T-440. Antiasthmatic. Phosphodiesterase IV inhibitor

Drugs of the Future

Volumn 22, Issue 7, 1997, Pages 729-732

  Graul, A ^a   Leeson, P ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 [6,7 DIETHOXY 2,3 BIS(HYDROXYMETHYL) 1 NAPHTHYL] 1 (2 METHOXYETHYL) 2(1H PYRIDINONE; 4 [6,7 DIETHOXY 2,3 BIS(HYDROXYMETHYL) 1 NAPHTHYL] 1 (2 METHOXYETHYL) 2(1H) PYRIDINONE; ANTIASTHMATIC AGENT; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; THEOPHYLLINE; UNCLASSIFIED DRUG;

ASTHMA; BRONCHOSPASM; DOG; DRUG SYNTHESIS; ENZYME INHIBITION; GUINEA PIG; IN VITRO STUDY; LYMPHOCYTIC INFILTRATION; METABOLISM; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SHORT SURVEY;

EID: 0030748720     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1997.022.07.414587     Document Type: Short Survey

References (13)

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4. Kaminuma, O., Mori, A., Suko, M., Kikkawa, H., Ikezawa, K., Okudaira, H. Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: Relation tophosphodiesterase inhibition. J Pharmacol Exp Ther 1996, 279: 240-6.
5. Kaminuma, O., Mori, A., Suko, M., Nishizaki, Y., Kikkawa, H., Ikezawa, K., Okudaira, H. A novel phosphodiesterase inhibitor, T-440: Possible management of eosinophilic inflammation by down-regulation of interleukin-5 production. Int Arch Allergy Immunol 1996, 111(Suppl. 1): 16-8.
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8. Kaminuma, O., Yoshikawa, H., Yamashina, S., Wada, K., Ikezawa, I. Action of T-440, a novel antiasthmatic agent, in a guinea pig model of bronchial asthma. Jpn J Allergol 1995, 44(8): Abst 300.
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