Leptin and body weight regulation;Leptine et regulation du poids corporel

Cahiers de Nutrition et de Dietetique

Volumn 32, Issue 4, 1997, Pages 217-223

  Oppert, J M ^a  

^a HÔTEL DIEU   (France)

Author keywords

Fat mass; Leptin; Ob gene; Obesity; Regulation

Indexed keywords

CYTOKINE RECEPTOR; GLUCOCORTICOID; HORMONE RECEPTOR; INSULIN; LEPTIN;

BODY FAT; BODY WEIGHT; CALORIC INTAKE; ENERGY EXPENDITURE; GENE EXPRESSION REGULATION; GENE MUTATION; HORMONAL REGULATION; HYPOTHALAMUS; NONHUMAN; OBESITY; REVIEW;

EID: 0030763294     PISSN: 00079960     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (56)

1. Spiegelman B.M., Flier J.S. - Adipogenesis and obesity: rounding out the big picture. Cell, 1996, 87, 377-389.
2. Kennedy G.C. - The role of depot fat in the hypothalamic control of food intake in the rat. Proc. R. Soc. Lond., 1953, 140, 578-592.
3. Hervey G.R. - The effects of lesions in the hypothalamus in parabiotic rats. J. Physiol., 1958, 145, 336-352.
4. Friedman J.M., Leibel R.L. - Tackling a weighty problem. Cell, 1992, 69, 217-220.
5. Hausberger F.X. - Parabiosis and transplantation experiments in hereditarily obese mice. Anat. Rec., 1939, 130, 313-314.
6. Coleman D.L. - Effects of parabiosis of obese with diabetes and normal mice. Diabetologia, 1973, 9, 294-298.
7. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. - Positional cloning of the mouse obese gene and its human homologue. Nature, 1994, 372, 425-432.
8. Geffroy S., De Vos P., Staels B., Duban B., Auwerx J., de Martinville B. - Localization of the human OB gene (OBS) to chromosome 7q32 by fluorescence in situ hybridization. Genomics, 1995, 28, 603-604.
9. Isse N., Ogawa Y., Tamura N., Masuzaki H., Mori K., Okazaki T., Satoh N., Shigemoto M., Yoshimasa Y., Nishi S., Hosoda K., Inazama J., Nakao K. - Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem., 1995, 270, 27728-27733.
10. Madej T., Boguski M.S., Bryant S.H. - Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Letters, 1995, 373, 13-18.
11. Frederich R.C., Löllmann B., Hamann A., Napolitano-Rosen A., Kahn B.B., Lowell B.B., Flier J.S. - Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest., 1995 96, 1658-1663.
12. Frederich R.C., Hamann A., Anderson S., Löllmann B., Lowell B.B., Flier J.S. - Leptin levels reflect body lipid content in mice : evidence for diet-induced resistance to leptin action. Nature Med., 1995, 1, 1311-1314.
13. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P.A., Friedman J.M. - Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med., 1995, 1, 1155-1161.
14. Considine R.V., Considine E.L., Williams C.J., Nyce M.R., Magosin S.A., Bauer T.A., Rosato E.L., Colberg J., Caro J.F. - Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J. Clin. Invest., 1995, 95, 2986-88.
15. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannessian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med., 1996, 334, 292-295.
16. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., Auwerx J. - Transient increase in obese gene expression after food intake or insulin administration. Nature, 1995, 377, 527-529.
17. Sinha M.K., Ohannesian J.P., Heimnan M.C., Kriauciunas A., Stephens T.W., Magosin S., Marco C., Caro J.F. - Nocturnal rise of leptin in lean, obese and non insulin dependent diabetes mellitus subjects. J. Clin Invest., 1996, 97, 1344-1347.
18. Trayhurn P., Thomas M.E.A., Duncan J.S., Rayner D.V. - Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Letters 1995, 368, 488-490.
19. Kolaczynski J.W., Considine R.V., Ohannessian J., Marco C., Opentanova I., Nyce M.R., Myint M., Caro J.F. - Responses of loptin to short-term fasting and refeeding in humans : a link with ketogenesis but not ketones themselves. Diabetes, 1996, 45, 1511-1515.
