Overexpression of a constitutively active form of Phosphatidylinositol 3 kinase is sufficient to Promote GLUT 4 translocation in transfected rat adipose cells

Experimental and Clinical Endocrinology and Diabetes

Volumn 104, Issue , 1996, Pages 25-26

  Tanti, Jean François ^a   Grémeaux, Thierry ^a   Ricort, J M ^a   Van Obberghen, Emmanuel ^a   Le Marchand Brustel, Yannick ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 12644295652     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0029-1211508     Document Type: Article

References (5)

1. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, and Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14: 4902-4911, 1994
2. Hu Q, Klippel A, Muslin JA, Fantl JW, and Williams TL: Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268: 100-102, 1995
3. Okada T, Kawano Y, Sakakibara T, Hazeki O, and Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem 269: 3568-3573, 1994
4. Quon MJ, Zarnowski M, Guerre-Millo M, De La Luz Sierra M, Taylor SI, and Cushman SW: Transfection of DNA into isolated rat adipose cells by electroporation. Evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture. Biochem Biophys Res Commun 194: 338-346, 1994
5. Quon MJ, Chen H, Ing BL, Miu M-L, Zarnowski MJ, Yonezawa K, Kasuga M, Cushman SW, and Taylor SI: Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biochem 15: 5403-5411, 1995