Primary small-cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations

International Journal of Cancer

Volumn 74, Issue 1, 1997, Pages 86-93

  Schwendel, Anke ^a   Langreck, Holger ^a   Reichel, Martin ^c   Schröck, Evelin ^b   Ried, Thomas ^b   Dietel, Manfred ^a   Petersen, Iver ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME DELETION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG SMALL CELL CANCER; MALE; METASTASIS; PHENOTYPE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; CARCINOMA, SMALL CELL; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOME MAPPING; DISEASE PROGRESSION; DNA, NEOPLASM; FEMALE; HUMANS; KARYOTYPING; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; RECURRENCE;

EID: 0030969493     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970220)74:1<86::AID-IJC15>3.0.CO;2-G     Document Type: Article

References (21)

1. BEDI, G.C., WESTRA, W.H., GABRIELSON, E., KOCH, W. and SIDRANSKY, D., Multiple head and neck tumors: evidence for a common clonal origin. Cancer Res., 56, 2484-2487 (1996).
2. BRENNAN, J., O'CONNOR, T., MAKUCH, R.W., SIMMONS, A.M., RUSSELL, E., LINNOILA, R.I., PHELPS, R.M., GAZDAR, A.F., IHDE, D.C. and JOHNSON, B.E., myc family DNA amplification in 107 tumors and tumor cell lines from patients with small-cell lung cancer treated with different combination chemotherapy regimens. Cancer Res., 51, 1708-1712 (1991).
3. EAGLE, L.R., YIN, X., BROTHMAN, A.R., WILLIAMS, B.J., ATKIN, N.B. and PROCHOVNIK, E.V., Mutation of the MXI1 gene in prostate cancer. Nature Genet., 9, 249-255 (1995).
4. GRAZIANO, S.L. and 13 OTHERS, The involvement of the RAF1 locus, at band 3p25, in the 3p deletion of small-cell lung cancer. Genes Chrom. Cancer, 3, 283-293 (1991).
5. GUNTHERT, U., HOFMANN, M., RUDY, W., REBER, S., ZOLLER, M., HAUSSMANN, I., MATZKU, S., WENZEL, A., PONTA, H. and HERRLICH, P., A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 65, 13-24 (1991).
6. KALLIONIEMI, A., KALLIONIEMI, O.P., PIPER, J., TANNER, M., STOKKE, T., CHEN, L., SMITH, H.S., PINKEL, D., GRAY, J.W. and WALDMAN, F.M., Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. nat. Acad. Sci. (Wash.), 91, 2156-2160 (1994).
7. KALLIONIEMI, A., KALLIONIEMI, O.P., SUDAR, D., RUTOVITZ, D., GRAY, J.W., WALDMAN, F. and PINKEL, D., Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (Wash.), 258, 818-821 (1992).
8. KELLEY, M.J., NAKAGAWA, K., STEINBERG, S.M., MULSHINE, J.L., KAMB, A. and JOHNSON, B.E., Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung-cancer cell lines. J. nat. Cancer Inst., 87, 756-761 (1995).
9. LEVIN, N.A., BRZOSKA, P., GUPTA, N., MINNA, J.D., GRAY, J.W. and CHRISTMAN, M.F., Identification of frequent novel genetic alterations in small-cell lung carcinoma. Cancer Res., 54, 5086-5091 (1994).
10. MIURA, I., GRAZIANO, S.L., CHENG, J.Q., DOYLE, A. and TESTA, J.R., Chromosome alterations in human small-cell lung cancer: frequent involvement of 5q. Cancer Res., 52, 1322-1328 (1992).
11. PETERSEN, I., LANGRECK, H., WOLF, G., SCHWENDEL, A., PSILLE, R., VOGT, P., REICHEL, M.B., RIED, T. and DIETEL, M., Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p. Brit. J. Cancer, 75, 79-85 (1997).
12. REICHEL, M.B., OHGAKI, H., PETERSEN, I. and KLEIHUES, P., p53 mutations in primary human lung tumors and their metastases. Mol. Carcinogen., 9, 105-109 (1994).
13. RIED, T., PETERSEN, I., HOLTGREVE-GREZ, H., SPEICHER, M.R., SCHRÖCK, E., DU MANOIR, S. and CREMER, T., Mapping of multiple DNA gains and losses in primary small-cell lung carcinomas by comparative genomic hybridization. Cancer Res., 54, 1801-1806 (1994).
14. SAMESHIMA, Y., MATSUNO, Y., HIROHASHI, S., SHIMOSATO, Y., MIZOGUCHI, H., SUGIMURA, T., TERADA, M. and YOKOTA, J., Alterations of the p53 gene are common and critical events for the maintenance of malignant pheno-types in small-cell lung carcinoma. Oncogene, 7, 451-457 (1992).
15. SCHREIBER-AGUS, N., CHIN, L., CHEN, K., TORRES, R., RAO, G., GUIDA, P., SKOULTCHI, A.I. and DEPINHO, R.A., An amino-terminal domain of the Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell, 80, 777-786 (1995).
16. SEKIDO, Y., TAKAHASHI, T., UEDA, R., TAKAHASHI, M., SUZUKI, H., NISHIDA, K., TSUKAMOTO, T., HIDA, T., SHIMOKATA, K., ZSEBO, K.M. and TAKAHASHI, T., Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit proto-oncogene. Cancer Res., 53, 1709-1714 (1993).
17. Sozzi, G., VERONESE, M.L., NEGRINI, M., BAFFA, R., COTTICEELI, M.G., INOVE, H., TORNIELLI, S., PILOTTI, S., DE GREGORIO, L., PASTORINO, V., PIEROTTI, M.A., OHTA, M., HUEBNER, K., and CROCE, C.M., The gene 3p14.2 is abnormal in lung cancer. Cell 85, 17-26 (1996).
18. SPEICHER, M.R., HOWE, C., CROTTY, P., DU MANOIR, S., COSTA, J. and WARD, D.C., Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous-cell carcinomas. Cancer Res., 55, 1010-1013 (1995).
19. TAKAHASHI, T., OBATA, Y., SEKIDO, Y., HIDA, T., UEDA, R., WATANABE, H., ARIYOSHI, Y., SUGIURA, T. and TAKAHASHI, T., Expression and amplification of myc gene family in small-cell lung cancer and its relation to biological characteristics. Cancer Res., 49, 2683-2688 (1989).
20. WHANG-PENG, J., KAO-SHAN, C.S., LEE, E.C., BUNN, P.A., CARNEY, D.N., GAZDAR, A.F. and MINNA, J.D., Specific chromosome defect associated with human small-cell lung cancer: deletion 3p(14-23). Science (Wash.), 215, 181-182 (1982).
21. WHITE, R.J., TROUCHE, D., MARTIN, K., JACKSON, S.P. and KOUZARIDES, T., Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature (Lond.), 382, 88-90 (1996).