-
1
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-
9544226450
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2 microglobulin transgenic rats
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2 microglobulin transgenic rats. J Clin Invest 1996, 98:945-953. An outstanding study demonstrating that normal luminal bacteria, in general, and Bacteroides, in particular, predictably and uniformly will induce chronic colonic, gastric, and systemic inflammation in a transgenic animal model of chronic intestinal inflammation.
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(1996)
J Clin Invest
, vol.98
, pp. 945-953
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-
Rath, H.C.1
Herfarth, H.H.2
Ikeda, J.S.3
Grenther, W.B.4
Hamm, T.E.5
Balish, E.6
Taurog, J.D.7
Hammer, R.E.8
Wilson, K.H.9
Sartor, R.B.10
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2
-
-
0029813545
-
+ TH1-like responses
-
1 cell activity and intestinal inflammation.
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(1996)
J Clin Invest
, vol.98
, pp. 1010-1020
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-
Berg, D.J.1
Davidson, N.2
Kuhn, R.3
Muller, W.4
Menon, S.5
Holland, G.6
Thompson-Snipes, L.7
Leach, M.W.8
Rennick, D.9
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3
-
-
0030480323
-
Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers
-
Herfarth HH, Mohanty SP, Rath HC, Tonkonogy S, Sartor RB: Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers. Gut 1996, 39:836-845. A useful study demonstrating the effectiveness of interleukin-10 treatment in an exogenoulsy induced animal model of chronic granulomatous intestinal inflammation.
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(1996)
Gut
, vol.39
, pp. 836-845
-
-
Herfarth, H.H.1
Mohanty, S.P.2
Rath, H.C.3
Tonkonogy, S.4
Sartor, R.B.5
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4
-
-
0029836444
-
Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice
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Neurath MF, Pettersson S, zum Buschenfelde KHM, Strober W: Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nature Med 1996, 2:998-1004, A novel approach to treating both exogenously induced as well as genetic knockout animal models of intestinal inflammation using antisense oligonucleotides against the transcription factor NF-κB p65.
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(1996)
Nature Med
, vol.2
, pp. 998-1004
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-
Neurath, M.F.1
Pettersson, S.2
Zum Buschenfelde, K.H.M.3
Strober, W.4
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5
-
-
0029975876
-
Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease
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Mizoguchi A, Mizoguchi E, Chiba C, Spiekermann GM, Tonegawa S, Nagler-Anderson C, Bhan AK: Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease. J Exp Med 1996, 183:847-856. An outstanding study examining ulcerative colitis-like colonic inflammation in mice mutant for the T-cell receptor alpha gene in which autoantibodies against tropomyosin are demonstrated.
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(1996)
J Exp Med
, vol.183
, pp. 847-856
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-
Mizoguchi, A.1
Mizoguchi, E.2
Chiba, C.3
Spiekermann, G.M.4
Tonegawa, S.5
Nagler-Anderson, C.6
Bhan, A.K.7
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6
-
-
0029866240
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+ cells
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+ cells. Am J Pathol 1996, 148:1503-1515. A valuable study describing the histopathologic alterations present in the inflamed intestines of a mouse model created by the transfer of a subset of highly activated T-cells into severe combined immunodeficient mice.
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(1996)
Am J Pathol
, vol.148
, pp. 1503-1515
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-
Leach, M.W.1
Bean, A.G.D.2
Mauze, S.3
Coffman, R.L.4
Powrie, F.5
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7
-
-
0029873909
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Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus
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Ward JM, Anver MR, Haines DC, Melhorn JM, Gorelick P, Yan L, Fox JG: Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus. Lab Anim Sci 1996, 46:15-20. An intriguing study demonstrating Helicobacter hepaticus infection as a causative factor in colonic inflammation in immunodeficient mice.
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(1996)
Lab Anim Sci
, vol.46
, pp. 15-20
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-
Ward, J.M.1
Anver, M.R.2
Haines, D.C.3
Melhorn, J.M.4
Gorelick, P.5
Yan, L.6
Fox, J.G.7
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9
-
-
0029773838
-
Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease
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Gulwani-Akolkar B, Akolkar PN, Minassian A, Pergolizzi R, McKinley M, Mullin G, Fisher S, Silver J: Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease. J Clin Invest 1996, 98:1344-1354. An important study that demonstrates a highly restricted T-cell response in Crohn's disease patients.
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(1996)
J Clin Invest
, vol.98
, pp. 1344-1354
-
-
Gulwani-Akolkar, B.1
Akolkar, P.N.2
Minassian, A.3
Pergolizzi, R.4
McKinley, M.5
Mullin, G.6
Fisher, S.7
Silver, J.8
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10
-
-
0029744262
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Involvement of interleukin-4 and -10 in inflammatory bowel disease
-
Nielsen OH, Koppen T, Rudiger N, Horn T, Eriksen J, Kirman I: Involvement of interleukin-4 and -10 in inflammatory bowel disease. Dig Dis Sci 1996, 41:1786-1793. An interesting study that demonstrates decreased suppressor cytokine mRNA expression in ulcerative colitis and Crohn's disease patients.
