Discrimination of Fibroblast subtypes by multivariate analysis of gene expression

International Journal of Cancer

Volumn 71, Issue 3, 1997, Pages 402-409

  Spanakis, Emmanuel ^a,c   Brouty Boyé, Danièle ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Inst Natl de la S et de la R   (France)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL TRANSFORMATION; CELL TYPE; DIAGNOSTIC VALUE; DISCRIMINANT ANALYSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; MYOFIBROBLAST; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS;

EID: 0030916030     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970502)71:3<402::AID-IJC17>3.0.CO;2-H     Document Type: Article

References (36)

1. ADAM, L., CRÉPIN, M., LELONG, J.C., SPANAKIS, E. and ISRAEL, L., Selective interactions between mammary epithelial cells and ribroblasts in co-culture. Int. J. Cancer, 59, 262-268 (1994).
2. APGAR, J.R., Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization. Mol. Biol. Cell, 6, 97-108 (1995).
3. ARMITAGE, P. and BERRY, G., Statistical methods in medical research, (2nd ed.) Blackwell, Oxford (1987).
4. BRENNEISEN, P., GOGOL, J. and BAYREUTHER, K., DNA synthesis and Fos and Jun protein expression in mitotic and postmitotic WI-38 ribroblasts in vitro. Exp. Cell Res., 211, 219-230 (1994).
5. BROUTY-BOYÉ, D. and MAGNIEN, V., Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue. Europ. J. Cancer, 30A, 66-73 (1994).
6. CANTLEY, L.C., AUGER, K.R., CARPENTER, C., DUCKWORTH, B., GRAZIANI, A., KAPELLER, R. and SOLTOFF, S., Oncogenes and signal transduction. Cell, 64, 281-302 (1991).
7. CHOMETTE, G., AURIOL, M., TRANBALOC, P. and BLONDON, J., Stromal changes in early invasive breast carcinoma: an immunohistochemical, histoenzymolugical and ultrastructural study. Pathol. Res. Pract., 186, 70-79 (1990).
8. CROSS, M. and DEXTER, T.M., Growth factors in development, transformation and tumorigenesis. Cell, 64, 271-280 (1991).
9. CULLEN, K.J., SMITH, H.S., HILL, S., ROSEN, N. and LIPPMAN, M.E., Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions. Cancer Res., 51, 4978-4985 (1991).
10. DAWSON, A.E., AUSTIN, R.E. and WEINBERG, D.S., Nuclear grading of breast carcinoma by image analysis: classification by multivariate and neural network analysis. Amer. J. clin. Pathol., 95, S29-S37 (1991).
11. ERLER, B.S., HSU, L., TRUONG, H.M., PETROVIC, L.M., KIM, S.S., HUH, M.H., FARRELL, L.D., THUNG, S.N., GELLER, S.A. and MARCHEVSKY, A.M., Image analysis and diagnostic classification of hepatocellular carcinoma using neural networks and multivariate discriminant functions. Lab. Invest., 71, 446-451 (1994).
12. EYDEN, B.P., PONTING, J., DAVIES, H., BARTLEY, C. and TORGERSEN, E., Defining the myofibroblast: normal tissues, with special reference to the stromal cells of Wharton's jelly in human umbilical cord. J. submìcrosc. Cytol. Pathol., 26, 347-355 (1994).
13. FRIES, K.M., BLIEDEN, T., LOONEY, R.J., SEMPOWSKI, G.D., SILVERA, M.R., WILLIS, R.A. and PHIPPS, R.P., Evidence of fibrobtast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin. Immunol. Immunopathol., 72, 283-292 (1994).
14. GAMBY, C., HAMELIN, R., RAUX, H., SALLÉ, V. and CRÉPIN, M., Establishment of human epithelial cell lines from normal tissue adjacent to carcinoma and from benign mastopathies. Cancer Detect. Prevent., 16, 71-74 (1992).
15. GASPARINI, G., POZZA, F. and HARRIS, A.L., Evaluating the potential usefulness of new prognostic and predictive indicators in node-negative breast cancer patients. J. nat. Cancer Inst., 85, 1206-1219 (1995).
