메뉴 건너뛰기




Volumn 10, Issue 6, 1997, Pages 485-490

Hepatitis C virus NS3/4A protease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; PROTEINASE INHIBITOR; RIBAVIRIN; SERINE PROTEINASE; VIRUS ENZYME; VIRUS PROTEIN; ZINC;

EID: 0030733423     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001432-199712000-00014     Document Type: Short Survey
Times cited : (13)

References (62)
  • 1
    • 0027176287 scopus 로고
    • NS3 is a serine protease required for processing of hepatitis C virus polyprotein
    • Tomei L, Failla C, Santolini E, de Francesco R, La Monica N: NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol 1993, 67:4017-4026.
    • (1993) J Virol , vol.67 , pp. 4017-4026
    • Tomei, L.1    Failla, C.2    Santolini, E.3    De Francesco, R.4    La Monica, N.5
  • 3
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H: Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Viral 1993, 67:3835-3844.
    • (1993) J Viral , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 4
    • 0029950090 scopus 로고    scopus 로고
    • Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells using the herpes simplex virus amplicon system
    • Hong Z, Ferrari E, Wright-Minogue J, Chase R, Risano C, Seelig G, Lee C-G, Kwong AD: Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells using the herpes simplex virus amplicon system. J Virol 1996, 70:4261-4268.
    • (1996) J Virol , vol.70 , pp. 4261-4268
    • Hong, Z.1    Ferrari, E.2    Wright-Minogue, J.3    Chase, R.4    Risano, C.5    Seelig, G.6    Lee, C.-G.7    Kwong, A.D.8
  • 5
    • 0028817781 scopus 로고
    • C-terminal of hepatitis C virus NS3 protein contains an RNA helicase activity
    • Kim DW, Gwack Y, Han JH, Choe J: C-terminal of hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun 1995, 215:160-166.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 160-166
    • Kim, D.W.1    Gwack, Y.2    Han, J.H.3    Choe, J.4
  • 6
    • 0029784485 scopus 로고    scopus 로고
    • A Steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain
    • Preugschat F, Averett DR, Clarke BE, Porter DJT: A Steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain. J Biol Chem 1996, 271:24449-24457.
    • (1996) J Biol Chem , vol.271 , pp. 24449-24457
    • Preugschat, F.1    Averett, D.R.2    Clarke, B.E.3    Porter, D.J.T.4
  • 7
    • 0027254336 scopus 로고
    • RNA-stimulated NTPase activity associated with the p80 protein of the pestivirus bovine viral diarrhea virus
    • Tamura JK, Warrener P, Collett MS: RNA-stimulated NTPase activity associated with the p80 protein of the pestivirus bovine viral diarrhea virus. Virology 1993, 193:1-10.
    • (1993) Virology , vol.193 , pp. 1-10
    • Tamura, J.K.1    Warrener, P.2    Collett, M.S.3
  • 8
    • 0027199917 scopus 로고
    • Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes
    • Suzich JA, Tamura JK, Palmer-Hill F, Warrener P, Grakoui A, Rice CM, Feinstone SM, Collett MS: Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol 1993, 67:6152-6158.
    • (1993) J Virol , vol.67 , pp. 6152-6158
    • Suzich, J.A.1    Tamura, J.K.2    Palmer-Hill, F.3    Warrener, P.4    Grakoui, A.5    Rice, C.M.6    Feinstone, S.M.7    Collett, M.S.8
  • 9
    • 0031000887 scopus 로고    scopus 로고
    • Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells
    • Morgenstern KA, Landro JA, Hsiao K, Lin C, Yong G, Su MS-S, Thomson JA: Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells. J Virol 1997, 71:3767-3775 The presence of polynucleotides [particularly poly (U)] modulated the protease, helicase, and NTPase activities of the full-length NS3/4A complex. The authors suggest that the domains within NS3 may influence and regulate each other.
    • (1997) J Virol , vol.71 , pp. 3767-3775
    • Morgenstern, K.A.1    Landro, J.A.2    Hsiao, K.3    Lin, C.4    Yong, G.5    Su, M.S.-S.6    Thomson, J.A.7
  • 10
    • 0025862146 scopus 로고
    • Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease
    • Houghton M, Weiner A, Han JH, Kuo G, Choo Q-L: Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology 1991, 14:381-388.
    • (1991) Hepatology , vol.14 , pp. 381-388
    • Houghton, M.1    Weiner, A.2    Han, J.H.3    Kuo, G.4    Choo, Q.-L.5
  • 11
    • 0028358227 scopus 로고
    • Hepatitis C virus: Historical perspective and current concepts
    • Purcell RH: Hepatitis C virus: historical perspective and current concepts. FEMS Microbiol Rev 1994, 14:181-192.
