Comparative genomic hybridisation for the analysis of chromosomal imbalances in solid tumours and haematological malignancies

Histochemistry and Cell Biology

Volumn 108, Issue 4-5, 1997, Pages 403-417

  Zitzelsberger, Horst ^a,b   Lehmann, Lars ^a   Werner, Martin ^c   Bauchinger, Manfred ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME ANALYSIS; DIAGNOSTIC VALUE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; KARYOTYPE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; REVIEW; SOLID TUMOR;

CHROMOSOME ABERRATIONS; FORECASTING; HEMATOLOGIC NEOPLASMS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; NEOPLASMS;

EID: 0030729306     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180050181     Document Type: Review

References (93)

1. Altura RA, Valentine M, Li H, Boyett JM, Shearer P, Grundy P, Shapiro DN, Look AT (1996) Identification of novel regions of deletion in familial Wilms' tumour by comparative genomic hybridisation. Cancer Res 56:3837-3841
2. Arnold N, Hägele L, Walz L, Schempp W, Pfisterer J, Bauknecht T, Kiechle M (1996) Overrepresentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer. Genes Chromosom Cancer 16:46-54
3. Becker I, Becker KF, Röhrl MH, Minkus G, Schütze K, Höfler H (1996) Single-cell mutation analysis of tumors from stained histologic slides. Lab Invest 75:801-807
4. Bentz M, Dohner H, Werner CA, Huk K, Baudis M, Joos S, Schlegelberger B, Trumper LH, Feller AC, Pfreundschuh M, et al. (1995a) Identification of genetic imbalances in malignant lymphoma using comparative genomic hybridisation. Stem Cells 13:83-87
5. Bentz M, Huck K, Manoir S du, Joos S, Fischer K, Dohner H, Lichter P (1995b) Comparative genomic hybridisation in chronic B-cell leukemias shows a high incidence of chromosomal gains and losses. Blood 85:3610-3618
6. Bentz M, Döhner H, Huck K, Schütz B, Ganser A, Joos S, Manoir S du, Lichter P (1995c) Comparative genomic hybridisation in the investigation of myeloid leukemias. Genes Chromosom Cancer 12:193-200
7. Bentz M, Werner CA, Dohner H, Joos S, Barth TF, Siebert R, Schroder M, Stilgenbauer S, Fischer K, Moller P, Lichter P (1996) High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma. Blood 88:1437-1444
8. Berner JM, Forus A, Elkahloun A, Meltzer PS, Fodstad O, Myklebost O (1996) Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas. Genes Chromosom Cancer 17:254-259
9. Bjorkqvist AM, Tammilehto L, Anttila S, Mattson K, Knuutila S (1997) Recurrent DNA copy number changes in 1q, 4q, 6q, 9p, 13q, 14q and 22q detected by comparative genomic hybridization in malignant mesothelioma. Br J Cancer 75:523-527
10. Bockmühl U, Schwendel A, Dietel M, Petersen I (1996) Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas. Cancer Res 56:5325-5329
11. Brzoska PM, Levin NA, Fu KK, Kaplan MJ, Singer MI, Gray JW, Christman MF (1995) Frequent novel DNA copy number increase in squamous cell head and neck tumours. Cancer Res 55:3055-3059
12. Cher ML, Bova GS, Moore DH, Small EJ, Carroll PR, Pin SS, Epstein JI, Isaacs WB, Jensen RH (1996) Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridisation and allelotyping. Cancer Res 56:3091-3102
13. El-Rifai W, Sarlomo-Rikala M, Miettinen M, Knuutila S, Andersson LC (1996) DNA copy number losses in chromosome 14: an early change in gastrointestinal stromal tumours. Cancer Res 56(14):3230-3233
14. Fletcher JA, Kozakewich HP, Hoffer FA, Lage JM, Weidner N, Trepper R, Pinkus GS, Morton CC, Corson JM (1991) Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumours. N Engl J Med 324:436-442
15. Forus A, Weghuis DO, Smeets D, Fodstad O, Myklebost O, Kessel AG van (1995a) Comparative genomic hybridisation analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas. Genes Chromosom Cancer 14:8-14
16. Forus A, Weghuis DO, Smeets D, Fodstad O, Myklebost O, Geurts van Kessel A (1995b) Comparative genomic hybridisation analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas. Genes Chromosom Cancer 14:15-21
