Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: Role of reverse sodium-calcium exchange

Journal of Neurochemistry

Volumn 66, Issue 2, 1996, Pages 493-500

  Lehning, Ellen J ^a   Doshi, Renu ^a   Isaksson, Norman ^a   Stys, Peter K ^b   LoPachin Jr , Richard M ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Acrylamide; Anoxia; Electron probe x ray microanalysis; Myelinated axons; Na+ Ca2+ exchanger; Peripheral nerve

Indexed keywords

ACRYLAMIDE; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ARTICLE; CALCIUM TRANSPORT; ELECTRON PROBE MICROANALYSIS; MALE; MYELINATION; NERVE FIBER MEMBRANE; NERVE INJURY; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; SODIUM CALCIUM EXCHANGE; WATER CONTENT;

ANIMALIA;

EID: 0030047415     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66020493.x     Document Type: Article

References (48)

1. Bulger R. E., Beeuwkes R., and Saubermann A. J. (1981) Application of scanning electron microscopy to x-ray analysis of frozen-hydrated sections. III. Elemental content of cells in the rat renal papillary tip. J. Cell Biol. 88, 274-280.
2. Cheung J. Y., Thompson I. G., and Bonventre J. V. (1982) Effects of extracellular calcium removal and anoxia on isolated rat myocytes. Am. J. Physiol. 243, C184-C190.
3. 2+ transport in nerve fibers. Biochim. Biophys. Acta 947, 549-569.
4. Edmondson J. W. and Bang N. U. (1981) Deleterious effects of calcium deprivation on freshly isolated hepatocytes. Am. J. Physiol. 241, C3-C8.
5. 2+ in rat brain synaptosomes. J. Neurochem. 60, 843-850.
6. Foster M. C. and Saubermann A. J. (1991) Personal-computer-based system for electron beam x-ray microanalysis of biological samples. J. Microsc. 161, 367-373.
7. 0. J. Neurosci. 13, 63-72.
8. Friedman J. E. and Haddad G. G. (1994) Removal of extracellular sodium prevents anoxia-induced injury in freshly dissociated rat CA1 hippocampal neurons. Brain Res. 641, 57-64.
9. 2+ channel inhibitors d-cis-diltiazem, (±)-bepridil, desmethoxyverapamil, and (+)-PN200-110 in skeletal muscle transverse tubule membrane. J. Biol. Chem. 261, 1393-1397.
10. Hall T. A., Anderson H. C., and Appleton T. (1973) The use of thin specimens for x-ray microanalysis in biology. J. Microsc. 99, 177-182.
11. Harry G. J. (1992) Acrylamide-induced alterations in axonal transport. Mol. Neurobiol. 6, 203-216.
12. Hille B. (1992) Na and K channels of axons, in Ionic Channels of Excitable Membranes, pp. 59-82. Sinauer Associates Inc., Sunderland, Massachusetts.
13. Kaczorowski G. J., Slaughter R. S., King F., and Garcia M. L. (1989) Inhibitors of sodium-calcium exchange: identification and development of probes of transport activity. Biochim. Biophys. Acta 988, 287-302.
14. Lehning E. J., LoPachin R. M., Mathew J., and Eichberg J. (1994) Changes in Na-K ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats. J. Toxicol. Environ. Health 42, 331-342.
15. Lehning E. J., Doshi R., Stys P. K., and LoPachin R. M. (1995) Mechanisms of injury-induced calcium entry in peripheral nerve axons: in vitro anoxia and ouabain. Brain Res. (in press).
16. Lev-Ram V. and Grinvald A. (1987) Activity-dependent calcium transients in central nervous system myelinated axons revealed by the calcium indicator fura-2. Biophys. J. 52, 571-576.
17. Levy J. and Gavin J. R. (1994) Diabetes mellitus: a disease of abnormal cellular calcium metabolism. Am. J. Med. 96, 260-273.
18. 2+ can cause nonspecific damage. J. Neurochem. 56, 1445-1448.
19. LoPachin R. M. Jr. and Lehning E. J. (1994) Acrylamide-induced distal axon degeneration: a proposed mechanism of action. Neurotoxicology 15, 247-260.
20. LoPachin R. M. Jr. and Saubermann A. J. (1990) Disruption of cellular elements and water in neurotoxicity: studies using electron probe x-ray microanalysis. Toxicol. Appl. Pharmacol. 106, 355-374.
21. LoPachin R. M. Jr. and Stys P. K. (1995) Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation J. Neurosci. 15, 6735-6746
