Sodium Channels and Therapy of Central Nervous System Diseases

Advances in Pharmacology

Volumn 39, Issue C, 1997, Pages 47-98

  Taylor, Charles P ^a   Narasimhan, Lakshmi S ^b  

^a Department of Neurological and Neurodegenerative Diseases ^*

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; NEUROPROTECTIVE AGENT; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

AMINO ACID SEQUENCE; ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM DISEASE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTICONVULSANTS; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROPROTECTIVE AGENTS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 0030626420     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60069-1     Document Type: Article

References (293)

1. Adler E.M., Yarn Y., David G., and Selzer M.E. Frequency-dependent action of phenytoin on lamprey spinal axons. Brain Res. 362 (1986) 271-280
2. Ahmed C.M., Ware D.H., Lee S.C., Patten C.D., Ferrer-Montiel A.V., Schinder A.F., McPherson J.D., Wagner-McPherson C.B., Wasmuth J.J., Evans G.A., and Montal M. Primary structure, chromosomal localization and functional expression of a voltage-gated sodium channel from human brain. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 8220-8224
3. Akopian A.N., Sivilotti L., and Wood J.N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature (London) 379 (1996) 257-262
4. Alexander G.J., Kopeloff L.M., Alexander R.B., and Chatterjie N. Mexiletine: Biphasic action on convulsive seizures in rodents. Neurobehav. Toxicol. Teratol. 8 (1986) 231-235
5. Alexis N.E., Back T., Zhao W., Dietrich W.D., Watson B.D., and Ginsberg M.D. Neurobehavioral consequences of induced spreading depression following photothrombic middle cerebral artery occlusion. Brain Res. 706 (1996) 273-282
6. Alzheimer C., Schwindt P.C., and Crill W.E. Postnatal development of a persistent Na+ current in pyramidal neurons from rat sensorimotor cortex. J. Neurophysiol. 69 (1993) 290-292
7. Alzheimer C., Schwindt P.C., and Crill W.E. Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex. J. Neurosci. 13 (1993) 660-673
8. Ambrose C., Cheng S., Fontaine B., Nadeau J.H., MacDonald M., and Gusella J.F. The alpha-subunit of the skeletal muscle sodium channel is encoded proximal to Tk-1 on mouse chromosome 11. Mamm. Genome 3 (1992) 151-155
9. Auld V.J., Goldin A.L., Krafte D.S., Marshall J., Dunn J.M., Catterall W.A., Lester H.A., Davidson N., and Dunn R.J. A rat brain Na+ channel alpha subunit with novel gating properties. Neuron 1 (1988) 449-461
10. Auld V.J., Goldin A.L., Krafte D.S., Catterall W.A., Lester H.A., Davidson N., and Dunn R.J. A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc. Natl. Acad. Set. U. S. A. 87 (1990) 323-327
11. Bach F.W., Jensen T.S., Kastrup J., Stigsby B., and Dejgard A. The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. Pain 40 (1990) 29-34
12. Bean B.P., Cohen C.J., and Tsien R.W. Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81 (1983) 613-642
13. Beckh S., Noda M., Lübbert H., and Numa S. Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. Nature (London) 8 (1989) 3611-3616
14. Belcher S.M., Zerillo C.A., Levenson R., Ritchie J.M., and Howe J.R. Cloning of a sodium channel alpha subunit from rabbit Schwann cells. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 11034-11038
15. Benazzouz A., Borad T., Dubedat P., Boireau A., Stutzmann J., and Gross C. Riluzole prevents MPTP-induced parkinsonism i the rhesus monkey: A pilot study. Eur. J. Pharmacol. 284 (1995) 299-307
16. Bennett P.B., Valenzuela C., Chen L.-Q., and Kallen R.G. On the molecular nature of the lidocaine receptor of cardiac Na+ channels-Modification of block by alterations in the alpha-subunit II-IV interdomain. Circ. Res. 77 (1995) 584-592
17. Bennett P.B., Yazawa K., Makita N., and George A.L.J. Molecular mechanism of an inherited cardiac arrhythmia. Nature (London) 376 (1995) 683-685
18. Benoit E., and Escande D. Riluzole specifically blocks inactivatied Na channels in myelinated nerve fibre. Pfluegers Arch. 419 (1991) 603-609
19. Benoit E., and Escande D. Fast K channels are more sensitive to riluzole than slow K channels in myelinated nerve fibre. Pfluegers Arch. 422 (1993) 536-538
20. Bensimon G., Lacomblez L., and Meininger V.A. Controlled trial of riluzole in amyotrophic lateral sclerosis. N. Engl. J. Med. 330 (1994) 585-591
21. Bezprozvanny I., and Tsien R.W. Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mebefradil (RO 40-5967). Mol. Pharmacol. 48 (1995) 540-549
22. Boening J.A., Kass I.S., Cottrell J.E., and Chambers G. The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice. NeuroScience 33 (1989) 263-268
23. Borin M.L., Tribe R.M., and Blaustein M.P. Increased intracellular Na+ augments mobilization of Ca2 + from SR in vascular smooth muscle cells. Am. J. Physiol. 266 (1994) C311-C317
24. Boxer P.A., Cordon J.J., Mann M.E., Rodolosi L.C., Vartanian M.G., Rock D.M., Taylor C.P., and Marcoux F.W. Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat. Stroke 21 (1990) 47-51
25. Brown A.M., Schwindt P.C., and Crill W.E. Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels. J. Neurophysiol. 71 (1994) 2562-2565
26. Brown C.M., Calder C., Linton C., Small C., Kenny B.A., Spedding M., and Patmore L. Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal ischemia. Br. J. Pharmacol. 115 (1995) 1425-1432
27. Brown D.L., Ransom D.M., Hall J.A., Leicht C.H., Schroeder D.R., and Offord K.P. Regional anesthesia and local anesthetic-induced systemic toxicity: Seizure frequency and accompanying cardiovascular changes. Anesth. Analg. (Cleveland) 81 (1995) 321-328
28. Brown N.A., Kemp J.A., and Seabrook G.R. Block of human voltage-sensitive Na + currents in differentiated SH-SY5Y cells by lifarizine. Br. J. Pharmacol. 113 (1994) 600-606
29. Burack M.A., Stasheff S.F., and Wilson W.A. Selective suppression of in vitro electrographic seizures by low-dose tetrodotoxin: A novel anticonvulsant effect. Epilepsy Res. 22 (1995) 115-126