    • (1994) FEMS Microbiol Rev , vol.14 , pp. 181-192
    • Purcell, R.H.1
  • 12
    • 0028236370 scopus 로고
    • Hepatitis C virus. Epidemiology, transmission and prevention
    • Edited by Reesink HW. Basel: Karger
    • Van der Poel CL: Hepatitis C virus. Epidemiology, transmission and prevention. In Current studies in hematology and blood transfusion. Edited by Reesink HW. Basel: Karger; 1994:137-163.
    • (1994) Current Studies in Hematology and Blood Transfusion , pp. 137-163
    • Van Der Poel, C.L.1
  • 13
    • 0028016286 scopus 로고
    • The epidemiology of viral hepatitis in the United States
    • Alter MJ, Mast EE: The epidemiology of viral hepatitis in the United States. Gastroenterol Clin North Am 1994, 23:437-455.
    • (1994) Gastroenterol Clin North Am , vol.23 , pp. 437-455
    • Alter, M.J.1    Mast, E.E.2
  • 15
    • 0027450808 scopus 로고
    • Hepatitis C virus RNA in southen African blacks with hepatocellular carcinoma
    • Bukh J, Miller RH, Kew MC, Purcell RH: Hepatitis C virus RNA in southen African blacks with hepatocellular carcinoma. Proc Natl Acad Sci USA 1993, 90:1848-1851.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1848-1851
    • Bukh, J.1    Miller, R.H.2    Kew, M.C.3    Purcell, R.H.4
  • 17
    • 0002526943 scopus 로고
    • Non-A, non-B hepatitis virus
    • Edited by Fields BN. New York: Raven Press
    • Hollinger FB: Non-A, non-B hepatitis virus. In Virology. Edited by Fields BN. New York: Raven Press; 1990:2239-2273.
    • (1990) Virology , pp. 2239-2273
    • Hollinger, F.B.1
  • 18
    • 0000361013 scopus 로고    scopus 로고
    • Hepatitis C viruses
    • Edited by Fields BN, Knipe DM, Howley PM. New York: Raven Press
    • Houghton M: Hepatitis C viruses. In Virology. Third edn. Edited by Fields BN, Knipe DM, Howley PM. New York: Raven Press; 1996:1035-1058.
    • (1996) Virology. Third Edn. , pp. 1035-1058
    • Houghton, M.1
  • 19
    • 0030864915 scopus 로고    scopus 로고
    • Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
    • Kolykhalov AA, Agapov E, Blight KJ, Mihalik K, Feinstone S, Rice CM: Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 1997, 277:570-574 This study describes the construction of functional HCV cDNA clones. RNA transcribed from the clones was found to be infectious and to cause disease in chimpanzees after direct intrahepatic inoculation.
    • (1997) Science , vol.277 , pp. 570-574
    • Kolykhalov, A.A.1    Agapov, E.2    Blight, K.J.3    Mihalik, K.4    Feinstone, S.5    Rice, C.M.6
  • 20
    • 0028263211 scopus 로고
    • Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C
    • Hino K, Sainokami S, Shimoda K, Lino S, Wang Y, Okamoto H, Miyakawa Y, Mayumi M: Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. J Med Virol 1994, 42:299-305.
    • (1994) J Med Virol , vol.42 , pp. 299-305
    • Hino, K.1    Sainokami, S.2    Shimoda, K.3    Lino, S.4    Wang, Y.5    Okamoto, H.6    Miyakawa, Y.7    Mayumi, M.8
  • 22
    • 0029610001 scopus 로고
    • Future studies of combination therapy for chronic hepatitis C: Optimizing response rate for each hepatitis C population
    • Main J: Future studies of combination therapy for chronic hepatitis C: optimizing response rate for each hepatitis C population. J Hepatol 1995, 23:32-36.
    • (1995) J Hepatol , vol.23 , pp. 32-36
    • Main, J.1
  • 24
    • 0026334457 scopus 로고
    • Nucleotide sequence and mutation rate of the H strain of hepatitis C virus
    • Ogata N, Alter HJ, Miller RH, Purcell RH: Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc Natl Acad Sci USA 1991, 88:3392-3396.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3392-3396
    • Ogata, N.1    Alter, H.J.2    Miller, R.H.3    Purcell, R.H.4
  • 26
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A, Wychowski C, Lin C, Feinstone SM, Rice CM: Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993, 67:1385-1395.
