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Volumn 18, Issue 3, 1997, Pages 167-247

Molecular mechanisms and future uses of antiestrogens

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; TAMOXIFEN;

EID: 0030757140     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0098-2997(96)00015-5     Document Type: Review
Times cited : (13)

References (295)
  • 3
    • 0023893921 scopus 로고
    • Inhibition of growth of human cancer by intermittent exposure to the antiestrogen droloxifene
    • Ahlemann, L. M., Staab, H. J., Loser, R., Seibel, K. and Huber, H. J. (1988). Inhibition of growth of human cancer by intermittent exposure to the antiestrogen droloxifene. Tumor Diagnosis and Therapy 9, 41-46.
    • (1988) Tumor Diagnosis and Therapy , vol.9 , pp. 41-46
    • Ahlemann, L.M.1    Staab, H.J.2    Loser, R.3    Seibel, K.4    Huber, H.J.5
  • 5
    • 0019132163 scopus 로고
    • Evidence for the metabolic activation of nonsteroidal antioestrogens: A study of structure activity relationships
    • Allen, K. E., Clark, E. R. and Jordan, V. C. (1980). Evidence for the metabolic activation of nonsteroidal antioestrogens: a study of structure activity relationships. British Journal of Pharmacology 71, 87-91.
    • (1980) British Journal of Pharmacology , vol.71 , pp. 87-91
    • Allen, K.E.1    Clark, E.R.2    Jordan, V.C.3
  • 7
    • 0027476886 scopus 로고
    • Efficacy and safety of high dose NK 622 (toremifene citrate) in tamoxifen failed patients with breast cancer
    • Asaishi, K., Tominaga, T., Abe, O., Izuo, M. and Nomula, Y. (1993). Efficacy and safety of high dose NK 622 (toremifene citrate) in tamoxifen failed patients with breast cancer [in Japanese]. Gan to Kagaku Ryoho 20, 91-99.
    • (1993) Gan to Kagaku Ryoho , vol.20 , pp. 91-99
    • Asaishi, K.1    Tominaga, T.2    Abe, O.3    Izuo, M.4    Nomula, Y.5
  • 8
    • 0029048753 scopus 로고
    • Gynecological effects of tamoxifen and the association with endometrial cancer
    • Assikis, V. J. and Jordan, V. C. (1995). Gynecological effects of tamoxifen and the association with endometrial cancer. International Journal of Gynecology and Obstetrics 49, 241-257.
    • (1995) International Journal of Gynecology and Obstetrics , vol.49 , pp. 241-257
    • Assikis, V.J.1    Jordan, V.C.2
  • 9
    • 0010169673 scopus 로고    scopus 로고
    • A realistic clinical perspective of tamoxifen and endometrial carcinogenesis
    • Assikis, V. J., Neven, P., Jordan, V. C. and Vergote I. (1996). A realistic clinical perspective of tamoxifen and endometrial carcinogenesis. European Journal of Cancer 32A, 1464-1476.
    • (1996) European Journal of Cancer , vol.32 A , pp. 1464-1476
    • Assikis, V.J.1    Neven, P.2    Jordan, V.C.3    Vergote, I.4
  • 10
    • 0038217674 scopus 로고
    • Studies of cholesterol biosynthesis: The identification of desmosterol in serum and tissues of animals and man treated with MER-29
    • Avigan, J., Steinberg, D., Vroman, H. E., Thompson, M. J. and Mosettig, E. (1960). Studies of cholesterol biosynthesis: the identification of desmosterol in serum and tissues of animals and man treated with MER-29. Journal of Biology and Chemistry 235, 3123-3126.
    • (1960) Journal of Biology and Chemistry , vol.235 , pp. 3123-3126
    • Avigan, J.1    Steinberg, D.2    Vroman, H.E.3    Thompson, M.J.4    Mosettig, E.5
  • 11
    • 0030939785 scopus 로고    scopus 로고
    • Benign and hyperplastic changes associated with tamoxifen use
    • Barakat, R. R. (1997). Benign and hyperplastic changes associated with tamoxifen use. Oncology 11 (Suppl), 35-37.
    • (1997) Oncology , vol.11 , Issue.SUPPL. , pp. 35-37
    • Barakat, R.R.1
  • 12
    • 0028020104 scopus 로고
    • Tamoxifen use in breast cancer patients who subsequently develop corpus cancer is not associated with a higher incidence of adverse histological features
    • Barakat, R. R., Wong, G., Curtin, J. D., Vlamis, V. and Hoskins, W. J. (1994). Tamoxifen use in breast cancer patients who subsequently develop corpus cancer is not associated with a higher incidence of adverse histological features. Gynecology and Oncology 55, 164-168.
    • (1994) Gynecology and Oncology , vol.55 , pp. 164-168
    • Barakat, R.R.1    Wong, G.2    Curtin, J.D.3    Vlamis, V.4    Hoskins, W.J.5
  • 13
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment with illustrative cases
    • Beatson, G. T. (1896). On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 2, 104-107.
    • (1896) Lancet , vol.2 , pp. 104-107
    • Beatson, G.T.1
  • 14
    • 0001761072 scopus 로고
    • Preparation and identification of cis and tram isomers of a substituted triarylethylene
    • Bedford, G. R. and Richardson, D. N. (1966). Preparation and identification of cis and tram isomers of a substituted triarylethylene. Nature 212, 733-734.
    • (1966) Nature , vol.212 , pp. 733-734
    • Bedford, G.R.1    Richardson, D.N.2
  • 15
    • 0026337142 scopus 로고
    • European early phase II dose finding study of droloxifene in advanced breast cancer
    • Bellmunt, J. and Sole, L. (1991). European early phase II dose finding study of droloxifene in advanced breast cancer. American Journal of Clinical Oncology 14, 536-539.
    • (1991) American Journal of Clinical Oncology , vol.14 , pp. 536-539
    • Bellmunt, J.1    Sole, L.2
  • 17
    • 2542464918 scopus 로고
    • Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen responsive cells in culture
    • Berthois, Y., Katzenellenbogen, J. A. and Katzenellenbogen, B. S. (1986). Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen responsive cells in culture. Proceedings of the National Academy of Science USA 83, 2496-2500.
    • (1986) Proceedings of the National Academy of Science USA , vol.83 , pp. 2496-2500
    • Berthois, Y.1    Katzenellenbogen, J.A.2    Katzenellenbogen, B.S.3
  • 18
    • 0027195827 scopus 로고
    • High performance liquid chromatographic analysis of tamoxifen, toremifene and their major human metabolites
    • Berthou, F. and Dreano, Y. (1993). High performance liquid chromatographic analysis of tamoxifen, toremifene and their major human metabolites. J. Chromatogr. B. Biomed. Appl. 616, 117-127.
    • (1993) J. Chromatogr. B. Biomed. Appl. , vol.616 , pp. 117-127
    • Berthou, F.1    Dreano, Y.2
  • 21
    • 0020694796 scopus 로고
    • Antagonism of estrogen action with a new benzothiophene-derived antiestrogen
    • Black, L. J., Jones, C. D. and Falcone, J. F. (1983). Antagonism of estrogen action with a new benzothiophene-derived antiestrogen. Life Sciences 32, 1031-1036.
    • (1983) Life Sciences , vol.32 , pp. 1031-1036
    • Black, L.J.1    Jones, C.D.2    Falcone, J.F.3
  • 23
    • 0014188385 scopus 로고
    • Sex hormones and renal neoplasia: Inhibition of tumor of hamster kidney by an estrogen antagonist, an agent of possible therapeutic value in man
    • Bloom, H. J. G., Roe, F. J. C. and Mitcheley, B. C. V. (1967). Sex hormones and renal neoplasia: inhibition of tumor of hamster kidney by an estrogen antagonist, an agent of possible therapeutic value in man. Cancer 20, 2118-2120.
    • (1967) Cancer , vol.20 , pp. 2118-2120
    • Bloom, H.J.G.1    Roe, F.J.C.2    Mitcheley, B.C.V.3
  • 24
    • 0019852254 scopus 로고
    • Estrogen-like action of tamoxifen on vaginal epithelium in breast cancer patients
    • Boccardo, F., Bruzzi, P., Rubagotti, A., Nicolo, G. U. and Rosso, R. (1981). Estrogen-like action of tamoxifen on vaginal epithelium in breast cancer patients. Oncology 38, 281-2825.
    • (1981) Oncology , vol.38 , pp. 281-2825
    • Boccardo, F.1    Bruzzi, P.2    Rubagotti, A.3    Nicolo, G.U.4    Rosso, R.5
  • 26
    • 0001733527 scopus 로고
    • On oophorectomy in cancer of the breast
    • Boyd, S. (1990). On oophorectomy in cancer of the breast. British Medical Journal 2, 1161-1167.
    • (1990) British Medical Journal , vol.2 , pp. 1161-1167
    • Boyd, S.1
  • 27
    • 0004496862 scopus 로고
    • Adjuvant tamoxifen in the management of operable breast cancer. The Scottish Trials
    • Breast Cancer Trials Committee, Scottish Trials Office (1987). Adjuvant tamoxifen in the management of operable breast cancer. The Scottish Trials. Lancet ii, 171-175.
    • (1987) Lancet , vol.2 , pp. 171-175
  • 30
    • 0023683229 scopus 로고
    • Phase II evaluation of LY156758 in metastatic breast cancer
    • Buzdar, A. U., Marcus, C., Holmes, F., Hug, V. and Hortobagyi, G. N. (1988). Phase II evaluation of LY156758 in metastatic breast cancer. Oncology 45, 344-345.
    • (1988) Oncology , vol.45 , pp. 344-345
    • Buzdar, A.U.1    Marcus, C.2    Holmes, F.3    Hug, V.4    Hortobagyi, G.N.5
  • 31
    • 0023642827 scopus 로고
    • Clinical significance of tamoxifen withdrawal response
    • Canney, P. A., Griffiths, T., Latief, T. N. and Priestman, T. J. (1987). (Letter). Clinical significance of tamoxifen withdrawal response. Lancet i, 36.
    • (1987) Lancet , vol.1 , pp. 36
    • Canney, P.A.1    Griffiths, T.2    Latief, T.N.3    Priestman, T.J.4
  • 34
    • 0026345105 scopus 로고
    • Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer
    • Chander, S. K., McCague, R., Lugmani, Y., Newton, C., Dowsett, M., Jarman, M. and Coombes, R. C. (1991). Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer. Cancer Research 51, 5851-5858.
    • (1991) Cancer Research , vol.51 , pp. 5851-5858
    • Chander, S.K.1    McCague, R.2    Lugmani, Y.3    Newton, C.4    Dowsett, M.5    Jarman, M.6    Coombes, R.C.7
  • 35
    • 0020582094 scopus 로고
    • Effects of a new antiestrogen keoxifene (LY156758) on growth of carcinogen induced mammary tumors and on lh and prolactin levels
    • Clemens, J. A., Bennett, D. R., Black, L. J. and Jones, C. D. (1983). Effects of a new antiestrogen keoxifene (LY156758) on growth of carcinogen induced mammary tumors and on LH and prolactin levels. Life Sciences 32, 2869-2875.
    • (1983) Life Sciences , vol.32 , pp. 2869-2875
    • Clemens, J.A.1    Bennett, D.R.2    Black, L.J.3    Jones, C.D.4
  • 36
    • 0015069359 scopus 로고
    • A new antioestrogenic agent in late breast cancer: An early clinical appraisal of ICI 46,474
    • Cole, M. P., Jones, C. T. A. and Todd, I. D. H. (1971). A new antioestrogenic agent in late breast cancer: an early clinical appraisal of ICI 46,474. British Journal of Cancer 25, 270-275.
    • (1971) British Journal of Cancer , vol.25 , pp. 270-275
    • Cole, M.P.1    Jones, C.T.A.2    Todd, I.D.H.3
  • 37
    • 0343715184 scopus 로고
    • The treatment of advanced carcinoma of the breast with the antineoplastic agent tamoxifen (ICI 46,474) - A series of 96 patients
    • Cole, M. P., Jones, C. T. A. and Todd, I. D. H. (1972). The treatment of advanced carcinoma of the breast with the antineoplastic agent tamoxifen (ICI 46,474) - a series of 96 patients. Advances in Antimicrobial Antineoplasia and Chemotherapy 2, 529-531.
    • (1972) Advances in Antimicrobial Antineoplasia and Chemotherapy , vol.2 , pp. 529-531
    • Cole, M.P.1    Jones, C.T.A.2    Todd, I.D.H.3
  • 42
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182 780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Dauvois, S., White, R. and Parker, M. G. (1993). The antiestrogen ICI 182 780 disrupts estrogen receptor nucleocytoplasmic shuttling. Journal of Cell Science 106, 1377-1388.