30. Burgess D.L., Kohrman D.C., Gait J., Plummer N.W., Jones J.M., Spear B., and Meisler M.H. Mutation of a new sodium channel gene, SCN8A, in the mouse mutant 'motor endplate disease'. Nat. Genet. 10 (1995) 461-465
31. Callaway J.C., and Ross W.N. Frequency-dependent propagation of sodium action potentials in dendrites of hippocampal CA1 pyramidal neurons. J. Neurophysiol. 74 (1995) 1395-1403
32. Cannon S.C. Ion-channel defects and aberrant excitability in myotonia and periodic paralysis. Trends Neurosci. 19 (1996) 3-10
33. Cafrerall W.A. Neurotoxins that act on voltage-sensititve sodium channels in excitable cells. Annu. Rev. Pharmacol. Toxicol. 20 (1980) 15-43
34. Catterall W.A. Voltage-dependent gating of sodium channels: Correlating structure and function. Trends Neurosci. 9 (1986) 7-10
35. Catterall W.A. Common modes of drug action on Na+ channels: Local anesthetics, antiarrhythmics and anticonvulsants. Trends Neurosci. 8 (1987) 57-65
36. Catterall W.A. Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 72 (1992) S15-S48
37. Catterall W.A., Trainer V., and Baden D.G. Molecular properties of the sodium channel: A receptor for multiple neurotoxins. Bull. Soc. Pathol. Exot. 85 (1992) 481-485
38. Cerne R., and Spain W.J. Bistability in the dendrites of rat neocortical pyramidal cells is mediated by persisitent sodium current. Soc. Neurosci. Abstr. 21 (1995) 585
39. Chao T.I., and Alzheimer C. Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones. NeuroReport 6 (1995) 1778-1780
40. Chaplan S.R., Bach F.W., Shafer S.L., and Yaksh T.L. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuopathic rats. Anesthesiology 83 (1995) 775-785
41. Charnet P., Labarca C., Leonard R.J., Vogelaar N.J., Czyzyk L., Gouin A., Davidson N., and Lester H.A. An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetykholine receptor. Neuron 4 (1990) 87-95
42. Chebabo S.R., and DoCarmo R.J. Phenytoin and retinal spreading depression. Brain Res. 551 (1991) 16-19
43. Chen J., Graham S.H., and Simon R.P. A comparison of the effects of a sodium channel blocker and an NMDA antagonist upon extracellular glutamate in rat focal cerebral ischemia. Brain Res. 699 (1995) 121-124
44. Chen Q., Chopp M., Bodzin G., and Chen H. Temperature modulation of cerbral depolarization during focal cerebral ischemia in rats: Correlation with ischemic injury. J. Cereb. Blood Flow Metab. 13 (1993) 389-394
45. Cheung H., Kamp D., and Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res. 13 (1992) 107-112
46. Choi D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7 (1987) 369-379
47. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
48. Choi D.W. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc. Brain Metab. Rev. 2 (1990) 105-147
49. Colling S.B., and Wheal H.V. Fast sodium action potentials are generated in the distal apical dendrites of rat. Neurosci. Lett. 172 (1994) 73-96
50. Coulter D.A., Sombati S., and DeLorenzo R.J. Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia 34 Suppl. (1993) 123 (Abstract)
51. Dayhoff M.O. "Atlas of Protein Structure," (1996), Natl. Biomed. Res. Found., Washington, DC
52. Debono M.W., Le Guern J., Canton T., Doble A., and Pradier L. Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 235 (1993) 283-289
53. Dejgard A., Petersen P., and Kastrup J. Mexiletine for treatment of chronic painful diabetic neuropathy. Lancet 1 (1988) 9-11
54. Denaro C.P., and Benowitz N.L. Poisoning due to class IB antiarrhythmic drugs. Lignocaine, mexiletine and tocainide. Med. Toxicol. Adverse Drug Exper. 4 (1989) 412-428
55. Dessi F., Ben Ari Y., and Charriaut Marlangue C. Riluzole prevents anoxic injury in cultured cerebellar granule neurons. Eur. J. Pharmacol. 250 (1993) 325-328
56. Devor M. The pathophysiology of damaged peripheral nerves. In: Wall P.D., and Smelzack R. (Eds). "Textbook of Pain" (1994), Churchill Livingstone, Edinburgh 79-100
57. Doble A., Hubert J.P., and Blanchard J.C. Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells. Neurosci. Lett. 140 (1992) 251-254
58. Doble A. The pharmacology and mechanism of action of riluzole. Neurol. 47 Suppl. 4 (1996) S233-S241
59. Durell S.R., and Guy H.R. Atomic scale structure and functional models of voltage-gated potassium channels. Biopbys. J. 62 (1992) 238-247
60. England J.D., Happel L.T., Kline D.G., Gamboni F., Thouron C.L., Liu Z.P., and Levinson S.R. Sodium channel accumulation in humans with painful neuromas. Neurol. 47 (1996) 272-276
61. Fern R., Ransom B.R., Stys P., and Waxman S.G. Pharmacological protection of CNS white matter during anoxia: Actions of phenytoin, carbamazepine and diazepam. J. Pharmacol. Exp. Ther. 266 (1993) 1549-1555
62. Fischer W., Bodewei R., and Satzinger G. Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. Naunyn-Sckmiedeberg's Arch. Pharmacol. 346 (1992) 442-452
63. Flatman J.A., Schwindt P.C., Crill W.E., and Stafström C.E. Multiple actions of N-methyl-D-aspartate on cat neocortical neurons in vitro. Brain Res. 266 (1983) 169-173
64. Flieg A., Fitch J.M., Goldin A.L., Rayner M.D., Starkus J.G., and Ruben P.C. Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches. Pfluegers Arch. 427 (1994) 406-412
65. Foong F.W., and Satoh M. Analgesic potencies of non-narcotiC., narcotic and anesthetic drugs as determined by the bradykinin-induced biting-like responses in rats. Jpn. J. Pharmacol. 33 (1983) 933-938
66. French C.R., Sah P., Buckett K.J., and Gage P.W. A voltage-dependent persistent sodium current in mammalian hippocampal neurons. J. Gen. Physiol. 95 (1990) 1139-1157
67. Fried E., Amorim P., Chambers G., Cottrell J.E., and Kass I.S. The importance of sodium for anoxic transmission damage in rat hippocampal slices: mechanisms of protection by lidocaine. J. Physiol. Land. 489 (1995) 557-565
68. Fujisawa H., Dawson D., Browne S.E., MacKay K.B., Bullock R., and McCulloch J. Pharmacological modification of glutamate neurotoxicity in vivo. Brain Res. 629 (1993) 73-78
69. Galer B.S. Neuropathic pain of peripheral origin: Advances in pharmacological treatment. Neurology 45 Suppl. 9 (1995) S17-S25
70. Gaspary H.L., Simon R.P., and Graham S.H. BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis. Eur. J. Pharmacol. 262 (1994) 197-203
