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Volumn 17, Issue 3, 1996, Pages 585-594

The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLNITROSAMINE; TAMOXIFEN;

EID: 0029865172     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.3.585     Document Type: Article
Times cited : (39)

References (106)
  • 2
    • 0015069359 scopus 로고
    • A new anti-estrogenic agent in late breast cancer: An early clinical appraisal of ICI 46.474
    • Cole,M., Jones,C and Todd,I. (1971) A new anti-estrogenic agent in late breast cancer: an early clinical appraisal of ICI 46.474. Br. J. Cancer. 25, 270-275
    • (1971) Br. J. Cancer. , vol.25 , pp. 270-275
    • Cole, M.1    Jones, C.2    Todd, I.3
  • 3
    • 0022617734 scopus 로고
    • Randomized trial of bilateral oophorectomy versus lamoxifen in premenopausal women with metastatic breast cancer
    • Ingle,J., Krook,J., Green,S. et al. (1986) Randomized trial of bilateral oophorectomy versus lamoxifen in premenopausal women with metastatic breast cancer. J. Clin. Oncol , 4, 178-185.
    • (1986) J. Clin. Oncol , vol.4 , pp. 178-185
    • Ingle, J.1    Krook, J.2    Green, S.3
  • 4
    • 0022468199 scopus 로고
    • Role and mechanism of action of tamoxifen in premenopausal women with metastatic breast cancer
    • Sawka,C., Pritchard,K., Paterson,D. and Sutherland,D. (1986) Role and mechanism of action of tamoxifen in premenopausal women with metastatic breast cancer. Cancer Res , 46, 3152-3156.
    • (1986) Cancer Res , vol.46 , pp. 3152-3156
    • Sawka, C.1    Pritchard, K.2    Paterson, D.3    Sutherland, D.4
  • 5
    • 0017028360 scopus 로고
    • Evaluation of tamoxifen in advanced breast cancer: A progress report
    • Tormey,D., Simon,R , Lippman,M., Bull,J. and Myers,C (1976) Evaluation of tamoxifen in advanced breast cancer: a progress report. Cancer Treatment Rep., 60, 1451-1459.
    • (1976) Cancer Treatment Rep. , vol.60 , pp. 1451-1459
    • Tormey, D.1    Simon, R.2    Lippman, M.3    Bull, J.4    Myers, C.5
  • 6
    • 0015915672 scopus 로고
    • Antiestrogen therapy for breast cancer: A trial of tamoxifen at two dose levels
    • Ward,H. (1973) Antiestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Br. Med. J , i, 13-14.
    • (1973) Br. Med. J , vol.1 , pp. 13-14
    • Ward, H.1
  • 7
    • 0021618186 scopus 로고
    • The pharmacology and clinical uses of tamoxifen
    • Furr,B.J.A. and Jordan,V.C. (1984) The pharmacology and clinical uses of tamoxifen. Ther. Pharmacol., 25, 127-205.
    • (1984) Ther. Pharmacol. , vol.25 , pp. 127-205
    • Furr, B.J.A.1    Jordan, V.C.2
  • 8
    • 0024269590 scopus 로고
    • Effect of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer
    • Early Breast Trials Cooperative Group. (1988) Effect of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. New Engl. J. Med , 319, 1681-1692.
    • (1988) New Engl. J. Med , vol.319 , pp. 1681-1692
  • 9
    • 0021681961 scopus 로고
    • Long-term tamoxifen adjuvant therapy in node positive breast cancer: A metabolic and pilot clinical study
    • Tormey,D and Jordan,V. (1984) Long-term tamoxifen adjuvant therapy in node positive breast cancer: a metabolic and pilot clinical study. Breast Cancer Res. Treatment, 4, 297-302.
    • (1984) Breast Cancer Res. Treatment , vol.4 , pp. 297-302
    • Tormey, D.1    Jordan, V.2
  • 11
    • 0023640816 scopus 로고
    • Tamoxifen and benign breast problems
    • Fentiman,I. and Powles,T. (1987) Tamoxifen and benign breast problems. Lancet, ii, 1070-1072
    • (1987) Lancet , vol.2 , pp. 1070-1072
    • Fentiman, I.1    Powles, T.2
  • 12
    • 0024506261 scopus 로고
    • A randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-receptor positive tumors
    • Fischer,B., Constantino,J., Redmond,C et al. (1989) A randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-receptor positive tumors. New Engl. J. Med., 320, 479-484.
    • (1989) New Engl. J. Med. , vol.320 , pp. 479-484
    • Fischer, B.1    Constantino, J.2    Redmond, C.3
  • 13
    • 0028129023 scopus 로고
    • The Royal Marsden Hospital pilot tamoxifen chemoprevention trial
    • Powles,T., Jones,A., Ashley,S. et al. (1994) The Royal Marsden Hospital pilot tamoxifen chemoprevention trial. Breast Cancer Res. Treatment, 31, 73-82.
    • (1994) Breast Cancer Res. Treatment , vol.31 , pp. 73-82
    • Powles, T.1    Jones, A.2    Ashley, S.3
  • 14
    • 0026765044 scopus 로고
    • Breast cancer study initiated in Italy
    • Vanchien,C. (1992) Breast cancer study initiated in Italy. J. Natl Cancer Inst., 84, 1555-1556.
    • (1992) J. Natl Cancer Inst. , vol.84 , pp. 1555-1556
    • Vanchien, C.1
  • 15
    • 0023199112 scopus 로고
    • Prolonging tamoxifen therapy for primary breast cancer
    • Fischer,B., Brown,A., Wolmark,N. et al. (1987) Prolonging tamoxifen therapy for primary breast cancer. Annls Internal Med., 106, 649-654.
