TCR Recognition of the Hb(64-76)/I-Ek Determinant: Single Conservative Amino Acid Changes in the Complementarity-Determining Region 3 Dramatically Alter Antigen Fine Specificity

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2291-2298

  Hsu, Benjamin L ^a   Donermeyer, David L ^a   Allen, Paul M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; EPITOPE; HEMOGLOBIN; HLA ANTIGEN CLASS 2; I E ANTIGEN; I-E-ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; GENETICS; HYBRIDOMA; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; T LYMPHOCYTE; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BASE SEQUENCE; EPITOPES; HEMOGLOBINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYBRIDOMAS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0030587070     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
2. Babbitt, B. P., P. M. Allen, G. Matsueda, E. Haber, and E. R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359.
3. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
4. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
5. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
6. Evavold, B. D., J. Sloan-Lancaster, B. L. Hsu, and P. M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131.
7. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand. Proc. Natl. Acad. Sci. USA 91:2300.
8. Chothia, C., D. R. Boswell, and A. M. Lesk. 1988. The outline structure of the T-cell αβ receptor. EMBO J. 7:3745.
9. Claverie, J. M., A. Prochnicka-Chalufour, and L. Bougueleret. 1989. Implications of a Fab-like structure for the T-cell receptor. Immunol. Today 10:10.
10. Bentley, G. A., G. Boulot, K. Karjalainen, and R. A. Mariuzza. 1995. Crystal structure of the β chain of a T cell antigen receptor. Scienre 267:1984.
11. α domain of a T cell antigen receptor. Science 270:1821.
12. Danska, J. S., A. M. Livingstone, V. Paragas, T. Ishihara, and C. G. Fathman. 1990. The presumptive CDR3 regions of both T cell receptor α and β chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172:27.
13. Sorger, S. B., Y. Paterson, P. J. Fink, and S. M. Hedrick. 1990. T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones. J. Immunol. 144:1127.
14. Jorgensen, J. L., P. A. Reay, E. W. Enrich, and M. M. Davis. 1992. Molecular components of T-cell recognition. Annu. Rev. Immunol. 10:835.
15. Engel, I., and S. M. Hedrick. 1988. Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition. Cell 54:473.
16. Nalefski, E. A., S. Kasibhatla, and A. Rao. 1992. Functional analysis of the antigen binding site on the T cell receptor α chain. J. Exp. Med. 175:1553.
17. Lai, M.-Z., Y.-J. Jang, L.-K. Chen, and M. L. Gefter. 1990. Restricted V-(D)-J junctional regions in the T cell response to lambda-repressor: identification of residues critical for antigen recognition. J. Immunol. 144:4851.
18. Lai, M.-Z., D. T. Ross, J.-G. Guillet, T. J. Briner, M. L. Gefter, and J. A. Smith. 1987. T lymphocyte response to bacteriophage lambda repressor cI protein: recognition of the same peptide presented by Ia molecules of different haplotypes. J. Immunol. 139:3973.
19. Wither, J., J. Pawling, L. Phillips, T. Delovitch, and N. Hozumi. 1991. Amino acid residues in the T cell receptor CDR3 determine the antigenic reactivity patterns of insulin-reactive hybridomas. J. Immunol. 146:3513.
20. Jorgensen, J. L., U. Esser, B. Fazekas de St. Groth, P. A. Reay, and M. M. Davis. 1992. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355:224.
21. Hsu, B. L., B. D. Evavold, and P. M. Allen. 1995. Modulation of T cell development by an endogenous altered peptide ligand. J. Exp. Med. 181:805.
22. Evavold, B. D., S. G. Williams, B. L. Hsu, S. Buus, and P. M. Allen. 1992. Complete dissection of the Hb(64-76) determinant using Th1, Th2 clones, and T cell hybridomas. J. Immunol. 148:347.
23. White, J., M. Blackman, J. Bill, J. Kappler, P. Marrack, D. Gold, and W. Born. 1989. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 143:1822.
24. Allen, P. M. 1987. Construction of murine T-T cell hybridomas. In: Monoclonal Antibody Production Techniques and Applications. L. B. Schock, ed. Marcel Dekker, New York, pp. 25-34.
25. + normal B cells. Immunol. Rev. 93:35.
26. Gough, N. M. 1988. Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells. Anal. Biochem. 173:93.
27. Williams, A. F., J. L. Strominger, J. Bell, T. W. Mak, J. Kappler, P. Marrack, B. Arden, M. P. Lefranc, L. Hood, S. Tonegawa, and M. Davis. 1993. Nomenclature for T-cell receptor (TCR) gene segments of the immune system. WHO Bull. 71:133.
28. Arden, B., S. P. Clark, D. Kabelitz, and T. W. Mak. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics 42:501.
29. Candéias, S., J. Katz, C. Benoist, D. Mathis, and K. Haskins. 1991. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc. Natl. Acad. Sci. USA 88:6167.
30. Falcioni, F., Z. Dembic, S. Muller, P. V. Lehmann, and Z. A. Nagy. 1990. Flexibility of the T cell repertoire: self tolerance causes a shift of T cell receptor gene usage in response to insulin. J. Exp. Med. 171:1665.
31. Lorenz, R. G., A. N. Tyler, and P. M. Allen. 1989. Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone. J. Exp. Med. 170:203.
