CD95/Fas/Apo-1-Mediated signal transduction

Cellular Physiology and Biochemistry

Volumn 6, Issue 6, 1996, Pages 345-360

  Schlottmann, K ^a   Coggeslwll, K M ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Apo 1; CD95; Fas; Signal transduction

Indexed keywords

CALCIUM; CELL SURFACE RECEPTOR; CERAMIDE; FAS ANTIGEN; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SPHINGOMYELIN; TRANSCRIPTION FACTOR;

APOPTOSIS; HUMAN; IMMUNE RESPONSE; MITOGENESIS; MOLECULAR CLONING; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030446491     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000154838     Document Type: Article

References (149)

1. Krammer PH. Dhcin J. Walczak H. Bchrmann I. Mariani S. Matiba B. Path M. Daniel PT, Knipping E, Westendorp MO. cl al: The role of APO-l-mcdiated apoptosis in the immune system (review). Immunol Rev 1994:142:175-191.
2. Steller H: Mechanisms and genes of cellular suicide (review). Science 1995:267:1445-1449.
3. Lynch DH. Ramsdell F. Alderson MR: Fas and Fast in the homeostatic regulation of immune responses. Immunol Today 1995:16:569-574.
4. van Parijs L. Abbas AK: Role of Fas-mediatcd cell death in the regulation of immune responses. Curr Opin Immunol 1996:8:355-361.
5. Lenardo MJ : Fas and the art of lymphocyte maintenance. J Exp Med 1996;183:721-724.
6. Trauth BC. Klas C, Peters AM. Matzku S. Moller P. Falk W. Dcba-tin KM. Krammer PH: Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989:245:301-305.
7. Yonehara S. Ishii A. Yonehara M: A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 1989:169:1747-1756.
8. Kischkel FC. Hellbardl S. Behr-mann I. Germer M. Pawlita M. Krammer PH. Peter ME: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO 1995:14: 5579-5588.
9. ltoh N. Yonchara S. Ishii A. Yone-hara M. Mizushima S. Samcshima M. Hasc A. Scto Y. Nagata S: The polypeptide encoded by the cDNA lor human cell surface antigen Fas can mediate apoptosis. Cell 1991: 66:233-243.
10. Smith CA. Farrah T, Goodwin RG: The TNF receptor superfamily of cellular and viral proteins: activation. Costimulation, and death. Cell 1994:76:959-962.
11. Tarlaglia LA. Ayres TM. Wong GH. Gocddel DV: A novel domain within the 55 kD TNF receptor signals cell death. Cell 1993:74:845-853.
12. ltoh N. Nagata S: A novel protein domain required for apoptosis: Mutational analysis of human Fas antigen. J Biol Client 1993:268:10932-10937.
13. Nagata S. Golstein P: The Fas death factor (review). Science 1995:267: 1449-1456.
14. Owcn-Schaub I.B. Angelo LS. Radinsky R. Ware CF. Gesner TG. Bartos DP: Soluble Fas/APO-l in tumor cells: A potential regulator of apoptosis? Cancer Lett 1995:94:1-8.
15. Suda T. Nagata S: Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med 1994;179:873-879.
16. Suda T. Takahashi T. Golstein P. Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993:75:1169-1178.
17. Armilagc RJ: Tumor necrosis factor receptor superfamily and their ligands. CurrOpin Immunol 1994:6: 407-413.
18. Banner DW. D'Arcy A. Janes W, Gentz R. Schocnfeld HJ, Broger C. Loctscher H. Lcsslauer W: Crystal structure of the soluble human 55 kD TNF receptor-human TNFb complex: Implications for TNF receptor activation. Cell 1993:73: 431-445.
19. Dhein J. Daniel PT. Trauth BC. Oehm A. Moller P. Krammer PH: Induction of apoptosis by montv clonal antibody anti-APO-l class switch variants is dependent on cross-linking of APO-1 cell surface antigens. J Immunol 1992:149: 3166-3173.