71. Gautron S., Dossantos G., Pintohenrique D., Koulakoff A., Gros F., and Berwaldnetter Y. The glial voltage-gated sodium channel: Cell-specific and tissue-specific messenger RNA expression. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 7272-7276
72. Gellens M.E., George Jr. A.L., Chen L., Chahine M., Horn R., Brachi R.L., and Kallen R.G. Primary stucture and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 554-558
73. George Jr. A.L., Ledbetter D.H., Kallen R.G., and Barchi R.L. Assignment of a human skeletal muscle sodium channel alpha-subunit gene (SCN4A) to 17q23.1-25.3. Genomics 9 (1991) 555-556
74. George Jr. A.L., Knittle T.J., and Tamkun M.M. Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: Evidence for a distinct gene family. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 4893-4897
75. George Jr. A.L., Komisarof J., Kallen R.G., and Barchi R.L. Primary structure of the adult human skeletal muscle voltage-dependent sodium channel. Ann. Neurol. 32 (1992) 131-137
76. George Jr. A.L., Knops J.F., Han J., Finley W.H., Knittle T.J., Tamkun M.M., and Brown G.B. Assignment of a human voltage-dependent sodium channel alpha-subunit gene (SCN6A) to 2q21-q23. Genomics 19 (1994) 395-397
77. George Jr. A.L., Varkony T.A., Drabkin H.A., Han J., Knops J.F., Finley W.H., Brown G.B., Ward D.C., and Haas M. Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21. Cyto-genet. Cell Genet. 68 (1995) 67-70
78. Gill R., Andinè O., Hillered L., Persson I., and Hagberg H. The effect of MK-801 on cortical spreading depression in the penumbra zone following focal ischemia in the rat. J. Cereb. Blood Flow Metab. 12 (1992) 371-379
79. Gilland E., Puka Sundvall M., Andine P., Bona E., and Hagberg H. Hypoxic-ischemic injury in the neonatal rat brain: Effects of pre- and post-treatment with the glutamate release inhibitor BW1003C87. Brain Res.: Dev. Brain Res. 83 (1994) 79-84
80. Goldin S.M. Neuroprotective use-dependent blockers of Na+ and Ca2+ channels controlling presynaptic release of glutamate. Ann. N. Y. Acad. Sci. 765 (1995) 210-229
81. Gonoi T., and Hille B. Gating of Na channels: Inactivation modifiers dicriminate among models. J. Gen. Physiol. 89 (1987) 253-274
82. Gordon D., Merrick D., Auld V.J., Dunn R., Goldin A.L., Davidson N., and Catterall W.A. Tissue-specific expression of the R1 and RII sodium channel subtypes. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 8682-8686
83. Green M.W., and Selman J.E. Review article: The medical management of trigeminal neuralgia. Headache 31 (1991) 588-592
84. Grinwald P.M., and Brosnahan C. Sodium imbalance as a cause of calcium overload in post-hypoxic reoxygenation injury. J. Mol. Cell. Cardiol. 19 (1987) 487-495
85. Gurney M.E., Cutting F.B., Zhai P., Doble A., Taylor C.P., Andrus P.K., and Hall E.D. Benefit of vitamin E, riluzole and gabapentin in a transgenic model of familial ALS. Ann. Neurol. 39 (1996) 147-157
86. Guy H.R., and Conti F. Pursuing the structure and function of voltage-gated channels. Trends Neurosci. 13 (1990) 201-206
87. Guy H.R., and Durell S.R. Using sequence homology to analyze the structure and function of voltage-gated ion channel proteins. Soc. Gen. Physiol. Ser. 49 (1994) 197-212
88. Hansen A.J. Effect of anoxia on ion distribution in the brain. Physiol. Rev. 65 (1985) 101-148
89. Hara H., Ozaki A., Yoshidomi M., and Sukamoto T. Protective effect of KB-2796, a new calcium antagonist, in cerebral hypoxia and ischemia. Arch. Int. Phartnacodyn. Ther. 304 (1990) 206-218
90. Hara H., Harada K., and Sukamoto T. Chronological atrophy after transient middle cerebral artery occlusion in rats. Brain Res. 618 (1993) 251-260
91. Hara H., Yokota K., Shimazawa M., and Sukamoto T. Effect of KB-2796, a new diphenylpiperizine Ca2+ antagonist, on glutamate-induced neurotoxicity in rat hippocampal primary cell cultures. Jpn. J. Pharmacol. 61 (1993) 361-365
92. Hayakawa T., Hamada Y., Maihara T., Hattori H., and Mikawa H. Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats. Life Sci. 54 (1994) 387-392
93. Hayakawa T., Higuchi Y., Nigami H., and Hattori H. Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect. Eur. J. Pharmacol. 257 (1994) 131-136
94. Hays S.J., Schwarz R.D., Boyd D.K., Coughenour L.L., Dooley D.J., Rock D.M., and Taylor C.P. PD 85639: A potent inhibitor of Na+ influx into rat neocortical slices. Soc. Neurosci. Abstr. 17 (1991) 956
95. Hays S.J., Rice M.J., Ortwine D.F., Johnson G., Schwarz R.D., Boyd D.K., Copeland L.F., Vartanian M.G., and Boxer P.A. Substituted 2-benzothiazoles as sodium flux inhibitors: Quantitative structure-activity relationships and anticonvulsant activity. J. Pharma. Sci. 83 (1994) 1425-1432
96. Hayward N.J., McKnight A.T., and Woodruff G.N. Neuroprotective effect of the kappa-agonist enadoline (CI-977) in rat models of focal cerbral ischaemia. Eur. J. Pharmacol. 5 (1993) 961-967
97. Hebert T., Drapeau P., Pradier L., and Dunn R.J. Block of rat brain IIA sodium channel α subunit by the neuroprotective drug riluzole. Mol. Pharmacol. 45 (1994) 1055-1060
98. Heinemann S.H., Terlau H., Stuhmer W., Imoto K., and Numa S. Calcium channel characteristics confered on the sodium channel by single mutations. Nature (London) 356 (1992) 441-443
99. Herring S., Bodewei R., and Wollenberger A. Sodium current in freshly isolated and in cultured single rat myocardial cells: Frequency and voltage-dependent block by mexiletine. J. Mol. Cell. Cardiol. 15 (1983) 431-444
100. Hille B. The receptor for tetrodotoxin and saxitoxin: A structural hypothesis. Biophys. J. 15 (1975) 615-619
101. Hille B. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69 (1977) 497-515
102. Hirschberg B., Rovner A., Lieberman M., and Patlack J. Transfer of twelve charges is needed to open skeletal muscle Na channels. J. Gen. Physiol. 106 (1995) 1053-1068
103. Hodgkin A.L., and Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (London) 117 (1952) 500-544
104. Hondeghem L.M., and Katzung B.G. Time- and voltage-dependent interaction of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta 472 (1977) 373-398