17. Ghazvini S, Char DH, Kroll S, Waldman FM, Pinkel D (1996) Comparative genomic hybridisation analysis of archival formalin-fixed paraffin-embedded uveal melanomas. Cancer Genet Cytogenet 90:95-101
18. Gordon KB, Thompson CT, Char DH, O'Brien JM, Kroll S, Ghazvini S, Gray JW (1994) Comparative genomic hybridisation in the detection of DNA copy number abnormalities in uveal melanoma. Cancer Res 54:4764-4768
19. Gronwald J, Storkel S, Holtgrevegrez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J, Cremer T (1997) Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of 1q and 3p copy number changes in metastatic events. Cancer Res 57:481-487
20. Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS (1996) Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res 56:3446-3450
21. Härle M, Arens N, Mol I, Back W, Schulz T, Scherthan H (1996) Comparative genomic hybridisation (CGH) discloses chromosomal and subchromosomal copy number changes in Merkel cell carcinomas. J Cutan Pathol 23:391-397
22. Heselmeyer K, Schröck E, Manoir S du, Blegen H, Shah K, Steinbeck R, Auer G, Ried T (1996) Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci USA 93:479-484
23. Houldworth J, Mathew S, Rao PH, Dyomina K, Louie DC, Parsa N, Offit K, Chaganti RS (1996) REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma. Blood 87:25-29
24. Isola J, DeVries S, Chu L, Ghazvini S, Waldman F (1994) Analysis of changes in DNA sequence copy number by comparative genomic hybridisation in archival paraffin-embedded tumour samples. Am J Pathol 145:1301-1308
25. Isola JJ, Kallioniemi OP, Chu LW, Fuqua SAW, Hilsenbeck SG, Osborne CK, Waldman FM (1995) Genetic aberrations detected by comparative genomic hybridisation predict outcome in node-negative breast cancer. Am J Hum Pathol 147:905-911
26. Iwabuchi H, Sakamoto M, Sakunaga H, Ma YY, Carcangiu ML, Pinkel D, Yang-Feng TL, Gray JW (1995) Genetic analysis of benign, low-grade, and high-grade ovarian tumours. Cancer Res 55:6172-6180
27. James L, Varley J (1996) Preparation, labelling and detection of DNA from archival tissue sections suitable for comparative genomic hybridisation. Chromosome Res 4(2):163-164
28. James LA, Mitchell ELD, Menasce L, Varley JM (1997) Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma. Oncogene 14:1059-1065
29. Joos S, Scherthan H, Speicher MR, Schlegel J, Cremer T, Lichter P (1993) Detection of amplified genomic sequences by reverse chromosome painting using genomic tumour DNA as probe. Hum Genet 90:584-589
30. Joos S, Bergerheim US, Pan Y, Matsuyama H, Bentz M, Manoir S du, Lichter P (1995) Mapping of chromosomal gains and losses in prostate cancer by comparative genomic hybridisation. Genes Chromosom Cancer 14:267-276
31. Joos S, Otano-Joos MI, Ziegler S, Bruderlein S, Manoir S du, Bentz, M, Moller P, Lichter P (1996) Primary mediastinal (thymic) B-cell lymphoma is characterised by gains of chromosomal material including 9p and amplification of the REL gene. Blood 87:1571-1578
32. Joos S, Ohl S, Lichter P (1997) Analysis of chromosomal imbalances in very small cell populations by universal PCR and comparative genomic hybridisation (CGH). Med Genet 1:47
33. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D (1992) Comparative genomic hybridisation for molecular cytogenetic analysis of solid tumours. Science 258:818-821
34. Kallioniemi OP, Kallioniemi A, Piper J, Isola J, Waldman FM, Gray JW, Pinkel D (1994a) Optimising comparative genomic hybridisation for analysis of DNA sequence copy number changes in solid tumours. Genes Chromosom Cancer 10:231-243
35. Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM (1994b) Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridisation. Proc Natl Acad Sci USA 91:2156-2160
36. Kallioniemi A, Kallioniemi OP, Citro G, Sauter G, DeVries S, Kerschmunn R, Caroll P, Waldman F (1995) Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridisation. Genes Chromosom Cancer 12:213-219
37. Kim DH, Mohapatra G, Bollen A, Waldman FM, Feuerstein BG (1995) Chromosomal abnormalities in glioblastoma multiforme tumours and glioma cell lines detected by comparative genomic hybridisation. Int J Cancer 60:812-819