    • (1987) Annls Internal Med. , vol.106 , pp. 649-654
    • Fischer, B.1    Brown, A.2    Wolmark, N.3
  • 16
    • 0025043542 scopus 로고
    • Long-term adjuvant tamoxifen therapy for breast cancer
    • Jordan,V.C. (1990) Long-term adjuvant tamoxifen therapy for breast cancer. Breast Cancer Res. Treatment, 15, 125-136.
    • (1990) Breast Cancer Res. Treatment , vol.15 , pp. 125-136
    • Jordan, V.C.1
  • 17
    • 0025324359 scopus 로고
    • Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node nesative disease
    • Love,R., Newcomb,P., Wiebe,D., Surawicz,T., Jordan,V., Carbone,P. and DeMets.D. (1990) Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node nesative disease. J. Natl Cancer Inst., 82, 1327-1332.
    • (1990) J. Natl Cancer Inst. , vol.82 , pp. 1327-1332
    • Love, R.1    Newcomb, P.2    Wiebe, D.3    Surawicz, T.4    Jordan, V.5    Carbone, P.6    DeMets, D.7
  • 18
    • 0025291890 scopus 로고
    • Long-term adjuvant tamoxifen in early breast cancer: Effect on bone mineral density in postmenopausal women
    • Fornander,T., Rutqvist,L., Sjoberg,H., Blomqvist,L., Mattison,A. and Glas,U. (1990) Long-term adjuvant tamoxifen in early breast cancer: effect on bone mineral density in postmenopausal women. J. Clin. Oncol., 8, 1019-1024.
    • (1990) J. Clin. Oncol. , vol.8 , pp. 1019-1024
    • Fornander, T.1    Rutqvist, L.2    Sjoberg, H.3    Blomqvist, L.4    Mattison, A.5    Glas, U.6
  • 19
    • 0025239673 scopus 로고
    • Tamoxifen for breast cancer: Associated endometrial cancer
    • Gusberg,S.B. (1990) Tamoxifen for breast cancer: associated endometrial cancer. Cancer, 65, 1463-1464.
    • (1990) Cancer , vol.65 , pp. 1463-1464
    • Gusberg, S.B.1
  • 20
    • 0027538672 scopus 로고
    • Long term effects of tamoxifen. Biological effects of tamoxifen working group
    • Cuzick,J., Allen,D., Baum,M. et al. (1993) Long term effects of tamoxifen. Biological effects of tamoxifen working group. Eur. J. Cancer, 29A, 15-21.
    • (1993) Eur. J. Cancer , vol.29 A , pp. 15-21
    • Cuzick, J.1    Allen, D.2    Baum, M.3
  • 21
    • 0027238781 scopus 로고
    • Risk benefit assessment of tamoxifen therapy
    • Catherino, W. and Jordan, V.C. (1993) Risk benefit assessment of tamoxifen therapy Drug Safety, 8, 381-397.
    • (1993) Drug Safety , vol.8 , pp. 381-397
    • Catherino, W.1    Jordan, V.C.2
  • 22
    • 0027397629 scopus 로고
    • Tamoxifen induces hepatocellular carcinoma in rat liver: A one year study with two anti-estrogens
    • Hirsamaki,P., Hirsamaki,Y., Nieminen,L. and Payne,B.J. (1993) Tamoxifen induces hepatocellular carcinoma in rat liver: a one year study with two anti-estrogens. Arch. Toxicol., 67, 49-54.
    • (1993) Arch. Toxicol. , vol.67 , pp. 49-54
    • Hirsamaki, P.1    Hirsamaki, Y.2    Nieminen, L.3    Payne, B.J.4
  • 24
    • 0027201501 scopus 로고
    • Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves,P., Goonetilleke,R., Nunn,G., Topham,J. and Orton,T. (1993) Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res., 53, 3919-3924.
    • (1993) Cancer Res. , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 25
    • 0025813170 scopus 로고
    • Tamoxifen: A carcinogen as a preventive agent
    • Sasco,A. (1991) Tamoxifen: a carcinogen as a preventive agent. Cancer J., 4, 217-218.
    • (1991) Cancer J. , vol.4 , pp. 217-218
    • Sasco, A.1
  • 26
    • 0026593828 scopus 로고
    • Tamoxifen - Panacea or Pandora's box?
    • Davidson,N. (1992) Tamoxifen - panacea or Pandora's box? New Engl. J Med., 326, 885-886.
    • (1992) New Engl. J Med. , vol.326 , pp. 885-886
    • Davidson, N.1
  • 28
    • 0026465583 scopus 로고
    • Should healthy women take tamoxifen?
    • Fugh-Berman,A. and Epstein,S. (1992) Should healthy women take tamoxifen? New Engl. J. Med., 22, 1596.
    • (1992) New Engl. J. Med. , vol.22 , pp. 1596
    • Fugh-Berman, A.1    Epstein, S.2
  • 30
    • 0026319776 scopus 로고
    • Cytochrome P450 mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: Possible involvement of flavin-containing monooxygenases in tamoxifen activation
    • Mani,C. and Kupfer,D. (1991) Cytochrome P450 mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation. Cancer Res., 51, 6052-6058.
    • (1991) Cancer Res. , vol.51 , pp. 6052-6058
    • Mani, C.1    Kupfer, D.2
  • 31
    • 0028670421 scopus 로고
    • Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent bindins to rat and human liver microsomes
    • Mani,C., Pearce,R , Parkinson,A. and Kufer,D. (1994) Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent bindins to rat and human liver microsomes. Carcinogenesis, 15, 2715-2720.