105. Hossmann K.A. Periinfarct depolarizations. Cerebrovasc. Brain Metab. Rev. 8 (1996) 195-208
106. Hu G.Y., and Hvalby O. Glutamate-induced action potentials are preceded by regenerative prepotentials in rat hippocampal pyramidal cells in vitro. Exp. Brain Res. 88 (1992) 485-494
107. Hubert J.P., Delumeau J.C., Glowinski J., Premont J., and Doble A. Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. Br. J. Pharmacol. 113 (1994) 261-267
108. Iijima T., Mies G., and Hossmann K.A. Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: Effect on volume of ischemic injury. J. Cereb. Blood Flow Metab. 12 (1992) 727-733
109. Isom L.L., Dejongh K.S., Patton D.E., Reber B.F.X., Offord J., and Charbonneau H. Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science 256 (1992) 839-842
110. Isom L.L., Ragsdale D.S., Dejongh K.S., Westenbroek R., Reber B.F.X., Scheuer T., and Catterall W.A. Structure and function of the beta-2 subunit of sodium channels, a transmembrane glycoprotein with a CAM motif. Cell (Cambridge, Mass.) 83 (1995) 433-442
111. Isom L.L., Scheuer T., Brownstein A.B., Ragsdale D.S., Murphy B.J., and Catterall W.A. Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. J. Biol. Chem. 270 (1995) 3306-3312
112. Joho R.H., Moorman J.R., VanDongen M.J., Kirsch G.E., Silberg H., Schuster G., and Brown A.M. Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. Mol. Brain Res. 7 (1990) 105-113
113. Kallen R.G., Sheng Z., Yang J., Chen L., Rogart R.B., and Barchi R.L. Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle. Neuron 4 (1990) 233-242
114. Kallen R.G., Cohen S.A., and Barchi R.L. Structure, function and expression of voltage-dependent sodium channels. Mol. Neurobiol. 7 (1993) 383-428
115. Kamei J., Hitosugi H., Kawahima N., Aoki T., Ohhashi Y., and Kasuya Y. Antinociceptive effect of mexiletine in diabetic mice. Res. Commun. Chem. Pathol. Pharmacol. 77 (1992) 245-248
116. Kanthasamy A.G., Matsumoto R.R., Gunasekar P.G., and Truong D.D. Excitoprotective effect of felbamate in cultured cortical neurons. Brain Res. 705 (1995) 97-104
117. M.A. Karolchyk (1996). Rufmamide (CGP-33101): A triazole derivative anticonvulsant. Southborough, MA: International Business Communications (oral conference presentation)
118. Kass I.S., Abramowicz A.E., Cottrell J.E., and Chambers G. The barbiturate thiopental reduces ATP levels during anoxia but improves electrophysiological recovery and ionic homeostasis in the rat hippocampal slice. NeuroScience 49 (1992) 537-543
119. Kayano T., Noda M., Flockerzi H., Takahashi H., and Numa S. Primary structure of rat brain sodium channel III deduced from the cDNA sequence. FEBS Lett. 228 (1988) 187-194
120. Keynes R.D. Bimodal gating of the Na+ channel. Trends Neurosci. 17 (1994) 58-61
121. Khodorov B.I. Role of inactivation in local anesthetic action. Ann. N. Y. Acad. Sci. 625 (1991) 225-248
122. Kiedrowski L., Brooker G., Costa E., and Wroblewski J.T. Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron 12 (1994) 295-300
123. Kinouchi H., Imaizumi S., Yoshimoto T., and Motomiya M. Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia. Stroke 21 (1990) 1326-1332
124. Kiskin N.I., Chizhmakov I.V., Tsyndrenko A.Y., Krishtal O.A., and Tegtmeier F. R56865 and flunarizine as Na(+)-channel blockers in isolated Purkinje neurons of rat cerebellum. NeuroScience 54 (1993) 575-585
125. Kloke M., Hoffken K., Olbrich H., and Schmidt C.G. Anti-depressants and anti-convulsants for the treatment of neuropathic pain syndromes in cancer patients. Onkologie 14 (1991) 40-43
126. Koch R.A., and Barish M.E. Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. J. Neurosci. 14 (1994) 2585-2593
127. Kohrman D.C., Harris J.B., and Meisler M.H. Mutation detection in the med and med j alleles of the sodium channel Scn8a: Unusual splicing due to a minor class AT-AC intron. J. Biol. Chem. 271 (1996) 17576-17581
128. Kohrman D.C., Smith M.R., Goldin A.L., Harris J., and Meisler M.H. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J. Neurosci. 16 (1996) 5993-5999
129. Krall R.L., Penry J.K., White B.G., Kupferberg H.J., and Swinyard E.A. Antiepileptic drug development: II. Anticonvulsant drug screening. Epilepsia 19 (1978) 409-428
130. Kucharczyk J., Mintorovitch J., Moseley M.E., Asgari H.S., Sevick R.J., Derugin N., Norman D., Leach M.J., Swan J.H., Eisenthal D., Dopson M., and Nobbs M. Ischemic brain damage: Reduction by sodium-calcium ion channel modulator RS- 87476. Stroke 24 (1993) 1063-1067
131. Kuo C.C., and Bean B.P. Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. J. Pharmacol. Exp. Ther. 46 (1994) 716-725
132. Kuo C.C., and Bean B.P. Na+ channels must deactivate to recover from inactivation. Neuron 12 (1994) 819-829
133. Lacomblez L., Bensimon G., Leigh P.N., Guillet P., and Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet 347 (1996) 1425-1428
134. Leach M.J., Marden C.M., and Miller A.A. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. neurochemical studies on the mechanism of action. Epilepsia 27 (1986) 490-497
135. Leach M.J., Baxter M.G., and Critchley M.A. Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 (1991) S4-S8
136. Leach M.J., Swan J.H., Eisenthal D., Dopson M., and Nobbs M. BW619C89, a glutamate release inhibitor, protects against focal cerbral ischemic damage. Stroke 24 (1993) 1063-1067
137. Lehning E.J., Doshi R., Isaksson N., Stys P.K., and LoPachin Jr. R.M. Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: Role of reverse sodium-calcium exchange. J. Neurochem. 66 (1996) 493-500
138. Lekieffre D., and Meldrum B.S. The pyrimidine derivative, BW 1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdi-alysis and histological study. Neurosci. 56 (1993) 93-99
139. Leschinger A., Stabel J., Igelmund P., and Heinemann U. Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices. Exp. Brain Res. 96 (1993) 230-240
140. Levy R.H., Mattson R.H., and Meldrum B.S. "Antiepileptic Drugs,". 4th ed. (1995), Raven Press, New York
141. Li M., West J.W., Numann R., Murphy B.J., Scheuer T., and Catterall W.A. Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase. Science 261 (1993) 1439-1442