20. Vidal H., Auboeuf D., De Vos P., Staels B., Riou J.P., Auwerx J., Laville M. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J. Clin. Invest. 1996, 98, 251-255.
21. Kolaczynski J.W., Ohannessian J., Considine R.V., Marco C.C., Caro J.F. - Response of leptin to short-term and prolonged overfeeding in humans. J. Clin. Endocrinol. Metab., 1996, 81, 4162-4165.
22. Becker D.J., Ongemba L.N., Brichard V., Henquin J-C., Brichard S.M. - Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Letters, 1995, 371, 324-328.
23. Wabitsch M., Jensen P.B., Blum W.F., Christoffersen C.T., Englaro P., Heinze E., Rascher W., Teller W., Tornqvist H., Hauner H. - Insulin and cortisol promote leptin production in cultured human fet cells. Diabetes, 1996, 45, 1435-1438.
24. Kolaczynski J.W., Nyce M.R., Considine R.V., Boden G., Nolan J.J., Henry R., Mudaliar S.R., Olefsky J. Caro J.F. - Acute and chronic effect of insulin on leptin production in humans. Studies in vivo and in vitro. Diabetes, 1996, 45, 699-701.
25. De Vos P., Saladin R., Auwerx J., Staels B. - Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J. Biol. Chem., 1995, 270, 15958-15961.
26. Slieker L.J., Sloop K.W., Surface P.L., Kriauciunas A., LaQuier F., Manetta J., Bue-Valleskey J., Stephens T.W. - Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem., 1996, 271, 5301-5304.
27. Berneis K., Vosmeer S., Keller U. - Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. Eur. J. Endocrinol., 1996, 135, 663-665.
28. Tataranni P.A., Pratley R., Maffei M., Ravussin E. -Acute and prolonged administration of glucocorticoids (methylprednisolone) does not affect plasma leptin concentration in humans. Int. J. Obes., 1997, 21, 327-330
29. Trayburn P., Duncan J.S., Rayner D.V. Acute cold-induced suppresion of ob (obese) gene expression in white-adipose tissue of mice : mediation by the sympathetic system. Biochem. J., 1995, 311, 729-733.
30. Grunfeld C., Zhao C., Fuller J., Pollock A., Moser A., Friedman J., Feingold K.R. - Endotoxin and cytokines induce expression of leptin, the ob gene product in hamsters. A role for leptin in the anorexia of infection. J. Clin. Invest., 1996, 97, 2152-2157.
31. Pelleymounter M.A., Cullen M.J., Bake M.B., Hecht R., Winters D., Boone T., Collins F. - Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 1995, 269, 540-543.
32. Halaas J.L., Gajimala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. - Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 1995, 269, 543-546.
33. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. - Recombinant mouse OB protein : evidence for a peripheral signal linking adiposity and central neural networks. Science, 1995, 269, 546-549.
34. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte D., Woods S.C., Seeley R.J., Weigle D.S. - Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes, 1996, 45, 531-535.
35. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., Hale J., Hoffmann J., Hsiung H.M., Kriauciunas A., MacKellar W., Rosteck P.R., Schoener B., Smith D., Tinsley F.C., Zhang X-Y., Heiman M. - The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature, 1995 377, 530-532.
36. Weigle D.S., Bukowski T.R., Foster D.C., Holderman S., Kramer J.M., Lasser G., Lofton-Day C.E., Prunkard D.E., Raymond C., Kuijper J.L. - Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J. Clin. Invest., 1995, 96, 2065-2070.
37. Chehab F.F., Lem M.E., Lu R. - Correction of the fertility defect in homozygous obese female mice by treatment with the human recombinant loptin. Nature Genet., 1996, 12, 318-320.
38. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., Maness L.M. - Leptin enters the brain by a saturable system independent of insulin. Peptides, 1996, 17, 305-311.