    • (1994) Carcinogenesis , vol.15 , pp. 2715-2720
    • Mani, C.1    Pearce, R.2    Parkinson, A.3    Kufer, D.4
  • 32
    • 0026606580 scopus 로고
    • Induction of covalent adducts in rodents by tamoxifen
    • Han,X. and Liehr,J. (1992) Induction of covalent adducts in rodents by tamoxifen. Cancer Res., 52, 1360-1363.
    • (1992) Cancer Res. , vol.52 , pp. 1360-1363
    • Han, X.1    Liehr, J.2
  • 34
    • 0027428568 scopus 로고
    • Major differences in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female CrL:CD(BR) rats
    • Hard,G., Iatropoulos,M., Jordan,K., Radi,L., Kaltenberg,O , Imondi,A. and Williams,G. (1993) Major differences in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female CrL:CD(BR) rats. Cancer Res., 53, 4334-4341.
    • (1993) Cancer Res. , vol.53 , pp. 4334-4341
    • Hard, G.1    Iatropoulos, M.2    Jordan, K.3    Radi, L.4    Kaltenberg, O.5    Imondi, A.6    Williams, G.7
  • 35
    • 1842280531 scopus 로고
    • A comparison of the genotoxic potential of tamoxifen and toremifene in female F344 rats
    • White,I., Davies,A., Jukes,R., Phillips,D. and de Matteis,F. (1993) A comparison of the genotoxic potential of tamoxifen and toremifene in female F344 rats. Hum. Exp. Toxicol., 12, 569.
    • (1993) Hum. Exp. Toxicol. , vol.12 , pp. 569
    • White, I.1    Davies, A.2    Jukes, R.3    Phillips, D.4    De Matteis, F.5
  • 36
    • 0028210878 scopus 로고
    • DMA adduct formtion by tamoxifen with rat and human microsomal activation systems
    • Pathak,D. and Bodell,W (1994) DMA adduct formtion by tamoxifen with rat and human microsomal activation systems. Carcinogenesis, 15, 529-532.
    • (1994) Carcinogenesis , vol.15 , pp. 529-532
    • Pathak, D.1    Bodell, W.2
  • 37
    • 0023034379 scopus 로고
    • Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase positive foci in female rats
    • Yager,J., Roebuck,B., Paluszcyk,T. and Memoli,V. (1986) Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase positive foci in female rats. Carcinogenesis, 7, 2007-2014.
    • (1986) Carcinogenesis , vol.7 , pp. 2007-2014
    • Yager, J.1    Roebuck, B.2    Paluszcyk, T.3    Memoli, V.4
  • 38
    • 0024148345 scopus 로고
    • Inhibitory effect of tamoxifen on DES-promoted hepatic tumorigenesis in male rats and its possible mechanism of action
    • Kohigashi,K., Fukuda,Y. and Imura,H (1988) Inhibitory effect of tamoxifen on DES-promoted hepatic tumorigenesis in male rats and its possible mechanism of action. Gann, 79, 1335-1339.
    • (1988) Gann , vol.79 , pp. 1335-1339
    • Kohigashi, K.1    Fukuda, Y.2    Imura, H.3
  • 39
    • 0024445141 scopus 로고
    • Induction and promotion of γ-glutamyltranspeptidase-positive foci in the livers of female rats treated with ethinyl estradiol, clomiphene, tamoxifen and their associations
    • Ghia,M. and Mereto,E. (1989) Induction and promotion of γ-glutamyltranspeptidase-positive foci in the livers of female rats treated with ethinyl estradiol, clomiphene, tamoxifen and their associations. Cancer Lett., 46, 195-202.
    • (1989) Cancer Lett. , vol.46 , pp. 195-202
    • Ghia, M.1    Mereto, E.2
  • 40
    • 0025980382 scopus 로고
    • Tumor promotion as a target of estrogen/anti-estrogen effects in rat hepatocarcinogenesis
    • Dragan,Y.P., Xu,Y.H. and Pitot,H.C. (1991) Tumor promotion as a target of estrogen/anti-estrogen effects in rat hepatocarcinogenesis. Preventive Med., 20, 15-26.
    • (1991) Preventive Med. , vol.20 , pp. 15-26
    • Dragan, Y.P.1    Xu, Y.H.2    Pitot, H.C.3
  • 43
    • 0026342683 scopus 로고
    • Structural requirements for the in vitro transformation of Syrian hamster embryo cells by stilbene estrogens and triphenylethylene type anti-estrogens
    • Metzler,M. and Schiffmann,D. (1991) Structural requirements for the in vitro transformation of Syrian hamster embryo cells by stilbene estrogens and triphenylethylene type anti-estrogens. Am. J. Clin. Oncol., 14, S30-S35.
    • (1991) Am. J. Clin. Oncol. , vol.14
    • Metzler, M.1    Schiffmann, D.2
  • 44
  • 45
    • 0018092719 scopus 로고
    • The effect of estradiol-17-phenylpropionate and estradiol benzoate on N-nitrosomorpholine-induced liver carcinogenesis in ovarectomized female rats
    • Taper,H.S. (1978) The effect of estradiol-17-phenylpropionate and estradiol benzoate on N-nitrosomorpholine-induced liver carcinogenesis in ovarectomized female rats. Cancer, 42, 462-467.
    • (1978) Cancer , vol.42 , pp. 462-467
    • Taper, H.S.1
  • 46
    • 0018941624 scopus 로고
    • Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats
    • Yager,J.D. and Yager,R. (1980) Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats. Cancer Res., 40, 3680-3685.
