Tumor suppressor genes and related molecules in leiomyosarcoma

American Journal of Pathology

Volumn 148, Issue 4, 1996, Pages 1037-1045

  Dei Tos, Angelo P ^a   Maestro, Roberta ^a   Doglioni, Claudio ^a   Piccinin, Sara ^a   Libera, Duilio Della ^a   Boiocchi, Mauro ^a   Fletcher, Christopher D M ^b,c  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE;

ARTICLE; CARCINOGENESIS; CELL CYCLE; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MESENCHYME; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; GENES, P53; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MOLECULAR SEQUENCE DATA; SOFT TISSUE NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029981711     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B: Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992, 358 80-86
2. Toguchida J, Yamaguchi T, Ritchie B, Beauchamp TL, Dayton SH, Herrera GE, Yamamuro T, Kotoura Y, Sasaki MS, Little JB, Weichselbaum RR, Ishizaki K, Yandell DW: Mutation spectrum of the p53 gene in bone and soft tissue. Cancer Res 1992, 52.6194-6199
3. Leach FS, Tokino T, Meltzer P, Burrell M, Oliner JD, Smith S, Hill DE, Sidransky D, Kinzler KW, Vogelstein B: p53 mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993, 53:2231-2234
4. Andreassen A, Oyjord T, Hovig E, Holm R, Florenes VA, Nesland JM, Myklebost O, Hoie J, Bruland OS, Borresen AL, Fodstad O. p53 abnormalities in different subtypes of human sarcomas. Cancer Res 1993, 53:468-471
5. Dei Tos AP, Doglioni C, Laurino L, Barbareschi M, Fletcher CDM. p53 protein expression in non neoplastic lesions and benign and malignant neoplasms of soft tissue Histopathology 1993, 22:45-50
6. Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF, Levine AJ. Molecular abnormalities of MDM2 and p53 genes in adult soft tissue sarcoma. Cancer Res 1994, 54:794-799
7. Latres E, Drobnjak M, Pollack D, Ramos M, Karpeh M, Woodruff JM, Cordon-Cardo C: Chromosome 17 abnormalities, and TP53 mutations in adult soft tissue sarcomas Am J Pathol 1994;145.345-355
8. Hunter T, Pines J Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell 1994, 79:573-582
9. Drobnjak M, Latres E, Pollack D, Karpeh M, Dudas M, Woodruff JM, Brennan MF, Cordon-Cardo C. Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft tissue sarcomas. J Natl Cancer Inst 1994, 86:549-554
10. Patterson H, Gill S, Fisher C, Law MG, Jayatilake H, Fletcher CDM, Thomas M, Grimer R, Gusterson BA, Cooper CS. Abnormalities of the p53, MDM2 and DCC genes in human leiomyosarcomas Br J Cancer 1994, 69:1052-1058
11. Fletcher CDM Soft tissue tumors Diagnostic Histopathology of Tumors. Edited by CDM Fletcher Edinburgh, Churchill-Livingstone, 1995, pp 1043-1096
12. Sanbrook J, Fritsch F, Maniatis T: Molecular Cloning: A Laboratory Manual Plainview, NY, Cold Spring Harbor Laboratory, 1989
13. Onadim Z, Hungelford J, Cowell JK. Follow-up of retinoblastoma patients having prenatal and perinatal predictions for mutant gene carrier status using intragenic polymorphic probes for the RB1 gene Br J Cancer 1992, 65:771-716
14. Maestro R, Dolcetti R, Gasparotto D, Doglioni C, Pelucchi S, Barzan L, Grandi E, Boiocchi M. High frequency of p53 alterations associated with overexpression in human squamous cell carcinoma of the larynx Oncogene 1992, 7 1159-1166
15. Maestro R, Gloghini A, Doglioni C, Gasparotto D, Vokosavljevic T, De Re V, Laurino L, Carbone A, Boiocchi M: MDM2 overexpression does not account for stabilization of wild type p53 protein in non-Hodgkin's lymphomas Blood 1995,11:3239-3246