22. LoPachin R. M. Jr., Lowery J., Eichberg J., Kirkpatrick J. B., Cartwright J. Jr., and Saubermann A. J. (1988) Distribution of elements in rat peripheral axons and nerve cell bodies determined by x-ray microprobe analysis. J. Neurochem. 51, 764-775.
23. LoPachin R. M. Jr., LoPachin V., and Saubermann A. J. (1990) Effects of axotomy on distribution and concentration of elements in rat sciatic nerve. J. Neurochem. 54, 320-332.
24. LoPachin R. M. Jr., Castiglia C. M., and Saubermann A. J. (1992a) Acrylamide disrupts elemental composition and water content of rat tibial nerve: I. Myelinated axons. Toxicol. Appl. Pharmacol. 115, 21-34.
25. LoPachin R. M. Jr., Castiglia C. M., and Saubermann A. J. (1992b) Perturbation of axonal elemental composition and water content: implications for neurotoxic mechanisms. Neurotoxicology 13, 123-138.
26. LoPachin R. M. Jr., Castiglia C. M , Saubermann A. J., and Eichberg J. (1993) Ganglioside treatment modifies abnormal elemental composition in peripheral nerve myelinated axons of experimentally diabetic rats. J. Neurochem. 60, 477-486.
27. Luther P. W., Yip R. K., Bloch R. J., Ambesi A., Lindenmayer G. E., and Blaustein M. P. (1992) Presynaptic localization of sodium/ calcium exchangers in neuromuscular preparations. J. Neurosci. 12, 4898-4904.
28. Marlier L. N. J.-L., Zheng T., Tang J., and Grayson D. R. (1993) Regional distribution in the rat central nervous system of a mRNA encoding a portion of the cardiac sodium-calcium exchanger isolated from cerebellar granule neurons. Mol. Brain Res. 20, 21-39.
29. Meves H. and Vogel W. (1973) Calcium inward currents in internally perfused giant axons. J. Physiol. (Lond.) 235, 225-265.
30. 2+ antiporter and immunoextraction with antibodies to a 36-kDa protein. J. Neurochem. 58, 147-157.
31. 2+ exchanger in neuronal and non-neuronal cells. Brain Res. 661, 104-116.
32. Mullins L. J. (1981) Ca entry upon depolarization of nerve J. Physiol. (Paris) 77, 1139-1144.
33. 0 conditions. J. Gen. Physiol. 87, 143-159.
34. Roy M. L. and Narahashi T. (1992) Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neurosci. 12, 2104-2111.
35. Saubermann A. J. and Heyman R. V. (1987) Quantitative digital x-ray imaging using frozen hydrated and frozen dried tissue sections. J. Microsc. 146, 169-182.
36. Saubermann A. J., Echlin P., Peters P. D., and Beeuwkes R., (1981a) Application of scanning electron microscopy to x-ray analysis of frozen-hydrated sections. I. Specimen handling techniques. J. Cell Biol. 88, 257-267.
37. Saubermann A. J., Beeuwkes R., and Peters P. D. (1981b) Application of scanning electron microscopy to x-ray analysis of frozen-hydrated sections. II. Analysis of standard solutions and artificial electrolyte gradients. J. Cell Biol. 88, 268-273.
38. Schlaepfer W. W. (1974) Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve. Brain Res. 69, 203-215.
39. Stys P. K., Ransom B. R., Waxman S. G., and Davis P. K. (1990a) Role of extracellular calcium in anoxic injury of mammalian central white matter. Proc. Natl. Acad. Sci. USA 87, 4212-4216.
40. Stys P. K., Ransom B. R., and Waxman S. G. (1990b) Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia. Neurosci. Lett. 115, 293-299.
41. 2+ exchanger mediates calcium influx during anoxia in mammalian central nervous system white matter. Ann. Neurol. 30, 375-380.
42. 2+ exchanger. J. Neurosci. 12, 430-439.
43. + conductance in rat optic nerve axons. Proc. Natl. Acad. Sci. USA 90, 6976-6980.
44. + -ATPase. Biochim. Biophys. Acta 988, 185-220.
45. + currents that fail to inactivate. Trends Neurosci. 16, 455-460.
46. Utzschneider D. A., Kocsis J. D., and Waxman S. G. (1991) Differential sensitivity of hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Res. 551, 136-141.
47. 2+-mediated injury in CNS white matter. Trends Neurosci. 14, 461-468.
48. 2+-mediated injury in myelinated CNS axons. Brain Res. 644, 197-204.