20. Boldin MP. Mctt IL. Varfolomeev EE. Chumakov I. Shcmer-Avni Y. Camonis JH. Wallach D: Self-association of the ‘death domains' of the p55 tumor necrosis factor (TNF) receptor and Fas/APOl prompts signaling for TNF and Fas/APOl effects. J Biol Chem 1995:270:387-391.
21. Nagata S. Suda T: F'as and Fas ligand: lpr and gld mutations (review). Immunol Today 1995:16:39-43.
22. Nagata S: Fas and Fas ligand: A death factor and its receptor (review). Adv Immunol 1994:57:129- 144.
23. Pitti RM. Marsiers SA. Ruppcrt S. Donahue CJ. Moore A. Ashkenazi A: Induction of apoptosis by Apo-‘ ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996:271:12687-12690.
24. Alderson MR. Armilage RJ. Maras-kovsky E, Tough TW. Roux E. Schooley K. Ramsdell F. Lynch DH: Fas transduces activation signals in normal human T lymphocytes. J Exp Med 1993:178:2231-2235.
25. Owen-Schaub LB. Radinsky R. Kru-zel E. Berry K, Yonchara S: Anti-Fas on nonhematopoietic tumors: Levels of Fas/APO-l and bcl-2 arc not predictive of biological responsiveness. Cancer Res 1994:54:1580- 1586.
26. Aggarwal BB. Singh S. LaPushin R. Tot pal K: Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor. FEBS Leu 1995:36:5-8.
27. Mapara MY. Bargou R. Zugk C. Dohncr H. Ustaoglu F, Jonker RR. Krammer PH. Dorken B: APO-I mediates apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl-2 oncogene expression. Eur J Immunol 1993:23:702-708.
28. Richardson BC. Lalwani ND. Johnson KJ. Marks RM: Fas ligation triggers apoptosis in macrophages but not endothelial cells. Eur J Immunol 1994:24:2640-2645.
29. Yoshino T. Cao L. Nishiuchi R. Matsuo Y. Yamadori I. Kondo E. Teramoto N. Hayashi K. Takahashi K. Kamikawaji N, et al: Ligation of HLA class II molecules promotes sensitivity to C'D95 Fas antigen. APO-1 D-mediated apoptosis. Eur J Immunol 1995:25:2190-2194.
30. Cascino I, Fiucei G. Papoff G. Ruberti G: Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. Journal of Immunology 1995:154:2706-2713.
31. Cascino I. Papoff G. De Maria R. Testi R. Ruberti G: Fas/Apo-I (CD95) receptor lacking the intraev-toplasmic signaling domain protects tumor cells from Fas-mediaied apoptosis. J Immunol 1996:156:13-17.
32. Kikuehi H. Sugiyama S, Imajoh-Olimi S: A novel anti-apoptosis serum factor that down-regulates fas-mediated apoptosis. J Biochcm 1995:1 17:936-939.
33. − between the p55 tumor necrosis factor receptor and Fas/Apol: Proteins binding to the death domains of the two receptors also bind to each other. J Exp Med 1996:183:1271-1275.
34. Chinnaiyan AM. Teppcr CG. Seldin MF. O'Rourke K. Kischkel FC, Hellbardt S. Krammer PH. Peter ME. Dixit VM: FADD/MORTI is a common mediator of CD95 (Fas/ Apo-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996:271:4961-4963.
35. Chinnaiyan AM, O'Rourke K. Tc-wari M. Dixit VM: FADD. A novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995:81:505-512.
36. Boldin MP. Varfolomeev EE. Panc-cr Z. Mett IL. Camonis JH. Wallach D: A novel protein that interacts with the death domain of Fas/APO 1 contains a sequence motif related to the death domain. J Biol Chem 1995:270:7795-7798.
37. Hsu H. Shu HB. Pan MG. Goed-del DV: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor I signal transduction pathways. Cell 1996: 84:299-308.