142. Lindstrom P., and Lindblom U. The analgesic effect of tocainide in trigeminal neuralgia. Pain 28 (1987) 45-50
143. Litt M., Luty J., Kwak M., Allen L., Magenis R.E., and Mandel G. Localization of a human brain sodium channel gene (SCN2A) to chromosome 2. Genomics 5 (1989) 204-208
144. Llinas R., and Sugimori M. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J. Physiol. (London) 305 (1980) 171-195
145. Lombardo A.J., Kuzniecky R., Powers R.E., and Brown G.B. Altered brain sodium channel transcript levels in human epilepsy. Brain Res. Mol. Brain Res. 35 (1996) 84-90
146. LoPachin R.M., and Stys P. Elemental composition and water content of rat optic nerve myelinated axons and glial cells: Effects of in vitro anoxia and reoxygenation. J. Neurosa. 15 (1995) 6735-6746
147. Lu H.R., Van Reempts J., Haseldonckx M., Borgers M., and Janssen P.A.J. Cerebroprotective effects of flunarizine in an experimental rat model of cardiac arrest. Am. J. Emerg. Med. 8 (1990) 1-6
148. Lucas L.F., West C.A., Rigor B.M., and Schurr A. Protection against cerebral hypoxia by local anesthetics: a study using brain slices. J. Neurosci. Methods 28 (1989) 47-50
149. Lynch J.J., Yu S.P., Canzoniero L.M., Sensi S.L., and Choi D.W. Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined withglutamate receptor antagonists. J. Pharmacol. Exp. Ther. 273 (1995) 554-560
150. Lysko P.G., Webb C.L., and Feuerstein G. Neuroprotective effects of carvedilol, a new antihypertensive, as a Na+ channel modulator and glutamate transport inhibitor. Neurosci. Lett. 171 (1994) 77-80
151. Lysko P.G., Webb C.L., Yue T., Gu J.G., and Feuerstein M.D. Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke 25 (1995) 2476-2482
152. Ma J.Y., Li M., Catterall W.A., and Scheuer T. Modulation of brain Na + channels by a G-protein-coupled pathway. Proc. Natl. Acad. Set. U. S. A. 91 (1994) 12351-12355
153. MacKinnon A.C., Wyatt K.M., McGivern J.G., Sheridan R.D., and Brown C.M. [3H]-Lifarizine, a high affinity probe for inactivated sodium channels. Br. J. Pharmacol. 115 (1995) 1103-1109
154. Malgouris C., Daniel M., and Doble A. Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices. Neurosci. Lett. 177 (1994) 95-99
155. Malo D., Schurr E., Dorfman J., Canfield V., Levenson R., and Gros P. Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Genomics 10 (1991) 666-672
156. Malo M.S., Blanchard B.J., Andresen J.M., Srivastava K., Chen X.N., Li X., Jabs E.W., Korenberg J.R., and Ingram V.M. Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24. Cytogenet. Cell Genet. 67 (1994) 178-186
157. Malo M.S., Srivastava K., Andresen J.M., Chen X.N., Korenberg J.R., and Ingram V.M. Targeted gene walking by low stringency polymerase chain reaction: As-usignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 2975-2979
158. Margolin L.D., Knapp A.G., and Sharma R. Block of voltage-gated sodium currents by the novel acenapthyl guanidine, CNS 11237. Soc. Neurosci. Abstr. 20 (1994) 718
159. Mary V., Wahl F., and Stutzmann J.M. Effect of riluzole on quinolinate-induced neuronal damage in rats: Comparison with blockers of glutamatergic neurotransmission. Neurosci. Lett. 201 (1995) 92-96
160. May G.R., Rowand W.S., McCormack J.G., and Sheridan R.D. Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurones in culture. Br.J. Pharmacol. 114 (1995) 1365-1370
161. J.G. McGivern L. Patmore R.D. Sheridan (1995). Effects of the neuroprotective agent, KB-2796, on the voltage-dependent sodium current in mouse neuroblastoma, N1E-115. Br. J. Pharmacol. (Proc. Suppl.), 137P
162. McGivern J.G., Patmore L., and Sheridan R.D. Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115. Br. J. Pharmacol. 114 (1995) 1738-1744
163. McLean M.J., and Macdonald R.L. Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. J. Pharmacol. Exp. Ther. 227 (1983) 779-789
164. McLean M.J., and Macdonald R.L. Carbamazepine and 10,11-epoxycarbabamazepine produce use- and voltage-depndent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J. Pharmacol. Exp. Ther. 238 (1986) 727-738
165. McNeil E.T., Lewandowski G.A., Daly J.W., and Crevling C.R. [3H]Batrachotoxinin A 20-a-bezoate binding to voltage-sensitive sodium channels: A rapid and quantitative assay for local anesthetic activity in a variety of drugs. J. Med. Chem. 28 (1985) 381-388
166. McPhee J.C., Ragsdale D.S., Scheuer T., and Catterall W.A. A mutation in segment IV S6 disrupts fast inactivation of sodium channels. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 12346-12350
167. McPhee J.C., Ragsdale D.S., Scheuer T., and Catterall W.A. A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation. J. Biol. Chem. 270 (1995) 12025-12034
168. Meldrum B.S., Swan J.H., Leach M.J., Millan M.H., Gwinn R., Kadota K., Graham S.H., Chen J., and Simon R.P. Reduction of glutatmate release and protection against ischemic brain damage by BW1003C87. Brain Res. 593 (1992) 1-6
169. Michelitti G., Vergnes M., Marescaux C., Reis J., Depaulis A., Rumbach L., and Warter J.M. Antiepileptic drug evaluation in a new animal model: Spontaneous petit mal epilepsy in the rat. Arzneim.-Forsch. 35 (1985) 483-485
170. Millan M.H., Chapman A.G., and Meldrum B.S. Dual inhibitory action of enadoline (CI977) on release of amino acids in the rat hippocampus. Eur.J. Pharmacol. 279 (1995) 75-81
171. Miller C. Annus mirabilis for potassium channels. Science 252 (1991) 1092-1096
172. Moorman J.R., Kirsch G.E., VanDongen M.J., Joho R.H., and Brown A.M. Fast and slow gating of sodium channels encoded by a single mRNA. Neuron 4 (1990) 243-252
173. Murakami A., and Furui T. Effects of the conventional anticonvulsants, phenytoin, carbamazepine and valproic acid on sodium-potassium-adenosine triphosphatase in acute ischemic brain. Neurosurgery 34 (1994) 1047-1051
174. Nakamura-Craig M., and Follenfant R.L. Effect of lamotrigine in the acute and chronic hyperalgesia induced by PGE2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes. Pain 63 (1995) 33-37