    • (1993) J Virol , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 27
    • 0025991559 scopus 로고
    • Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
    • Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Shimotohno K: Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci USA 1991, 88:5547-5551.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5547-5551
    • Hijikata, M.1    Kato, N.2    Ootsuyama, Y.3    Nakagawa, M.4    Shimotohno, K.5
  • 28
    • 0028290389 scopus 로고
    • Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • Lin C, Lindenbach BD, Pragai BM, McCourt DW, Rice CM: Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J Virol 1994, 68:5063-5073.
    • (1994) J Virol , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Pragai, B.M.3    McCourt, D.W.4    Rice, C.M.5
  • 29
    • 0025201350 scopus 로고
    • Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein
    • Chambers TJ, Weir RC, Grakoui A, McCourt DW, Bazan JF, Fletterick RJ, Rice CM: Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc Natl Acad Sci USA 1990, 87:8898-8902.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8898-8902
    • Chambers, T.J.1    Weir, R.C.2    Grakoui, A.3    McCourt, D.W.4    Bazan, J.F.5    Fletterick, R.J.6    Rice, C.M.7
  • 30
    • 0030592514 scopus 로고    scopus 로고
    • The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
    • Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z: The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 1996, 87:331-342 The structure of the NS3 protease domain in the absence of the NS4A activator was determined by X-ray crystallography at 2.4Å resolution.
    • (1996) Cell , vol.87 , pp. 331-342
    • Love, R.A.1    Parge, H.E.2    Wickersham, J.A.3    Hostomsky, Z.4    Habuka, N.5    Moomaw, E.W.6    Adachi, T.7    Hostomska, Z.8
  • 31
    • 16044364658 scopus 로고    scopus 로고
    • Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
    • Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET et al.: Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 1996, 87:343-355 The structure of the NS3 protease domain in the presence of a synthetic NS4A activator peptide was determined by X-ray crystallography at 2.5Å resolution.
    • (1996) Cell , vol.87 , pp. 343-355
    • Kim, J.L.1    Morgenstern, K.A.2    Lin, C.3    Fox, T.4    Dwyer, M.D.5    Landro, J.A.6    Chambers, S.P.7    Markland, W.8    Lepre, C.A.9    O'Malley, E.T.10
  • 33
    • 0029076837 scopus 로고
    • The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A
    • Satoh S, Tanji Y, Hijikata M, Kimura K, Shimotohno K: The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A. J Virol 1995, 69:4255-4260.
    • (1995) J Virol , vol.69 , pp. 4255-4260
    • Satoh, S.1    Tanji, Y.2    Hijikata, M.3    Kimura, K.4    Shimotohno, K.5
  • 34
    • 0028851296 scopus 로고
    • An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A
    • Failla C, Tomei L, De Francesco R: An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J Virol 1995, 69:1769-1777.
    • (1995) J Virol , vol.69 , pp. 1769-1777
    • Failla, C.1    Tomei, L.2    De Francesco, R.3
  • 35
    • 0028820118 scopus 로고
    • Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation
    • Bartenschlager R, Lohmann V, Wilkinson T, Koch JO: Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation. J Virol 1995, 69:7519-7528.
    • (1995) J Virol , vol.69 , pp. 7519-7528
    • Bartenschlager, R.1    Lohmann, V.2    Wilkinson, T.3    Koch, J.O.4
  • 36
    • 0030589011 scopus 로고    scopus 로고
    • Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: Identification of sequence and critical residues of NS4A for the cofactor activity
    • Butkiewicz N, Wendel M, Zhang R, Jubin R, Pichardo J, Smith EB, Hart AM, Ingram R, Durkin J, Mui PW et al.: Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity. Virology 1996, 225:328-338.
    • (1996) Virology , vol.225 , pp. 328-338
    • Butkiewicz, N.1    Wendel, M.2    Zhang, R.3    Jubin, R.4    Pichardo, J.5    Smith, E.B.6    Hart, A.M.7    Ingram, R.8    Durkin, J.9    Mui, P.W.10
  • 37
    • 0029074519 scopus 로고
    • A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
    • Lin C, Thomson JA, Rice CM: A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J Virol 1995, 69:4373-4380.
    • (1995) J Virol , vol.69 , pp. 4373-4380
    • Lin, C.1    Thomson, J.A.2    Rice, C.M.3
  • 38
    • 0029655995 scopus 로고    scopus 로고
    • Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease
    • Shimizu Y, Yamaji K, Masuho Y, Yokota T, Inoue H, Sudo K, Satoh S, Shimotohno K: Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease. J Virol 1996, 70:127-132.