38. Hsu H. Huang J. Shu H-B. Baichwal V. Goeddel DV: TNF dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996:4:387- 396.
39. Boldin MP. Goncharov TM, Goltsov YV. Wallaeh D: Involvement of MACH, a novel MORTI/FADD interacting protease, in Fas/APO-l-and TNF receptor-induced cell death. Cell 1996:85:803-815.
40. Muzio M. Chinnaivan AM. Kisch-kcl FC, O'Rourke K. Shevchenko A. Ni J, Scalïidi C. Brctz JD. Zhang M. Gcntz R. Mann M. Krammcr PH. Peter ME. Dixit VM: FLICE. A novel FADD-homologous ICE/CED-3-likc protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996:85: 817-827.
41. Fernandes-Alnemri T.R.C.A. Krebs J. Srinvasula SM. Wang L, Bullrich F. Fritz IX. Trapani JA, Tomaselli KJ, Litwack G. Alncntri ES: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-likc domains. Proc Natl Acad Sci USA 1996:93: 7464-7469.
42. Chu K. Niu X. Williams LT: A Fas-associated protein factor. FAFI. Potentiates Fas-mediated apoptosis. Proc Natl Acad Sci USA 1995:92: 11894-11898.
43. Sato T. Irie S. Kitada S. Reed JC: FAP-I: A protein tyrosine phosphatase that associates with Fas. Science 1995:268:411-415.
44. Maekawa K. Imagawa N. Nagamat-su M. Harada S: Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. FEBSLett 1994:337:200-206.
45. Moller NPH, Moller KB. Lammers R. Kharitonenkov A. Sures I. Ullrich A: Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-Iike domain. Proc Natl Acad Sci USA 1994:91:7477-7481.
46. Green M. Shultz LD: Mothcaten. An immunodeficicnt mutant of the mouse. I. Genetics and pathology. J Hcrcd 1975:66:250.
47. Shultz LD. Schweitzer PA. Rajan TV. Yi T. Mile N. Matthews RJ. Thomas ML. Bcicr DR: Mutations at the murine mothcaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 1993:73:1445.
48. Tsui HW, Siminovitch KA. dc Souza L, Tsui FW: Mothcaten and viable mothcaten mice have mutations in the hematopoietic cell phosphatase gene. Nature Genet 1993:4: 124.
49. Su X. Zhou T. Wang Z. Yang P. Jope RS, Mountz .ID: Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mcdiaicd apoptosis. Immunity 1995:2:353-362.
50. Klingmullcr U. Lorenz U. Cantlev LC. Neel BG. Lodislt HF: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 1995:80: 729-738.
51. Eischen CM. Dick CM, Leibson PJ: Tyrosine kinase activation provides an early and requisite signal for Fas-induccd apoptosis. J Immunol 1994; 153:1947-1954.
52. Schravcn B. Peter ME: APO-(CD95)-medialcd apoptosis in Jur-kat cells does not involve src kinases or CD45. FEBS Lett 1995:368:491-494.
53. Schlottmann K. Gulbins E. Lau SM. Coggeshall KM: Activation of Src-family tyrosine kinases during Fas-induccd apoptosis. J Leukocyte Biol (in press).
54. Atkinson F.A. Ostorgaard H. Kane K. Pinkoski M.I. Caputo A. Olszowy M. Bleackley RC: A physical interaction between the cell death protein Fas and the tyrosine kinase p59fynT. J Biol Chem 1996;271.
55. Vaux DL, Strasser A: The molecular biology of apoptosis. Proc Natl Acad Sci USA 1996;93:2239-2244.
56. Hcngartncr MO. Horvitz HR: C. Elegant cell survival gene ccd-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994;76:665-676.