    • (1993) Journal of Cell Science , vol.106 , pp. 1377-1388
    • Dauvois, S.1    White, R.2    Parker, M.G.3
  • 44
    • 0025301011 scopus 로고
    • Antioestrogenic and antitumour properties of the new triphenylethylene derivative toremifene in the rat
    • DiSalle, E., Zaccheo, T. and Ornati, G. (1990). Antioestrogenic and antitumour properties of the new triphenylethylene derivative toremifene in the rat. Journal of Steroid Biochemistry 36, 203-206.
    • (1990) Journal of Steroid Biochemistry , vol.36 , pp. 203-206
    • DiSalle, E.1    Zaccheo, T.2    Ornati, G.3
  • 46
    • 0029865172 scopus 로고    scopus 로고
    • Effects of tamoxifen and two fixed ring analogs on multistage rat hepatocarcinogenesis
    • Dragan, Y. P., Nawaysir, E., Fahey, S., Vaughn, J., McCague, Jordan, V. C. and Pitot, H. C. (1996). Effects of tamoxifen and two fixed ring analogs on multistage rat hepatocarcinogenesis. Carcinogenesis 17, 585-594.
    • (1996) Carcinogenesis , vol.17 , pp. 585-594
    • Dragan, Y.P.1    Nawaysir, E.2    Fahey, S.3    Vaughn, J.4    McCague5    Jordan, V.C.6    Pitot, H.C.7
  • 47
    • 0028810502 scopus 로고
    • Comparison of tamoxifen and toremifene on liver and kidney tumor promotion in female rats
    • Dragan, Y. P., Vaughan, J., Jordan, V. C. and Pitot, H. C. (1995). Comparison of tamoxifen and toremifene on liver and kidney tumor promotion in female rats. Carcinogenesis 16, 2733-2741.
    • (1995) Carcinogenesis , vol.16 , pp. 2733-2741
    • Dragan, Y.P.1    Vaughan, J.2    Jordan, V.C.3    Pitot, H.C.4
  • 48
    • 0002658633 scopus 로고
    • Effects of raloxifene (LY 139481 HCL) on biochemical markers of bone and lipid metabolism in healthy postmenopausal women
    • Handelstrykkeriet Aalborg ApS., Aalborg, Denmark
    • Draper, M. W., Flowers, D. E. and Hester, W. J. (1993). Effects of raloxifene (LY 139481 HCL) on biochemical markers of bone and lipid metabolism in healthy postmenopausal women. Proceeding of the Fourth International Symposium on Osteoporosis. Handelstrykkeriet Aalborg ApS., Aalborg, Denmark.
    • (1993) Proceeding of the Fourth International Symposium on Osteoporosis
    • Draper, M.W.1    Flowers, D.E.2    Hester, W.J.3
  • 50
    • 0028361384 scopus 로고
    • Effects of a non-steroidal pure antiestrogen ZM 189,154, on estrogen target organs of the rat including bones
    • Dukes, M., Chester, R., Yarwood, L. and Wakeling, A. E. (1994). Effects of a non-steroidal pure antiestrogen ZM 189,154, on estrogen target organs of the rat including bones. Joumal of Endocrinology 141, 335-341.
    • (1994) Joumal of Endocrinology , vol.141 , pp. 335-341
    • Dukes, M.1    Chester, R.2    Yarwood, L.3    Wakeling, A.E.4
  • 51
    • 0026776174 scopus 로고
    • Antiuterotrophic effect of a pure antioestrogen ICI 182,780: Magnetic resonance imaging of the uterus in ovariectomized monkeys
    • Dukes, M., Miller, D., Wakeling, A. E. and Waterton, J. C. (1992). Antiuterotrophic effect of a pure antioestrogen ICI 182,780: magnetic resonance imaging of the uterus in ovariectomized monkeys. Journal of Endocrinology 135, 239-247.
    • (1992) Journal of Endocrinology , vol.135 , pp. 239-247
    • Dukes, M.1    Miller, D.2    Wakeling, A.E.3    Waterton, J.C.4
  • 52
    • 0027433696 scopus 로고
    • Antiuterotrophic effect of the pure antiestrogen ICI 182,780 in adult female monkeys (Macaca nemestrina): Quantitative magnetic resonance imaging
    • Dukes, M., Waterton, J. C. and Wakeling, A. E. (1993). Antiuterotrophic effect of the pure antiestrogen ICI 182,780 in adult female monkeys (Macaca nemestrina): quantitative magnetic resonance imaging. Journal of Endocrinology 138, 203-210.
    • (1993) Journal of Endocrinology , vol.138 , pp. 203-210
    • Dukes, M.1    Waterton, J.C.2    Wakeling, A.E.3
  • 54
    • 0024269590 scopus 로고
    • Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women
    • Early Breast Cancer Trialists' Collaborative Group (1988). Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women. New England Journal of Medicine 319, 1681-1692.
    • (1988) New England Journal of Medicine , vol.319 , pp. 1681-1692
  • 55
    • 0026557343 scopus 로고
    • Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy. 133 randomized trials involving 31,000 recurrences and 24,000 deaths among 75,000 women
    • Early Breast Cancer Trialists' Collaborative Group (1992). Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy. 133 randomized trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 339, 1-15.
    • (1992) Lancet , vol.339 , pp. 1-15
  • 56
    • 0025295506 scopus 로고
    • Response to toremifene (Fc-1157a) therapy in tamoxifen failed patients with breast cancer. Preliminary communication
    • Ebbs, S. R., Roberts, J. and Baum, M. (1990). Response to toremifene (Fc-1157a) therapy in tamoxifen failed patients with breast cancer. Preliminary communication. Journal of Steroid Biochemistry 36, 239.
    • (1990) Journal of Steroid Biochemistry , vol.36 , pp. 239
    • Ebbs, S.R.1    Roberts, J.2    Baum, M.3
  • 58
    • 0017231499 scopus 로고
    • Stereochemistry of geometric isomers of clomiphene: A correction of the literature and re-examination of structure activity relationships
    • Ernst, S., Hite, G., Cantrell, J. S., Richardson, A. Jr. and Benson, H. D. (1976). Stereochemistry of geometric isomers of clomiphene: A correction of the literature and re-examination of structure activity relationships. Journal of Pharmacological Science 65, 148-150.
    • (1976) Journal of Pharmacological Science , vol.65 , pp. 148-150
    • Ernst, S.1    Hite, G.2    Cantrell, J.S.3    Richardson A., Jr.4    Benson, H.D.5
  • 59
    • 0028212448 scopus 로고
    • The effects of raloxifene on tibia histomorphometry in ovariectomized rats
    • Evans, G. L., Bryant, H. U., Magee, D., Sato, M. and Turner, R. T. (1994). The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology 134, 2283-2288.
    • (1994) Endocrinology , vol.134 , pp. 2283-2288
    • Evans, G.L.1    Bryant, H.U.2    Magee, D.3    Sato, M.4    Turner, R.T.5
  • 60
    • 0025194009 scopus 로고
    • Adjuvant trial of 12 cycles of CMFPT followed by observation or continuous tamoxifen versus four cycles of CMFPT in postmenopausal women with breast cancer
    • An Eastern Cooperative Oncology Group Phase III Study.
    • Falkson, H. C., Gray, R., Wolberg, W. A., Gilchrist, K. W., Harris, J. E., Tormey, D. C. and Falkson, G. (1990). Adjuvant trial of 12 cycles of CMFPT followed by observation or continuous tamoxifen versus four cycles of CMFPT in postmenopausal women with breast cancer. An Eastern Cooperative Oncology Group Phase III Study. Journal of Clinical Oncology 8, 599-607.
    • (1990) Journal of Clinical Oncology , vol.8 , pp. 599-607
    • Falkson, H.C.1    Gray, R.2    Wolberg, W.A.3    Gilchrist, K.W.4    Harris, J.E.5    Tormey, D.C.6    Falkson, G.7
  • 61
    • 0025084510 scopus 로고
    • Inhibition of estrogen receptor DNA binding by the pure antiestrogen ICI 164 384 appears to be mediated by impaired receptor dimerization
    • Fawell, S. E., White, R., Hoare, S., Sydenham, M., Page, M. and Parker, M. G. (1990). Inhibition of estrogen receptor DNA binding by the pure antiestrogen ICI 164 384 appears to be mediated by impaired receptor dimerization. Proceedings of the National Academy of Science 87, 6883-6887.
    • (1990) Proceedings of the National Academy of Science , vol.87 , pp. 6883-6887
    • Fawell, S.E.1    White, R.2    Hoare, S.3    Sydenham, M.4    Page, M.5    Parker, M.G.6
  • 62
    • 0028208456 scopus 로고
    • Endometrial cancer in tamoxifen treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
    • Fisher, B., Costantino, J. P., Redmond, C. K., Fisher, E. R., Wickerman, D. L. and Clonin, W. M. (1994). Endometrial cancer in tamoxifen treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. Journal of the National Cancer Institute 86, 527-537.
    • (1994) Journal of the National Cancer Institute , vol.86 , pp. 527-537
    • Fisher, B.1    Costantino, J.P.2    Redmond, C.K.3    Fisher, E.R.4    Wickerman, D.L.5    Clonin, W.M.6
  • 64
    • 0022623005 scopus 로고
    • Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer. 5 year results from the National Surgical Adjuvant Breast and Bowel Project Trial
    • Fisher, B., Redmond, C., Brown, A., Fisher, E. R., Wolmark, N., Bowman, D., Plotkin, D., Wolter, J., Bornstein, R. and Legault-Poisson, S. (1986). Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer. 5 year results from the National Surgical Adjuvant Breast and Bowel Project Trial. Journal of Clinical Oncology 4, 459-471.
    • (1986) Journal of Clinical Oncology , vol.4 , pp. 459-471
    • Fisher, B.1    Redmond, C.2    Brown, A.3    Fisher, E.R.4    Wolmark, N.5    Bowman, D.6    Plotkin, D.7    Wolter, J.8    Bornstein, R.9    Legault-Poisson, S.10
  • 67
  • 69
    • 0021618186 scopus 로고
    • The pharmacology and clinical uses of tamoxifen
    • Furr, B. J. A. and Jordan, V. C. (1984). The pharmacology and clinical uses of tamoxifen. Pharmacology and Therapeutics 25, 127-205.
    • (1984) Pharmacology and Therapeutics , vol.25 , pp. 127-205
    • Furr, B.J.A.1    Jordan, V.C.2
  • 70
    • 0027139169 scopus 로고
    • The estrogen antagonist ICI 182,780 reduces cancellous bone volumes in female rats
    • Gallagher, A., Chambers, T. J. and Tobias, J. H. (1993). The estrogen antagonist ICI 182,780 reduces cancellous bone volumes in female rats. Endocrinology 133, 2787-2791.
    • (1993) Endocrinology , vol.133 , pp. 2787-2791
    • Gallagher, A.1    Chambers, T.J.2    Tobias, J.H.3
  • 72
    • 0028810645 scopus 로고
    • Influence of droloxifene (3-hydroxytamoxifen) 40 mg daily on plasma gonadotrophins, sex hormone binding globulin and estrogen levels in postmenopausal breast cancer patients
    • Geisler, J., Ekse, D. and Hosch, S. (1995). Influence of droloxifene (3-hydroxytamoxifen) 40 mg daily on plasma gonadotrophins, sex hormone binding globulin and estrogen levels in postmenopausal breast cancer patients. Journal of Steroid Biochemistry and Molecular Biology 55, 193-195.
    • (1995) Journal of Steroid Biochemistry and Molecular Biology , vol.55 , pp. 193-195
    • Geisler, J.1    Ekse, D.2    Hosch, S.3
  • 73
    • 0026040217 scopus 로고
    • The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue
    • Gibson, M. K., Nemmers, L. A., Beckman, W. C., Davis, V. L., Curtis, S. W. and Korach, K. S. (1991). The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology 129, 2000-2010.
    • (1991) Endocrinology , vol.129 , pp. 2000-2010
    • Gibson, M.K.1    Nemmers, L.A.2    Beckman, W.C.3    Davis, V.L.4    Curtis, S.W.5    Korach, K.S.6
  • 75
    • 0023229345 scopus 로고
    • The antitumor action of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model
    • Gottardis, M. M. and Jordan, V. C. (1987). The antitumor action of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Research 47, 4020-4024.
    • (1987) Cancer Research , vol.47 , pp. 4020-4024
    • Gottardis, M.M.1    Jordan, V.C.2
  • 76
    • 0023760993 scopus 로고
    • Development of tamoxifen stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration
    • Gottardis, M. M. and Jordan, V. C. (1988). Development of tamoxifen stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Research 48, 5183-5187.
