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of outstanding interest. This is a comprehensive analysis of a large portion of the Washington University/Merck and Company human EST data set. They also analyse and discuss the extent and source of sequence errors and other discrepancies.
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The construction of Arabidopsis expressed sequence tag assemblies. A new resource to facilitate gene identification
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Karp PD. Database links are a foundation for interoperability. Trends Biotechnol. 14:1996;273-279.
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Wells TN, Peitsch MC. The chemokine information source: identification and characterization of novel chemokines using the World Wide Web and expressed sequence tag databases. J Leukoc Biol. 61:1997;545-550.
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of special interest. This is one of the most comprehensive motif databases described. It is derived from Hidden Markov model profiles.
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Sonnhammer EL, Eddy SR, Durbin R. Pfam: a comprehensive database of protein domain families based on seed alignments. of special interest Proteins - Struct Funct Genet. 28:1997;405-420 This is one of the most comprehensive motif databases described. It is derived from Hidden Markov model profiles.
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Sonnhammer, E.L.1
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Discrimination of fibroblast subtypes by multivariate analysis of gene expression
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of special interest. In this paper statistical analysis is applied to gene expression data from a small set of genes in a small set of cell lines. It is an example that foretells the power of statistical analysis in multi-gene expression studies.
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Spanakis E, Brouty-Boye D. Discrimination of fibroblast subtypes by multivariate analysis of gene expression. of special interest Int J Cancer. 71:1997;402-409 In this paper statistical analysis is applied to gene expression data from a small set of genes in a small set of cell lines. It is an example that foretells the power of statistical analysis in multi-gene expression studies.
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Int J Cancer
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Spanakis, E.1
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Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
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A gene map of the human genome
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of special interest. A transcript map is presented as a special chart and discussed in this review article. An initial 16,000 genes are mapped and many more are promised. This growing database may greatly help efforts to identify disease genes.
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Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tome P, Aggarwal A, et al. A gene map of the human genome. of special interest Science. 274:1996;540-546 A transcript map is presented as a special chart and discussed in this review article. An initial 16,000 genes are mapped and many more are promised. This growing database may greatly help efforts to identify disease genes.
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Comparative genomics, genome cross-referencing and XREFdb
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of special interest. The database presented here will facilitate the use of model organisms for determining human gene function.
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of outstanding interest. The inadequacies of focusing on single genes, the genetic determinism paradigm, are pointed out. Epigenetics, where multiple genes and environmental factors interact and elicit emergent properties, is suggested as a successor paradigm. We feel that the use of expressed sequence tags, related technologies and bioinformatic software in combination will yield interpretive and predictive powers that will strengthen this revolutionary paradigm which we term 'epigenomics'.
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Nat Biotechnol
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