32. Evavold, B. D., S. G. Williams, J. S. Chen, and P. M. Allen. 1991. T cell inducing determinants contains hierarchy of residues contacting the T cell receptor. Semin. Immunol. 3:225.
33. Fremont, D. H., W. A. Hendrickson, P. Marrack, and J. Kappler. 1996. Structures of an MHC class II molecule with covalently bound single peptides. Science 272:1001.
34. Wilson, R. K., E. Lai, P. Concannon, R. K. Barth, and L. E. Hood. 1988. Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families. Immunol. Rev. 101:149.
35. Koop, B. F., R. K. Wilson, K. Wang, B. Vernooij, D. Zallwer, C. L. Kuo, D. Seto, M. Toda, and L. Hood. 1992. Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor C alpha/C delta region. Genomics 13:1209.
36. Yague, J., M. Blackman, W. Born, P. Marrack, J. Kappler, and E. Palmer. 1988. The structure of V α and J α segments in the mouse. Nucleic Acids Res. 16: 11355.
37. Behlke, M. A., H. S. Chou, K. Huppi, and D. Y. Loh. 1986. Murine T-cell receptor mutants with deletions of β-chain variable region genes. Proc. Natl. Acad. Sci. USA 83:767.
38. Williams, A. F., J. L. Strominger, J. Bell, T. W. Mak, J. Kappler, P. Marrack, B. Arden, M. P. Lefranc, L. Hood, S. Tonegawa, and M. Davis. 1995. Nomenclature for T-cell receptor (TCR) gene segments of the immune system. Immunogenetics 42:451.
39. Winoto, A., J. L. Urban, N. C. Lan, J. Goverman, L. Hood, and D. Hansburg. 1986. Predominant use of a V α gene segment in mouse T-cell receptors for cytochrome c. Nature 324:679.
40. Fink, P. J., L. A. Matis, D. L. McElligott, M. Bookman, and S. M. Hedrick. 1986. Correlations between T-cell specificity and the structure of the antigen receptor. Nature 321:219.
41. Hedrick, S. M., I. Engel, D. L. McElligott, P. J. Fink, M.-L. Hsu, D. Hansburg, and L. A. Matis. 1988. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science 239:1541.
42. Fink, P. J., M . J. Blair, L. A. Malis, and S. M. Hedrick. 1990. Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire. J. Exp. Med. 172:139.
43. Acha-Orbea, H., D. J. Mitchell, L. Timmermann, D. C. Wraith, G. S. Tausch, M. K. Waldor, S. S. Zamvil, H. O. McDevitt, and L. Steinman. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263.
44. Taylor, A. H., A. M. Haberman, W. Gerhard, and A. J. Caton. 1990. Structure-function relationships among highly diverse T cells that recognize a determinant from influenza virus hemagglutinin. J. Exp. Med. 172:1643.
45. Boitel, B., M. Ermonval, P. Panina-Bordignon, R. A. Mariuzza, A. Lanzavecchia, and O. Acuto. 1992. Preferential Vβ gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/ major histocompatibility complex recognition. J. Exp. Med. 175:765.
46. Katayama, C. D., F. J. Eidelman, A. Duncan, F. Hooshmand, and S. M. Hedrick. 1995. Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity. EMBO J. 14:927.
47. Chen, W., J. McCluskey, S. Rodda, and F. R. Carbone. 1993. Changes at peptide residues buried in the major histocompatibilty complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. J. Exp. Med. 177:869.
48. Schiffer, M., T. T. Wu, and E. A. Kabat. 1986. Subgroups of variable region genes of β chains of T-cell receptor for antigen. Proc. Natl. Acad. Sci. USA 83:4461.
49. Poindexter, N. J., C. Landon, P. J. Whiteley, and J. A. Kapp. 1992. Comparison of the T cell receptors on insulin-specific hybridomas from insulin transgenic and nontransgemc mice: loss of a subpopulation of self-reactive clones. J. Immunol. 149:38.
50. Levraud, J.-P., C. Pannetier, P. Langlade-Demoyen, V. Brichard, and P. Kourilsky. 1996. Recurrent T cell receptor rearrangements in the cytotoxic T lymphocyte response in vivo against the P815 murine tumor. J. Exp. Med. 183: 439.
51. Fry, A. M., M. M. Cotterman, and L. A. Matis. 1989. The influence of self-MHC and non-MHC antigens on the selection of an antigen-specific T cell receptor repertoire. J. Immunol. 143:2723.
52. Ehrich, E. W., B. Devaux, E. P. Rock, J. L. Jorgensen, M. M. Davis, and Y.-H. Chien. 1993. T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. J. Exp. Med. 178:713.
53. Kasibhatla, S., E. A. Nalefski, and A. Rao. 1993. Simultaneous involvement of all six predicted antigen binding loops of the T cell receptor in recognition of the MHC/antigenic peptide complex. J. Immunol. 151:3140.
54. Patten, P. A., E. P. Rock, T. Sonoda, B. Fazekas de St. Groth, J. L. Jorgensen, and M. M. Davis. 1993. Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity. J. Immunol. 150:2281.
55. Sloan-Lancaster, J., and Allen, P. M. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
56. Jameson, S. C., and Bevan, M. J. 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
57. Vidal, K., B. L. Hsu, C. B. Williams, and P. M. Allen. 1996. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311.