Vitamin supplementation therapy in the elderly

Drugs and Aging

Volumn 11, Issue 6, 1997, Pages 433-449

  Thurman, Jerome E ^a   Mooradian, Arshag D ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ANTICONVULSIVE AGENT; ANTIOXIDANT; ASCORBIC ACID; CAROTENOID; COLCHICINE; COLESTYRAMINE; CORTICOSTEROID; CYANOCOBALAMIN; DIGITALIS; DIURETIC AGENT; FOLIC ACID; ISONIAZID; LAXATIVE; METFORMIN; METHOTREXATE; NICOTINAMIDE; NICOTINIC ACID; PYRIDOXINE; RETINOID; RETINOL; RIBOFLAVIN; THIAMINE; TRIAMTERENE; VITAMIN; VITAMIN B GROUP; VITAMIN D; VITAMIN K GROUP;

AGED; ANAPHYLAXIS; ANTIOXIDANT ACTIVITY; DESQUAMATION; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG SAFETY; FLUSHING; GALLSTONE FORMATION; GLUCOSE INTOLERANCE; HEADACHE; HEMOLYSIS; HEMOLYTIC ANEMIA; HIGH RISK POPULATION; HUMAN; HYPERCALCEMIA; INTRACRANIAL PRESSURE; IRON METABOLISM; ISCHEMIC HEART DISEASE; LIVER TOXICITY; MYOSITIS; ORAL DRUG ADMINISTRATION; PERIPHERAL NEUROPATHY; PHOTOSENSITIVITY DISORDER; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; SEIZURE SUSCEPTIBILITY; VERTIGO; VITAMIN DEFICIENCY;

EID: 0030732588     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-199711060-00003     Document Type: Review

References (164)

1. Blumberg J. Nutrient requirements of the healthy elderly: should there be specific RDAs? Nutr Rev 1994; 52 (8 Suppl.): S15-8
2. Dwyer J. Nutritional problems of elderly minorities. Nutr Rev 1994; 52 (8Suppl.): S24-7
3. Silver AJ. Anorexia of aging. Ann Intern Med 1988; 109: 892-4
4. Greska LP, Parraga IM, Clark CA. The dietary adequacy of edentulous older adults. J Prosthet Dent 1995; 73 (2): 142-5
5. Rudman D, Abbasi AA, Isaacson K, et al. Observations on the nutrient intakes of eating-dependent nursing home residents: underutilisation of micronutrient supplements. J Am Coll Nutr 1995; 14 (6): 604-13
6. Posner BM, Jette A, Smigelski C, et al. Nutritional risk in New England elders. J Gerontol 1994; 49 (3 Suppl.): M123-32
7. Shock NW, Grenlich RC, Andres R, et al. for the National Institute of Health (NIH). Normal human aging: the Baltimore Longitudinal Study of Aging. NIH Publication No. 84-2450. Baltimore (MD): US Department of Health and Human Services, 1984 Nov: 105-12
8. National Research Council. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press, 1989
9. Jylha M. Ten-year change in the use of medical drugs among the elderly: a longitudinal study and cohort comparison. J Clin Epidemiol 1994; 47 (1): 69-79
10. Mant A, Whicker S, Sook Kwok Y. Over-the-counter self-medication: the issues. Drugs Aging 1992; 2 (4): 257-61
11. Barone J, Taibli E, Muscat J, et al. Vitamin supplement use in a hospital-based population. Eur J Cancer Prev 1992; 1: 139-48
12. Alfin-Slater RB. Vitamin use and abuse in elderly persons. Ann Intern Med 1988; 109: 896-9
13. Barnett YA. Nutrition and the ageing process. Br J Biomed Sci 1994; 51: 278-87
14. Gray GE, Paganini-Hill A, Ross RK. Dietary intake and nutrient supplement use in a Southern California retirement community. Am J Clin Nutr 1983; 38: 122-8
15. Pitt HA, Costrini AM. Vitamin C prophylaxis in marine recruits. JAMA 1979; 241 (9): 908-11
16. Schectman G. Estimating ascorbic acid requirements for cigarette smokers. Ann N Y Acad Sci 1993; 686: 335-45
17. Schectman G, Byrd JC, Hoffmann R. Ascorbic acid requirements for smokers: analysis of a population study. Am J Clin Nutr 1991; 53: 1466-70
18. Dawson EB, Harris WA, Teter MC, et al. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992; 58 (5): 1034-9
19. Paolisso G, D'Amore A, Balbi V, et al. Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics. Am J Physiol 1994; 266: E261-8
20. Stankova L, Riddle M, Larned J, et al. Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus. Metabolism 1984; 33 (4): 347-53