    • (1988) Cancer Research , vol.48 , pp. 5183-5187
    • Gottardis, M.M.1    Jordan, V.C.2
  • 77
    • 0025300620 scopus 로고
    • Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice
    • Gottardis, M. M., Ricchio, M. D., Satyaswaroop, P. G. and Jordan, V. C. (1990). Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice. Cancer Research 50, 3189-3192.
    • (1990) Cancer Research , vol.50 , pp. 3189-3192
    • Gottardis, M.M.1    Ricchio, M.D.2    Satyaswaroop, P.G.3    Jordan, V.C.4
  • 78
    • 0023915865 scopus 로고
    • Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse
    • Gottardis, M. M., Robinson, S. P., Satyaswaroop, P. G. and Jordan, V. C. (1988). Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Research 48, 812-815.
    • (1988) Cancer Research , vol.48 , pp. 812-815
    • Gottardis, M.M.1    Robinson, S.P.2    Satyaswaroop, P.G.3    Jordan, V.C.4
  • 79
    • 0024316533 scopus 로고
    • Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro
    • Gottardis, M. M., Wagner, R. J., Borden, E. C. and Jordan, V. C. (1989a). Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro. Cancer Research 49, 4765-4769.
    • (1989) Cancer Research , vol.49 , pp. 4765-4769
    • Gottardis, M.M.1    Wagner, R.J.2    Borden, E.C.3    Jordan, V.C.4
  • 80
    • 0024319781 scopus 로고
    • Inhibition of tamoxifen stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens
    • Gottardis, M. M., Jiang, S. Y., Jeng, M. H. and Jordan, V. C. (1989b). Inhibition of tamoxifen stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Research 49, 4090-4093.
    • (1989) Cancer Research , vol.49 , pp. 4090-4093
    • Gottardis, M.M.1    Jiang, S.Y.2    Jeng, M.H.3    Jordan, V.C.4
  • 81
    • 0027201501 scopus 로고
    • Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves, P., Goonetilleke, R., Nunn, G., Topham, J. and Orton, T. (1993). Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Research 53, 3919-3924.
    • (1993) Cancer Research , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 82
    • 0002883428 scopus 로고
    • The oestrogen receptor: From perception to mechanism
    • (Parker, M. G., eds), Academic Press, New York
    • Green, S. and Chambon, P. (1991). The oestrogen receptor: from perception to mechanism. In: Nuclear Hormone Receptors (Parker, M. G., eds), pp. 15-38. Academic Press, New York.
    • (1991) Nuclear Hormone Receptors , pp. 15-38
    • Green, S.1    Chambon, P.2
  • 83
    • 0022653964 scopus 로고
    • Human oestrogen receptor cDNA: Sequence, expression and homology with v-erb A
    • Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J. M., Argos, P. and Chambon, P. (1986). Human oestrogen receptor cDNA: Sequence, expression and homology with v-erb A. Nature 320, 139-143.
    • (1986) Nature , vol.320 , pp. 139-143
    • Green, S.1    Walter, P.2    Kumar, V.3    Krust, A.4    Bornert, J.M.5    Argos, P.6    Chambon, P.7
  • 86
    • 0022473069 scopus 로고
    • Sequence and expression of human estrogen receptor complementary DNA
    • Greene, G. L., Gilna, P., Waterfield, M., Baker, A., Hort, Y. and Shine, J. (1986). Sequence and expression of human estrogen receptor complementary DNA. Science 231, 1150-1154.
    • (1986) Science , vol.231 , pp. 1150-1154
    • Greene, G.L.1    Gilna, P.2    Waterfield, M.3    Baker, A.4    Hort, Y.5    Shine, J.6
  • 87
    • 0012803658 scopus 로고
    • Effects of a dihydronaphthalene derivative (U-11, 100A) on pregnancy in the rat
    • Greenwald, G. S. (1965). Effects of a dihydronaphthalene derivative (U-11, 100A) on pregnancy in the rat. Fertility and Sterility 16, 185-194.
    • (1965) Fertility and Sterility , vol.16 , pp. 185-194
    • Greenwald, G.S.1
  • 89
    • 0026342682 scopus 로고
    • Pharmacokinetics of droloxifene and its metabolites in breast cancer patients
    • Grill, H. J. and Pollow, K. (1991). Pharmacokinetics of droloxifene and its metabolites in breast cancer patients. American Journal of Clinical Oncology 14(2), s21-s29.
    • (1991) American Journal of Clinical Oncology , vol.14 , Issue.2
    • Grill, H.J.1    Pollow, K.2
  • 90
    • 0023913406 scopus 로고
    • Toremifene, a new antiestrogenic compound in the treatment of advanced breast cancer. Phase II study
    • Gunderson, S. (1990). Toremifene, a new antiestrogenic compound in the treatment of advanced breast cancer. Phase II study. European Journal of Cancer 24A, 785-790.
    • (1990) European Journal of Cancer , vol.24 A , pp. 785-790
    • Gunderson, S.1
  • 91
    • 0028835120 scopus 로고
    • Tamoxifen and toremifene lower serum cholesterol by inhibition of Δ8-cholestenol conversion to lathosterol in women with breast cancer
    • Gylling, H., Pyrhonen, S., Mantyla, E., Maenpaa, H., Kangas, L. and Miettinen, T. A. (1995). Tamoxifen and toremifene lower serum cholesterol by inhibition of Δ8-cholestenol conversion to lathosterol in women with breast cancer. Journal of Clinical Oncology 13, 2900-2905.
    • (1995) Journal of Clinical Oncology , vol.13 , pp. 2900-2905
    • Gylling, H.1    Pyrhonen, S.2    Mantyla, E.3    Maenpaa, H.4    Kangas, L.5    Miettinen, T.A.6
  • 93
    • 84965250913 scopus 로고
    • Influence of synthetic oestrogens upon advanced malignant disease
    • Haddow, A., Watkinson, J. M. and Paterson, E. (1994). Influence of synthetic oestrogens upon advanced malignant disease. British Medical Journal 2, 393-398.
    • (1994) British Medical Journal , vol.2 , pp. 393-398
    • Haddow, A.1    Watkinson, J.M.2    Paterson, E.3
  • 94
    • 0028233383 scopus 로고
    • Estrogen receptor associated proteins possible mediators of hormone-induced transcription
    • Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C. and Brown, M. (1993). Estrogen receptor associated proteins possible mediators of hormone-induced transcription. Science 264, 1455-1458.
    • (1993) Science , vol.264 , pp. 1455-1458
    • Halachmi, S.1    Marden, E.2    Martin, G.3    MacKay, H.4    Abbondanza, C.5    Brown, M.6
  • 96
    • 0026606580 scopus 로고
    • Induction of covalent DNA adducts in rodents by tamoxifen
    • Han, X. and Liehr, J. G. (1992). Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Research 52, 1360-1363.
    • (1992) Cancer Research , vol.52 , pp. 1360-1363
    • Han, X.1    Liehr, J.G.2
  • 97
    • 0027428568 scopus 로고
    • Major differences in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl;CD (BR) rats
    • Hard, G. C., Iatropoulos, M. J., Jordan, K., Radi, K., Kaltenberg, O. P., Imondi, A. R. and Williams, G. M. (1993). Major differences in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl;CD (BR) rats. Cancer Research 53, 4534-4541.
    • (1993) Cancer Research , vol.53 , pp. 4534-4541
    • Hard, G.C.1    Iatropoulos, M.J.2    Jordan, K.3    Radi, K.4    Kaltenberg, O.P.5    Imondi, A.R.6    Williams, G.M.7
  • 98
    • 36949059277 scopus 로고
    • Contrasting endocrine activities of cis and trans isomers in a series of substituted triphenylethylenes
    • Harper, M. J. K. and Walpole, A. L. (1966). Contrasting endocrine activities of cis and trans isomers in a series of substituted triphenylethylenes. Nature 212, 87.
    • (1966) Nature , vol.212 , pp. 87
    • Harper, M.J.K.1    Walpole, A.L.2
  • 99
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper, M. J. K. and Walpole, A. L. (1967). A new derivative of triphenylethylene: effect on implantation and mode of action in rats. Journal of Reproduction and Fertility 13, 101-119.
    • (1967) Journal of Reproduction and Fertility , vol.13 , pp. 101-119
    • Harper, M.J.K.1    Walpole, A.L.2
  • 100
    • 0028170305 scopus 로고
    • Preclinical data for droloxifene
    • Hasman, M., Rattel, B. and Loser, R. (1994). Preclinical data for droloxifene. Cancer Letters 84, 101-116.
    • (1994) Cancer Letters , vol.84 , pp. 101-116
    • Hasman, M.1    Rattel, B.2    Loser, R.3
  • 104
    • 0025605574 scopus 로고
    • High dose toremifene (240 mg daily) is effective as first line hormonal treatment in advanced breast cancer - An ongoing phase-II multicenter Finnish-Latvian cooperative study
    • Hietanen, T., Baltina, D., Johansson, R., Numminen, S., Hakala, T., Helle, L. and Valavaara, R. (1990). High dose toremifene (240 mg daily) is effective as first line hormonal treatment in advanced breast cancer - an ongoing phase-II multicenter Finnish-Latvian cooperative study. Breast Cancer Research and Treatment 16, 37-40.
    • (1990) Breast Cancer Research and Treatment , vol.16 , pp. 37-40
    • Hietanen, T.1    Baltina, D.2    Johansson, R.3    Numminen, S.4    Hakala, T.5    Helle, L.6    Valavaara, R.7
  • 105
    • 0025311655 scopus 로고
    • Effect of toremifene in breast cancer patients. Preliminary communication
    • Hindy, I., Juhos, E., Szanto, J. and Szamel, I. (1990). Effect of toremifene in breast cancer patients. Preliminary communication. Journal of Steroid Biochemistry 36, 225-226.
    • (1990) Journal of Steroid Biochemistry , vol.36 , pp. 225-226
    • Hindy, I.1    Juhos, E.2    Szanto, J.3    Szamel, I.4
  • 106
    • 0027397629 scopus 로고
    • Tamoxifen induces hepatocellular carcinoma in rat liver: A 1 year study with 2 antiestrogens
    • Hirsimaki, P., Hirsimaki, Y., Nieminen, L. and Payne, B. J. (1993). Tamoxifen induces hepatocellular carcinoma in rat liver: A 1 year study with 2 antiestrogens. Archives of Toxicology 67, 49-59.
    • (1993) Archives of Toxicology , vol.67 , pp. 49-59
    • Hirsimaki, P.1    Hirsimaki, Y.2    Nieminen, L.3    Payne, B.J.4
  • 107
  • 108
    • 0343715151 scopus 로고
    • Research and development of clomiphene citrate
    • (Asch, R. H., ed.), Fondaizione per Gli Studi sulla riproduzione Umana
    • Holtkamp, D. E. (1987). Research and development of clomiphene citrate. In: Recent Advances in Human Reproduction (Asch, R. H., ed.), pp. 17-27. Fondaizione per Gli Studi sulla riproduzione Umana.
    • (1987) Recent Advances in Human Reproduction , pp. 17-27
    • Holtkamp, D.E.1
  • 112
    • 0028861402 scopus 로고
    • Response to a specific antioestrogen (ICI 182,780) in tamoxifen-resistant breast cancer
    • Howell, A., DeFriend, D., Robertson, J., Blamey, R. and Walton, P. (1995). Response to a specific antioestrogen (ICI 182,780) in tamoxifen-resistant breast cancer. Lancet 345, 29-30.
    • (1995) Lancet , vol.345 , pp. 29-30
    • Howell, A.1    Defriend, D.2    Robertson, J.3    Blamey, R.4    Walton, P.5
  • 113
    • 0026768801 scopus 로고
    • Response after withdrawal of tamoxifen and progestogen in advanced breast cancer
    • Howell, A., Dodwell, D. J., Anderson, H. and Redford, J. (1992). Response after withdrawal of tamoxifen and progestogen in advanced breast cancer. Annals of Oncology 3, 611-617.
    • (1992) Annals of Oncology , vol.3 , pp. 611-617
    • Howell, A.1    Dodwell, D.J.2    Anderson, H.3    Redford, J.4
  • 114
    • 0029026574 scopus 로고
    • Cell proliferation in dimethylbenz(A) anthracene-induced rat mammary carcinoma treated with antiestrogen toremifene
    • Huovinen, R. L., Alanen, K. A. and Collan, Y. (1995). Cell proliferation in dimethylbenz(A) anthracene-induced rat mammary carcinoma treated with antiestrogen toremifene. Acta Oncologica 34, 479-485.
