Asessment of the nutritional effects of olestra, a nonabsorbed fat replacement: Summary

Journal of Nutrition

Volumn 127, Issue 8 SUPPL., 1997, Pages

  Peters, John C ^a   Lawson, Kenneth D ^a   Middleton, Suzette J ^a   Triebwasser, Keith C ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Nutrition; Olestra; Subgroups; Water soluble vitamins

Indexed keywords

SUCROSE POLYESTER; BETA CAROTENE; CAROTENOID; DRUG DERIVATIVE; EDIBLE OIL; FATTY ACID; RETINOL; SUCROSE; VITAMIN;

DIARRHEA; FAT INTAKE; HUMAN; LIPID DIET; LIPOPHILICITY; NONHUMAN; NUTRITIONAL REQUIREMENT; NUTRITIONAL STATUS; REVIEW; ANIMAL; ARTICLE; BIOAVAILABILITY; BLOOD; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DIET; DRUG EFFECT; FAT SUBSTITUTE; LIVER;

ANIMALS; BETA CAROTENE; BIOLOGICAL AVAILABILITY; CAROTENOIDS; DIARRHEA; DIET; DIETARY FATS, UNSATURATED; FAT SUBSTITUTES; FATTY ACIDS; HUMANS; LIVER; NUTRITIONAL STATUS; SUCROSE; VITAMIN A; VITAMINS;