38. Kivipensas P, Bjorkqvist AM, Karhu R, Pelin K, Linnainmaa K, Tammilehto L, Mattson K, Kallioniemi OP, Knuutila S (1996) Gains and losses of DNA sequences in malignant mesothelioma by comparative genomic hybridisation. Cancer Genet Cytogenet 89:7-13
39. Kjellman M, Kallioniemi OP, Karhu R, Hoog A, Farnebo LO, Auer G, Larsson C, Backdahl M (1996) Genetic aberrations in adrenocortical tumours detected using comparative genomic hybridisation correlate with tumour size and malignancy. Cancer Res 56:4219-4223
40. Korn WM, Weghuis DEMO, Suijkerbuijk RF, Schmidt U, Otto T, Manoir S du, Kessel AG van, Harstrick A, Seeber S, Becher R (1996) Detection of chromosomal DNA gains and losses in testicular germ cell tumours by comparative genomic hybridisation. Genes Chromosom Cancer 17:78-87
41. Kuukasjärvi T, Tanner M, Pennanen S, Karhu R, Visakorpi T, Isola J (1997) Optimizing DOP-PCR for universal amplification of small DNA samples in comparative genomic hybridization. Genes Chromosom Cancer 18:94-101
42. Larramendy ML, Tarkkanen M, Valle J, Kivioja AH, Ervasti H, Karaharju E, Salmivalli T, Elomaa I, Knuutila S (1997) Gains, losses, and amplifications of DNA sequences evaluated by comparative genomic hybridisation in chondrosarcomas. Am J Pathol 150:685-691
43. Levin NA, Brzoska P, Gupta N, Minna JD, Gray JW, Christman MF (1994) Identification of frequent novel genetic alterations in small cell lung carcinoma. Cancer Res 54(19):5086-5091
44. Levin NA, Brzoska PM, Warnock ML, Gray JW, Christman MF (1995) Identification of novel regions of altered DNA copy number in small cell lung tumours. Genes Chromosom Cancer 13:175-185
45. Liyanage M, Coleman A, Manoir S du, Veldman T, McCormack S, Dickson RB, Barlow C, Wynshaw-Boris A, Janz S, Wienberg J, Ferguson-Smith MA, Schröck E, Ried T (1996) Multicolour spectral karyotyping of mouse chromosomes. Nat Genet 14:312-315
46. Lothe RA, Karhu R, Mandahl N, Mertens F, Saeter G, Heim S, Borresen-Dale AL, Kallioniemi OP (1996) Gain of 17q24-qter detected by comparative genomic hybridisation in malignant tumours from patients with von Recklinghausen's neurofibromatosis. Cancer Res 56:4778-4781
47. Lundsteen C, Maahr J, Christensen B, Bryndorf T, Bentz, M, Lichter P, Gerdes T (1995) Image analysis in comparative genomic hybridisation. Cytometry 19:42-50
48. Manoir S du, Speicher MR, Joos S, Schröck E, Popp S, Dohner H, Kovacs G, Robert-Nicoud M, Lichter P, Cremer T (1993) Detection of complete and partial chromosome gains and losses by comparative genomic hybridisation. Hum Genet 90: 590-610
49. Manoir S du, Kallioniemi OP, Lichter P, Piper J, Benedetti PA, Carothers AD, Fantes JA, Garcia-Sagredo JM, Gerdes T, Giollant M, Hemery B, Isola J, Maahr J, Morrison H, Perry P, Stark M, Sudar D, Vliet LJ van, Verwoerd N, Vrolijk J (1995) Hardware and software requirements for quantitative analysis of comparative genomic hybridisation. Cytometry 19:4-9
50. Moch H, Presti JC Jr, Sauter G, Buchholz, N, Jordan P, Wihatsch MJ, Waldman FM (1996) Genetic aberrations detected by comparative genomic hybridisation are associated with clinical outcome in renal cell carcinoma. Cancer Res 56:27-30
51. Mohamed AN, Macoska JA, Kallioniemi A, Kallioniemi OP, Waldman F, Ratanatharathorn V, Wolman SR (1993) Extrachromosomal gene amplification in acute myeloid leukemia, characterisation by metaphase analysis, comparative genomic hybridisation, and semi-quantitative PCR. Genes Chromosom Cancer 8:185-189
52. Monni O, Joensuu H, Franssila K, Knuutila S (1996) DNA copy number changes in diffuse large B-cell lymphoma - a comparative genomic hybridisation study. Blood 87:5269-5278
53. Muleris M, Almeida A, Gerbault-Seuureau M, Malfoy B, Dutrillaux B (1994) Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridisation technique. Genes Chromosom Cancer 10:160-170
54. Nacheva E, Grace C, Holloway TL, Green AR (1995) Comparative genomic hybridisation in acute myeloid leukemia. A comparison with G-banding and chromosome painting. Cancer Genet Cytogenet 82:9-16