    • (1995) Acta Oncologica , vol.34 , pp. 479-485
    • Huovinen, R.L.1    Alanen, K.A.2    Collan, Y.3
  • 116
    • 0027425753 scopus 로고
    • Mitotic activity, apoptosis and TRPM-2 messenger RNA expression in DMBA-induced rat mammary carcinoma treated with antiestrogen toremifene
    • Huovinen, R., Warri, A. and Collan, Y. (1993). Mitotic activity, apoptosis and TRPM-2 messenger RNA expression in DMBA-induced rat mammary carcinoma treated with antiestrogen toremifene. International Journal of Cancer 55, 685-691.
    • (1993) International Journal of Cancer , vol.55 , pp. 685-691
    • Huovinen, R.1    Warri, A.2    Collan, Y.3
  • 117
    • 0018429114 scopus 로고
    • Induction of ovulation with clomiphene citrate
    • Huppert, L. C. (1979). Induction of ovulation with clomiphene citrate. Fertility and Sterility 31, 1-8.
    • (1979) Fertility and Sterility , vol.31 , pp. 1-8
    • Huppert, L.C.1
  • 118
    • 0028068127 scopus 로고
    • A new triphenylethylene derivative TAT-59: Hormone receptors, insulin-like growth factor 1 and growth supression of hormone dependent MCF-7 tumors in athymic mice
    • Iino, Y., Takai, Y., Ando, T., Chwada, S., Yokoe, T., Sugamata, N., Takei, H., Houghchi, J., Iijima, K. and Morishita, Y. (1994). A new triphenylethylene derivative TAT-59: hormone receptors, insulin-like growth factor 1 and growth supression of hormone dependent MCF-7 tumors in athymic mice. Cancer Chemotherapy and Pharmacology 34, 372-376.
    • (1994) Cancer Chemotherapy and Pharmacology , vol.34 , pp. 372-376
    • Iino, Y.1    Takai, Y.2    Ando, T.3    Chwada, S.4    Yokoe, T.5    Sugamata, N.6    Takei, H.7    Houghchi, J.8    Iijima, K.9    Morishita, Y.10
  • 121
  • 122
    • 0021201213 scopus 로고
    • Antiestrogens 2, structure activity studies in a series of 3-aroyl-2-(4-hydroxyphenyl)benzo [b] thiene-3-yl [4-[2-(1-piperidinyl) ethoxy] phenyl] methanone hydrochloride (LY156,758) a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity
    • Jones, C. D., Jevnikar, M. G., Pike, A. J., Peters, M. K., Black, L. J., Thompson, A. R., Falcone, J. F. and Clemens, J. A. (1984). Antiestrogens 2, structure activity studies in a series of 3-aroyl-2-(4-hydroxyphenyl)benzo [b] thiene-3-yl] [4-[2-(1-piperidinyl) ethoxy] phenyl] methanone hydrochloride (LY156,758) a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity. Journal of Medicine and Chemistry 27, 1057-1066.
    • (1984) Journal of Medicine and Chemistry , vol.27 , pp. 1057-1066
    • Jones, C.D.1    Jevnikar, M.G.2    Pike, A.J.3    Peters, M.K.4    Black, L.J.5    Thompson, A.R.6    Falcone, J.F.7    Clemens, J.A.8
  • 123
    • 0018721780 scopus 로고
    • Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthenyl] [4-2-(1-p-pyrrolidinyl ethoxy)-phenyl] methanone methane sulfonic acid
    • Jones, C. D., Suarez, T., Massey, E. H., Black, L. J. and Tinsley, F. C. (1979). Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthenyl] [4-(2-(1-p-pyrrolidinyl ethoxy)-phenyl] methanone methane sulfonic acid. Journal of Medicine and Chemistry 22, 962-966.
    • (1979) Journal of Medicine and Chemistry , vol.22 , pp. 962-966
    • Jones, C.D.1    Suarez, T.2    Massey, E.H.3    Black, L.J.4    Tinsley, F.C.5
  • 124
    • 0025786896 scopus 로고
    • Phase II study of high dose toremifene in advanced breast cancer progressing during tamoxifen treatment
    • Jönsson, P. E., Malmberg, M., Bergljung, L. and Ingvar, C. (1991). Phase II study of high dose toremifene in advanced breast cancer progressing during tamoxifen treatment. AntiCancer Research 11, 873-876.
    • (1991) Anticancer Research , vol.11 , pp. 873-876
    • Jönsson, P.E.1    Malmberg, M.2    Bergljung, L.3    Ingvar, C.4
  • 125
    • 0001626384 scopus 로고
    • Antitumour activity of the antioestrogen ICI 46,474 (tamoxifen) in the dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma model
    • Jordan, V. C. (1974). Antitumour activity of the antioestrogen ICI 46,474 (tamoxifen) in the dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma model. Journal of Steroid Biochemistry 5, 354.
    • (1974) Journal of Steroid Biochemistry , vol.5 , pp. 354
    • Jordan, V.C.1
  • 126
    • 0017078344 scopus 로고
    • Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata
    • Jordan, V. C. (1976). Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. European Journal of Cancer 12, 419-424.
    • (1976) European Journal of Cancer , vol.12 , pp. 419-424
    • Jordan, V.C.1
  • 127
    • 0002420533 scopus 로고
    • Use of the DMBA-induced rat mammary carcinoma system for the evaluation of tamoxifen as a potential adjuvant therapy
    • Jordan, V.C. (1978). Use of the DMBA-induced rat mammary carcinoma system for the evaluation of tamoxifen as a potential adjuvant therapy. Rev. Endocrine Rel. Cancer October suppl, 49-55.
    • (1978) Rev. Endocrine Rel. Cancer , vol.OCTOBER SUPPL , pp. 49-55
    • Jordan, V.C.1
  • 128
    • 0020963216 scopus 로고
    • Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogen: Problems and potential for future clinical applications
    • Jordan, V. C. (1983). Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogen: problems and potential for future clinical applications. Breast Cancer Research and Treatment 3, 573-586.
    • (1983) Breast Cancer Research and Treatment , vol.3 , pp. 573-586
    • Jordan, V.C.1
  • 129
    • 0021709492 scopus 로고
    • Biochemical pharmacology of antiestrogen action
    • Jordan, V. C. (1984). Biochemical pharmacology of antiestrogen action. Pharmacological Reviews 36, 245-276.
    • (1984) Pharmacological Reviews , vol.36 , pp. 245-276
    • Jordan, V.C.1
  • 130
    • 0023773272 scopus 로고
    • The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole
    • Jordan, V. C. (1988). The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole. Breast Cancer Research and Treatment 11, 197-209.
    • (1988) Breast Cancer Research and Treatment , vol.11 , pp. 197-209
    • Jordan, V.C.1
  • 131
    • 0027172047 scopus 로고
    • Current view of the use of tamoxifen for the treatment and prevention of breast cancer
    • Gaddum Memorial Lecture
    • Jordan, V. C. (1993). Current view of the use of tamoxifen for the treatment and prevention of breast cancer. Gaddum Memorial Lecture. British Journal of Pharmacology 110, 507-517.
    • (1993) British Journal of Pharmacology , vol.110 , pp. 507-517
    • Jordan, V.C.1
  • 133
    • 0342844840 scopus 로고
    • Alternate antiestrogens and strategies for the prevention of breast cancer
    • Jordan, V. C. (1995a). Alternate antiestrogens and strategies for the prevention of breast cancer. Journal of Cell Biochemistry 22, 557-561.
    • (1995) Journal of Cell Biochemistry , vol.22 , pp. 557-561
    • Jordan, V.C.1
  • 134
    • 0028936687 scopus 로고
    • Tamoxifen and tumorigenicity: A predictable concern
    • Jordan, V. C. (1995b). Tamoxifen and tumorigenicity: a predictable concern. Journal of the National Cancer Institute 87, 623-626.
    • (1995) Journal of the National Cancer Institute , vol.87 , pp. 623-626
    • Jordan, V.C.1
  • 135
    • 0028796491 scopus 로고
    • What if tamoxifen had been found to produce rat liver tumors in 1973?
    • Jordan, V. C. (1995c). What if tamoxifen had been found to produce rat liver tumors in 1973? Annals of Oncology 6, 29-33.
    • (1995) Annals of Oncology , vol.6 , pp. 29-33
    • Jordan, V.C.1
  • 136
    • 0029015862 scopus 로고
    • Tamoxifen and endometrial cancer: Clearing up a controversy
    • Jordan, V. C. and Assikis, V. J. (1995). Tamoxifen and endometrial cancer: clearing up a controversy. Clinical Cancer Research 1, 467-472.
    • (1995) Clinical Cancer Research , vol.1 , pp. 467-472
    • Jordan, V.C.1    Assikis, V.J.2
  • 137
    • 0020825481 scopus 로고
    • Differential antiestrogen actions in the immature rat uterus: A comparision of hydroxylated antiestrogens with high affinity for the estrogen receptor
    • Jordan, V. C. and Gosden, B. (1983a). Differential antiestrogen actions in the immature rat uterus: a comparision of hydroxylated antiestrogens with high affinity for the estrogen receptor. Journal of Steroid Biochemistry 19, 1249-1258.
    • (1983) Journal of Steroid Biochemistry , vol.19 , pp. 1249-1258
    • Jordan, V.C.1    Gosden, B.2
  • 138
    • 0020636027 scopus 로고
    • Inhibition of the uterotrophic activity of estrogens and antiestrogens by the short acting antiestrogen LY 117 018
    • Jordan, V. C. and Gosden, B. (1983b). Inhibition of the uterotrophic activity of estrogens and antiestrogens by the short acting antiestrogen LY 117 018. Endocrinology 113, 463-468.
    • (1983) Endocrinology , vol.113 , pp. 463-468
    • Jordan, V.C.1    Gosden, B.2
  • 139
    • 0027942428 scopus 로고
    • Should clinicians be concerned about the carcinogenic potential of tamoxifen?
    • Jordan, V. C. and Morrow, M. (1994). Should clinicians be concerned about the carcinogenic potential of tamoxifen? European Journal of Cancer 30A, 1714-1721.
    • (1994) European Journal of Cancer , vol.30 A , pp. 1714-1721
    • Jordan, V.C.1    Morrow, M.2
  • 140
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan, V. C., Collins, M. M., Rowsby, L. and Prestwich, G. (1977). A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. Journal of Endocrinology 75, 305-316.
    • (1977) Journal of Endocrinology , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3    Prestwich, G.4
  • 141
    • 0002487846 scopus 로고
    • The effectiveness of long-term treatment in a laboratory model for adjuvant hormone therapy of breast cancer
    • (Salmon, S. E. and Jones, S. E., eds), Grune and Stratton, New York.
    • Jordan, V. C., Dix, C. J. and Allen, K. E. (1979). The effectiveness of long-term treatment in a laboratory model for adjuvant hormone therapy of breast cancer. In: Adjuvant Therapy of Cancer. II (Salmon, S. E. and Jones, S. E., eds), pp. 19-26. Grune and Stratton, New York.
    • (1979) Adjuvant Therapy of Cancer , vol.2 , pp. 19-26
    • Jordan, V.C.1    Dix, C.J.2    Allen, K.E.3
  • 145
    • 0021735339 scopus 로고
    • Structural requirements for the pharmacological activity of non-steroidal antiestrogens in vitro
    • Jordan, V. C., Lieberman, M. E., Cormier, E., Koch, R., Bagley, J. R. and Ruenitz, P. C. (1984). Structural requirements for the pharmacological activity of non-steroidal antiestrogens in vitro. Molecular Pharmacology 2261, 272-278.
    • (1984) Molecular Pharmacology , vol.2261 , pp. 272-278
    • Jordan, V.C.1    Lieberman, M.E.2    Cormier, E.3    Koch, R.4    Bagley, J.R.5    Ruenitz, P.C.6
  • 148
    • 0025292192 scopus 로고
    • Review of the pharmacological properties of toremifene
    • Kangas, L. (1990a). Review of the pharmacological properties of toremifene. Journal of Steroid Biochemistry 36, 191-195.
    • (1990) Journal of Steroid Biochemistry , vol.36 , pp. 191-195
    • Kangas, L.1
  • 149
    • 0025608019 scopus 로고
    • Biochemical and pharmacological effects of toremifene metabolites
    • Kangas, L. (1990b). Biochemical and pharmacological effects of toremifene metabolites. Cancer Chemotherapy and Pharmacology 27, 8-12.
    • (1990) Cancer Chemotherapy and Pharmacology , vol.27 , pp. 8-12
    • Kangas, L.1
  • 151
    • 0023199060 scopus 로고
    • Proliferation, hormonal responsiveness and estrogen receptor content of MCF-7 human breast cancer cell in the short and long-term absence of estrogens
    • Katzenellenbogen, B. S., Kendra, K. L., Norman, M. J. and Berthois, Y. (1987). Proliferation, hormonal responsiveness and estrogen receptor content of MCF-7 human breast cancer cell in the short and long-term absence of estrogens. Cancer Research 47, 4355-4360.