-
(1996)
Dig Dis Sci
, vol.41
, pp. 1786-1793
-
-
Nielsen, O.H.1
Koppen, T.2
Rudiger, N.3
Horn, T.4
Eriksen, J.5
Kirman, I.6
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11
-
-
0030067724
-
Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease
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Daig R, Andus T, Aschenbrenner E, Falk W, Scholmerich J, Gross V: Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996, 38:216-222. A useful study demonstrating an excellent correlation between mucosal mRNA expression of interleukin-8 with mucosal interleukin-8 protein levels, and with histologic amounts of intestinal inflammation.
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(1996)
Gut
, vol.38
, pp. 216-222
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-
Daig, R.1
Andus, T.2
Aschenbrenner, E.3
Falk, W.4
Scholmerich, J.5
Gross, V.6
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12
-
-
0030071347
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Interleukin 8: Cells of origin in inflammatory bowel disease
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Grimm MC, Elsbury SKO, Pavli P, Doe WF: Interleukin 8: cells of origin in inflammatory bowel disease. Gut 1996, 38:90-98. A solid study showing that neutrophils and macrophages are responsible for the production of interleukin 8 in IBD.
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(1996)
Gut
, vol.38
, pp. 90-98
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-
Grimm, M.C.1
Elsbury, S.K.O.2
Pavli, P.3
Doe, W.F.4
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13
-
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0030041142
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Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease
-
Mazzucchelli L, Hauser C, Zgraggen K, Wagner HE, Heiss MW, Laissue JA, Mueller C: Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J Pathol 1996, 178:201-206. An interesting study demonstrating increased numbers of MCP-1 and RANTES mRNA-expressing cells in the mucosa of patients with IBD.
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(1996)
J Pathol
, vol.178
, pp. 201-206
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-
Mazzucchelli, L.1
Hauser, C.2
Zgraggen, K.3
Wagner, H.E.4
Heiss, M.W.5
Laissue, J.A.6
Mueller, C.7
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14
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0030037374
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Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease
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McKenzie SJ, Baker MS, Buffinton GD, Doe WF: Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J CIm Invest 1996, 98:136-141. An excellent study providing clear evidence of reactive oxygen-nitrogen species-induced injury to the intestine in IBD.
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(1996)
J CIm Invest
, vol.98
, pp. 136-141
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-
McKenzie, S.J.1
Baker, M.S.2
Buffinton, G.D.3
Doe, W.F.4
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15
-
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0029666096
-
Colitis and interleukin 1b up-regulate inducible nitric oxide synthase and Superoxide dismutase in rat myenteric neurons
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Valentine JF, Tannahill CL, Stevenot SA, Sallustio JE, Nick HS, Eaker EY: Colitis and interleukin 1b up-regulate inducible nitric oxide synthase and Superoxide dismutase in rat myenteric neurons. Gastroenterology 1996, 111:56-64. An intriguing study that begins to outline the molecules involved m inducing as opposed to protecting against nitric oxide cytotoxicity in experimental colitis.
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(1996)
Gastroenterology
, vol.111
, pp. 56-64
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-
Valentine, J.F.1
Tannahill, C.L.2
Stevenot, S.A.3
Sallustio, J.E.4
Nick, H.S.5
Eaker, E.Y.6
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16
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0030023110
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Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease
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Finch PW, Pricolo V, Wu A, Finkelstein SD: Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology 1996, 110:441-451. A valuable study showing increased expression of keratinoctye growth factor mRNA in human inflamed IBD tissue.
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(1996)
Gastroenterology
, vol.110
, pp. 441-451
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-
Finch, P.W.1
Pricolo, V.2
Wu, A.3
Finkelstein, S.D.4
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17
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0030006150
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Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats
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Zeeh JM, Procaccino F, Hoffmann P, Aukerman SL, McRoberts JA, Soltani S, Pierce GF, Lakshmanan J, Lacey D, Eysselem VE: Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats. Gastroenterology 1996, 110:1077-1083. A provocative study demonstrating that administration of keratinocyte growth factor could reduce ulcerations and intestinal inflammation in an exogenously induced animal model of colitis.