57. Hcngartncr MO, Ellis RE. Horvitz HR: Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 1992:356: 494-499.
58. Henkart PA: ICE family proteases: Mediators of all apoptotic cell death? Immunity 1996:4:195-201.
59. Tewari M. Dixit VM: Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chcm 1995: 270:3255-3260.
60. Tewari M. Quan LT. O’Rourke K, Desnoyers S. Zeng Z. Beidler DR. Poirier GG. Salvcsen GS. Dixit VM : Yama/CPP32 beta, a mammalian homolog of CED-3. is a CrmA-in-hibitable protease that cleaves the death substrate polv(ADP-ribose) polymerase. Cell 1995:81:801-809.
61. Tewari M. Telford WG. Miller RA. Dixit VM: CrmA. A poxvirus-encoded serpin. inhibits cytotoxic T-lymphocyte-mediated apoptosis. J Bio Chem 1995;270:22705-22708.
62. Xue D. Horvitz HR: Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 1995;377:248-251.
63. Beidler DR. Tewari M. Friesen PD. Poirier G. Dixit VM: The baculovirus p.35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J Biol Chcm 1995:270:16526-16528.
64. Martin SJ. Green DR: Protease activation during apoptosis: Death by a thousand cuts? Cell 1995:82:349- 352.
65. Emoto Y. Manóme Y. Meinhardt G. Kisaki H. Kharbanda S. Robertson M. Ghayur T. Wong WW. Kamen R. Wcichselbaum R. Kufe D: Proteolytic activation of protein kinase C by an ICE-like protease in apoptotic cells. EMBOJ 1995:24:6148-6156.
66. Schlcgel J. Peters I. Orrenius S: Isolation and partial characterization of a protease involved in Fas-in-duccd apoptosis. FEBS Lett 1995: 364:139-142.
67. Los M. Van de Cracn M. Penning LC. Schenk H. Westendorp M. Bacuerle PA, Drogo W. Krammcr PH. Fiers W. Schulze-OsthofT K: Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 1995:375:81-83.
68. Enari M. Hug H. Nagata S: Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 1995: 375:78-81.
69. Duan H. Chinnaiyan AM. Hudson PL. Wing JP. He WW. Dixit VM: ICE-LAP3. A novel mammalian homologue of the Caenorrhabdiiis ele-gans cell death protein Ced-3 is activated during Pas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1996;271:1621-1625.
70. Schlegcl J. Peters I. Orrenius S. Miller DK. Thornberry NA. Yamin TT. Nicholson DW: CPP32/apopain is a key interleukin IB converting enzyme-like protease involved in Pas-mediated apoptosis. J Biol Chem 1996:271:1841-1844.
71. Deiss LP. Galinka H. Berissi H. Cohen O. Kimchi A: Cathcpsin D pro-lease mediates programmed cell death induced by interferon-g. Fas and TNF-a. EM BO J 1996:15: 3861-3870.
72. Williams MS, Henkart PA: Apop-totic cell death induced by intracellular proteolysis. Immunol 1994: 153:4247-4255.
73. Obcid LM. Hannun YA: Ceramide: A stress signal and mediator of growth suppression and apoptosis (review). J Cell Biochcm 1995:58: 191-198.
74. Hannun YA: The spingomyelin cycle and second messenger function of ceramide. J Biol Chem 1994:269: 3125-3128.
75. Hannun YA, Obeid LM: Ceramide: An intracellular signal for apoptosis (review). Trends Biochcm Sci 1995: 20:73-77.
76. Okazaki T. Bell RM. Hannun YA: Sphingomyelin turnover induced by vitamin D3 in HL-60 cells: Role in cell differentiation. J Biol Chem 1989:264:19076-19080.
77. Olivera A. Buckley NE. Spiegel S: Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts. J Biol Chem 1992: 267:26121-26127.
78. Jayadev S. Liu B. Bielawska AE. Lee JY. Nazaire F. Pushkareva M. Obeid LM. Hannun YA: Role for ceramide in cell cycle arrest. J Biol Chem 1995:270:2047-2052.