    • (1987) Cancer Research , vol.47 , pp. 4355-4360
    • Katzenellenbogen, B.S.1    Kendra, K.L.2    Norman, M.J.3    Berthois, Y.4
  • 152
    • 0026079558 scopus 로고
    • Antitumor effects of droloxifene, a new antiestrogen drug against 7,12 dimethylbenz (a) anthracene-induced mammary tumor in rats
    • Kawamura, I., Mizota, T., Kondo, N., Shimomura, L. and Kohsaka, M. (1991). Antitumor effects of droloxifene, a new antiestrogen drug against 7,12 dimethylbenz (a) anthracene-induced mammary tumor in rats. Japan Journal of Pharmacology 57, 215-224.
    • (1991) Japan Journal of Pharmacology , vol.57 , pp. 215-224
    • Kawamura, I.1    Mizota, T.2    Kondo, N.3    Shimomura, L.4    Kohsaka, M.5
  • 154
    • 0029016173 scopus 로고
    • Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats
    • Ke, H. Z., Simmons, H. A., Pirie, C. M., Crawford, D. T. and Thompson, D. D. (1995). Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats. Endocrinology 136, 2435-2441.
    • (1995) Endocrinology , vol.136 , pp. 2435-2441
    • Ke, H.Z.1    Simmons, H.A.2    Pirie, C.M.3    Crawford, D.T.4    Thompson, D.D.5
  • 156
    • 0013833184 scopus 로고
    • Induction of ovulation with clomiphene citrate (Clomid)
    • Kistner, R. B. (1965). Induction of ovulation with clomiphene citrate (Clomid). Obstetrics and Gynecology Surveys 20, 873-900.
    • (1965) Obstetrics and Gynecology Surveys , vol.20 , pp. 873-900
    • Kistner, R.B.1
  • 157
    • 0010444537 scopus 로고
    • Observations on the use of non-steroidal estrogen antagonist-MER-25
    • Kistner, R. W. and Smith, O. W. (1960). Observations on the use of non-steroidal estrogen antagonist-MER-25. Surgical Forum 10, 725-729.
    • (1960) Surgical Forum , vol.10 , pp. 725-729
    • Kistner, R.W.1    Smith, O.W.2
  • 158
    • 0025302085 scopus 로고
    • Effect of toremifene on clinical hematological and hormonal parameters at different dose levels in healthy postmenopausal volunteers: Phase I study
    • Kivinen, S. and Maenpaa, J. (1990). Effect of toremifene on clinical hematological and hormonal parameters at different dose levels in healthy postmenopausal volunteers: phase I study. Journal of Steroid Biochemistry 36, 217-220.
    • (1990) Journal of Steroid Biochemistry , vol.36 , pp. 217-220
    • Kivinen, S.1    Maenpaa, J.2
  • 159
    • 0026320235 scopus 로고
    • Induction of transforming growth factor beta by the antiestrogens droloxifene, tamoxifen and toremifene in MCF-7 cells
    • Knabbe, C., Zugmaier, G., Schmahl, M., Dietel, M., Lippman, M. E. and Dickson, R. B. (1991). Induction of transforming growth factor beta by the antiestrogens droloxifene, tamoxifen and toremifene in MCF-7 cells. American Journal of Clinical Oncology 14, 15-20.
    • (1991) American Journal of Clinical Oncology , vol.14 , pp. 15-20
    • Knabbe, C.1    Zugmaier, G.2    Schmahl, M.3    Dietel, M.4    Lippman, M.E.5    Dickson, R.B.6
  • 162
    • 0025619361 scopus 로고
    • Results of comparative clinical evaluation of antiestrogens toremifene and tamoxifen in locally advanced and disseminated breast cancer
    • Konstantinova, M. M. and Gershanovich, M. L. (1990). Results of comparative clinical evaluation of antiestrogens toremifene and tamoxifen in locally advanced and disseminated breast cancer [in Russian] Vopr. Onkol. 36, 1182-1186.
    • (1990) Vopr. Onkol. , vol.36 , pp. 1182-1186
    • Konstantinova, M.M.1    Gershanovich, M.L.2
  • 163
    • 0242356764 scopus 로고
    • Triparanol in the treatment of disseminated mammary carcinoma
    • Kraft, R. O. (1962). Triparanol in the treatment of disseminated mammary carcinoma. Cancer Chemotherapy Reports 25, 113-115.
    • (1962) Cancer Chemotherapy Reports , vol.25 , pp. 113-115
    • Kraft, R.O.1
  • 166
    • 0022655909 scopus 로고
    • Trioxifene mesylate in the treatment of advanced breast cancer
    • Lee, R. W., Buzdar, A. U., Blumenschein, G. R. and Hortobagyi, G. N. (1986). Trioxifene mesylate in the treatment of advanced breast cancer. Cancer 57, 40-43.
    • (1986) Cancer , vol.57 , pp. 40-43
    • Lee, R.W.1    Buzdar, A.U.2    Blumenschein, G.R.3    Hortobagyi, G.N.4
  • 167
    • 0017166858 scopus 로고
    • Nafoxidine - An antiestrogen for the treatment of breast cancer
    • Legha, S. S., Slavik, M. and Carter, S. K. (1976). Nafoxidine - an antiestrogen for the treatment of breast cancer. Cancer 38, 1535-1541.
    • (1976) Cancer , vol.38 , pp. 1535-1541
    • Legha, S.S.1    Slavik, M.2    Carter, S.K.3
  • 168
    • 0029005436 scopus 로고
    • Determination of droloxifene and two metabolites in serum by high pressure liquid chromatography
    • Lien, E. A., Anker, G., Lonning, P. E. and Veland, D. M. (1995). Determination of droloxifene and two metabolites in serum by high pressure liquid chromatography. Therapy and Drug Monitoring 17, 259-265.
    • (1995) Therapy and Drug Monitoring , vol.17 , pp. 259-265
    • Lien, E.A.1    Anker, G.2    Lonning, P.E.3    Veland, D.M.4
  • 169
    • 0002844490 scopus 로고
    • The first non-steroidal antioestrogen-MER-25
    • (Sutherland, R. L. and Jordan, V. C., eds), Academic Press, Sydney
    • Lerner, L. J. (1981). The first non-steroidal antioestrogen-MER-25. In: Non-steroidal Antioestrogens: Molecular Pharmacology and Antitumour Activity (Sutherland, R. L. and Jordan, V. C., eds), pp. 1-16. Academic Press, Sydney.
    • (1981) Non-steroidal Antioestrogens: Molecular Pharmacology and Antitumour Activity , pp. 1-16
    • Lerner, L.J.1
  • 170
    • 0025338591 scopus 로고
    • Development of antiestrogens and their use in breast cancer. Eighth Cain Memorial Lecture
    • Lerner, L. J. and Jordan, V. C. (1990). Development of antiestrogens and their use in breast cancer. Eighth Cain Memorial Lecture. Cancer Research 50, 4177-4189.
    • (1990) Cancer Research , vol.50 , pp. 4177-4189
    • Lerner, L.J.1    Jordan, V.C.2
  • 171
    • 70449221678 scopus 로고
    • A non-steroidal estrogen antagonist 1-(p-2-diethylaminoethoxyphenyl) -1-phenyl-2-p-methoxyphenyl-ethanol
    • Lerner, L. J., Holthaus, J. F. and Thompson, C. R. (1958). A non-steroidal estrogen antagonist 1-(p-2-diethylaminoethoxyphenyl) -1-phenyl-2-p-methoxyphenyl-ethanol. Endocrinology 63, 295-318.
    • (1958) Endocrinology , vol.63 , pp. 295-318
    • Lerner, L.J.1    Holthaus, J.F.2    Thompson, C.R.3
  • 172
    • 0020587401 scopus 로고
    • An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro
    • Lieberman, M. E., Gorski, J. and Jordan, V. C. (1983). An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro. Journal of Biology and Chemistry 258, 4741-4745.
    • (1983) Journal of Biology and Chemistry , vol.258 , pp. 4741-4745
    • Lieberman, M.E.1    Gorski, J.2    Jordan, V.C.3
  • 173
    • 0028177045 scopus 로고
    • A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes
    • Lim, C. K., Zhi-Xin, Y., Lamb, J. H., White, I. N. H., De Matteis, F. and Smith, L. L. (1994). A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes. Carcinogenesis 15, 589-593.
    • (1994) Carcinogenesis , vol.15 , pp. 589-593
    • Lim, C.K.1    Zhi-Xin, Y.2    Lamb, J.H.3    White, I.N.H.4    De Matteis, F.5    Smith, L.L.6
  • 174
    • 0022407653 scopus 로고
    • No loss of estrogenic and antiestrogenic activity after demethylation of droloxifene (3-OH tamoxifen)
    • Loser, R., Seibel, K. and Eppenberger, U. (1985a). No loss of estrogenic and antiestrogenic activity after demethylation of droloxifene (3-OH tamoxifen). International Journal of Cancer 36, 701-703.
    • (1985) International Journal of Cancer , vol.36 , pp. 701-703
    • Loser, R.1    Seibel, K.2    Eppenberger, U.3
  • 175
    • 0021829829 scopus 로고
    • In vivo and in vitro antiestrogenic action of 3-hydroxy-tamoxifen, tamoxifen and 4-hydroxy-tamoxifen
    • European Journal of Cancer.
    • Loser, R., Seibel, K., Roos, W. and Eppenberger, U. (1985b). In vivo and in vitro antiestrogenic action of 3-hydroxy-tamoxifen, tamoxifen and 4-hydroxy-tamoxifen, European Journal of Cancer. Clinical Oncology 21, 900-985.
    • (1985) Clinical Oncology , vol.21 , pp. 900-985
    • Loser, R.1    Seibel, K.2    Roos, W.3    Eppenberger, U.4
  • 176
    • 0028033883 scopus 로고
    • Effect of tamoxifen on lumber spine bone mineral density in postmenopausal women after 5 years
    • Love, R. R., Barden, H. S., Mazess, R., Epstein, S. and Chappell, R. J. (1994). Effect of tamoxifen on lumber spine bone mineral density in postmenopausal women after 5 years. Archives of Internal Medicine 154, 2585-2586.
    • (1994) Archives of Internal Medicine , vol.154 , pp. 2585-2586
    • Love, R.R.1    Barden, H.S.2    Mazess, R.3    Epstein, S.4    Chappell, R.J.5
  • 178
  • 182
    • 84913734164 scopus 로고
    • Changes in endocrine status following antiestrogen administration to premenopausal and postmenopausal women
    • (Sutherland, R. L. and Jordan, V. C., eds), Academic Press, Sydney
    • Manni, A., Arafah, B. and Pearson, O. H. (1981). Changes in endocrine status following antiestrogen administration to premenopausal and postmenopausal women. In: Non-steroidal Antioestrogens, Molecular Pharmacology and Antitumour Activity (Sutherland, R. L. and Jordan, V. C., eds), pp. 435-452. Academic Press, Sydney.
    • (1981) Non-steroidal Antioestrogens, Molecular Pharmacology and Antitumour Activity , pp. 435-452
    • Manni, A.1    Arafah, B.2    Pearson, O.H.3
  • 184
    • 0010734092 scopus 로고
    • Binding of antiestrogen exposes an occult antigenic determinant in the human estrogen receptor
    • Martin, P. M., Berthois, Y. and Jensen, E. V. (1988). Binding of antiestrogen exposes an occult antigenic determinant in the human estrogen receptor. Proceedings of the National Academy of Science 85, 2533-2537.
    • (1988) Proceedings of the National Academy of Science , vol.85 , pp. 2533-2537
    • Martin, P.M.1    Berthois, Y.2    Jensen, E.V.3
  • 186
    • 0025010197 scopus 로고
    • Metabolism of the 4 iodo derivative of tamoxifen by isolated rat hepatocytes. Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites
    • McCague, R., Parr, I. B. and Haynes, B. P. (1990). Metabolism of the 4 iodo derivative of tamoxifen by isolated rat hepatocytes. Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites. Biochemical Pharmacology 40, 2277-2283.
    • (1990) Biochemical Pharmacology , vol.40 , pp. 2277-2283
    • McCague, R.1    Parr, I.B.2    Haynes, B.P.3
  • 187
    • 0025833585 scopus 로고
    • Fatal myocardial infarction in the scottish tamoxifen trail
    • McDonald, C. C. and Stewart, H. J. (1991). Fatal myocardial infarction in the Scottish tamoxifen trail. British Medical Journal 303, 435-437.