    • (1980) Cancer Res. , vol.40 , pp. 3680-3685
    • Yager, J.D.1    Yager, R.2
  • 47
    • 0020054312 scopus 로고
    • Role of estrogens as promoters of hepatic neopiasia
    • Wanless,I.R. and Medline,A. (1982) Role of estrogens as promoters of hepatic neopiasia. Lab. Invest., 46, 313-320.
    • (1982) Lab. Invest. , vol.46 , pp. 313-320
    • Wanless, I.R.1    Medline, A.2
  • 48
    • 0017345218 scopus 로고
    • Regression of liver cell adenomas associated with oral contraceptives
    • Edmonson,H A., Reynolds,T.B. and Henderson,B. (1977) Regression of liver cell adenomas associated with oral contraceptives. Annls Internal Med., 86, 180-182.
    • (1977) Annls Internal Med. , vol.86 , pp. 180-182
    • Edmonson, H.A.1    Reynolds, T.B.2    Henderson, B.3
  • 49
    • 0026720681 scopus 로고
    • The effects of diethylstilbesterol, tamoxifen, and toremifene on estrogen inducible hepatic protein and estrogen receptor proteins in female rats
    • Kendall,M.E. and Rose,D.P. (1992) The effects of diethylstilbesterol, tamoxifen, and toremifene on estrogen inducible hepatic protein and estrogen receptor proteins in female rats. Toxicol. Appl. Pharmacol., 114, 127-131.
    • (1992) Toxicol. Appl. Pharmacol. , vol.114 , pp. 127-131
    • Kendall, M.E.1    Rose, D.P.2
  • 50
    • 0017796895 scopus 로고
    • Increases in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast
    • Sakai,F., Cheix,F., Clavel,M., Colon,J., Mayer,M., Pannata,E. and Saez,S. (1978) Increases in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast. J. Endocrinol., 76, 219-226.
    • (1978) J. Endocrinol. , vol.76 , pp. 219-226
    • Sakai, F.1    Cheix, F.2    Clavel, M.3    Colon, J.4    Mayer, M.5    Pannata, E.6    Saez, S.7
  • 51
    • 0026068370 scopus 로고
    • Acquired tamoxifen resistance: Correlation with reduced breast tumor levels of tamoxifen and non-isomerization of trans-4 hydroxy tamoxifen
    • Osborne,C., Coranado,E., Allred,D., Wiebe,V. and DeGregorio,M. (1991) Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and non-isomerization of trans-4 hydroxy tamoxifen. J. Natl Cancer Inst , 83, 1477-1482.
    • (1991) J. Natl Cancer Inst , vol.83 , pp. 1477-1482
    • Osborne, C.1    Coranado, E.2    Allred, D.3    Wiebe, V.4    DeGregorio, M.5
  • 52
    • 0028596462 scopus 로고
    • Interindividual variation in the isomerization of 4-hydroxy tamoxifen by human liver microsomes: Involvement of cytochromes P450
    • Williams,M., Lennard,M., Martin,I, and Tucker,G. (1994) Interindividual variation in the isomerization of 4-hydroxy tamoxifen by human liver microsomes: involvement of cytochromes P450. Carcinogenesis, 15, 2733-2738.
    • (1994) Carcinogenesis , vol.15 , pp. 2733-2738
    • Williams, M.1    Lennard, M.2    Martin, I.3    Tucker, G.4
  • 53
    • 0021872966 scopus 로고
    • Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers
    • Katzenellenbogan,J., Carlson,K. and Katzenealenbogan,B. (1985) Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: limitations to the interpretation of experiments characterizing the activity of individual isomers. J. Steroid Biochem., 22, 589-596.
    • (1985) J. Steroid Biochem. , vol.22 , pp. 589-596
    • Katzenellenbogan, J.1    Carlson, K.2    Katzenealenbogan, B.3
  • 54
    • 36949059277 scopus 로고
    • Contrasting endocrine activities of cis and trons isomers in a series of substituted triphenylethylenes
    • Harper,M.J.K. and Walpole,A.L. (1966) Contrasting endocrine activities of cis and trons isomers in a series of substituted triphenylethylenes. Nature, 21, 87.
    • (1966) Nature , vol.21 , pp. 87
    • Harper, M.J.K.1    Walpole, A.L.2
  • 55
    • 0022922221 scopus 로고
    • Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-{4-[2-(dimethylamino)ethoxy]phenyl}-5H-benzocycloheptene, a nonisomerizable analogue of tamoxifen. X-ray crystallographic studies
    • Mc Cague,R., Kuroda,R., Leclercq,G. and Stoessel,S. (1986) Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-{4-[2-(dimethylamino)ethoxy]phenyl}-5H-benzocycloheptene, a nonisomerizable analogue of tamoxifen. X-ray crystallographic studies. J. Med. Chem., 29, 2053-2059.
    • (1986) J. Med. Chem. , vol.29 , pp. 2053-2059
    • Mc Cague, R.1    Kuroda, R.2    Leclercq, G.3    Stoessel, S.4
  • 57
    • 0023726546 scopus 로고
    • Nonisomerizable analogues of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes
    • McCague,R , Leclercq,G. and Jordan,V.C (1988) Nonisomerizable analogues of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes. J. Med. Chem., 31, 1285-1290.
    • (1988) J. Med. Chem. , vol.31 , pp. 1285-1290
    • McCague, R.1    Leclercq, G.2    Jordan, V.C.3
  • 58
    • 0025896783 scopus 로고
    • Structure-activity relationships of nonisomerizable derivatives of tamoxifen: Importance of hydroxyl group and side chain positioning for biological activity
    • Murphy,C., Parker,C., McCague,R. and Jordan,V.C. (1991) Structure-activity relationships of nonisomerizable derivatives of tamoxifen: importance of hydroxyl group and side chain positioning for biological activity. Mol. Pharmacol., 39, 421-428.