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(1996)
Gastroenterology
, vol.110
, pp. 1077-1083
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-
Zeeh, J.M.1
Procaccino, F.2
Hoffmann, P.3
Aukerman, S.L.4
McRoberts, J.A.5
Soltani, S.6
Pierce, G.F.7
Lakshmanan, J.8
Lacey, D.9
Eysselem, V.E.10
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18
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0029913624
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Expression of transforming growth factors α and β in colonic mucosa in inflammatory bowel disease
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Babyatsky MW, Rossiter G, Podolsky DK: Expression of transforming growth factors α and β in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996, 110:975-984. An intriguing study demonstrating enhanced expression of transforming growth factors in IBD, suggesting that they may play a role in the promotion of healing and enhancement of mucosal restitution.
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(1996)
Gastroenterology
, vol.110
, pp. 975-984
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-
Babyatsky, M.W.1
Rossiter, G.2
Podolsky, D.K.3
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19
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0029963139
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Activation of CD4+ T lymphocytes from interleukin 2-deficient mice by costimulatory B7 molecules
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Razi-Wolf Z, Hollander GA, Reiser H: Activation of CD4+ T lymphocytes from interleukin 2-deficient mice by costimulatory B7 molecules. Proc Natl Acad Sci U S A 1996, 93:2903-2908.
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(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 2903-2908
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Razi-Wolf, Z.1
Hollander, G.A.2
Reiser, H.3
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20
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0029918501
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+-cell depleted, athymic and NK-cell depleted SCID mice
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+-cell depleted, athymic and NK-cell depleted SCID mice. Inflamm Res 1996, 45:181-191.
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(1996)
Inflamm Res
, vol.45
, pp. 181-191
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Axelsson, L.G.1
Landstrom, E.2
Goldschmidt, T.J.3
Gronberg, A.4
Bylund-Fellenius, A.C.5
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21
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0030239820
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Hapten-induced model of murine inflammatory bowel disease. Mucosal immune responses and protection by tolerance
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Elson CO, Beagley KW, Sharmanov AT, Fujihashi K, Kiyono H, Tennyson GS, Cong Y, Black CA, Ridwan BW, McGhee JR: Hapten-induced model of murine inflammatory bowel disease. Mucosal immune responses and protection by tolerance. J Immunol 1996, 157:2174-2185.
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(1996)
J Immunol
, vol.157
, pp. 2174-2185
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-
Elson, C.O.1
Beagley, K.W.2
Sharmanov, A.T.3
Fujihashi, K.4
Kiyono, H.5
Tennyson, G.S.6
Cong, Y.7
Black, C.A.8
Ridwan, B.W.9
McGhee, J.R.10
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22
-
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0029979529
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Increased frequency of abnormal gd T cells in blood of patients with inflammatory bowel diseases
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Soderstrom K, Bucht A, Halapi E, Gronberg A, Magnusson I, Kiessling R: Increased frequency of abnormal gd T cells in blood of patients with inflammatory bowel diseases. J Immunol 1996, 156:2331-2339.
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(1996)
J Immunol
, vol.156
, pp. 2331-2339
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-
Soderstrom, K.1
Bucht, A.2
Halapi, E.3
Gronberg, A.4
Magnusson, I.5
Kiessling, R.6
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23
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0029931508
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Bacteria-specific T-cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease
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Duchmann R, Hermann EM, zum Buschenfelde KHM: Bacteria-specific T-cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease. Scand J Immunol 1996, 44:71-79.
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(1996)
Scand J Immunol
, vol.44
, pp. 71-79
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Duchmann, R.1
Hermann, E.M.2
Zum Buschenfelde, K.H.M.3
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24
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0030028796
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Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein
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Monajemi H, Meenan J, Lamping R, Obradov DO, Radema SA, Trown PW, Tytgat GN, VanDeventer SJH: Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein. Gastroenterology 1996, 110:733-739.
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(1996)
Gastroenterology
, vol.110
, pp. 733-739
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Monajemi, H.1
Meenan, J.2
Lamping, R.3
Obradov, D.O.4
Radema, S.A.5
Trown, P.W.6
Tytgat, G.N.7
VanDeventer, S.J.H.8
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25
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0029882833
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Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): A new seromarker for inflammatory bowel disease and associated disorders
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Stoffel MP, Csernok E, Herzberg C, Johnston T, Carroll SF, Gross WL: Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 1996, 104:54-59.
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(1996)
Clin Exp Immunol
, vol.104
, pp. 54-59
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Stoffel, M.P.1
Csernok, E.2
Herzberg, C.3
Johnston, T.4
Carroll, S.F.5
Gross, W.L.6
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26
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0029782122
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Increased mucosal concentrations of soluble intercellular adhesion molecule-1 (slCAM-1), sE-selectin, and interleukin-8 in active ulcerative colitis
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Nielsen OH, Brynskov J, Vainer B: Increased mucosal concentrations of soluble intercellular adhesion molecule-1 (slCAM-1), sE-selectin, and interleukin-8 in active ulcerative colitis. Dig Dis Sci 1996, 41:1780-1785.