    • (1991) British Medical Journal , vol.303 , pp. 435-437
    • McDonald, C.C.1    Stewart, H.J.2
  • 188
  • 189
    • 0029038986 scopus 로고
    • Analysis of estrogen receptor function reveals three distinct classes of antiestrogens
    • McDonnell, D. P., Clemm, D. L., Hermann, T., Goldman, M. E. and Pike, J. W. (1995). Analysis of estrogen receptor function reveals three distinct classes of antiestrogens. Molecular Endocrinology 9, 659-669.
    • (1995) Molecular Endocrinology , vol.9 , pp. 659-669
    • McDonnell, D.P.1    Clemm, D.L.2    Hermann, T.3    Goldman, M.E.4    Pike, J.W.5
  • 191
    • 0007780424 scopus 로고
    • Clomiphene Citrate (Clomid)
    • W. S. Merrill Company (1967). Clomiphene Citrate (Clomid). Clinical Pharmacology and Therapeutics 8, 891-897.
    • (1967) Clinical Pharmacology and Therapeutics , vol.8 , pp. 891-897
  • 192
    • 0023895442 scopus 로고
    • The human estrogen receptor functions in yeast
    • Metzger, D., White, J. and Chambon, P. (1988). The human estrogen receptor functions in yeast. Nature 334, 31-36.
    • (1988) Nature , vol.334 , pp. 31-36
    • Metzger, D.1    White, J.2    Chambon, P.3
  • 193
    • 0026342683 scopus 로고
    • Structural requirements for the in vitro transformation of Syrian hamster embryo cells by stilbene estrogens and triphenylethylene-type antiestrogens
    • Metzler, M. and Schiffmann, D. (1991). Structural requirements for the in vitro transformation of Syrian hamster embryo cells by stilbene estrogens and triphenylethylene-type antiestrogens. American Journal of Clinical Oncology 14(2), s30-s35.
    • (1991) American Journal of Clinical Oncology , vol.14 , Issue.2
    • Metzler, M.1    Schiffmann, D.2
  • 194
    • 0025294422 scopus 로고
    • Phase II clinical study of toremifene in patients with metastatic breast cancer
    • Modig, H., Borgstrom, M., Nilsson, I. and Westman, G. (1990). Phase II clinical study of toremifene in patients with metastatic breast cancer. Journal of Steroid Biochemistry 36, 235-236.
    • (1990) Journal of Steroid Biochemistry , vol.36 , pp. 235-236
    • Modig, H.1    Borgstrom, M.2    Nilsson, I.3    Westman, G.4
  • 195
    • 0030069966 scopus 로고    scopus 로고
    • Tamoxifen metabolic activation: Comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo
    • Moorthy, B., Sriram, P., Pathak, D., Bodell, W. J. and Randerath, K. (1996). Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo. Cancer Research 56, 53-57.
    • (1996) Cancer Research , vol.56 , pp. 53-57
    • Moorthy, B.1    Sriram, P.2    Pathak, D.3    Bodell, W.J.4    Randerath, K.5
  • 196
    • 0027361914 scopus 로고
    • Molecular mechanism of resistance to tamoxifen therapy in breast cancer
    • Morrow, M. and Jordan, V. C. (1993). Molecular mechanism of resistance to tamoxifen therapy in breast cancer. Archives of Surgery 128, 1187-1191.
    • (1993) Archives of Surgery , vol.128 , pp. 1187-1191
    • Morrow, M.1    Jordan, V.C.2
  • 197
    • 0028038046 scopus 로고
    • The incidence of hepatocellular carcinoma in US white women with breast cancer after the introduction of tamoxifen in 1977
    • Muhleman, K., Cook, L. S. and Weiss, N. S. (1994). The incidence of hepatocellular carcinoma in US white women with breast cancer after the introduction of tamoxifen in 1977. Breast Cancer Research and Treatment 30, 201-204.
    • (1994) Breast Cancer Research and Treatment , vol.30 , pp. 201-204
    • Muhleman, K.1    Cook, L.S.2    Weiss, N.S.3
  • 198
    • 0025201414 scopus 로고
    • Characterization of a receptor-negative, hormone non responsive clone derived from T47D human breast cancer cell line kept under estrogen free conditions
    • Murphy, C. S., Pink, J. J. and Jordan, V. C. (1992). Characterization of a receptor-negative, hormone non responsive clone derived from T47D human breast cancer cell line kept under estrogen free conditions. Cancer Research 50, 7285-7292.
    • (1992) Cancer Research , vol.50 , pp. 7285-7292
    • Murphy, C.S.1    Pink, J.J.2    Jordan, V.C.3
  • 200
    • 77956028902 scopus 로고
    • Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. Interim analysis at 4 years
    • Nolvadex Adjuvant Trial Organization [NATO] (1983). Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. Interim analysis at 4 years. Lancet i, 257-261.
    • (1983) Lancet , vol.1 , pp. 257-261
  • 201
    • 0023888245 scopus 로고
    • Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. Interim analysis at eight years
    • Nolvadex Adjuvant Trial Organization [NATO] (1988). Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. Interim analysis at eight years. British Journal of Cancer 57, 608-611.
    • (1988) British Journal of Cancer , vol.57 , pp. 608-611
  • 202
    • 0027516435 scopus 로고
    • Clinical evaluation of NK 22 (toremifene citrate) in advanced or recurrent breast cancer - A comparative study by a double blind method with tamoxifen
    • Nomura, Y., Tominaga, T., Abe, O., Izuo, M. and Ogawa, N. (1993). Clinical evaluation of NK 22 (toremifene citrate) in advanced or recurrent breast cancer - a comparative study by a double blind method with tamoxifen [in Japanse]. Gan to Kagaku Ryoho 20, 247-258.
    • (1993) Gan to Kagaku Ryoho , vol.20 , pp. 247-258
    • Nomura, Y.1    Tominaga, T.2    Abe, O.3    Izuo, M.4    Ogawa, N.5
  • 204
    • 0023235522 scopus 로고
    • Human breast cancer in athymic nude mice: Cytostatic effects of long-term antiestrogenic activity
    • Osborne, C. K., Coronado, E. B. and Robinson, J. P. (1987). Human breast cancer in athymic nude mice: cytostatic effects of long-term antiestrogenic activity. European Journal of Cancer 23, 1189-1196.
    • (1987) European Journal of Cancer , vol.23 , pp. 1189-1196
    • Osborne, C.K.1    Coronado, E.B.2    Robinson, J.P.3
  • 206
    • 0021958425 scopus 로고
    • Effects of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice
    • Osborne, C. K., Hobbs, K. and Clark, G. M. (1985). Effects of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Research 45, 584-590.
    • (1985) Cancer Research , vol.45 , pp. 584-590
    • Osborne, C.K.1    Hobbs, K.2    Clark, G.M.3
  • 208
    • 0030050137 scopus 로고    scopus 로고
    • Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen
    • Osborne, M. R., Hewer, A., Hardcastle, I. R., Carmichael, P. L. and Phillips, D. H. (1996). Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen. Cancer Research 56, 66-71.
    • (1996) Cancer Research , vol.56 , pp. 66-71
    • Osborne, M.R.1    Hewer, A.2    Hardcastle, I.R.3    Carmichael, P.L.4    Phillips, D.H.5
  • 210
    • 0029034037 scopus 로고
    • High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer. A phase II trial of the Cancer and Leukemia Group B (CALGB)
    • Perry, J. J., Berry, D. A., Weiss, R. B., Hayes, D. M., Duggan, D. B. and Henderson, I. C. (1995). High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer. A phase II trial of the Cancer and Leukemia Group B (CALGB). Breast Cancer Research and Treatment 36, 35-40.
    • (1995) Breast Cancer Research and Treatment , vol.36 , pp. 35-40
    • Perry, J.J.1    Berry, D.A.2    Weiss, R.B.3    Hayes, D.M.4    Duggan, D.B.5    Henderson, I.C.6
  • 212
    • 0029985407 scopus 로고    scopus 로고
    • Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: Comparison between human, rat and mouse hepatocytes
    • Phillips, D. H., Carmichael, P. L., Hewer, A., Cole, K. J., Hardcastle, I. R., Poon, G. K. and Deogh, A. (1996a). Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: comparison between human, rat and mouse hepatocytes. Carcinogenesis 17, 89-94.
    • (1996) Carcinogenesis , vol.17 , pp. 89-94
    • Phillips, D.H.1    Carmichael, P.L.2    Hewer, A.3    Cole, K.J.4    Hardcastle, I.R.5    Poon, G.K.6    Deogh, A.7
  • 213
    • 0028179723 scopus 로고
    • Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats
    • Phillips, D. H., Hewer, A., White, I. N. H. and Farmer, P. B. (1994a). Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats. Carcinogenesis 15, 793-795.
    • (1994) Carcinogenesis , vol.15 , pp. 793-795
    • Phillips, D.H.1    Hewer, A.2    White, I.N.H.3    Farmer, P.B.4
  • 214
    • 0029903222 scopus 로고    scopus 로고
    • Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients
    • Phillips, D. H., Hewer, A., Grover, P. L., Poon, G. K. and Carmichael, P. L. (1996b). Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients. Carcinogenesis 17, 1149-1152.
    • (1996) Carcinogenesis , vol.17 , pp. 1149-1152
    • Phillips, D.H.1    Hewer, A.2    Grover, P.L.3    Poon, G.K.4    Carmichael, P.L.5
  • 216
    • 0028172242 scopus 로고
    • α-hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes
    • Phillips, D. H., Carmichael, P. L., Hewer, A., Cole, K. J. and Poon, G. K. (1994c). α-hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Research. 54, 5518-5522.
    • (1994) Cancer Research. , vol.54 , pp. 5518-5522
    • Phillips, D.H.1    Carmichael, P.L.2    Hewer, A.3    Cole, K.J.4    Poon, G.K.5
  • 217
    • 0029883292 scopus 로고    scopus 로고
    • Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines
    • Pink, J. J. and Jordan, V. C. (1996). Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Research 56, 2321-2330.
    • (1996) Cancer Research , vol.56 , pp. 2321-2330
    • Pink, J.J.1    Jordan, V.C.2
  • 218
    • 0029844145 scopus 로고    scopus 로고
    • Irreversible loss of the estrogen receptor in T47D breast cancer cells following prolonged estrogen deprivation
    • in press
    • Pink, J. J., Bilimoria, M. M., Assikis, V. J. and Jordan, V. C. (1996b). Irreversible loss of the estrogen receptor in T47D breast cancer cells following prolonged estrogen deprivation. British Journal of Cancer (in press).
    • (1996) British Journal of Cancer
    • Pink, J.J.1    Bilimoria, M.M.2    Assikis, V.J.3    Jordan, V.C.4
  • 219
    • 85046166699 scopus 로고    scopus 로고
    • Cloning and characterization of a 77 kilodalton oestrogen receptor isolated from a human breast cancer cell line
    • in press.
    • Pink, J. J., Fritsch, M., Bilimoria, M. M., Assikis, V. J. and Jordan, V. C. (in press). Cloning and Characterization of a 77 kilodalton oestrogen receptor isolated from a human breast cancer cell line. British Journal of Cancer.
    • British Journal of Cancer
    • Pink, J.J.1    Fritsch, M.2    Bilimoria, M.M.3    Assikis, V.J.4    Jordan, V.C.5
  • 220
    • 0029041374 scopus 로고
    • An estrogen independent MCF-7 breast cancer cell line which contains a novel 80 kilodalton estrogen receptor related protein
    • Pink, J. J., Jiang, S. Y., Fritsch, M. and Jordan, V. C. (1995). An estrogen independent MCF-7 breast cancer cell line which contains a novel 80 kilodalton estrogen receptor related protein. Cancer Research 55, 2583-2590.
    • (1995) Cancer Research , vol.55 , pp. 2583-2590
    • Pink, J.J.1    Jiang, S.Y.2    Fritsch, M.3    Jordan, V.C.4
  • 221
    • 0029865898 scopus 로고    scopus 로고
    • A novel 80 kilodalton human estrogen receptor containing a duplication of exons 6 and 7
    • Pink, J. J., Wu, S. Q., Wolf, D. M., Bilimoria, M. M. and Jordan, V. C. (1996a). A novel 80 kilodalton human estrogen receptor containing a duplication of exons 6 and 7. Nucleic Acids Research 24, 962-969.
    • (1996) Nucleic Acids Research , vol.24 , pp. 962-969
    • Pink, J.J.1    Wu, S.Q.2    Wolf, D.M.3    Bilimoria, M.M.4    Jordan, V.C.5
  • 222
    • 0024788816 scopus 로고
    • Antiestrogenic properties of keoxifene, trans 4-hydroxytamoxifen and ICI 164,384, a new steroidal antiestrogen in ZR-75-1 human breast cancer cells
    • Poulin, R., Merand, Y., Poirier, D., Levesque, C., DuFour, J. M. and Labrie, F. (1989). Antiestrogenic properties of keoxifene, trans 4-hydroxytamoxifen and ICI 164,384, a new steroidal antiestrogen in ZR-75-1 human breast cancer cells. Breast Cancer Research and Treatment 14, 655-667.