    • (1991) Mol. Pharmacol. , vol.39 , pp. 421-428
    • Murphy, C.1    Parker, C.2    McCague, R.3    Jordan, V.C.4
  • 59
    • 0027280831 scopus 로고
    • Investigation of the mechanism of tamoxifen-stimulated breast tumor growth with nonisomenzable analogues of tamoxifen and metabolites
    • Wolf,D., Langan-Fahey.S., Parker,C., McCague,R. and Jordan,V.C (1993) Investigation of the mechanism of tamoxifen-stimulated breast tumor growth with nonisomenzable analogues of tamoxifen and metabolites. J. Natl Cancer Inst., 85, 806-812.
    • (1993) J. Natl Cancer Inst. , vol.85 , pp. 806-812
    • Wolf, D.1    Langan-Fahey, S.2    Parker, C.3    McCague, R.4    Jordan, V.C.5
  • 60
    • 0015763703 scopus 로고
    • The metabolism of tamoxifen (ICI 46.474)
    • Fromson,J., Pearson,J. and Braman,S (1973) The metabolism of tamoxifen (ICI 46.474). Xenobiotica, 3, 693-709.
    • (1973) Xenobiotica , vol.3 , pp. 693-709
    • Fromson, J.1    Pearson, J.2    Braman, S.3
  • 61
    • 0023259551 scopus 로고
    • Analysis of lamoxifen and its metabolites in human plasma by GC-MS using selected ion monitoring (SIM)
    • Murphy,C., Poster,T., Panzan,P., Adlercreutz,H. and Martin,F. (1987) Analysis of lamoxifen and its metabolites in human plasma by GC-MS using selected ion monitoring (SIM). J. Steroid Biochem., 26, 547-555.
    • (1987) J. Steroid Biochem. , vol.26 , pp. 547-555
    • Murphy, C.1    Poster, T.2    Panzan, P.3    Adlercreutz, H.4    Martin, F.5
  • 62
    • 0015748908 scopus 로고
    • The metabolism of tamoxifen (ICI 46.474). Part 2. In female patients
    • Fromson,J., Pearson,S. and Braman,S. (1974) The metabolism of tamoxifen (ICI 46.474). Part 2. In female patients. Xenobiotica, 3, 711-714.
    • (1974) Xenobiotica , vol.3 , pp. 711-714
    • Fromson, J.1    Pearson, S.2    Braman, S.3
  • 63
    • 0025251643 scopus 로고
    • Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer
    • Langan-Fahey,S., Tormey,D. and Jordan,V.C. (1990) Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer. Eur. J. Cancer, 26, 883-888.
    • (1990) Eur. J. Cancer , vol.26 , pp. 883-888
    • Langan-Fahey, S.1    Tormey, D.2    Jordan, V.C.3
  • 65
    • 0026425653 scopus 로고
    • Distribution of tamoxifen and its metabolites in rat and human tissues during steady state treatment
    • Lien,E., Solheim,E. and Veland,P. (1991) Distribution of tamoxifen and its metabolites in rat and human tissues during steady state treatment. Cancer Res., 51, 4837-4844.
    • (1991) Cancer Res. , vol.51 , pp. 4837-4844
    • Lien, E.1    Solheim, E.2    Veland, P.3
  • 67
    • 0022971448 scopus 로고
    • Modification of the basic side chain in tamoxifen effects on microsomal metabolism and in vitro biological activity
    • Foster,A., McCague,R., Seago,A., Leclercq,G., Stoessel,S. and Roy,F. (1986) Modification of the basic side chain in tamoxifen effects on microsomal metabolism and in vitro biological activity. Anti-Cancer Drug Design, 1, 245-257.
    • (1986) Anti-Cancer Drug Design , vol.1 , pp. 245-257
    • Foster, A.1    McCague, R.2    Seago, A.3    Leclercq, G.4    Stoessel, S.5    Roy, F.6
  • 68
    • 0017853462 scopus 로고
    • Biochemical characterization of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine
    • Pitot,H C., Bareness,L., Goldsworthy,T. and Kitagawa,T. (1978) Biochemical characterization of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine. Nature (Lond.), 271, 456-458.
    • (1978) Nature (Lond.) , vol.271 , pp. 456-458
    • Pitot, H.C.1    Bareness, L.2    Goldsworthy, T.3    Kitagawa, T.4
  • 69
    • 0022313058 scopus 로고
    • An approach to the development of a short-term whole animal bioassay to distinguish imitating (incomplete) carcinogens, complete carcinogens, and noncarcinogens in the rat liver
    • Goldsworthy,T. and Pitot,H.C. (1986) An approach to the development of a short-term whole animal bioassay to distinguish imitating (incomplete) carcinogens, complete carcinogens, and noncarcinogens in the rat liver. J. Toxicol. Environ. Hlth, 16, 389-402.
    • (1986) J. Toxicol. Environ. Hlth , vol.16 , pp. 389-402
    • Goldsworthy, T.1    Pitot, H.C.2
  • 70
    • 0023192233 scopus 로고
    • Quantitative stereological evaluation of four histochemical markers of altered hepatic foci in multistage hepatocarcinogenesis in the rat
    • Hendrich,S., Campbell,H, and Pitot,H.C. (1987) Quantitative stereological evaluation of four histochemical markers of altered hepatic foci in multistage hepatocarcinogenesis in the rat. Carcinogenesis, 8, 1245-1250.