21. Paolisso G, Balbi V, Volpe C, et al. Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. J Am Coll Nutr 1995; 14 (4): 387-92
22. Schorah CJ, Tormey WP, Brooks GH, et al. The effect of vitamin C supplements on body weight, serum proteins, and general health of an elderly population. Am J Clin Nutr 1994; 34: 871-6
23. Breslow R. Nutritional status and dietary intake of patients with pressure ulcers: review of research literature 1943 to 1989. Decubitus 1991; 4 (1): 16-21
24. Klaassen CD. Principles of toxicology and treatment of poisoning. In: Hardman JG, Limbird LE, editors. Goodman and Gilman's the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, 1996: 63-75
25. Ghosh SK, Ekpo EB, Shah IU, et al. A double-blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology 1994; 40 (5): 268-72
26. Lovat LB, Lu U, Palmer AJ, et al. Double-blind trial of vitamin C in elderly hypertensives. J Hum Hypertens 1993; 7: 403-5
27. Levine M, Dhariwal KR, Welch RW, et al. Determination of optimal vitamin C requirements in humans. Am J Clin Nutr 1995; 62 Suppl.: 1347S-56S
28. van der Wielen RPJ, van Heereveld HAEM, de Groot CPGM, et al. Nutritional status of elderly female nursing home residents: the effect of supplementation with a physiological dose of waler-soluble vitamins. Eur J Clin Nutr 1995; 49: 665-74
29. Flagg EW, Coates RJ, Greenberg RS. Epidemiologic studies of antioxidants and cancer in humans. J Am Coll Nutr 1995; 14 (5): 419-27
30. Jacob RA, Vitamin C. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed. Philadelphia: Lea and Febiger, 1994: 432-48
31. Bendich A. Safety issues regarding the use of vitamin supplements. Ann N Y Acad Sci 1992; 669: 300-10
32. Bendich A, Langseth L. Safety of vitamin A. Am J Clin Nutr 1989; 44: 358-71
33. Strijdom JG, Marais BJ, Koeslag JH. Ascorbic acid causes spuriously low blood glucose measurements. S Afr Med J 1993; 83: 64-5
34. 12 by ascorbic acid. JAMA 1974; 230: 241-2
35. 12 assay. Am J Clin Nutr 1978; 31: 253-8
36. Wandzilak TR, D'Andre SD, Davis PA, et al. Effect of high dose vitamin C on urinary oxalate levels. J Urol 1994; 151: 834-7
37. Rees DC, Kelsey H, Richards JDM. Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency. BMJ 1993; 306: 841-2
38. Vatassery GT, Johnson GJ, Krezowski AM. Changes in vitamin E concentrations in human plasma and platelets with age. J Am Coll Nutr 1983; 4: 369-75
39. Farrell PM, Roberts RJ. Vitamin E. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed. Philadelphia: Lea and Febiger, 1994: 326-41
40. Kilic F, Mitton K, Dzialoszynski T, et al. Modelling cortical cataractogenesis: 14. Reduction in lens damage in diabetic rats by a dietary regimen combining vitamins C and E and β-carotene. Dev Ophthalmol 1994; 26: 63-71
41. Augustin AJ, Briepohl W, Boker T, et al. Evidence for the prevention of oxidative tissue damage in the inner eye by vitamins E and C. Ger J Ophthalmol 1992; 1: 394-8
42. Meydani SN, Wu D, Santos MS, et al. Antioxidants and immune response in aged persons: overview of present evidence. Am J Clin Nutr 1995; 62 Suppl.: 1462S-76S
43. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 1997; 336 (17): 1216-22
44. Paolisso G, Di Marco G, Galzerano D, et al. Pharmacologic doses of vitamin E and insulin action in elderly subjects. Am J Clin Nutr 1994; 59: 1291-6
45. Boyle P, Zaridze DG, Smans M. Descriptive epidemiology of colorectal cancer. Int J Cancer 1985; 36 (1): 9-18
46. Sandler RS, Lyles CM, Peipins LA, et al. Diel and risk of colorectal adenomas: macronutrients, cholesterol, and fiber. J Natl Cancer Inst 1993; 85 (11): 884-91
47. Byers T, Perry G. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr 1992; 12: 139-59