79. Ito A. Horigome K: Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation. J Ncurochem 1995: 65:463-466.
80. Obeid LM. Linardic CM. Karolak LA. Hannun YA: Programmed cell death induced by ceramide. Science 1993;259:1769-1771.
81. Jarvis WD, Kolesnick RN, Fomari FA. Traylor RS. Gewirtz DA. Grant S: Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sei USA 1994:91:73-77.
82. Kolesnick RN. Haimovitz-Fried-man A. Fuks Z: The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor. Fas. And ionizing radiation. Biochcm Cell Biol 1994:72:471-474.
83. Cifonc MG. De Maria R. Roncaioli P. Rippo MR. Azuma M. Lanier LL. Sanloni A. Testi R: Apoptotic signaling through CD95 (Fas Apo-l) activates an acidic sphingomyelinase. J Exp Med 1994:180:1547-1552.
84. Cifone MG. Roncaioli P. De Maria R. Camarda G. Santoni A. Ruberti G. Testi R: Multiple pathways originate at the Fas/Apo-I (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. J Biol Chem 1995:14:5859-5868.
85. Gulbins E. Bissonnettc R. Mahbou-bi A. Martin S. Nishioka W, Brunner T. Baier G, Baier-Bitterlich G. Byrd C. Lang F. Et al: FAS-induced apoptosis is mediated via a ceram-ide-initiated RAS signaling pathway. Immunity 1995:2:341-351.
86. Schutze S. Potthoff K. Machleidt T. Bcrkovic D. Wiegmann K. Kronke M: INF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell 1992;71 : 765-776.
87. Garnen S. Marzo I. Anel A, Pineiro A. Naval J: CPP32 inhibition prevents Fas-indueed ceramide generation and apoptosis in human cells. FEBS Lett 1996:390:233-237.
88. Andrieu N, Salvayre R. Levade T: Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor-and intcr-lcukin-l-induced sphingomyelin cycle and cell proliferation in human fibroblasts. Biochcm J 1994:303: 341-345.
89. Horinouchi K. Erlich S. Perl DP. Ferlinz K. Bisgaier CL. Sandhoff K. Desniek RJ. Stewart CL. Schuch-man F.H: Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nature Genet 1995:10:288-293.
90. Santana P. Pena LA. Haimo-vitz-Friedmann A. Martin SG, McLoughlin M. Cordon-Cardo C. Schuchmann EH. Fuks Z. Kolesnick R: Acid sphingomyelinase-deficient human lymphoblasts and mice arc defective in radiation-induced apoptosis. Cell 1996:86:189-199.
91. Goldkorn T. Dressier KA. Muindi J. Radin NS. Mendelsohn J. Menaldi-no D, Liotta D. Kolesnick RN: Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. J Biol Chem 1991:266:16092-16097.
92. Raines MA. Kolesnick RN. Golde DW: Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. J Biol Chem 1996:268:14572-14575.
93. Joseph CK, Byun MS. Biltmann R. Kolesniek RN: Substrate recognition by ceramidc-activatcd protein kinase; J Biol Chem 1993:268: 20002-20006.
94. Liu J, Mathias S. Yang Z. Kolesnick RN: Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide activated protein kinase. J Biol Chem 1994:269:3047-3052.
95. Dombrowskv RT. Hannun YA: Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem 1992:267: 5048-5051.
96. Wilson DJ. Fortner KA. Lynch DH. Mattingly RR. Macara IG. Posada JA. Budd RC: JNK. but not MAPK. Activation is associated with Fas-mediated apoptosis in human T cells. Eur J Immunol 1996:26:989-994.
97. Sluss HK. Barrett T, Derijard B. Davis RJ: Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 1994: 14:8376-8384.
98. Raingeaud J, Gupta S, Rogers JS. Dickens M. Han J, Ulevitch RJ. Davis RJ: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chcm 1995:270: 7420-7426.