    • (1989) Breast Cancer Research and Treatment , vol.14 , pp. 655-667
    • Poulin, R.1    Merand, Y.2    Poirier, D.3    Levesque, C.4    DuFour, J.M.5    Labrie, F.6
  • 223
    • 0029011746 scopus 로고
    • Activation of the tamoxifen derivative metabolite E to form DNA adducts: Comparison with the adducts formed by microsomal activation of tamoxifen
    • Pongracz, K., Pathak, D. N., Nakamura, T., Burgingame, A. L. and Bodell, W. J. (1995). Activation of the tamoxifen derivative metabolite E to form DNA adducts: comparison with the adducts formed by microsomal activation of tamoxifen. Cancer Research 55, 3012-3015.
    • (1995) Cancer Research , vol.55 , pp. 3012-3015
    • Pongracz, K.1    Pathak, D.N.2    Nakamura, T.3    Burgingame, A.L.4    Bodell, W.J.5
  • 224
    • 0028326053 scopus 로고
    • A mechanistic hypothesis for DNA adduct formation by tamoxifen following oxidative metabolism
    • Potter, G. A., McCague, R. and Jarman, M. (1994). A mechanistic hypothesis for DNA adduct formation by tamoxifen following oxidative metabolism. Carcinogenesis 15, 439-442.
    • (1994) Carcinogenesis , vol.15 , pp. 439-442
    • Potter, G.A.1    McCague, R.2    Jarman, M.3
  • 225
    • 0026087647 scopus 로고
    • Epidemiologic data on exogenous hormones and hepatocellular carcinoma and selected other cancers
    • Prentice, R. L. (1991). Epidemiologic data on exogenous hormones and hepatocellular carcinoma and selected other cancers. Preventive Medicine 20, 38-46.
    • (1991) Preventive Medicine , vol.20 , pp. 38-46
    • Prentice, R.L.1
  • 226
    • 0028210694 scopus 로고
    • High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen treatment
    • Pyrhönen, S., Valavaara, R., Vuorinen, J. and Hajba, A. (1994). High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen treatment. Breast Cancer Research and Treatment 29, 223-228.
    • (1994) Breast Cancer Research and Treatment , vol.29 , pp. 223-228
    • Pyrhönen, S.1    Valavaara, R.2    Vuorinen, J.3    Hajba, A.4
  • 227
    • 0028172454 scopus 로고
    • 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite
    • 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite. Carcinogenesis 15, 2087-2094.
    • (1994) Carcinogenesis , vol.15 , pp. 2087-2094
    • Randerath, K.1    Moorthy, B.2    Mabon, N.3    Sriram, P.4
  • 228
    • 0028068906 scopus 로고
    • Droloxifene, a new antiestrogen: Its role in metastatic breast cancer
    • Raushning, W. and Pritchard, K. I. (1994). Droloxifene, a new antiestrogen: its role in metastatic breast cancer. Breast Cancer Research and Treatment 31, 83-94.
    • (1994) Breast Cancer Research and Treatment , vol.31 , pp. 83-94
    • Raushning, W.1    Pritchard, K.I.2
  • 229
    • 0021734042 scopus 로고
    • Tamoxifen stimulation of human breast cancer cell proliferation in vitro: A possible model for tamoxifen tumor flare
    • Reddel, R. R. and Sutherland, R. L. (1984). Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumor flare. European Journal of Cancer 20, 1419-1425.
    • (1984) European Journal of Cancer , vol.20 , pp. 1419-1425
    • Reddel, R.R.1    Sutherland, R.L.2
  • 230
    • 0024509832 scopus 로고
    • Antiestrogen action of toremifene on hormone-dependent, independent and heterogeneous breast tumor growth in the athymic mouse
    • Robinson, S. P. and Jordan, V. C. (1989). Antiestrogen action of toremifene on hormone-dependent, independent and heterogeneous breast tumor growth in the athymic mouse. Cancer Research 49, 1758-1762.
    • (1989) Cancer Research , vol.49 , pp. 1758-1762
    • Robinson, S.P.1    Jordan, V.C.2
  • 231
    • 0025264436 scopus 로고
    • Inhibition of hormone dependent and independent breast cancer cell growth in vivo and in vitro with the antiestrogen toremifene and recombinant human interferon α2
    • Robinson, S. P., Goldstein, D., Witt, P. L., Borden, E. C. and Jordan, V. C. (1990). Inhibition of hormone dependent and independent breast cancer cell growth in vivo and in vitro with the antiestrogen toremifene and recombinant human interferon α2. Breast Cancer Research and Treatment 15, 95-101.
    • (1990) Breast Cancer Research and Treatment , vol.15 , pp. 95-101
    • Robinson, S.P.1    Goldstein, D.2    Witt, P.L.3    Borden, E.C.4    Jordan, V.C.5
  • 232
    • 0026064491 scopus 로고
    • Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
    • Robinson, S. P., Langan-Fahey, S. M., Johnson, D. A. and Jordan, V. C. (1991). Metabolites, pharmacodynamics and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Met. Disp. 19, 36-43.
    • (1991) Drug Met. Disp. , vol.19 , pp. 36-43
    • Robinson, S.P.1    Langan-Fahey, S.M.2    Johnson, D.A.3    Jordan, V.C.4
  • 233
    • 0024241588 scopus 로고
    • Antitumor actions of toremifene in the 7, 12 dimethylbenzanthracene (DMBA)-induced rat mammary tumor model
    • Robinson, S. P., Mauel, D. A. and Jordan, V. C. (1988). Antitumor actions of toremifene in the 7, 12 dimethylbenzanthracene (DMBA)-induced rat mammary tumor model. European Journal of Cancer 24, 1817-1821.
    • (1988) European Journal of Cancer , vol.24 , pp. 1817-1821
    • Robinson, S.P.1    Mauel, D.A.2    Jordan, V.C.3
  • 234
    • 0008174249 scopus 로고
    • Duration of action of natural and synthetic estrogens
    • Robson, J. M., Schonberg, A. and Fahim, H. A. (1938). Duration of action of natural and synthetic estrogens. Nature 142, 292-293.
    • (1938) Nature , vol.142 , pp. 292-293
    • Robson, J.M.1    Schonberg, A.2    Fahim, H.A.3
  • 235
  • 236
    • 0019416798 scopus 로고
    • Activity of the antiestrogen trioxifene against N-nitrosomethylurea-induced rat mammary carcinomas
    • Rose, D. P., Fischer, A. H. and Jordan, V. C. (1981). Activity of the antiestrogen trioxifene against N-nitrosomethylurea-induced rat mammary carcinomas. European Journal of Cancer and Clinical Oncology 17, 893-898.
    • (1981) European Journal of Cancer and Clinical Oncology , vol.17 , pp. 893-898
    • Rose, D.P.1    Fischer, A.H.2    Jordan, V.C.3
  • 238
    • 0027325734 scopus 로고
    • Cardiac and thromboembolic morbidity among postmenopausal women with early-stage breast cancer in a randomized trial of tamoxifen
    • The Stockholm Breast Cancer Study Group
    • Rutqvist, L. E. and Matte son, A. (1993). Cardiac and thromboembolic morbidity among postmenopausal women with early-stage breast cancer in a randomized trial of tamoxifen. The Stockholm Breast Cancer Study Group. Journal of the National Cancer Institute 85, 1398-1406.
    • (1993) Journal of the National Cancer Institute , vol.85 , pp. 1398-1406
    • Rutqvist, L.E.1    Matte Son, A.2
  • 240
    • 0026011089 scopus 로고
    • Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response elements
    • Sabbah, M., Grouilleux, F., Sola, B., Redeuil, G. R. and Baulieu, E. E. (1991). Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response elements. Proceedings of the National Academy of Science USA 88, 390-394.
    • (1991) Proceedings of the National Academy of Science USA , vol.88 , pp. 390-394
    • Sabbah, M.1    Grouilleux, F.2    Sola, B.3    Redeuil, G.R.4    Baulieu, E.E.5
  • 241
    • 0021129120 scopus 로고
    • Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice
    • Satyaswaroop, P. G., Zaino, R. J. and Mortel, R. (1984). Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice. Cancer Research 44, 4006-4010.
    • (1984) Cancer Research , vol.44 , pp. 4006-4010
    • Satyaswaroop, P.G.1    Zaino, R.J.2    Mortel, R.3
  • 242
    • 0020516248 scopus 로고
    • Antiestrogenic effects of LY117018 in MCF-7 cells
    • Scholl, M., Huff, K. K. and Lippman, M. E. (1983). Antiestrogenic effects of LY117018 in MCF-7 cells. Endocrinology 113, 611-617.
    • (1983) Endocrinology , vol.113 , pp. 611-617
    • Scholl, M.1    Huff, K.K.2    Lippman, M.E.3
  • 245
    • 0000755347 scopus 로고
    • Effects of triparanol (MER-29) on cholesterol biosynthesis and on blood sterol levels in man
    • Steinberg, D., Avigan, J. and Feigelson, E. G. (1961). Effects of triparanol (MER-29) on cholesterol biosynthesis and on blood sterol levels in man. Journal of Clinical Investigations 40, 884-888.
    • (1961) Journal of Clinical Investigations , vol.40 , pp. 884-888
    • Steinberg, D.1    Avigan, J.2    Feigelson, E.G.3
  • 247
    • 0030055509 scopus 로고    scopus 로고
    • On behalf of the Scottish Cancer Trials Breast Group, Randomized comparison of 5 years of adjuvant tamoxifen with continuous therapy for operable breast cancer
    • Stewart, H.J., Forrest, A.P., Everington, D., McDonald, C.C., Dewar, J.A., Hawkins, R.A., Prescott, R.J.and George, W.D. (1996). on behalf of the Scottish Cancer Trials Breast Group, Randomized comparison of 5 years of adjuvant tamoxifen with continuous therapy for operable breast cancer. British Journal of Cancer 74, 297-299.
    • (1996) British Journal of Cancer , vol.74 , pp. 297-299
    • Stewart, H.J.1    Forrest, A.P.2    Everington, D.3    McDonald, C.C.4    Dewar, J.A.5    Hawkins, R.A.6    Prescott, R.J.7    George, W.D.8
  • 248
    • 0028035492 scopus 로고
    • Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450's
    • Styles, J. A., Davies, A., Lim, C. K., De Matteis, F., Stanley, L. A., White, I. N., Yuan, Z. X. and Smith, L. L. (1994). Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450's. Carcinogenesis 15, 5-9.
    • (1994) Carcinogenesis , vol.15 , pp. 5-9
    • Styles, J.A.1    Davies, A.2    Lim, C.K.3    De Matteis, F.4    Stanley, L.A.5    White, I.N.6    Yuan, Z.X.7    Smith, L.L.8
  • 251
    • 0021365432 scopus 로고
    • Differences between estrogen and antiestrogen-estrogen receptor complexes identified with an antibody raised against the estrogen receptor
    • Tate, A. C., Greene, G. L., DeSombre, E. R., Jensen, E. V. and Jordan, V. C. (1984). Differences between estrogen and antiestrogen-estrogen receptor complexes identified with an antibody raised against the estrogen receptor. Cancer Research 44, 1012-1018.
    • (1984) Cancer Research , vol.44 , pp. 1012-1018
    • Tate, A.C.1    Greene, G.L.2    DeSombre, E.R.3    Jensen, E.V.4    Jordan, V.C.5
  • 252
    • 0024841171 scopus 로고
    • ICI 164,384, a pure antagonist of estrogen stimulated MCF-7 cell proliferation and invasiveness
    • Thompson, E. W., Katz, D., Shima, T. B., Wakeling, A. E., Lippman, M. E. and Dickson, R. B. (1989). ICI 164,384, a pure antagonist of estrogen stimulated MCF-7 cell proliferation and invasiveness. Cancer Research 49, 6929-6934.
    • (1989) Cancer Research , vol.49 , pp. 6929-6934
    • Thompson, E.W.1    Katz, D.2    Shima, T.B.3    Wakeling, A.E.4    Lippman, M.E.5    Dickson, R.B.6
  • 255
    • 0028793801 scopus 로고
    • Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients
    • Tomas, E., Kauppila, A., Blanco, G., Apaja-Sarkkinen, M. and Laatikainen, T. (1995). Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients. Gynecology and Oncology 59, 261-266.