175. Nedergaard M., and Astrup J. Infarct rim: Effect of hyperglycemia on direct current potential and [14C]2- deoxyglucose phosphorylation. J. Cereb. Blood Flow Metab. 6 (1986) 607-615
176. Nedergaard M., and Hansen A.J. Characterization of cortical depolarizations evoked in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 13 (1993) 568-574
177. Nelson L.S., and Hoffman R.S. Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. J. Toxicol., Clin. Toxicol. 32 (1994) 731-736
178. Noda M., Shimizu S., Tanabe T., Takai T., Kayano T., Ikeda T., Takahashi H., Nakayama H., Kanaoka Y., Minamino N., Kangawa K., Matsuo H., Raftery M., Hirose T., Inayama S., Hayashida H., Miyata T., and Numa S. Primary structure of Electrophorus-electricus sodium channel deduced from complimentary DNA sequence. Nature (London) 312 (1984) 121-127
179. Noda M., Ikeda M., Kayano T., Suzuki H., Takeshima H., Kurasaki M., Takahashi H., and Numa S. Existence of distinct sodium channel messenger RNAs in rat brain. Nature (London) 320 (1986) 188-192
180. Noda M., Suziki S., Numa S., and Stuhmer W. A single point mutation confers tetrodo-toxin and saxitoxin insensitivity on the sodium channel II. FEBS Lett. 259 (1989) 213-216
181. Numann R., Hauschka S.D., Catterall W.A., and Scheuer T. Modulation of skeletal muscle sodium channels in a satellite cell line by protein kinase C. J. Neurosci. 14 (1994) 4226-4236
182. Okiyama K., Smith D.H., Gennarelli T.A., Simon R.P., Leach M., and Mclntosh T.K. The sodium channel blocker and glutamate release inhibitor BW1003C87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat. J. Neurocbem. 64 (1995) 802-809
183. Ordy J.M., Volpe B., Murray R., Thomas G., Bialobok P., Wengenack T.M., and Dunlap W. Pharmacological effects of remacemide and MK-801 on memory and hippo-campal CA1 damage in the rat four-vessel occlusion (4-VO) model of global ischemia. In: Globus M., and Dietrich W.D. (Eds). "The Role of Neurotranstnitters in Brain Injury." (1992), Plenum Press, New York 83-92
184. Osorio I., Burnstine T.H., Remler B., Manon Espaillat R., and Reed R.C. Phenytoin-induced seizures: A paradoxical effect at toxic concentrations in epileptic patients. Epilepsia 30 (1989) 230-234
185. Palmer G.C., Cregan E.F., Borrelli A.R., and Willett F. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann. N. Y. Acad. Sci. 765 (1995) 236-247
186. Patton D.E., and Goldin A.L. A voltage-dependent gating transition induces use-dependent block by tetrodotoxin of rat IIA sodium channels expressed in Xenopus oocytes. Neuron 7 (1991) 637-647
187. Patton D.E., West J.W., Catterall W.A., and Goldin A.L. Amino acid residues required for fast Na+-channel inactivation: Charge neutralizations and deletions in the III-IV linker. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 10905-10909
188. Pauwels P.J., VanAssouw H.P., Peeters L., and Leysen J.E. Neurotoxic action of veratridine in rat brain neuronal cultures: Mechanism of neuroprotection by Ca+ + antagonists nonselective for slow Ca++ channels. J. Pharmacol. Exp. Ther. 255 (1990) 1117-1122
189. Perez-Pinzon M.A., Rosenthal M., Sick T.J., Lutz P.L., Pablo J., and Mash D. Downregulation of sodium channels during anoxia: A putative survival strategy of turtle brain. Am. J. Physiol. 31 (1992) R712-R715
190. Pisani A., Stefani A., Siniscalchi A., Mercuri N.B., Bernardi G., and Calabresi P. Electrophysiological actions of felbamate on rat striatal neurones. Br. J. Pharmacol. 116 (1995) 2053-2061
191. Postma S.W., and Catterall W.A. Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics. Mol. Pharmacol. 25 (1984) 219-227
192. Potts J.F., Regan M.R., Rochelle J.M., Seldin M.F., and Agnew W.S. A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2. Biochem. Biophys. Res. Commun. 197 (1993) 100-104
193. Pratt J., Rataud J., Bardot F., Roux M., Blanchard J.C., Laduron P.M., and Stutzmann J.M. Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischemia. Neurosci. Lett. 140 (1992) 225-230
194. Prenen G.H.M., Gwan G.K., Postema F., Zuiderveen F., and Korf J. Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Exp. Neurol. 99 (1988) 118-132
195. Quandt F.N. Modification of slow inactivation of single sodium channels by phenytoin in neuroblastoma cells. Mol. Pharmacol. 34 (1988) 557-565
196. Ragsdale D.S., Scheuer T., and Catterall W.A. Frequency and voltage-dependent inhibition of type HA Na+ channels, expressed in a mammalian cell line, by local anesthetiC., antiarrhythmiC. and anticonvulsant drugs. Mol. Pharmacol. 40 (1991) 756-765
197. Ragsdale D.S., Numann R., Catterall W.A., and Scheuer T. Inhibition of Na+ channels by the novel blocker PD85,639. Mol. Pharmacol. 43 (1993) 949-954
198. Ragsdale D.S., McPhee J.C., Scheuer T., and Catterall W.A. Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science 265 (1994) 1724-1728
199. Ragsdale D.S., McPhee J.C., Scheuer T., and Catterall W.A. Common molecular determinants of local anesthetiC., antiarrhythmic and anticonvulsant block of voltage-gated Na+ channels. Proc. Natl. head. Sci. U. S. A. 93 (1996) 9270-9275
200. Rando T.A., Wang G.K., and Strichartz G.R. The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels. Mol. Pharmacol. 29 (1986) 467-477
201. Rasool N., Faroqui M., and Rubinstein E.H. Lidocaine accelerates neuroelectric recovery after incomplete global ischemia in rabbits. Stroke 21 (1990) 929-935
202. Rataud J., Debanot F., Mary V., Pratt J., Stutzmann J.M., Silverstein F.S., Buchanan K., Hudson C., and Johnston M.V. Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents. Neurosci. Lett. 172 (1994) 19-23
203. Rock D.M., McLean M.J., Macdonald R.L., Catterall W.A., and Taylor C.P. Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro. Epilepsy Res. 8 (1991) 197-203
204. Rogart R.B., Cribbs L.L., Muglia L.K., Kephart D.D., and Kaiser M.W. Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 8170-8174
205. Rogawski M.A., and Porter R.J. Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42 (1990) 223-286
206. Rostock A., Rundfeldt C., Tober C., and Bartsch R. AWD 140-190: A new anticonvulsant with sodium channel blocking properties. Soc. Neurosci. Abstr. 21 (1995) 203 (abstr.)
