP, Leong SPL, Sandberg AA (1991) Trisomy 8 as a nonrandom secondary change in myxoid liposarcoma. Cancer Genet Cytogenet 51:195-205
102. Sreekantaiah C, Ladanyi M, Rodriguez, E, Chaganti RSK (1994) Chromosomal aberrations in soft tissue tumors. Relevance to diagnosis, classification, and molecular mechanisms. Am J Pathol 144:1121-1134
103. Tallini G, Akerman M, Dal Cin P, De Wever I, Fletcher CDM, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Van den Berghe H, Van de Veil W, Vanni R. Willén H (1996) Combined morphologic and karyotypic study of 28 myxoid liposarcomas: implications for a revised morphologic typing. Am J Surg Pathol 20:1047-1055
104. Thorner P (1996) Is the EWS/FLIl fusion transcript specific for Ewing's sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types. Am J Pathol 148:1125-1138
105. Turc-Carel C, PHilip I, Berger M-P, Philip T, Lenoir GM (1984) Chromosome study of Ewing's sarcoma (ES) cll lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet 12:1-19
106. Van den Berghe H (1996) The marriage of pathology and genetics in soft tissue tumours. EACR - Mühlbock Memorial Lecture. Eur J Cancer [A] 32:1849-1856
107. Weber-Hall S, Anderson J, McManus A, Abe S, Nojima T, Pinkerton R, Pritchurd-Jones K, Shipley J (1996) Gains, losses, and amplification of genomic material in rhabdomyosarcoma analyzed by comparative genomic hybridization. Cancer Res 56:3220-3224
108. Weiss SW (1994) WHO histological typing of soft tissue tumours, 2nd edn. Springer, Berlin Heidelberg New York
109. Whang-Peng J, Knutsen T, Theil K, Horowitz ME, Triche T (1992) Cytogenetic studies in subgroups of rhabdomyosarcoma. Genes Chromosom Cancer 5:299-310
110. Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletcher CD, Aurias A, Thomas G (1993) EWS and ATF-I gene fusion induced by the recurrent t(12;22) translocation in malignant melanoma of soft parts. Nature Genet 4:341-345