48. Greenberg ER, Baron JA, Karagas MR, et al. Mortality associated with low plasma concentration of β-carotene and the effect of oral supplementation. JAMA 1996; 275 (9): 699-703
49. The α-Tocopherol, β-Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330 (15): 1029-35
50. Kushi LH, Fee RM, Sellers TA, et al. Intake of vitamins A, C, and E and postmenopausal breast cancer: the Iowa Women's Health Study. Am J Epidemiol 1996; 144 (2): 165-74
51. Rapola JM, Virtamo J, Haukka JK, et al. Effect of vitamin E and β-carotene on the incidence of angina pectoris: a randomized, double-blind, controlled trial. JAMA 1996; 275 (9): 693-8
52. Stampfer M, Hennekens CH, Manson JE, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993; 328 (20): 1444-9
53. Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993; 328 (20): 1450-6
54. Kushi LH, Folsom AR, Prineas RJ, et al. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996; 334 (18): 1156-62
55. Hodis HN, Mack WJ, LaBree L, et al. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 1995; 273 (23): 1849-54
56. Tardif JC, Cote G, Lesperance J, et al. Prohucol and multivitamins in the prevention of restenosis after coronary angioplasty. N Engl J Med 1997; 337 (6): 365-72
57. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996; 347:781-6
58. Dieber-Rotheneder M, Puhl H, Waeg G, et al. Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 1991; 32: 1325-32
59. Reaven PD, Herold DA, Barnett J, et al. Effects of vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM. Diabetes Care 1995; 18 (6): 807-16
60. Corrigan JJ. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982; 393: 361-8
61. Marcus R, Coulston AM. Water-soluble vitamins: the vitamin B complex and ascorbic acid. In: Wonsiewecz M, McCurdy P, editors. Goodman and Gilman's the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, 1996: 1535-72
62. Wang XD. Review: absorption and metabolism of β-carotene. J Am Coll Nutr 1994; 13 (4): 314-25
63. Burton GW, Ingold KU. β-Carotene: an unusual type of lipid antioxidant. Science 1984; 224: 569-73
64. Basu TK, Donald FA, Gargreaves JA, et al. Seasonal variation of vitamin A (retinol) status in older men and women. J Am Coll Nutr 1994; 13 (6): 641-5
65. Garry PJ, Hunt WC, Bandrofchak JL, et al. Vitamin A intake and plasma retinol levels in healthy elderly men and women. Am J Clin Nutr 1987; 46: 989-94
66. Shimizu H, Nagata C, Komatsu S, et al. Decreased serum retinol levels in women with cervical dysplasia. Br J Cancer 1996; 73 (12): 1600-4
67. Zheng W, Sellers TA, Doyle TJ, et al. Retinol, antioxidant vitamins and cancers of the upper digestive tract in a prospective cohort study of postmenopausal women. Am J Epidemiol 1995; 142 (9): 955-60
68. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334 (18): 1150-5
69. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334 (18): 1145-9
70. Greenberg ER, Baron JA, Tosteson TD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 1994; 331 (3): 141-7
71. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990; 52 (2): 183-202
72. Olson JA. Vitamin A, retinoids, and carotenoids. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed. Philadelphia: Lea and Febiger, 1994: 287-307
73. Garewal HS, Diplock AT. How 'safe' are antioxidant vitamins? Drug Saf 1995; 13 (1): 8-14
74. Marwick C. Trials reveal no benefit, possible harm of β-carotene and vitamin A for lung cancer prevention. JAMA 1996; 275 (6): 422-3
75. Walters MR. Newly identified actions of the vitamin D endocrine system. Endocr Rev 1992; 13 (4): 719-64
76. Lips P, Hackeng WHL, Jongen MJM, et al. Seasonal variation in serum concentrations of parathyroid hormone in elderly people. J Clin Endocrinol Metab 1983; 57 (1): 204-6