207. Rothstein J.D., and Kuncl R.W. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J. Neurochem. 65 (1995) 643-651
208. Rothstein J.D., Dykes Hoberg M., and Kuncl R.W. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 6591-6595
209. Rowbotham M.C., Reisner-Keller L.A., and Fields H.L. Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology 441 (1991) 1024-1028
210. Roy M.L., and Narahashi T. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neurosci. 12 (1992) 2104-2111
211. Sanchez D.Y., and Harris E.W. The effects of the anticonvulsant remacemide HC1 at neuronal sodium channels. Soc. Neurosci. Abstr. 21 (1995) 2117
212. Sangameswaran L., Delgado S.G., Fish L.M., Koch B.D., Jakeman L.B., Stewart G.R., Sze P., Hunter J.C., Eglen R.M., and Herman R.C. Structure and function of a novel voltage-gated, tetrodoxtoxin-resistant sodium channel specific to sensory neurons. J. Biol. Chem. 271 (1996) 5953-5956
213. Satin J.J., Kyle J.W., Chen M., Bell P., Cribbs L.L., and Fozzard H.A. A mutatant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science 256 (1992) 1202-1205
214. Schaller K.L., Krzemien D.M., Yarowsky P.J., Krueger B.K., and Caldweli J.H. A novel, abundant sodium channel expressed in neurons and glia. J. Neurosci. 15 (1995) 3231-3242
215. Schauf C.L. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Res. 413 (1987) 185-189
216. Schleef M., Werner K., Satzger U., Kaupmann K., and Jockusch H. Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1. Genomics 17 (1993) 519-521
217. Schmidt J.W., and Catterall W.A. Biosynthesis and processing of the alpha subunit of the voltage-sensistive sodium channel in rat brain neurons. Cell (Cambridge, Mass.) 46 (1986) 437-444
218. Schwindt P.C., and Crill W.E. Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons. J. Neurophysiol. 74 (1995) 2220-2224
219. Segal M.M. Endogenous bursts underlie seizurelike activity in solitary excitatory hippocampal neurons in microcultures. J. Neurophysiol. 72 (1994) 1874-1884
220. Segal M.M., Zurakowski D., and Douglas A.F. Late sodium channel openings underlie ictal epileptiform activity and are preferentially dimished by the anticonvulsant phenytoin. Soc. Neurosci. Abstr. 21 (1995) 777
221. Sheldon R.S., Duff H.J., Thakore E., and Hill R.J. Class I antiarrhythmic drugs: Allosteric inhibitors of [3H]batrachotoxinin binding to rat cardiac sodium channels. J. Pharmacol. Exp. Ther. 268 (1994) 187-194
222. Siesjo B.K. Historical overview. Calcium, ischemia and death of brain cells. Ann. N. Y. Acad. Sci. 522 (1988) 638-661
223. Silverstein F.S., Buchanan K., Hudson C., and Johnston M.V. Flunarizine limits hypoxia-ischemia induced morphologic injury in immature rat brain. Stroke 17 (1986) 477-482
224. Smith S.E., and Meldrum B.S. Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke 26 (1995) 117-121
225. Smith S.E., Lekieffre D., Sowinski P., and Meldrum B.S. Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat. NeuroReport 4 (1993) 1339-1342
226. Soares H.D., Thomas M., Cloherty K., and Mclntosh T.K. Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in the rat. J. Neurochem. 58 (1992) 1845-1852
227. Squire I.B., Lees K.R., Pryse-Phillips W., Kertesz A., and Bamford J. Efficacy and tolerability of lifarizine in acute ischemic stroke. A pilot study. Ann. N. Y. Acad. Sci. 765 (1995) 317-318
228. Staden R. An interactive graphic program of comparing and aligning nucleic acid and amino acid sequences. Nucleic Acids Res. 10 (1982) 2951-2961
229. Stafstrom C.E., Schwindt P.C., Chubb M.C., and Crill W.E. Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro. J. Neurophysiol. 53 (1985) 153-170
230. Stanton P.K., and Moskal J.R. Diphenylhydantoin protects against hypoxia-induced impairment of hippocampal synaptic transmission. Brain Res. 546 (1991) 351-354
231. Steinberg I.Z. Computer simulations of electrical bistability in excitable cells due to non-inactivating sodium channels: Space and time-dependent behavior. J. Theor. Biol. 144 (1990) 75-92
232. Stone W.E., and Javid M.J. Anticonvulsive and convulsive effects of lidocaine: Comparison with those of phenytoin and implications for mechanism of action concepts. Neurol. Res 10 (1988) 161-168
233. Striessnig J., Glossmann H., and Catterall W.A. Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 9108-9112
234. Strijbos P.J.L.M., Leach M.J., and Garthwaite J. Vicious cycle involving Na+ channels, glutamate release and NMDA receptors mediates delayed neurodgeneration through nitric oxide formation. J Neurosci. 16 (1996) 5004-5013
235. Stuart G.J., and Sakmann B. Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature (London) 367 (1994) 69-72
236. Stuart G.J., and Sakmann B. Amplification of EPSPs by axosomatic sodium channels. Neuron 15 (1995) 1065-1076
237. Stuhmer W., Conti F., Suzuki H., Wang X., Noda M., Yahadi N., Kubo H., and Numa S. Structural parts involved in activation and inactivation of the sodium channel. Nature (London) 339 (1989) 597-603
238. Stys P. Protective effects of antiarrhythmic agents against anoxic injury in CNS white matter. J. Cereb. Blood Flow Metab. 15 (1995) 425-432
239. Stys P.K., and Lesiuk H. Correlation between electrophysiological effects of mexiletine and ischemic protection in CNS white matter. NeuroScience 71 (1996) 27-36
240. Stys P., Ransom B.R., and Waxman S.G. Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability. J. Neurophysiol. 67 (1992) 236-240
241. Stys P., Waxman S.G., and Ransom B.R. Ionic mechanisms of anoxic injury in mammalian CNS white matter: Role of Na+ channels and Na+-Ca2+ exchanger. J. Neurosci. 12 (1992) 430-439
242. Stys P., Sontheimer H., Ransom B.R., and Waxman S.G. Non-inactivating, TTX-sensitive Na+ conductance in rat optic nerve axons. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 6976-6980
243. Sun F.Y., and Faden A.I. Neuroprotective effects of BW619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury. Brain Res. 637 (1995) 133-140
244. Szatkowski M., and Attwell D. Triggering and execution of neuronal death in brain ischemia: Two phases of glutamate release by different mechanisms. Trends Neurosci. 17 (1994) 359-365
245. Taft W.C., Clifton G.L., Blair R.E., and DeLorenzo R.J. Phenytoin protects against ischemia-produced neuronal cell death. Brain Res. 483 (1989) 143-148
246. Tagaki H., Takashima M., Liou S.Y., and Kunihara M. Effects of KB-2796, a novel Ca2+ channel blocker, on spreading depression and Ca2+ uptake in rat hippocampal slices. Jpn. J. Pharmacol. 64 (1994) 302
247. Tanelian D.L., and Brose W.G. Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: Lidocaine, carbamazepine and mexiletine. Anesthesiology 74 (1991) 949951
248. Tang L., Smith C.P., Huger F.P., and Kongsamut S. Effects of besipirdine at the voltage-dependent sodium channel. Br. J. Pharmacol. 116 (1995) 2468-2472
249. Tasker R.C., Coyle J.T., and Vornov J.J. The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: Protection by early tetrodo-toxin or delayed MK-801. J. Neurosci. 12 (1992) 4298-4308
250. Taylor C.P. Na+ currents that fail to inactivate. Trends Neurosci. 16 (1993) 455-460
251. Taylor C.P., and Meldrum B.S. Na+ channels as targets for neuroprotective drugs. Trends Pharmacol. Sci. 16 (1995) 309-316