    • (1996) J Virol , vol.70 , pp. 127-132
    • Shimizu, Y.1    Yamaji, K.2    Masuho, Y.3    Yokota, T.4    Inoue, H.5    Sudo, K.6    Satoh, S.7    Shimotohno, K.8
  • 39
    • 0028831056 scopus 로고
    • Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing
    • Tanji Y, Hijikata M, Satoh S, Kaneko T, Shimotohno K: Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol 1995, 69:1575-1581.
    • (1995) J Virol , vol.69 , pp. 1575-1581
    • Tanji, Y.1    Hijikata, M.2    Satoh, S.3    Kaneko, T.4    Shimotohno, K.5
  • 40
    • 0029814495 scopus 로고    scopus 로고
    • Activity of purified hepatitis C virus protease NS3 on peptide substrates
    • Steinkuhler C, Urbani A, Tomei L, Biasiol MS, Bianchi E, Pessi A, De Francesco R: Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol 1996, 70:6694-6700 The activity of the NS3 protease domain was optimized and the cleavage kinetics on peptides corresponding to the different trans-cleavage sites in the HCV polyprotein was examined.
    • (1996) J Virol , vol.70 , pp. 6694-6700
    • Steinkuhler, C.1    Urbani, A.2    Tomei, L.3    Biasiol, M.S.4    Bianchi, E.5    Pessi, A.6    De Francesco, R.7
  • 41
    • 0030839639 scopus 로고    scopus 로고
    • Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide
    • Bianchi E, Urbani A, Biasiol G, Brunetti M, Pessi A, De Francesco R, Steinkuhler C: Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide. Biochemistry 1997, 36:7890-7897 The effect of NS4A peptide binding to NS3 was examined by far and near-ultraviolet circular dichronism spectrum analysis.
    • (1997) Biochemistry , vol.36 , pp. 7890-7897
    • Bianchi, E.1    Urbani, A.2    Biasiol, G.3    Brunetti, M.4    Pessi, A.5    De Francesco, R.6    Steinkuhler, C.7
  • 42
    • 0027414062 scopus 로고
    • Characterization of the hepatitis C virus-encoded serine proteinase: Determination of the proteinase-dependent polyprotein cleavage sites
    • Grakoui A, McCourt DW, Wychowski C, Feinstone SM, Rice CM: Characterization of the hepatitis C virus-encoded serine proteinase: determination of the proteinase-dependent polyprotein cleavage sites. J Virol 1993, 67:2832-2843.
    • (1993) J Virol , vol.67 , pp. 2832-2843
    • Grakoui, A.1    McCourt, D.W.2    Wychowski, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 43
    • 0030334850 scopus 로고    scopus 로고
    • Redesigning the substrate specificity of the hepatitis C virus NS3 protease
    • Failla CM, Pizzi E, De Francesco R, Tramontano A: Redesigning the substrate specificity of the hepatitis C virus NS3 protease. Folding Design 1996, 1:35-42.
    • (1996) Folding Design , vol.1 , pp. 35-42
    • Failla, C.M.1    Pizzi, E.2    De Francesco, R.3    Tramontano, A.4
  • 45
    • 0030944102 scopus 로고    scopus 로고
    • Substrate specificity of the hepatitis C virus serine protease NS3
    • Urbani A, Bianchi E, Narjes F, Tramontano A, De Francesco R, Steinkuhler C, Pessi A: Substrate specificity of the hepatitis C virus serine protease NS3. J Biol Chem 1997, 272:9204-9209. Natural and non-natural amino acid modifications were introduced into peptides derived from the NS4A/NS4B cleavage site. Kinetic analyses in the presence and absence of a NS4A activator peptide and the NS3 protease domain were determined.
    • (1997) J Biol Chem , vol.272 , pp. 9204-9209
    • Urbani, A.1    Bianchi, E.2    Narjes, F.3    Tramontano, A.4    De Francesco, R.5    Steinkuhler, C.6    Pessi, A.7
  • 46
    • 0030844455 scopus 로고    scopus 로고
    • Probing the Substrate Specificity of Hepatitis C Virus NS3 Serine Protease by Using Synthetic Peptides
    • m values. A stringent stereochemical requirement for the native P1 Cys in the S1 pocket was observed-alteration of the sulfhydryl function and/or the steric characteristics (bulkiness or chirality) resulted in a 20- to 12 500-fold loss of cleavage efficiency.
    • (1997) J Virol , vol.71 , pp. 6208-6213
    • Zhang, R.1    Durkin, J.2    Windsor, W.T.3    McNemar, C.4    Ramanathan, L.5    Le, H.V.6
  • 48
    • 0029042438 scopus 로고
    • In vitro cleavage of hepatitis C virus polyprotein substrates by purified recombinant NS3 protease
    • D'Souza EDA, Grace K, Sangar DV, Rowlands DJ, Clarke BE: In vitro cleavage of hepatitis C virus polyprotein substrates by purified recombinant NS3 protease. J Gen Virol 1995, 76:1729-1736.