    • (1987) Carcinogenesis , vol.8 , pp. 1245-1250
    • Hendrich, S.1    Campbell, H.2    Pitot, H.C.3
  • 71
    • 0016685925 scopus 로고
    • Workshop on classification of specific hepatocellular lesions in the rat
    • Squire,R. and Levitt,R. (1975) Workshop on classification of specific hepatocellular lesions in the rat. Cancer Res, 35, 3214-3223.
    • (1975) Cancer Res , vol.35 , pp. 3214-3223
    • Squire, R.1    Levitt, R.2
  • 72
    • 0021080431 scopus 로고
    • Comparison of formalin and acetone fixation for immunohistochemical detection of carcinoembryonic antigen (CEA) and keratin
    • Kaku,T., Ekem,J., Lindayen,C., Bailey,D., van Nostrand,A. and Farber,E. (1983) Comparison of formalin and acetone fixation for immunohistochemical detection of carcinoembryonic antigen (CEA) and keratin. Am. J. Clin Pathol., 80, 806-815.
    • (1983) Am. J. Clin Pathol. , vol.80 , pp. 806-815
    • Kaku, T.1    Ekem, J.2    Lindayen, C.3    Bailey, D.4    Van Nostrand, A.5    Farber, E.6
  • 73
    • 0019492861 scopus 로고
    • A comparative study of the peroxidase-antiperoxidase method for studying polypeptide hormones with radioimmunoassay antibodies
    • Hsu,S., Raine,L. and Fanger,H. (1981) A comparative study of the peroxidase-antiperoxidase method for studying polypeptide hormones with radioimmunoassay antibodies. Am. J. Clin. Pathol., 75, 734-738.
    • (1981) Am. J. Clin. Pathol. , vol.75 , pp. 734-738
    • Hsu, S.1    Raine, L.2    Fanger, H.3
  • 74
    • 0021797851 scopus 로고
    • Purification, induction, and distribution of PGST: A new marker enzyme for preneoplastic cells in rat chemical hepatocarcinogenesis
    • Satoh.K., Kitahara,A., Soma,Y., Inaha,Y., Hatayama,I. and Sato,K. (1985) Purification, induction, and distribution of PGST: a new marker enzyme for preneoplastic cells in rat chemical hepatocarcinogenesis. Proc. Natl Acad. Sci. USA, 82, 3964-3968.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3964-3968
    • Satoh, K.1    Kitahara, A.2    Soma, Y.3    Inaha, Y.4    Hatayama, I.5    Sato, K.6
  • 75
    • 0020070809 scopus 로고
    • Application of quantitative stereology to the evaluation of enzyme altered foci in rat liver
    • Campbell,H., Pitot,H.C., Potter,V. and Laishes,B. (1982) Application of quantitative stereology to the evaluation of enzyme altered foci in rat liver. Cancer Res., 42, 465-472.
    • (1982) Cancer Res. , vol.42 , pp. 465-472
    • Campbell, H.1    Pitot, H.C.2    Potter, V.3    Laishes, B.4
  • 76
    • 0022637560 scopus 로고
    • Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver
    • Campbell,H., Xu,Y., Hanigan,M. and Pitot,H.C. (1982) Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver. J. Natl Cancer Inst., 76, 751-767.
    • (1982) J. Natl Cancer Inst. , vol.76 , pp. 751-767
    • Campbell, H.1    Xu, Y.2    Hanigan, M.3    Pitot, H.C.4
  • 77
    • 0024348029 scopus 로고
    • 3H]thymidine for studies of hepatocellular proliferation in rodents
    • 3H]thymidine for studies of hepatocellular proliferation in rodents. Carcinogenesis, 10, 1341-1343.
    • (1989) Carcinogenesis , vol.10 , pp. 1341-1343
    • Lamer, T.1    Berger, F.2    Eacho, P.3
  • 79
    • 0020676409 scopus 로고
    • Determination of tamoxifen and metabolites in human serum by high pressure liquid chromatography with post column fluorescense activation
    • Brown,R.R., Bain,R.R. and Jordan,V.C. (1983) Determination of tamoxifen and metabolites in human serum by high pressure liquid chromatography with post column fluorescense activation. J. Chromatogr , 272, 351-358.
    • (1983) J. Chromatogr , vol.272 , pp. 351-358
    • Brown, R.R.1    Bain, R.R.2    Jordan, V.C.3
  • 80
    • 13344259763 scopus 로고
    • Vitamin E deficiency as hepatic peroxisomal proliferator: Qualitative and quantitative electron microscopic study
    • Dabholkar,A.S. (1982) Vitamin E deficiency as hepatic peroxisomal proliferator: qualitative and quantitative electron microscopic study. Annls NY Acad. Sci., 386, 475-477.
    • (1982) Annls NY Acad. Sci. , vol.386 , pp. 475-477
    • Dabholkar, A.S.1
  • 81
    • 0019742075 scopus 로고
    • Assay of peroxisomal β oxidation of fatty acids
    • Lazarow,P. (1981) Assay of peroxisomal β oxidation of fatty acids. Methods Enzymol., 72, 315-318
    • (1981) Methods Enzymol. , vol.72 , pp. 315-318
    • Lazarow, P.1
  • 82
    • 0016174577 scopus 로고
    • Preparation and properties of partially purified cytochrome P450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome 450 reductase from rabbit microsomes
    • van der Hoeven,T. and Coon,M (1974) Preparation and properties of partially purified cytochrome P450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome 450 reductase from rabbit microsomes. J. Biol. Chem., 249, 6302-6310.