252. Taylor C.P., Burke S.P., and Weber M.L. Hippocampal slices: Glutamate release and cellular damage from ischemia are reduced by sodium channel blockade. J. Neurosci. Methods 59 (1995) 121-128
253. Taylor C.P., Patrylo P.R., Weber M.L., Bloomquist J.L., and Dudek F.E. Na+ Channel blockers reduce prolonged seizure-like activity in low-[Ca2+]0 solutions. Epilepsia 37 Suppl.5 (1996) 21 (Abstract)
254. Terlau H., Heinemann S.H., Stuhmer W., Pusch M., Conti F., Imoto K., and Numa S. Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett. 293 (1991) 93-96
255. Thompson M., and Bones M. Nontraditional analgesics for the management of postherpetic neuralgia. Clin. Pharm. 4 (1985) 170-176
256. Thomsen W.J., Hays S.J., Hicks J.L., Schwarz R.D., and Catterall W.A. Specific binding of the novel Na+ channel blocker PD85,639 to the alpha subunit of rat brain Na+ channels. Mol. Pharmacol. 43 (1993) 955-964
257. Torp R., Arvin B., Le Peillet E., Chapman A.G., Ottersen O.P., and Meldrum B.S. Effect of ischaemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87. Exp. Brain Res. 96 (1993) 365-376
258. Trimmer J.S., and Agnew W.S. Molecular diversity of voltage-sensitive Na channels. Annu. Rev. Physiol. 51 (1989) 401-418
259. Trimmer J.S., Cooperman S.S., Tomiko S.A., Zhou J.Y., Crean S.M., Boyle M.B., Kallen R.G., Sheng Z.H., Barchi R.L., Sigworth F.J., Goodman R.H., Agnew W.S., and Mandel G. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron 3 (1989) 33-49
260. Tsuchida E., Harms J.F., Woodward J.J., and Bullock R. A use-dependent sodium channel antagonist, 619C89, in reduction of ischemic brain damage and glutamate release after acute subdural hematoma in the rat. J. Neurosurg. 85 (1996) 104-111
261. Vandenberg C.A., and Bezanilla F. A sodium channel gating model based on single channel, macroscopic ionic. and gating currents in the squid giant axon. Biophys. J. 60 (1991) 1511-1533
262. Van Reempts J., Haseldonckx M., Van Deuren B., Wouters L., and Borgers M. Structural damage of the ischemic brain: Involvement of calcium and effects of postischemic treatment with calcium entry blockers. Drug Dev. Res. 8 (1986) 387-395
263. Vassilev P.M., Scheuer T., and Catterall W.A. Inhibition of inactivation of single sodium channels by a site- directed antibody. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 8147-8151
264. Wahl F., Allix M., Plotkine M., and Boulu R.G. Effect of riluzole on focal cerebral ischemia in rats. Eur. J. Pharmacol. 230 (1993) 209-214
265. Waldmeier P.C., Baumann P.A., Wicki P., Feldtrauer J.- J., Stierlin C., and Schmutz M. Similar potency of carbamazepine, oxcarbazepine and lamotrigine in inhibiting the release of glutamate and other neurotransmitters. Neurology 45 (1995) 1907-1913
266. Wallis R.A., and Panizzon K.L. Felbamate neuroprotection against CA1 traumatic neuronal injury. Eur. J. Pharmacol. 294 (1995) 475-482
267. Wallis R.A., Panizzon K.L., Fairchild M.D., and Wasterlain C.G. Protective effects of felbamate against hypoxia in the rat hippocampal slices. Stroke 23 (1992) 547-551
268. Wasterlain C.G., Adams L.M., Hattori H., and Schwartz P.H. Felbamate reduces hypoxic-ischemic brain damage in vivo. Eur. J. Pharmacol. 212 (1992) 275-278
269. Wauquier A., Melis W., and Janssen P.A.J. Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischeamia. Neuropharmacology 28 (1989) 837-846
270. Waxman S.G., Kocsis J.D., and Black J.A. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons and is reexpressed following axotomy. J. Neurophysiol. 72 (1994) 466-470
271. Weber M.L., and Taylor C.P. Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials. Brain Res. 664 (1994) 167-177
272. West J.W., Patton D.E., Scheuer T., Wang Y., Goldin A.L., and Catterall W.A. A cluster of hydrophobic amino acid residues required for fast Na+ channel inactivation. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 10910-10914
273. West J.W., Scheuer T., Maechler L., and Catterall W.A. Efficient expression of rat brain type IIA Na+ channel alpha subunits in a somatic cell line. Neuron 8 (1992) 59-70
274. Westenbroek R.E., Merrick D.K., and Catterall W.A. Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron 3 (1989) 695-704
275. White M.M., Chen L., Keinfield R., Kallen R.G., and Barchi R.L. SkM2, a Na+ Channel cDNA clone from denervated skeletal muscle, encodes a tetrodotoxin-insensitive Na+ channel. Mol. Pharmacol. 39 (1991) 604-608
276. Wiard R.S., Dickerson M.C., Beek O., Norton R., and Cooper B.R. Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke 26 (1995) 466-472
277. Willow M., and Catterall W.A. Inhibition of the binding of [3H]batrachotoxinin A 20-a-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol. Pharmacol 22 (1982) 627-635
278. Willow M., Gonoi T., and Catterall W.A. Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Mol. Pharmacol. 27 (1985) 549-558
279. Woolf C.J., and Wiesenfeld-Hallin Z. The systemic administration of local anesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord. Pain 23 (1985) 361-374
280. Xie Y., Dengler K., Zacharias E., Wilffert B., and Tegtmeier F. Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischemia. Brain Res. 652 (1994) 216-224
281. Xie Y., Lancaster B., Peakman T., and Garthwaite J. Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones. Pfluegers Arch. 430 (1995) 437-446
282. Xie Y., Zacharias E., Hoff P., and Tegtmeier F. Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain. J. Cereb. Blood Flow Metab. 15 (1995) 587-594
283. Yaari Y., and Devor M. Phenytoin suppresses spontaneous ectopic discharge in rat sciatic nerve neuromas. Neurosci. Lett. 58 (1985) 117-122
284. Yajnik S., Singh G.P., Singh G., and Kumar M. Phenytoin as a coanalgesic in cancer pain. J. Pain Symptom. Manage. 7 (1992) 209-213
285. Yamaguchi S., and Rogawski M.A. Effects of anticonvulsant drugs on 4-aminopyri-dine-induced seizures in mice. Epilepsy Res. 11 (1992) 9-16
286. Yamakami I., and Mclntosh T.K. Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres. J. Cereb. Blood Flow Metab. 9 (1989) 117-124
287. Yamasaki Y., Kogure K., Hara H., Ban H., and Akaike N. The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus. Neurosci. Lett. 121 (1991) 251-254
288. Yang N., George A.L.J., and Horn R. Molecular basis of charge movement in voltage-gated sodium channels. Neuron 16 (1996) 113-122
289. Yoshidomi M., Hayashi T., Abe K., and Kogure K. Effects of a new calcium channel blocker, KB-2796, on protein synthesis of the CA1 pyramidal cell and delayed neuronal death following transient forebrain ishemia. J. Neurochem. 53 (1989) 1589-1594
290. Zha H., Remmers E.F., Du Y., Goldmuntz E.A., Mathern P., Zhang H., Cash J.M., Crofford L.J., and Wilder R.L. A single linkage group comprising 11 polymorphic DNA markers on rat chromosome 3. Mamm. Genome 5 (1994) 538-541
291. Zhang Y.-L., and Lipton P. Mitochondria and endoplasmic reticulum are major sources of increased cytosolic calcium during ischemia in the rat hippocampus. Soc. Neurosci. Abstr. 21 (1995) 217
292. Zhu Y., and Im W.B. Block of sodium channel current by anticonvulsant U-54494A in mouse neuroblastoma cells. J. Pharmacol. Exp. Ther. 260 (1992) 110-116
293. Zimanyi I., Weiss S.R.B., Lajtha A., Post R.M., and Reith M.E.A. Evidence for a common site of action of lidocaine and carbamazepine in voltage-dependent sodium channels. Eur. J. Pharmacol. 167 (1989) 419-442