EID: 0030612305     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

1. Anderson, J. W. & Akanji, A. D. (1991) Dietary fiber - an overview. Diabetes Care 4: 1126-1131.
2. Block, G., Patterson, B. & Subar, A. (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer 18: 1-29.
3. Cooper, D. A., Berry, D. A., Jones, M. B., Kiorpes, A. L. & Peters, J. C. (1997a) Olestra's effect on the status of vitamins A, D, and E in the pig can be offset by increasing dietary levels of these vitamins. J. Nutr. 127: 1589S-1608S.
4. Cooper, D. A., Berry, D. A., Spendel, V. A., Jones, M. B., Kiorpes, A. L. & Peters, J. C. (1997b). Nutritional status of pigs fed olestra with and without increased dietary levels of vitamins A and E in long-term studies. J. Nutr. 127: 1609S-1635S.
5. Cooper, D. A., Berry, D. A., Spendel, V. A., King, D., Kiorpes, A. L. & Peters, J. C. (1997c) Olestra dose response on fat-soluble and water-soluble nutrients in the pig. J. Nutr. 127: 1573S-1588S.
6. Cooper, D A., Berry, D. A., Spendel, V. A., Kiorpes, A. L. & Peters, J. C. (1997d) The domestic pig as a model for evaluating olestra's nutritional effects. J. Nutr. 127: 1555S-1565S.
7. Cooper, D. A., Webb, D. R. & Peters, J. C. (1997e) Evaluation of the potential for olestra to affect the availability of dietary phytochemicals. J. Nutr. 127: 1699S-1709S.
8. Corazza, G. R., Strocchia, A., Russi, R., Sirola, D. & Gasbarrini, G. (1988) Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. Gut 29: 44-48.
9. Curry C.E.J. (1986) Laxative products. In: Handbook of Nonprescription Drugs, pp. 75-97. American Pharmaceutical Association, Washington, DC.
10. Daher, G. C., Cooper, D. A. & Peters, J. C. (1997a) Physical or temporal separation of olestra and vitamins A, E and D intake decreases the effect of olestra on the status of the vitamins in the pig. J. Nutr. 127: 1566S-1572S.
11. Daher, G. C., Cooper, D. A., Zorich, N. L., King, D., Riccardi, K. A. & Peters, J. C. (1997b) Olestra ingestion and retinyl palmitate absorption in humans. J. Nutr. 127: 1686S-1693S.
12. Daher, G. C., Cooper, D. A., Zorich, N. L., King, D., Riccardi, K. A. & Peters, J. C. (1997c) Olestra ingestion and dietary fat absorption in humans. J. Nutr. 127: 1694S-1698S.
13. Deehr, M. S., Dallai, G. E., Smith, K. T., Taubee, J. D. & Dawson-Hughes, B. D. (1990) Effects of different calcium sources on iron absorption in postmenopausal women. Am. J. Clin. Nutr. 51: 95-97.
14. Delvin, E. E., Glorieux, F. H., Dussault, M., Bourbonnais, R. & Watters, G. (1979) Simultaneous measurement of serum 25-hydroxycholecalciferol and 25-hydroxyergocalciferol. Med. Biol. 57: 165-170.
15. Dimitrov, N. V., Meyer, C., Ullrey, D. E., Chenoweth, W., Michelakis, A., Malone, W., Boone C. & Fink, G. (1988) Bioavailability of β-carotene in humans. Am. J. Clin. Nutr. 48: 298-304.
16. Doll, R. & Peto, R. (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66: 1191-1308.
17. Federal Register, Part III, U.S. Department of Health and Human Services, Food and Drug Administration, 21 CFR Part 172, Food additives permitted for direct addition to food for human consumption: olestra; final rule. 62: 3118-3173, January 30, 1996.
18. Gaziano, J. M. (1996) Antioxidants in cardiovascular disease: randomized trials. Nutr. Rev. 54: 175-177.
19. Haddad, J. G. & Hahn, T. J. (1973) Natural and synthetic sources of circulating 25-hydroxyvitamin D in man. Nature (Lond.) 244: 515-517.
20. Hyams, J. S. (1983) Sorbitol intolerance: an unappreciated cause of functional gastrointestinal complaints. Gastroenterology 84: 30-33.
21. Institute of Food Technologists (1993) Potential mechanisms for food-related carcinogens and anticarcinogens. Food Technol. 2: 105-118.
22. Jandacek, R. J. (1982) The effect of nonabsorbable lipids on the intestinal absorption of lipophiles. Drug Metab. Rev. 13: 695-714.
23. Jandacek, R. J., Ramirez, M. M. & Crouse, J. R. (1990) Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man. Metabolism 39: 848-852.
24. Jones, D. Y., Miller, K. W., Koonsvitsky, B. P., Ebert, M. L., Lin, P.Y.T., Jones, M. B. & DeLuca, H. F. (1991) Serum 25-hydroxyvitamin D concentrations of free-living subjects consuming olestra. Am. J. Clin. Nutr. 53: 1281-1287.
25. 3 in human plasma by high performance liquid chromatography. Clin. Chem. 24: 287-298.
26. Koonsvitsky, B. P., Berry, D. A., Jones, M. B., Lin, P.Y.T., Cooper, D. A., Jones, D. Y. & Jackson, J. E. (1997) Olestra affects serum concentrations of α-tocopherol and carotenoids but not vitamin D or vitamin K status in free-living subjects. J. Nutr. 127: 1636S-1645S.
27. Lawson, K. D., Middleton, S. J. & Hassall, C. D. (1997) Olestra, a nonabsorbed, noncaloric replacement for dietary fat. A review. Drug Metab. Rev. (in press).
28. Linscheer, W. G. & Vergrosen, A. J. (1988) Lipids. In: Modem Nutrition in Health and Disease (Shils, M. E. & Young, V. R., eds.), 7th ed., pp. 72-107. Lea & Febiger, Philadelphia, PA.
29. Middleton, S.J., Dwyer, J. & Peters, J.C. (1997) An indirect means of assessing potential nutritional effects of dietary olestra in healthy subgroups of the general population. J. Nutr. 127: 1710S-1718S.
30. Peters, J. C., Lawson, K. D., Middleton, S. J. & Triebwasser, K. C. (1997) Assessment of the nutritional effects of olestra, a nonabsorbable fat replacement: introduction and overview. J. Nutr. 127: 1539S-1546S.
31. Peto, R., Doll, R., Buckley, J. D. & Sporn, M. B. (1981) Can dietary β-carotene materially reduce human cancer rates? Nature (Lond.) 290: 201-208.
32. Rock, C. L., Swendseid, M. E., Jacob, R. A. & McKee, R. W. (1992) Plasma carotenoid levels in human subjects fed a low-carotenoid diet. J. Nutr. 122: 96-100.
33. Rossander, L., Hallberg, L. & Bjorn-Rasmussen, C. (1979) Absorption of iron from breakfast meals. Am. J. Clin. Nutr. 32: 2484-2489.
34. Schlagheck, T. G., McEdwards, J. M., Jones, M. B., Dugan, L. D., Davidson, M. H., Zorich, N. L. & Peters, J. C. (1997a) Olestra's effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins. J. Nutr. 127: 1666S-1685S.
35. Schlagheck, T. G., Riccardi, K. A., Torri, S. A., Dugan, L. D., Zorich, N. L. & Peters, J. C. (1997b) Olestra dose response on fat-soluble and water-soluble nutrients in humans. J. Nutr. 127: 1646S-1665S.
36. 1) in man. In: Vitamins and Hormones: Advances in Research and Applications (Harris, R. S., Diczfalusy, E., Munson, P. L. & Glover, J., eds.), pp. 513-542. Academic Press, New York, NY.
37. Steinmetz, K. A. & Potter, J. D. (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer. Causes Contr. 2: 427-442.
38. Suttie, J. W. (1992) Vitamin K and human nutrition. J. Am. Diet. Assoc. 92: 585-590.
39. Tanka, T. (1994) Cancer chemoprevention by natural products (review). Oncol. Rep. 1: 1139-1155.
40. Webb, D. R., Harrison G. G., Lee, M.-J. & Huang, M.-H. (1997) Estimated consumption and eating frequency of olestra from savory snacks using menu census data. J. Nutr. 127: 1547S-1554S.
41. Weststrate, J. A. & van het Hof, K. H. (1995) Sucrose polyester and plasma carotenoid concentration in healthy subjects. Am. J. Clin. Nutr. 62: 591-597.
42. Zorich, N. L., Jones, M. B., Kesler, J. M., Carter, S. B., Sutton, M. A. & Bayless, T. (1997) A randomized, double-blind study of the effect of olestra on disease activity in patients with quiescent inflammatory bowel disease. J. Am. Med. Assoc. (in press).