    • (1974) J. Biol. Chem. , vol.249 , pp. 6302-6310
    • Van Der Hoeven, T.1    Coon, M.2
  • 83
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford,M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.1
  • 85
    • 0025069255 scopus 로고
    • Altered hepatic foci: Their role in murine hepatocarcinogenesis
    • Pitot,H.C. (1990) Altered hepatic foci: their role in murine hepatocarcinogenesis. Annu. Rev. Pharmacol. Toxicol., 30, 465-500.
    • (1990) Annu. Rev. Pharmacol. Toxicol. , vol.30 , pp. 465-500
    • Pitot, H.C.1
  • 86
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon,E. and Vogelstein,B. (1990) A genetic model for colorectal tumorigenesis. Cell. 60, 759-767.
    • (1990) Cell , vol.60 , pp. 759-767
    • Fearon, E.1    Vogelstein, B.2
  • 87
    • 0027892994 scopus 로고
    • Measurement of ploidy and cell proliferation in the rodent liver
    • Styles,J.A. (1993) Measurement of ploidy and cell proliferation in the rodent liver. Environ. Hlth Perspect., 101 (Suppl. 5), 67-72.
    • (1993) Environ. Hlth Perspect. , vol.101 , Issue.5 SUPPL. , pp. 67-72
    • Styles, J.A.1
  • 88
    • 0028899660 scopus 로고
    • Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: Promotion by phenobarbital
    • Carthew,P., Martin,E., White,I., de Matteis,F., Edwards,R., Dorman,B., Heydon,R. and Smith,L. (1995) Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: promotion by phenobarbital. Cancer Res., 55, 544-547.
    • (1995) Cancer Res. , vol.55 , pp. 544-547
    • Carthew, P.1    Martin, E.2    White, I.3    De Matteis, F.4    Edwards, R.5    Dorman, B.6    Heydon, R.7    Smith, L.8
  • 89
    • 0025242415 scopus 로고
    • Endocrine pharmacology of antiestrogens as antitumor agents
    • Jordan,V.C. and Murphy,C. (1990) Endocrine pharmacology of antiestrogens as antitumor agents. Endocrinol. Rev., 11, 578-610.
    • (1990) Endocrinol. Rev. , vol.11 , pp. 578-610
    • Jordan, V.C.1    Murphy, C.2
  • 90
    • 0019994312 scopus 로고
    • A comparative study of the estrogenic effects of tamoxifen and 17β estradiol in postmenopausal women
    • Helgason,S., Wilking,N., Carlstron,K., Damber,M.-G. and von Schoultz,B. (1982) A comparative study of the estrogenic effects of tamoxifen and 17β estradiol in postmenopausal women. J. Clin. Endocrinol. Metab., 54, 404-408.
    • (1982) J. Clin. Endocrinol. Metab. , vol.54 , pp. 404-408
    • Helgason, S.1    Wilking, N.2    Carlstron, K.3    Damber, M.-G.4    Von Schoultz, B.5
  • 91
    • 0020033521 scopus 로고
    • Tamoxifen antiestrogens, a comparison of the activity, pharmacokinetics. and metabolic activation of the cis and trans isomers of tamoxifen
    • Robertson,D., Katzenellenbogen,J., Long,D , Rorke,E. and Katzenellenbogan,B. (1982) Tamoxifen antiestrogens, a comparison of the activity, pharmacokinetics. and metabolic activation of the cis and trans isomers of tamoxifen. J. Steroid Biochem., 16, 1-13.
    • (1982) J. Steroid Biochem. , vol.16 , pp. 1-13
    • Robertson, D.1    Katzenellenbogen, J.2    Long, D.3    Rorke, E.4    Katzenellenbogan, B.5
  • 92
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity
    • Jordan,V.C. Collins,M. Rowsby,L. and Prestwich,G. (1977) A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity. J. Endocrinol., 75, 305-316.
    • (1977) J. Endocrinol. , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.2    Rowsby, L.3    Prestwich, G.4
  • 93
    • 0024241608 scopus 로고
    • Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6(2.3 xylidino)-2-pyrimidinylthio]-acetic acid (WY-14,463) in rats
    • Marsman,D , Cattley,R., Conway,J. and Popp.J. (1988) Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6(2.3 xylidino)-2-pyrimidinylthio]-acetic acid (WY-14,463) in rats. Cancer Res., 48, 6739-6744.
    • (1988) Cancer Res. , vol.48 , pp. 6739-6744
    • Marsman, D.1    Cattley, R.2    Conway, J.3    Popp, J.4
  • 94
    • 0025806938 scopus 로고
    • Cell proliferation and tumor promotion by ethinyl estradiol in rat hepatocarcinogenesis
    • Mayol,X., Perez-Tomas,R., Cullere,X , Romero,A., Estadella,M. and Domingo,J. (1991) Cell proliferation and tumor promotion by ethinyl estradiol in rat hepatocarcinogenesis. Carcinogenesis, 12, 1133-1136.
    • (1991) Carcinogenesis , vol.12 , pp. 1133-1136
    • Mayol, X.1    Perez-Tomas, R.2    Cullere, X.3    Romero, A.4    Estadella, M.5    Domingo, J.6
  • 95
    • 0022414636 scopus 로고
    • Tumor promotion in the liver
    • Schulte-Hermann,R. (1985) Tumor promotion in the liver. Arch. Toxicol., 57, 147-158.
    • (1985) Arch. Toxicol. , vol.57 , pp. 147-158
    • Schulte-Hermann, R.1
  • 96
    • 0027996471 scopus 로고
    • Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol
    • Yager,J., Zurlo,J., Sewall,C., Lucier,G. and He,H (1994) Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol. Carcinogenesis, 15, 2117-2123.