    • (1995) J Gen Virol , vol.76 , pp. 1729-1736
    • D'Souza, E.D.A.1    Grace, K.2    Sangar, D.V.3    Rowlands, D.J.4    Clarke, B.E.5
  • 49
    • 0029094449 scopus 로고
    • The hepatitis C virus NS3 serine proteinase and NS4A cofactor: Establishment of a cell-free trans-processing assay
    • Lin C, Rice CM: The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay. Proc Natl Acad Sci USA 1995, 92:7622-7626.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7622-7626
    • Lin, C.1    Rice, C.M.2
  • 53
    • 0030933215 scopus 로고    scopus 로고
    • The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme
    • Stempniak M, Hostomska Z, Nodes BR, Hostomsky Z: The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme. J Virol 1997, 71:2881-2886.
    • (1997) J Virol , vol.71 , pp. 2881-2886
    • Stempniak, M.1    Hostomska, Z.2    Nodes, B.R.3    Hostomsky, Z.4
  • 54
    • 0028960558 scopus 로고
    • Identification of the protease domain in NS3 of hepatitis C virus
    • Hans DS, Hahm B, Rho H-M, Jang SK: Identification of the protease domain in NS3 of hepatitis C virus. J Gen Virol 1995, 76:985-993.
    • (1995) J Gen Virol , vol.76 , pp. 985-993
    • Hans, D.S.1    Hahm, B.2    Rho, H.-M.3    Jang, S.K.4
  • 55
    • 0000686943 scopus 로고
    • Viral cysteine proteases are homologous to the trypsin-like family of serine protease: Structural and functional implications
    • Bazen JF, Fletterick RJ: Viral cysteine proteases are homologous to the trypsin-like family of serine protease: structural and functional implications. Proc Natl Acad Sci USA 1988, 85:7872-7876.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7872-7876
    • Bazen, J.F.1    Fletterick, R.J.2
  • 56
    • 0026606515 scopus 로고
    • Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease
    • Yu SF, Loyd RE: Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease. Virology 1992, 186:725-735.
    • (1992) Virology , vol.186 , pp. 725-735
    • Yu, S.F.1    Loyd, R.E.2
  • 57
    • 0028846684 scopus 로고
    • Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity
    • Voss T, Meyer R, Sommergruber W: Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity. Protein Sci 1995, 4:2256-2531.
    • (1995) Protein Sci , vol.4 , pp. 2256-2531
    • Voss, T.1    Meyer, R.2    Sommergruber, W.3
  • 58
    • 0028080452 scopus 로고
    • The 2A proteinase of human rhinovirus is a zinc containing enzyme
    • Sommergruber W, Casari G, Fessl F, Seipelt J, Skern T: The 2A proteinase of human rhinovirus is a zinc containing enzyme. Virology 1994, 204:815-818.
    • (1994) Virology , vol.204 , pp. 815-818
    • Sommergruber, W.1    Casari, G.2    Fessl, F.3    Seipelt, J.4    Skern, T.5
  • 59
    • 0028089739 scopus 로고
    • Hepatitis C virus NS3 serine proteinase: Trans-cleavage requirements and processing kinetics
    • Lin C, Pragai BM, Grakoui A, Xu J, Rice CM: Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol 1994, 68:8147-8157.
    • (1994) J Virol , vol.68 , pp. 8147-8157
    • Lin, C.1    Pragai, B.M.2    Grakoui, A.3    Xu, J.4    Rice, C.M.5
  • 61
    • 0031036325 scopus 로고    scopus 로고
    • Chimeric sindbis viruses dependent on the NS3 protease of hepatitis C virus
    • Filocamo G, Pacini L, Migliaccio G: Chimeric sindbis viruses dependent on the NS3 protease of hepatitis C virus. J Virol 1997, 71:1417-1427.
    • (1997) J Virol , vol.71 , pp. 1417-1427
    • Filocamo, G.1    Pacini, L.2    Migliaccio, G.3
  • 62
    • 0030589469 scopus 로고    scopus 로고
    • Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity
    • Hahm B, Back SH, Lee TG, Wimmer E, Jang SK: Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity. Virology 1996, 226:318-326.
    • (1996) Virology , vol.226 , pp. 318-326
    • Hahm, B.1    Back, S.H.2    Lee, T.G.3    Wimmer, E.4    Jang, S.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.