16. KOMMOSS, F., COLLEY, M., HART, C.E. and FRANKLIN, W.A., In situ distribution of oncogene products and growth factor receptors in breast carcinoma: c-erbB-2 oncoprotein. EGFr and PDGFr-beta-subunit. Mol. cell Probes, 4, 11-23 (1990).
17. KOITSOUKOS, A.D., RUBINSTEIN, L.V., FARAGGI, D., SIMON, R.M. KALYANDRUG, S., WEINSTEIN, J.N., KOHN, K.W. and PAULL, K.D., Discrimination techniques applied to the NCl in vitro anti-tumour drug screen: predicting biochemical mechanism of action. Stat. Med., 13, 719-730 (1994).
18. LEWIN, B., Oncosenic conversion by regulatory changes in transcription factors. Cell, 64, 303-312 (1991).
19. MORRISON, D.F., Multivariate statistical methods, McGraw-Hill, New York (1967).
20. NORUSIS, M.J., SPSSx advanced statistics guide. McGraw-Hill. New York (1985).
21. PERES, R., BETSHOLTZ, C., WESTERMARK, B. and HELDIN, C.H., Frequent expression of growth factors for mesenchymal cells. in human mammary carcinoma cell lines. Cancer Res., 47, 3425-3429 (1987).
22. SAPPING, A.P., SCHÜRCH, W. and GABBIANI, G., Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab. Invest., 63, 144-161 (1990).
23. SCHATZKIN, A., GOLDSTEIN, A. and FREEDMAN, L.S., What does it mean to be a cancer gene carrier? Problems in establishing causality from the molecular genetics of cancer. J. nat. Cancer Inst., 87, 1126-1130 (1995).
24. SCHULZER, M., Diagnostic tests: a statistical review. Muscle Nerve. 17, 815-819 (1994).
25. SIDRANSKY, D., Molecular markers in cancer: can we make better predictions? Im. J. Cancer, 64, 1-2 (1995).
26. SNEATH, P.H.A. and SOKAL R.R., Numerical taxonomy, W.H. Freeman, San Francisco (1973).
27. SPANAKIS, E., Determining the specificity of quantitative variation in gene expression. J. nat. Cancer Inst., 87, 1179-1180 (1995).
28. SPANAKIS, E., Problems related to the interpretation of autoradiographic data on gene expression usina common constitutive transcripts as controls. Nucleic Acids Res., 21, 3809-3819 (1993).
29. SPANAKIS, E. and BROUTY-BOYÉ D., Evaluation of quantitative variation in gene expression. Nucleic Acids Res., 22, 799-806 (1994).
30. SPANAKIS, E. and BROUTA-BOYÉ, D., Quantitative variation of protooncogene and cytokine sene expression in isolated breast fibroblasts. Int. J. Cancer, 61, 698-705 (1995).
31. SPANAKIS, E. and BROUTY-BOYÉ, D., On the distribution of insulin-like growth factors in breast tissues. Int. J. Cancer, 68, 555-556 (1996).
32. TORRY, D.J., RICHARDS, C.D., PODOK, T.J. and GAULDIE, J., Anchorageindependeat colony growth, of pulmonary ftbroblasts derived from firotic human lung tissue. J. clin. Invest., 93, 1525-1532 (1994).
33. VAN ROOZENTAAL, K-E.P. KLUN, J.G.M., VAN OOIJEN, B., CLAASSEN, C., EGGHRMONT, A.M.M. HENZEN-LOGMANS, S.C. and FOEKENS, J.A., Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources. Int. J. Cancer, 65, 120-125 (1996).
34. WILKINSON, L., HILL, M.A. and VANG, E., SYSTAT: Statistics, Version 5 (2nd ed.) SYSTAT Inc. Evanston, IL (1992).
35. YARNOLD, P.R., SOLTYSIK, R.C. and MARTIN, G.J., Heart rate variability and susceptibility for sudden cardiac death: an example of multivariable optimal discriminant analysis. Stat. Med., 13, 1015-1021 (1994).
36. YEE, D., ROSEN, N., FAVONI, R.E. and CULLEN, K.J., The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer. Cancer Treat. Res., 53, 93-106 (1991).