39. Schwartz M.W., Peskind E., Raskind M., Boyko E.J., Porte D,-Cerebrospinal fluid leptin levels : relationship to plasma levels and to adiposity in human. Nature Med., 1996, 2, 589-593.
40. Devos R., Richards J.G., Campfield L.A., Tartaglia L.A., Guisez Y., Van der Heyden J., Travernier J., Plaetinck G., Burn P. - OB protein binds specifically to the choroid plexus of mice and rats. Proc. Natl. Acad. Sci. USA, 1996, 93, 5668-5673.
41. Lynn R.B., Cao G-Y., Considine R.V., Hyde T.M., Caro J.F. - Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem. Biophys. Res. Commun., 1996, 219, 884-889.
42. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., Tepper R.I. - Identification and expression cloning of a leptin receptor, OB-R. Cell, 1995, 83, 1263-1271.
43. Chen H., Charlat O., Tartaglia L.A., Woolf E.A., Weng X., Ellis S.J., Lakey N.D., Culpepper J., Moore K.J., Breitbart R.E., Duyk G.M., Tepper R.I., Morgenstern J.P. - Evidence that the diabetes gene encodes the leptin receptor : identification of a mutation in the leptin receptor gene in db/db mice. Cell, 1996, 84, 491-495.
44. Lee G-H., Proenca R., Montez J.M., Caroll K.M., Davishzadeh J.G., Lee J.I., Friedman J.M. - Abnormal splicing of the leptin receptor in diabetic mice. Nature, 1996, 379, 632-635.
45. Cioffi J.A., Shafer A.W., Zupancic T.J., Smith-Gbur J., Mikhail A., Platika D., Snodgrass H.R. Novel B219/OB receptor isoforms : possible role of loptin in hematopoie-sis and reproduction. Nature Med., 1996, 2, 585-589.
46. Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., Skoda R.C. - Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA, 1996, 93, 6231-6235.
47. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. - Localization of leptin receptor mRNA and the long splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett., 1996, 387, 113-116.
48. Baumann H., Morella K.K., White D.W., Dembski M., Bailon P.S., Kim H., Lai C-F., Tartaglia L.A. - The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA, 1996, 93, 8374-8378.
49. Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E., Stoffel M., Friedman J.M. - Leptin activation of STAT3 in hypothalamus of wild type and ob/ob mice but not db/db mice. Nature Genet., 1996, 14, 95-97.
50. Rohner-Jeanrenaud F., Cusin I., Sainsbury A., Zakrzewska K.E., Jeaurenaud B. - The loop system between neuropeptide Y and leptin in normal and obese rodents. Horm. Metab. Res., 1996, 28, 642-648.
51. Emilsson V., Liu Y-L., Cawthorne M.A., Morton N.M., Davenport M. - Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes, 1997, 46, 313-316.
52. Chua S.C., Chung W.K., Wu-Peng S., Zhang Y., Liu S-M., Tartaglia L., Leibel R.L. - Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 1996, 271, 994-996.
53. Maffei M., Stoffel M., Barone M., Moon B., Dammerman M., Ravussin E., Bogardus C., Ludwig D.S., Flier J.S., Talley M., Auerbach S., Friedman J.M. - Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes, 1996, 45, 679-682.
54. Considine R.V., Considine E.L., Williams C.J., Hyde T.M., Caro J.F. - The hypothalamic leptin receptor in humans. Identification of incidental sequence polymorphisms and absence of the db/db and fa/fa rat mutations. Diabetes, 1996, 19, 992-996.
55. Clement K., Garner C., Hager J., Philippi A., LeDuc C., Carey A., Harris T.J.R., Jury C., Cardon L.R., Basdevant A., Demenais F., Guy-Grand B., North M., Froguel P. - Indication for linkage of the human OB gene region with extreme obesity. Diabetes, 1996, 45, 687-690.
56. Reed D.R., Ding Y., Xu W., Cather C., Green E.D., Price R.A. - Extreme obesity may be linked to markers flanking the human OB gene. Diabetes, 1996, 45, 691-694.