16. Greenblatt MS, Benett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene, clues to cancer etiology and molecular pathogenesis. Cancer Res 1994, 54.4855-4878
17. Gillet C, Fanti V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 1994, 53.4813-4817
18. Shauer IE, Siriwardana S, Langan TA, Sclafani A: Cyclin D1 overexpression vs. retinoblastoma inactivation implications for growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 1994, 91:7827-7831
19. Harper JW, Adami GR, Wei N: The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 1993, 75:805-816
20. White E: p53, guardian of Rb Nature 1994, 371.21-22
21. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WH, Givol D: Induction of WAF1/CIP1 by a p53 independent pathway. Cancer Res 1994, 54:3391-3395
22. Li J-G, Laurent-Puig P, Salmon RJ, Thomas G, Hamelin R Polymorphism and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer Oncogene 1995, 10 599-601
23. Yoo GH, Xu H-J, Brennan JA, Westra W, Hruban HR, Koch W, Benedict WF, Sidransky D Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res 1994, 54:4603-4606
24. Dodson MK, Cliby WA, Xu H-J, DeLacey KA, Hu S-X, Keeney GL, Li J, Podratz KC, Jenkins RB, Benedict WF Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RBG locus. Cancer Res 1994, 54.610-613
25. Knudson AG Jr. Mutation and cancer, statistical study of retinoblastoma Proc Natl Acad Sci USA 1971, 68. 820-823
26. Cance WG, Brennan MF, Dudas ME, Huang CM, Cordon-Cardo C: Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 1990, 323 1457-1462
27. Stratton MR, Moss S, Warren W, Patterson H, Clark J, Fisher C, Fletcher CDM Ball A, Thomas M, Gusterson BA: Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene Oncogene 1990, 5:1297-1301
28. Karpeh MS, Brennan MF, Cance WG, Woodruff JM, Pollack D, Casper ES, Dudas ME, Latres E, Drobnjack M, Cordon-Cardo C: Altered patterns of retinoblastoma gene product expression in adult soft tissue sarcomas Br J Cancer 1995, 72:986-991
29. De Chiara A, T'Ang A, Triche TJ Expression of the retinoblastoma susceptibility gene in childhood rhabdomyosarcoma J Natl Cancer Inst 1993, 85:152-157
30. Arnold A, Kim HG, Gaz RD, Eddy RL, Fukushima Y, Byers MG, Shows TB, Kronenberg HM: Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest 1989, 83:2034-2040
31. Rosenberg CL, Wong E, Petty EM: PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma Proc Natl Acad Sci USA 1991, 88: 9638-9642
32. Muller H, Lukas J, Schneider A, Warthoe P, Bartek J, Eilers M, Strauss M. Cyclin D1 expression is regulated by the retinoblastoma protein Proc Natl Acad Sci USA 1994, 91.2945-2949
33. Tam SW, Theodoras AM, Shay JW, Draetta GF, Pagano M Differential expression and regulation of cyclin D1 protein in normal and tumor cells, association with cdk4 is required for cyclin D1 function in G1 progression. Oncogene 1994, 9:2663-2674
34. Medema RH, Herrera RE, Lam F, Weinberg RA. Growth suppression by p16INK4 requires functional retinoblastoma protein. Proc Natl Acad Sci USA 1995, 92: 6289-6293
35. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994, 264.436-440
36. INK4A tumor suppressor protein Cancer Res 1995, 55:2503-2506
37. Guan K-L, Jenkins CW, Li Y, Nicholas MA, Wu X, O'Keefe CL, Matera AG, Xiong Y Growth suppression by p18, a p16ink4/MTS1 and p15ink4B/MTS2 related CDK6 inhibitor, correlates with wild-type pRb function Genes & Dev 1994, 8:239-2952
38. Serrano M, Hannon GJ, Beach D A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366:704-707