77. Lips P, Wiersinga A, van Ginkel FC, et al. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 1988; 67 (4): 644-50
78. Krall EA, Sahyoun N, Tannenbaum S, et al. Effect of vitamin D intake on seasonal variation in parathyroid hormone secretion in postmenopausal women. N Engl J Med 1989; 321 (26): 1777-83
79. Quesada JM, Coopmans W, Ruiz B, et al. Influence of vitamin D on parathyroid function in the elderly. J Clin Endocrinol Metab 1992; 75 (2): 494-501
80. Baynes KCR, Boucher BJ, Feskens EJM, et al. Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 1997; 40 (3): 344-7
81. Salamone LM, Dallal GE, Zantos D, et al. Contributions of vitamin D intake and seasonal sunlight exposure to plasma 25-hydroxyvitamin D concentration in elderly women. Am J Clin Nutr 1994; 59 (1): 80-6
82. Gloth FM, Gundberg CM, Hollis BW, et al. Vitamin D deficiency in homebound elderly persons. JAMA 1995; 274 (21): 1683-6
83. Keane EM, Rochfort A, Cox J, et al. Vitamin-D-fortified liquid milk: a highly effective method of vitamin D administration for house-bound and institutionalised elderly. Gerontology 1992; 38 (5): 280-4
84. van der Wielen RP, Lowik MR, van den Berg H, et al. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995; 346: 207-10
85. McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study. Ann Intern Med 1996; 125 (5): 353-9
86. Ooms ME, Roos JC, Bezemer PD, et al. Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial. J Clin Endocrinol Metab 1995; 80 (4): 1052-8
87. Prestwood KM, Pannullo AM, Denny AM, et al. The effect of a short course of calcium and vitamin D on bone turnover in older women. Osteoporos Int 1996; 6: 314-9
88. 3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992; 327 (23): 1637-42
89. Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. Ann Intern Med 1996; 124 (4): 400-6
90. Dawson-Hughes B, Harris SS, Krall EA, et al. Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr 1995; 61 (5): 1140-5
91. Rao DR, Bello H, Warren AP, et al. Prevalence of lactose maldigestion: influence and interaction of age, race and sex. Dig Dis Sci 1994; 39 (7): 1519-24
92. McKenna MJ. Differences in vitamin D status between countries in young adults and the elderly. Am J Med 1992; 93 (1): 69-77
93. Thorp JA, Gaston L, Caspers DR, et al. Current concepts and controversies in the use of vitamin K. Drugs 1995; 49 (3): 376-87
94. Heaney RP. Bone mass, nutrition and other lifestyle factors. Am J Med 1993; 95 Suppl. 5A: 29S-33S
95. Sokoll LJ, Sadowski JA. Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. Am J Clin Nutr 1996; 63 (4): 566-73
96. Ferland G, Sadoski JA, O'Brien ME. Dietary induced subclinical vitamin K deficiency in normal human subjects. J Clin Invest 1993; 91 (4): 1761-8
97. Jie KS, Bots ML, Vermeer C, et al. Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 1995; 116 (1): 117-23
98. Szule P, Chapuy MC, Meunier PJ, et al. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 1993; 91 (4): 1769-74
99. 2 decreased in elderly women with hip fracture. J Bone Miner Res 1993; 8 (10): 1241-5
100. 2 in human cortical and trabecular bone. J Bone Miner Res 1993; 8 (8): 1005-8
101. Knapen MH, Jie KS, Hamulyak K, et al. Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif Tissue Int 1993; 53 (2): 81-5
102. Binkley NC, Suttie JW. Vitamin K nutrition and osteoporosis. J Nutr 1995; 125: 1812-21
103. Reed RL, Mooradian AD. Nutritional status and dietary management of elderly diabetic patients. Clin Geriatr Med 1990; 6 (4): 883-901
104. Bettendorff L, Mastrogiacomo F, Kish SJ, et al. Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain. J Neurochem 1996; 66 (1): 250-8