    • (1994) Carcinogenesis , vol.15 , pp. 2117-2123
    • Yager, J.1    Zurlo, J.2    Sewall, C.3    Lucier, G.4    He, H.5
  • 97
    • 13344277034 scopus 로고
    • Effects of cell cycle kinetics as a possible mechanism of estradiol promotion of hepatocarcinogenesis
    • A1069
    • Bower,N., Mylecraine,L., Philbert,M. and Gallo,M. (1995) Effects of cell cycle kinetics as a possible mechanism of estradiol promotion of hepatocarcinogenesis. Toxicologist, 15, 200 (A1069).
    • (1995) Toxicologist , vol.15 , pp. 200
    • Bower, N.1    Mylecraine, L.2    Philbert, M.3    Gallo, M.4
  • 99
    • 12644276031 scopus 로고
    • The effects of tamoxifen citrate and toremifene citrate on the ultrastructure of the rat liver
    • Hirsimaki,R, Hirsamaki,Y. and Nieminen,L. (1988) The effects of tamoxifen citrate and toremifene citrate on the ultrastructure of the rat liver. Inst. Phys. Conf. Ser., 3, 235-236.
    • (1988) Inst. Phys. Conf. Ser. , vol.3 , pp. 235-236
    • Hirsimaki, R.1    Hirsamaki, Y.2    Nieminen, L.3
  • 100
    • 0018838395 scopus 로고
    • Induction of peroxisomal β-oxidation in rat liver by high fat diets
    • Neal,C., Thomassen,M. and Osmundsen,H. (1980) Induction of peroxisomal β-oxidation in rat liver by high fat diets. Biochem. J., 186, 369-371.
    • (1980) Biochem. J. , vol.186 , pp. 369-371
    • Neal, C.1    Thomassen, M.2    Osmundsen, H.3
  • 101
    • 0023929892 scopus 로고
    • Rapid stimulation of liver palmitoyl-CoA synthetase. carnitine palmitoyltransferase and glycerophosphate acyltransferase compared to peroxisomal β-oxidation and palmitoyl-CoA hydrolase in rats fed high-fat diets
    • Berge,R., Nilsson,A. and Husoy,A.-M. (1988) Rapid stimulation of liver palmitoyl-CoA synthetase. carnitine palmitoyltransferase and glycerophosphate acyltransferase compared to peroxisomal β-oxidation and palmitoyl-CoA hydrolase in rats fed high-fat diets. Biochim. Biophys. Acta, 960, 417-126.
    • (1988) Biochim. Biophys. Acta , vol.960 , pp. 417-1126
    • Berge, R.1    Nilsson, A.2    Husoy, A.-M.3
  • 102
    • 0024210066 scopus 로고
    • Tumor and serum tamoxifen concentrations in the athymic nude mouse
    • DeGregorio,M., Coronado,E and Osbome,C. (1989) Tumor and serum tamoxifen concentrations in the athymic nude mouse. Cancer Chemother. Pharmacol., 23, 68-70
    • (1989) Cancer Chemother. Pharmacol. , vol.23 , pp. 68-70
    • DeGregorio, M.1    Coronado, E.2    Osbome, C.3
  • 103
    • 0026343499 scopus 로고
    • Reversible control of estradiol-stimulated growth of MCF-7 tumors by tamoxifen in the athymic nude mouse
    • Iino,Y., Wolf,D., Langan-Fahey,S., Johnson,D., Ricchio,M., Thompson,M. and Jordan,V.C. (1991) Reversible control of estradiol-stimulated growth of MCF-7 tumors by tamoxifen in the athymic nude mouse. Br. J. Cancer. 64, 1019-1024.
    • (1991) Br. J. Cancer , vol.64 , pp. 1019-1024
    • Iino, Y.1    Wolf, D.2    Langan-Fahey, S.3    Johnson, D.4    Ricchio, M.5    Thompson, M.6    Jordan, V.C.7
  • 104
    • 0019813814 scopus 로고
    • Determination of tamoxifen and biologically active metabolites in human breast tumors and plasma
    • Darnel,P., Gaskell,S., Bishop,H., Campbell,C. and Nicholson,R. (1981) Determination of tamoxifen and biologically active metabolites in human breast tumors and plasma. Eur J. Clin. Oncol., 17, 1183-1189.
    • (1981) Eur J. Clin. Oncol. , vol.17 , pp. 1183-1189
    • Darnel, P.1    Gaskell, S.2    Bishop, H.3    Campbell, C.4    Nicholson, R.5
  • 105
    • 0027389764 scopus 로고
    • Induction of CYP2B1 and 3A1. and associated monooxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice
    • White,I., Davies,A., Smith,L., Dawson,S. and de Matteis,F. (1993) Induction of CYP2B1 and 3A1. and associated monooxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice. Biochem. Pharmacol., 45, 21-30.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 21-30
    • White, I.1    Davies, A.2    Smith, L.3    Dawson, S.4    De Matteis, F.5
  • 106
    • 0028925204 scopus 로고
    • Effect of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver
    • Nuwaysir,E, Dragan,Y. Jefcoate,C., Jordan,VC. and Pitot,H.C. (1995) Effect of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver. Cancer Res., 55, 1780-1786.
    • (1995) Cancer Res. , vol.55 , pp. 1780-1786
    • Nuwaysir, E.1    Dragan, Y.2    Jefcoate, C.3    Jordan, V.C.4    Pitot, H.C.5


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