55. Nguyen C, Rocha D, Granjeaud S, Baldit M, Bernard K, Naquet P, Jordan BR (1995) Differential gene expression in the murine thymus assayed by quantitative hybridisation of arraye cDNA clones. Genomics 29:207-216
56. Pardue ML, Gall JG (1969) Molecular hybridisation of radioactive DNA to the DNA of cytological preparations. Proc Natl Acad Sci USA 64:600-604
57. Petersen I, Langreck H, Wolf G, Schwendel A, Psille R, Vogt P, Reichel MB, Ried T, Diefel M (1997) Small-cell lung cancer is characterised by a high incidence of deletions on chromosomes 3p, 4q, 5q, 13q and 17p. Br J Cancer 75:79-86
58. Piper J, Rutovitz D, Sudar D, Kallioniemi A, Kallioniemi OP, Waldman FM, Gray JW, Pinkel D (1995) Computer image analysis of comparative genomic hybridisation. Cytometry 19: 10-26
59. Presti JC Jr, Moch H, Reuter VE, Cordon-Cardo C, Waldman FM (1996a) Renal cell carcinoma genetic analysis by comparative genomic hybridisation and restriction fragment length polymorphism analysis. J Urol 156:281-285
60. Presti JC, Moch H, Reuter VE, Huynh D, Waldman FM (1996b) Comparative genomic hybridisation for genetic analysis of renal oncocytomas. Genes Chromosom Cancer 17:199-204
61. Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schröck E, Manoir S du, Cremer T (1994) Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridisation. Cancer Res 54:1801-1806
62. Ried T, Just KE, Holtgreve-Grez H, Manoir S du, Speicher MR, Schröck E, Latham C, Biegen H, Zetterberg A, Cremer T, Auer G (1995) Comparative genomic hybridisation of formalin-fixed, paraffin-embedded breast tumours reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res 55:5415-5423
63. Ried T, Knutzen R, Steinbeck R, Biegen H, Schröck E, Heselmeyer K, Manoir S du, Auer G (1996) Comparative genomic hybridisation reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumours. Genes Chromosom Cancer 15:234-245
64. Sandberg AA, Turc-Carel C, Gemmill RM (1988) Chromosomes in solid tumours and beyond. Cancer Res 488:1049-1059
65. Schena M, Shalon D, Davis RW, Brown PO (1995) Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467-470
66. Schlegel J, Scherthan H, Arens N, Stumm G, Kiessling M (1996) Detection of complex genetic alterations in human glioblastoma multiforme using comparative genomic hybridisation. J Neuropathol Exp Neurol 55:81-87
67. Schröck E, Thiel G, Lozanova T, Manoir S du, Meffert MC, Jauch A, Speicher MR, Nürnberg P, Vogel S, Jänisch W, Donis-Keller H, Ried T, Witkowski R, Cremer T (1994) Comparative genomic hybridisation of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses. Am J Pathol 144:1203-1218
68. Schröck E, Blume C, Meffert MC, Manoir S du, Bersch W, Kiessling M, Lozanowa T, Thiel G, Witkowski R, Ried T, Cremer T (1996) Recurrent gain of chromosome arm 7q in low-grade astrocytic tumours studied by comparative genomic hybridisation. Genes Chromosom Cancer 15:199-205
69. Schütze K, Clement-Sengewald A (1994) Catch and move - cut or fuse. Nature 368:667-669
70. Schwendel A, Langreck H, Reichel M, Schröck E, Ried T, Dietel M, Petersen I (1997) Primary small-cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations. Int J Cancer 74:86-93
71. Solinas-Toldo S, Wallrapp C, Müller-Pillasch F, Bentz M, Gress T, Lichter P (1996) Mapping of chromosomal imbalances in pancreatic carcinoma by comparative genomic hybridisation. Cancer Res 56:3803-3807
72. Sonoda G, Dumanoir S, Godwin AK, Bell DW, Liu ZM, Hogan M, Yakushiji M, Testa JR (1997) Detection of DNA gains and losses in primary endometrial carcinomas by comparative genomic hybridization. Genes Chromsom Cancer 18:115-125
73. Speicher MR, Manoir S du, Schröck E, Holtgreve-Grez H, Schoell B, Lengauer Ch, Cremer T, Ried T (1993) Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumours by comparative genomic hybridisation after universal DNA-amplification. Hum Mol Genet 2:1907-1914
74. Speicher MR, Schoell B, Manoir S du, Schröck E, Ried T, Cremer T, Storkel S, Kovacs A, Kovacs G (1994a) Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridisation. Am J Phatol 145(2):356-364