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(1996)
Dig Dis Sci
, vol.41
, pp. 1780-1785
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Nielsen, O.H.1
Brynskov, J.2
Vainer, B.3
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27
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0029964289
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LFA-1 subunit expression in ulcerative colitis patients
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Kirman I, Nielsen OH: LFA-1 subunit expression in ulcerative colitis patients. Dig Dis Sci 1996, 41:670-676.
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(1996)
Dig Dis Sci
, vol.41
, pp. 670-676
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Kirman, I.1
Nielsen, O.H.2
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28
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0029681588
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Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats
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Loguercio C, D'Argenio G, Cave MD, Cosenza V, Valle ND, Mazzacca G, Blanco CDV: Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats. Dig Dis Sci 1996, 41:1204-1211.
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(1996)
Dig Dis Sci
, vol.41
, pp. 1204-1211
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Loguercio, C.1
D'Argenio, G.2
Cave, M.D.3
Cosenza, V.4
Valle, N.D.5
Mazzacca, G.6
Blanco, C.D.V.7
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29
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10344264959
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Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease
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Lih-Brody L, Powell SR, Collier KP, Reddy GM, Cerchia R, Kahn E, Weissman GS, Katz S, Floyd RA, McKinley MJ, Fisher SE, Mulin GE: Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci 1996, 41:2078-2086.
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(1996)
Dig Dis Sci
, vol.41
, pp. 2078-2086
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Lih-Brody, L.1
Powell, S.R.2
Collier, K.P.3
Reddy, G.M.4
Cerchia, R.5
Kahn, E.6
Weissman, G.S.7
Katz, S.8
Floyd, R.A.9
McKinley, M.J.10
Fisher, S.E.11
Mulin, G.E.12
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0029978763
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Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis
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Sartor RB, DeLaCadena RA, Green KD, Stadnicki A, Davis SW, Schwab JH, Adam AA, Raymond P, Colman RW: Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis. Gastroenterology 1996, 110:1467-1481.
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Gastroenterology
, vol.110
, pp. 1467-1481
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Sartor, R.B.1
DeLaCadena, R.A.2
Green, K.D.3
Stadnicki, A.4
Davis, S.W.5
Schwab, J.H.6
Adam, A.A.7
Raymond, P.8
Colman, R.W.9
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31
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0029987878
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Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in lewis rat
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Stadnicki A, DeLaCadena RA, Sartor RB, Bender D, Kettner CA, Rath HC, Adam A, Colman RW: Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in lewis rat. Dig Dis Sci 1996, 41:912-920.
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(1996)
Dig Dis Sci
, vol.41
, pp. 912-920
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Stadnicki, A.1
DeLaCadena, R.A.2
Sartor, R.B.3
Bender, D.4
Kettner, C.A.5
Rath, H.C.6
Adam, A.7
Colman, R.W.8
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0029793102
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On the etiology of Crohn's disease
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Mishina D, Katsel P, Brown ST, Gilberts E CAM, Greenstein Rj: On the etiology of Crohn's disease. Proc Natl Acad Sci U S A 1996, 93:9816-9820.
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Proc Natl Acad Sci U S A
, vol.93
, pp. 9816-9820
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Mishina, D.1
Katsel, P.2
Brown, S.T.3
Gilberts E, C.A.M.4
Greenstein, Rj.5
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33
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0029871597
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No Mycobacterium paratuberculosis found in Crohn's disease using the polymerase chain reaction
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Dumonceau JM, Vanossum A, Adler M, Fonteyne PA, Vanvooren JP, Deviere J, Porteais F: No Mycobacterium paratuberculosis found in Crohn's disease using the polymerase chain reaction. Dig Dis Sci 1996, 41:421-426,
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(1996)
Dig Dis Sci
, vol.41
, pp. 421-426
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Dumonceau, J.M.1
Vanossum, A.2
Adler, M.3
Fonteyne, P.A.4
Vanvooren, J.P.5
Deviere, J.6
Porteais, F.7
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0030008134
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Antibodies against Mycobacterium paratuberculosis in Crohn's disease
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Walmsley RS, Ibbotson JP, Chahal H. Allan RN: Antibodies against Mycobacterium paratuberculosis in Crohn's disease. Q J Med 1996, 89:217-221.
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(1996)
Q J Med
, vol.89
, pp. 217-221
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Walmsley, R.S.1
Ibbotson, J.P.2
Chahal, H.3
Allan, R.N.4
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Inflammatory bowel disease
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MacDermolt RP: Inflammatory bowel disease [commentary]. Curr Opin Gastroenterol 1994, 10:355-357.
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, vol.10
, pp. 355-357
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MacDermolt, R.P.1
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