    • (1995) Gynecology and Oncology , vol.59 , pp. 261-266
    • Tomas, E.1    Kauppila, A.2    Blanco, G.3    Apaja-Sarkkinen, M.4    Laatikainen, T.5
  • 257
    • 0029144331 scopus 로고
    • Possible mechanisms in the emergence of tamoxifen-resistant breast cancer
    • Tonetti, D. A. and Jordan, V. C. (1995). Possible mechanisms in the emergence of tamoxifen-resistant breast cancer. Anticancer Drugs 9, 498-507.
    • (1995) Anticancer Drugs , vol.9 , pp. 498-507
    • Tonetti, D.A.1    Jordan, V.C.2
  • 258
    • 0030139852 scopus 로고    scopus 로고
    • The development of targeted antiestrogens to prevent diseases in women
    • Tonetti, D. A. and Jordan, V. C. (1996). The development of targeted antiestrogens to prevent diseases in women. Molecular Medicine Today 2, 218-223.
    • (1996) Molecular Medicine Today , vol.2 , pp. 218-223
    • Tonetti, D.A.1    Jordan, V.C.2
  • 259
    • 0027082479 scopus 로고
    • Adjuvant therapy with a doxarubicin regimen and long term tamoxifen in premenopausal breast cancer patients: A Eastern Cooperative Oncology Group Trial
    • Tormey, D. C., Gray, R., Abeloff, M. D., Roseman, D. L., Gilchrist, K. W., Barylak, E. J., Stott, D. and Falkson, G. (1992). Adjuvant therapy with a doxarubicin regimen and long term tamoxifen in premenopausal breast cancer patients: A Eastern Cooperative Oncology Group Trial. Journal of Clinical Oncology 10, 1848-1855.
    • (1992) Journal of Clinical Oncology , vol.10 , pp. 1848-1855
    • Tormey, D.C.1    Gray, R.2    Abeloff, M.D.3    Roseman, D.L.4    Gilchrist, K.W.5    Barylak, E.J.6    Stott, D.7    Falkson, G.8
  • 261
  • 262
    • 0023930991 scopus 로고
    • Tamoxifen inhibits osteoclast mediated resorption of trabecular bone in ovarian hormone-deficient rats
    • Turner, R. T., Wakley, G. K., Hannon, K. S. and Bell, N. H. (1988). Tamoxifen inhibits osteoclast mediated resorption of trabecular bone in ovarian hormone-deficient rats. Endocrinology 122, 1146-1150.
    • (1988) Endocrinology , vol.122 , pp. 1146-1150
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3    Bell, N.H.4
  • 264
    • 84995870933 scopus 로고
    • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
    • Tzukerman, M. T., Esty, A., Santiso-Mere, D., Danelian, D., Parker, M. G., Stein, R. B., Pike, J. W. and McDonnell, D. P. (1994). Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Molecular Endocrinology 8, 21-30.
    • (1994) Molecular Endocrinology , vol.8 , pp. 21-30
    • Tzukerman, M.T.1    Esty, A.2    Santiso-Mere, D.3    Danelian, D.4    Parker, M.G.5    Stein, R.B.6    Pike, J.W.7    McDonnell, D.P.8
  • 265
    • 0025081706 scopus 로고
    • Phase II experience with toremifene in the treatment of ER-positive breast cancer of postmenopausal women
    • Valavaara, R. (1990). Phase II experience with toremifene in the treatment of ER-positive breast cancer of postmenopausal women. Cancer Investigations 8, 275-276.
    • (1990) Cancer Investigations , vol.8 , pp. 275-276
    • Valavaara, R.1
  • 266
    • 0024313769 scopus 로고
    • Low-dose toremifene in the treatment of estrogen-receptor-positive advanced breast cancer in postmenopausal women
    • Valavaara, R. and Pyrhonen, S. (1989). Low-dose toremifene in the treatment of estrogen-receptor-positive advanced breast cancer in postmenopausal women. Current Therapy and Research 46, 966-973.
    • (1989) Current Therapy and Research , vol.46 , pp. 966-973
    • Valavaara, R.1    Pyrhonen, S.2
  • 270
    • 0029038292 scopus 로고
    • Worsening bone scan in the evaluation of antitumor response during hormonal therapy for breast cancer
    • Vogel, C. L., Schoenfelder, J., Shermano, L., Hayes, D. F. and Gams, R. A. (1995). Worsening bone scan in the evaluation of antitumor response during hormonal therapy for breast cancer. Journal of Clinical Oncology 13, 1123-1328.
    • (1995) Journal of Clinical Oncology , vol.13 , pp. 1123-1328
    • Vogel, C.L.1    Schoenfelder, J.2    Shermano, L.3    Hayes, D.F.4    Gams, R.A.5
  • 271
    • 0027409546 scopus 로고
    • Multicenter phase II efficacy trial of toremifene in tamoxifen refractory patients with advanced breast cancer
    • Vogel, C. L., Shemano, I., Schoenfelder, J., Gams, R. A. and Green, M. R. (1993). Multicenter phase II efficacy trial of toremifene in tamoxifen refractory patients with advanced breast cancer. Journal of Clinical Oncology 11, 345-350.
    • (1993) Journal of Clinical Oncology , vol.11 , pp. 345-350
    • Vogel, C.L.1    Shemano, I.2    Schoenfelder, J.3    Gams, R.A.4    Green, M.R.5
  • 274
    • 0001559063 scopus 로고
    • A new approach to breast cancer therapy-total estrogen ablation with pure antiestrogens
    • (Jordan, V. C., ed.), University of Wisconsin Press, Madison
    • Wakeling, A. E. (1994). A new approach to breast cancer therapy-total estrogen ablation with pure antiestrogens. In: Long-term Tamoxifen Treatment for Breast Cancer. (Jordan, V. C., ed.), pp. 219-234. University of Wisconsin Press, Madison.
    • (1994) Long-term Tamoxifen Treatment for Breast Cancer , pp. 219-234
    • Wakeling, A.E.1
  • 276
    • 0023701360 scopus 로고
    • Novel antiestrogens without partial agonist activity
    • Wakeling, A. E. and Bowler, J. (1988). Novel antiestrogens without partial agonist activity. Journal of Steroid Biochemistry 31, 645-653.
    • (1988) Journal of Steroid Biochemistry , vol.31 , pp. 645-653
    • Wakeling, A.E.1    Bowler, J.2
  • 277
    • 0021038981 scopus 로고
    • Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens
    • Wakeling, A. E. and Valcaccia, B. (1983). Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens. Journal of Endocrinology 99, 455-464.
    • (1983) Journal of Endocrinology , vol.99 , pp. 455-464
    • Wakeling, A.E.1    Valcaccia, B.2
  • 278
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling, A. E., Dukes, M. and Bowler, J. (1991). A potent specific pure antiestrogen with clinical potential. Cancer Research 51, 3867-3873.
    • (1991) Cancer Research , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 279
    • 0001528477 scopus 로고
    • Synthetic oestrogens in mammary cancer
    • Walpole, A. L. and Paterson, E. (1949). Synthetic oestrogens in mammary cancer. Lancet ii, 783-789.
    • (1949) Lancet , vol.2 , pp. 783-789
    • Walpole, A.L.1    Paterson, E.2
  • 280
    • 0015915672 scopus 로고
    • Antioestrogen therapy for breast cancer: A trial of tamoxifen at two dose levels
    • Ward, H. W. C. (1973). Antioestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. British Medical Journal i, 13-14.
    • (1973) British Medical Journal , vol.1 , pp. 13-14
    • Ward, H.W.C.1
  • 281
    • 0027251016 scopus 로고
    • Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women
    • Ward, R. L., Morgan, G., Dalley, D. and Kelly, P. J. (1993). Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women. Bone Mineralogy 22, 87-94.
    • (1993) Bone Mineralogy , vol.22 , pp. 87-94
    • Ward, R.L.1    Morgan, G.2    Dalley, D.3    Kelly, P.J.4
  • 283
    • 0025793178 scopus 로고
    • High performance liquid chromatographic method for the determination of toremifene and its major human metabolites
    • Webster, L. K., Crinis, N. A., Stokes, K. H. and Bishop, J. F. (1991). High performance liquid chromatographic method for the determination of toremifene and its major human metabolites. J. Chromatogr. B. Biomed. Appl. 565, 482-487.
    • (1991) J. Chromatogr. B. Biomed. Appl. , vol.565 , pp. 482-487
    • Webster, L.K.1    Crinis, N.A.2    Stokes, K.H.3    Bishop, J.F.4
  • 284
    • 0023606475 scopus 로고
    • Adaption of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture
    • Welshons, W. V. and Jordan, V. C. (1987). Adaption of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture. European Journal of Cancer 23, 1935-1939.
    • (1987) European Journal of Cancer , vol.23 , pp. 1935-1939
    • Welshons, W.V.1    Jordan, V.C.2
  • 285
    • 0027054733 scopus 로고
    • Genotoxic potential of tamoxifen and analogues in female Fischer 344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
    • White, I. N. H., deMatteis, F., Davies, A., Smith, L. L., Crofton-Sleigh, C., Venitt, S., Hewer, A. and Philips, D. H. (1992). Genotoxic potential of tamoxifen and analogues in female Fischer 344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis 13, 2197-2203.
    • (1992) Carcinogenesis , vol.13 , pp. 2197-2203
    • White, I.N.H.1    DeMatteis, F.2    Davies, A.3    Smith, L.L.4    Crofton-Sleigh, C.5    Venitt, S.6    Hewer, A.7    Philips, D.H.8
  • 287
    • 0027308685 scopus 로고
    • The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat
    • Williams, G. M., Iatropoulos, M. J., Djordjevic, M. V. and Kaltenberg, O. P. (1993). The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis 14, 315-317.
    • (1993) Carcinogenesis , vol.14 , pp. 315-317
    • Williams, G.M.1    Iatropoulos, M.J.2    Djordjevic, M.V.3    Kaltenberg, O.P.4
  • 290
    • 0027174999 scopus 로고
    • Tamoxifen inhibits lipid peroxidation in cardiac microsomes. Comparison with liver microsomes and potential relevance to the cardiovascular benefits associated with cancer prevention and treatment by tamoxifen
    • Wiseman, H., Cannon, M., Astein, H. R. V. and Halliwell, B. (1993a). Tamoxifen inhibits lipid peroxidation in cardiac microsomes. Comparison with liver microsomes and potential relevance to the cardiovascular benefits associated with cancer prevention and treatment by tamoxifen. Biochemical Pharmacology 45, 1851-1855.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 1851-1855
    • Wiseman, H.1    Cannon, M.2    Astein, H.R.V.3    Halliwell, B.4
  • 291
    • 0027220631 scopus 로고
    • Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: A mechanism accounting for the cardioprotective action of tamoxifen?
    • Wiseman, H., Paganga, G., Rice-Evans, C. and Halliwell, B. (1993b). Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen? Biochemical Journal 292, 635-638.
    • (1993) Biochemical Journal , vol.292 , pp. 635-638
    • Wiseman, H.1    Paganga, G.2    Rice-Evans, C.3    Halliwell, B.4
  • 293
    • 0027280831 scopus 로고
    • Investigation on the mechanism of tamoxifen-stimulated breast tumor growth using nonisomerizable analogs of tamoxifen and metabolites
    • Wolf, D. M., Langan-Fahey, S. M., Parker, C. J., McCague, R. and Jordan, V. C. (1993). Investigation on the mechanism of tamoxifen-stimulated breast tumor growth using nonisomerizable analogs of tamoxifen and metabolites. Journal of the National Cancer Institute 85, 806-812.
    • (1993) Journal of the National Cancer Institute , vol.85 , pp. 806-812
    • Wolf, D.M.1    Langan-Fahey, S.M.2    Parker, C.J.3    McCague, R.4    Jordan, V.C.5
  • 294
    • 0027509551 scopus 로고
    • Inhibition of growth factor activated proliferation by antiestrogens and effects on early gene expression of MCF-7 cells
    • Wosikowski, K., Kung, W., Hasmann, M., Loser, R. and Eppenberger, U. (1993). Inhibition of growth factor activated proliferation by antiestrogens and effects on early gene expression of MCF-7 cells. International Journal of Cancer 53, 290-297.
    • (1993) International Journal of Cancer , vol.53 , pp. 290-297
    • Wosikowski, K.1    Kung, W.2    Hasmann, M.3    Loser, R.4    Eppenberger, U.5
  • 295
    • 0029841146 scopus 로고    scopus 로고
    • Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifene
    • Yang, N. N., Venugopalan, M., Hardikar, S. and Glasebrook, A. (1996). Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifene. Science 273, 1222-1225.
    • (1996) Science , vol.273 , pp. 1222-1225
    • Yang, N.N.1    Venugopalan, M.2    Hardikar, S.3    Glasebrook, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.