105. Tanphaichitr V, Thiamin. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed. Philadelphia: Lea and Febiger, 1994: 359-65
106. Kwok T, Falconer-Smith JF, Potter JF, et al. Thiamine status of elderly patients with cardiac failure. Age Ageing 1992; 21 (1): 67-71
107. Bates CJ. Human riboflavin requirements and metabolic consequences of deficiency in man and animals. World Rev Nutr Diet 1987; 50: 215-65
108. Boisvert WA, Castaneda C, Mendoza I, et al. Prevalence of riboflavin deficiency among Guatemalan elderly people and its relationship to milk intake. Am J Clin Nutr 1993; 58 (1): 85-90
109. 6 among elderly people (Dutch Nutrition Surveillance System). Int J Vitam Nutr Res 1994; 64 (3): 198-203
110. Leske MC, Wu SY, Hyman L, et al. Biochemical factors in the lens opacities: case-control study. The Lens Opacities Case-Control Study Group. Arch Ophthalmol 1995; 113 (9): 1113-9
111. Winters LR, Yoon JS, Kalkwarf HJ, et al. Riboflavin requirements and exercise adaptation in older women. Am J Clin Nutr 1992; 56 (3): 526-32
112. Boisvert WA, Mendoza I, Castaneda C, et al. Riboflavin requirement of healthy elderly humans and its relationship to macronutrient composition of the diet. J Nutr 1993; 123 (5): 915-25
113. McCormick DB. Rihollavin. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed Philadelphia: Lea and Febiger, 1994: 366-75
114. Riggs KM, Spiro III A, Tucker K, et al. Relations of vitamin B-12, vitamin B-6, folate and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 1996; 63 (3): 306-14
115. 6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology 1992; 109: 489-96
116. Joosten E, van den Berg A, Riezler R, et al. Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 1993; 58 (4): 468-76
117. 6. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed. Philadelphia: Lea and Febiger, 1994: 383-94
118. Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992; 55: 1237S-43S
119. 6 on immune response. Ann N Y Acad Sci 1992; 669: 125-39
120. 6 deficient: controlled study of serum pyridoxal-5′-phosphate. Acta Orthop Scand 1992; 63 (6): 635-8
121. 6 reservoirs, receptors and red-cell reactions. Ann N Y Acad Sci 1992; 669: 34-41
122. 6 and hypertension. Ann N Y Acad Sci 1990; 585: 241-9
123. 6 deficiency-induced hypertension. J Hypertens 1993; 11 (12): 1357-62
124. 6: impact of restricted intake on physical performance in man. J Am Coll Nutr 1994; 13 (6): 629-40
125. Ubbink JB, van der Merwe A, Delport R, et al. The effect of a subnormal vitamin B-6 status on homocysteine metabolism. J Clin Invest 1996; 98 (1): 177-84
126. 6. Res Commun Mol Pathol Pharmacol 1995; 89 (2): 208-20
127. Talbott MC, Miller LT, Kerkvlict NI. Pyridoxine supplementation: effect on lymphocyte responses in elderly persons. Am J Clin Nutr 1987; 46 (4): 659-64
128. 6. Ann N Y Acad Sci 1990; 585: 302-20
129. 6 in clinical neurology. Ann N Y Acad Sci 1990; 585: 250-60
130. Schaumburg H, Kaplan J, Windebank A, et al. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Engl J Med 1983; 309 (8): 445-8
131. Berger AR, Schaumburg HH, Schroeder C, et al. Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity. Neurology 1992; 42 (7): 1367-70
132. 6). J Am Acad Dermatol 1996; 35 (Pt 2): 304-5
133. Wilson JD. Vitamin deficiency and excess. In: Isselhacher KJ, Martin JB, Braunwald E, et al., editors. Harrison's principles of internal medicine. 13th ed. New York: McGraw-Hill, 1994: 472-80
134. Durringlon PN. Drug therapy of hyperlipidaemia. In: Hyperlipidaemia: diagnosis and management. 2nd ed. Cambridge: Cambridge University Press, 1995: 258-90
135. Miller NE. Pharmacological intervention for altering lipid metabolism. Drugs 1990; 40 Suppl. 1: 26-31
