Effect of a novel phosphodiesterase IV inhibitor, T-440, on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo

Japanese Journal of Pharmacology

Volumn 72, Issue 1, 1996, Pages 1-8

  Kaminuma, Osamu ^a   Kikkawa, Hideo ^a   Matsubara, Shigeki ^a   Ikezawa, Katsuo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Airway; Asthma; Bronchoconstriction; Phosphodiesterase

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 [6,7 DIETHOXY 2,3 BIS(HYDROXYMETHYL) 1 NAPHTHYL] 1 (2 METHOXYETHYL) 2(1H) PYRIDINONE; ACETYLCHOLINE; ANTIGEN; ENDOTHELIN 1; HISTAMINE; LEUKOTRIENE D4; NEUROKININ A; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; THEOPHYLLINE; UNCLASSIFIED DRUG; ANTIHISTAMINIC AGENT; DRUG DERIVATIVE; NAPHTHALENE DERIVATIVE; PROSTAGLANDIN ENDOPEROXIDE; PYRIDONE DERIVATIVE; THROMBOXANE A2; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOSPASM; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; GUINEA PIG; INTRADUODENAL DRUG ADMINISTRATION; INTRATRACHEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ANALYSIS OF VARIANCE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; RABBIT;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANALYSIS OF VARIANCE; ANIMALS; ASTHMA; BRONCHOCONSTRICTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HISTAMINE ANTAGONISTS; INJECTIONS, INTRAVENOUS; LEUKOTRIENE D4; MALE; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PYRIDONES; RABBITS; THROMBOXANE A2; VASOCONSTRICTOR AGENTS;

EID: 0029856906     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.72.1     Document Type: Article

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