Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice

Diabetologia

Volumn 39, Issue 1, 1996, Pages 119-122

  Rothe, H ^a,b   Burkart, V ^a   Faust, A ^a   Kolb, H ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Cyclophosphamide; Interleukin 12; Non obese diabetic mice; T helper type 1 2

Indexed keywords

CYCLOPHOSPHAMIDE; INTERLEUKIN 12; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; HELPER CELL; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CYCLOPHOSPHAMIDE; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; FEMALE; GENE EXPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-12; KINETICS; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; PANCREAS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0030032393     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Rothe H, Faust A, Schade U et al. (1994) Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not interleukin-4. Diabetologia 37: 1154-1158
2. Trinchieri G (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunregulatory functions in the generation of T-helper cells type I and cytotoxic lymphocytes. Blood 48: 4008-4027
3. Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (1992) CD28 mediated signalling co-stimulates murine T cells and prevents induction of anergy in T cell clones. Nature 356: 607-609
4. Linsey PS, Ledbetter JA (1993) The role of CD28 receptor during T cell responses to antigen. Annu Rev Immunol 11: 191-196
5. Lee K-U, Amano K, Yoon J-W (1988) Evidence for initial involvement of macrophages in development of insulitis in NOD mice. Diabetes 37: 989-991
6. Rabinovitch A, Sorensen O, Suarez-Pinzon WL, Power RF, Rajotte RV, Bleackley RC (1994) Analysis of cytokine mRNA expression in syngenic islet grafts of NOD mice: interleukin 2 and interferon-gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival. Diabetologia 37: 833-845
7. Bette M, Jin SC, Germann MKH, Weihe E, Rüde E, Fleischer B (1994) Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur J Immunol 24: 2435-2440
8. Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L (1995) Interleukin 12 administration induces T helper type I cells and accelerates autoimmune diabetes in NOD mice. J Exp Med 181: 817-821
9. Pennline KJ, Roque-Gaffney E, Monahan M (1994) Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 71: 169-175
10. Kolb-Bachofen V, Kolb H (1989) A role for macrophages in the pathogenesis of type I diabetes. Autoimmunity 3: 145-155