Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3- bis(hydroxymethyl)naphthalene lignans

Journal of Medicinal Chemistry

Volumn 39, Issue 14, 1996, Pages 2696-2704

  Iwasaki, Tameo ^a   Kondo, Kazuhiko ^a   Kuroda, Tooru ^a   Moritani, Yasunori ^a   Yamagata, Shinsuke ^a   Sugiura, Masaki ^a   Kikkawa, Hideo ^a   Kaminuma, Osamu ^a   Ikezawa, Katsuo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIETHOXY 2,3 BIS(HYDROXYMETHYL) 1 [1 (2 METHOXYETHYL) 2 OXOPYRID 4 YL]NAPHTHALENE; ANTIGEN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIPYRONE; HISTAMINE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOSPASM; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTI-ASTHMATIC AGENTS; GUINEA PIGS; HEART RATE; LIGNANS; MALE; NAPHTHALENES; PARASYMPATHOLYTICS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029945418     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9509096     Document Type: Article

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