75. Speicher MR, Prescher G, Manoir S du, Jauch A, Horsthemke B, Bornfeld N, Becher R, Cremer T (1994b) Chromosomal gains and losses in uveal melanomas detected by comparative genomic hybridisation. Cancer Res 54:3817-3823
76. Speicher MR, Jauch A, Walt H, Manoir S du, Ried T, Jochum W, Sulser T, Cremer T (1995a) Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumour with universal DNA amplification, comparative genomic hybridisation and interphase cytogenetics. Am J Pathol 146:1332-1340
77. Speicher MR, Howe C, Crotty P, Manoir S du, Costa J, Ward DC (1995b) Comparative genomic hybridisation detects novel deletions and amplifications in head and neck squamous cell carcinomas. Cancer Res 55:1010-1013
78. Speicher MR, Ballard SG, Ward DC (1996) Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nat Genet 12:368-375
79. Steilen-gimbel H, Remberger K, Graf N, Steudel WI, Zang KD, Henn W (1996) A novel site of DNA amplification on chromosome 1p32-33 in a rhabdomyosarcoma revealed by comparative genomic hybridisation. Hum Genet 97:87-90
80. Suzuki H, Komiya A, Emi M, Kuramochi H, Shiraishi T, Yatani R, Shimazaki J (1996) Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers. Genes Chromosom Cancer 17:225-233
81. Szymanska J, Tarkkanen M, Wiklund T, Virolainen M, Blomqvist C, Asko-Seljavaara S, Tukiainen E, Elomaa I, Knuutila S (1996) Gains and losses of DNA sequences in liposarcomas evaluated by comparative genomic hybridisation. Genes Chromosom Cancer 15:89-94
82. Tarkklanen M, Karhu R, Kallioniemi A, Elomaa I, Kivioja AH, Nevalainen J, Böhling T, Kakaharju E, Hyytinen E, Knuutila S, Kallioniemi O (1995) Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridisation. Cancer Res 55:1334-1338
83. Telenius H, Carter NP, Bebb ChE, Nordenskjöld M, Ponder BAJ, Tunnacliffe A (1992) Dengerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer. Genomics 13:718-725
84. Tirkkonen M, Karhu R, Kallioniemi O, Isola J (1996) Evaluation of camera requirements for comparative genomic hybridization. Cytometry 25:394-398
85. Trent JM (1989) Clinical correltions of chromosome change in human solid tumours: the tip of the iceberg? J Natl Cancer Inst 81:1852-1853
86. Trent JM, Bittner MH, Zhang J, Wiltshire R, Ray M, Su Y, Gracia E, Meltzer P, Derisi J, Penland L, Brown P (1997) Use of microgenomic technology for analysis of alterations in DNA copy number and gene expression in malignant melanoma. Clin Exp Immunol 107:33-40
87. Visakorpi T, Kallioniemi AH, Syvänen AC, Hyytinen ER, Karhu R, Tammela T, Isola JJ, Kallioniemi OP (1995) Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridisation. Cancer Res 55:342-347
88. Voorter C, Joos S, Bringuier PP, Vallinga M, Poddighe P, Schalken J, Manoir S du, Ramaekers F, Lichter P, Hopman A (1995) Detection of chromosomal imbalances in transitional cell carcinoma of the bladder by comparative genomichybridisation. Am J Pathol 146:1341-1354
89. Weber RG, Sommer C, Albert FK, Kiessling M, Cremer T (1996a) Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridisation. Lab Invest 74: 108-119
90. Weber RG, Sabel M, Reifenberger J, Sommer C, Oberstraß J, Reifenberger G, Kiessling M, Cremer T (1996b) Characterization of genomic alterations associated with glioma progression by comparative genomic hybridisation. Oncogene 13:983-994
91. Weber-Hall S, Anderson J, McManus A, Abe S, Nojima T, Pinkerton R, Pritchard-Jones K, Shipley J (1996) Gains, losses, and amplification of genomic material in rhabdomyosarcoma analysed by comparative genomic hybridistion. Cancer Res 56: 3220-3224
92. Wiltshire RN, Duray P, Bittner ML, Visakorpi T, Meltzer PS, Tuthill RJ, Liotta LA, Trent JM (1995) Direct visualisation of the clonal progression of primary cutaneous melanoma: application of tissue microdissection and comparative genomic hybridisation. Cancer Res 55:3954-3957
93. Zhuang Z, Bertheau P, Emmert-Buck MR, Liotta LA, Gnarra J, Linehan WM, Lubensky IA (1995) A microdissection technique for archival DNA analysis of specific cell populations in lesions <1 mm in size. Am J Pathol 146:620-625