136. Oster G, Borok GM, Menzin J, et al. Cholesterol-Reduction Intervention Study (CRIS): a randomized trial to assess effectiveness and costs in clinical practice. Arch Intern Med 1996; 156 (7): 731-9
137. Illingworth DR, Slein EA, Mitchel YB, et al. Comparative effects of lovastatin and niacin in primary hypercholesterolemia: a prospective trial. Arch Intern Med 1994; 154 (14): 1586-95
138. Dalton TA, Berry RS. Hepatotoxicity associated with sustained-release niacin. Am J Med 1992; 93 (1): 102-4
139. Gharavi AG, Diamond A, Smith DA, et al. Niacin-induced myopathy. Am J Cardiol 1994; 74 (8): 841-2
140. Fraunfelder FW, Fraunfelder FT, Illingworth DR. Adverse ocular effects associated with niacin therapy. Br J Ophthalmol 1995; 79 (1): 54-6
141. Shakir KM, Droll S, Aorill BS, et al. Nicotinic acid decreases serum thyroid hormone levels while maintaining a euthyroid state. Mayo Clin Proc 1995; 70 (6): 556-8
142. Wahlberg G, Walldius G, Efendic S. Effects of nicotinic acid on glucose tolerance and glucose incorporation into adipose tissue in hypertriglyceridaemia. Scand J Clin Lab Invest 1992; 52 (6): 537-45
143. Lipman TO. Vitamins: hormonal and metabolic interrelationships. In: Becker KL, editor. Principles and practice of endocrinology and metabolism. 2nd ed. Philadelphia: J.B. Lippincott, 1995: 50-6
144. Lindenbaum J, Rosenberg IH, Wilson PWF, et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60: 2-11
145. Pennypacker LC, Allen RH, Kelly JP, et al. High prevalency of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992; 40 (12): 1197-204
146. 12 deficiency and dementia. Int Psychogeriatr 1995; 7 (1): 85-8
147. 12 levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study. J Am Geriatr Soc 1994; 42 (9): 933-6
148. Beck WS. Diagnosis of megaloblastic anemia. Annu Rev Med 1991; 42: 311-22
149. Fairbanks VF. Tests for pernicious anemia: the 'Schilling test'. Mayo Clin Proc 1983; 58: 541-4
150. 12 level [letter]. JAMA 1944; 272 (16): 1233
151. Carmel R, Sinow RM, Siegel ME, et al. Food cobalamin malabsorption occurs frequently in patients with unexplained low serum cobalamin levels. Arch Intern Med 1988; 148 (8): 1715-9
152. Carmel R. Subtle and atypical cobalamin deficiency states. Am J Hematol 1990; 34: 108-14
153. 12) and folate deficiency. FASEB J 1993; 7: 1344-53
154. Allen LH, Casterlinc J. Vitamin B-12 deficiency in elderly individuals: diagnosis and requirements. Am J Nutr 1994; 60: 12-4
155. Boushey CJ, Beresford SAA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995; 274 (13): 1049-57
156. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotid artery stenosis. N Engl J Med 1995; 332 (5): 286-91
157. Selhub J, Jacques PF, Wilson PWF, et al. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270 (22): 2693-8
158. Stampfer MJ, Willett WC. Homocysteine and marginal vitamin deficiency: the importance of adequate vitamin intake. JAMA 1993; 270 (22): 2726-7
159. Drinka PJ, Langer EH, Voeks SK, et al. Low serum folic acid levels in a nursing home population: a clinical experience. J Am Coll Nutr 1993; 12 (2): 186-9
160. Oakley GP, Adams MJ, Dickinson CM. More folic acid for everyone, now. J Nutr 1996; 126 Suppl.: 751S-5S
161. Ubbink JB, Vermaak WJ, van der Merwe A, et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994; 124 (10): 1927-33
162. Stampfer MJ, Malinow MR. Can lowering homocysteine levels reduce cardiovascular risk? N Engl J Med 1995; 332 (5): 328-9
163. Omaye ST. Safety of megavitamin therapy. In: Friedman M, editor. Advances in experimental medicine and biology. Vol. 177. New York: Plenum Press, 1984: 169-203
164. Campbell RK, Thom SL. Micronutrients and diabetes: the supplementation controversy. Diabetes Spectrum 1995; 8 (4): 238-46