99. Berberich I. Shu G, Sicbelt F. Woodgctt JR. Kyriakis JM. Clark EA: Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBOJ 1996:15:92-101.
100. Coso OA, Chiariello M. Kalinec G. Kyriakis JM. Woodgctt J. Gutkind JS: Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. J Biol Chem 1995:270:5620-5624.
101. Vojtek AB. Cooper J A: Rho family members: Activators of MAP kinase cascades. Cell 1995:82:527- 529.
102. Cano E. Mahadcvan LC: Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 1995:20:117-122.
103. Hibi M. Lin A. Smcal T. Minden A. Karin M: Identification of an oncoprotein- and UV-rcsponsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993:7:2135- 2148.
104. Minden A, Lin A, Smeal T, Deri-jard B, Cobb M. Davis R, Karin M: c-Jun N-tcrminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol 1994;14:6683-6688.
105. O'Reilly MA. Geiser AG. Kim SJ. Bruggcman LA, Luu AX, Roberts AB. Sporn MB: Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter. J Biol Chem 1992:267: 19938-19943.
106. Gupta S, Campbell D. Derijard B. Davis RJ: Transcription factor ATF2 regulation by the J N K signal transduction pathway. Science 1995:267:389-393.
107. Verheij M. Bose R, Lin XH. Yao B. Jarvis WD. Grant S. Birrer MJ. Szabo E. Zon LI. Kyriakis JM. Haimovitz-Friedman A. Fuks Z. Kolesnick RN: Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996:380:75-79.
108. Schlottmann K. Rampcrsaud A. Wolfgang CD. Lau S. Hai T. Cog-geshall KM: Fas/CD95 mediates activation of the stress response kinases p38/Mpk2 and c-Jun NI L-terminal kinase. 1996: submitted.
109. Latinis KM. Koretzky GA: Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. Blood 1996:87:871-875.
110. Hai TW. Liu F, Coukos WJ. Green MR: Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev 1989:3: 2083-2090.
111. Liang G. Wolfgang CD. Chen BP. Chen TH. Hai T: ATF3 gene: Genomic organization, promoter, and regulation. J Biol Chem 1996: 271:1695-1701.
112. Munkcr R. Grcither L, Darsow M. Pander S. Wilmanns W: TNF induces cytoplasmic vesicles in acti-nomycin D-trealcd K 562 cells. Ann Hematol 1992:65:50-52.
113. Schulze-Osthoff K, Krantmer PH. Drogc W: Divergent signalling via APO-l/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBOJ 1994;13:4587-4596.
114. Higuchi M. Singh S. Chan H. Ag-garwal BB: Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor kappa B activation, cytotoxicity. And differentiation. Blood 1995:86:2248-2256.
115. Leist M. Gantner F. Bohlinger I. Tiegs G. Germann PG. Wendel A: Tumor necrosis factor-induced hépatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 1995: 146:1220-1234.
116. Luciani MF. Golstein P: Fas-based dl OS-mediated cytotoxicity requires macromolecular synthesis for effector cell activation but not for target cell death. Phil Trans R Soc Lond B 1994;345:303-309.
117. Ponton A. Clement V. Stamcnkov-ic I: The CD95 (APO-l/Fas) receptor activates NF-kB independently of its cytotoxic function. J Biol Chem 1996:271:8991-8995.
118. Frcshney NW. Rawlinson L, Gues-don F. Jones E, Cowley S. Hsuan J. Saklatvala J: Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 1994.78: 1039-1049.
119. Rouse J. Cohen P. Trigon S, Mo-range M. Alonso-Llamazares A, Zantanillo D. Hunt T. Ncbreda AR: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell I994;78: 1027-1037.
120. Mehlen P. Schulze-Osthoff K, Ar-rigo AP: Small stress proteins as novel regulators of apoptosis. J Biol Chem 1996;271:16310-16314.
121. Wang HCi. Millan JA, Cox AD. Der CJ. Rapp UR. Beck T. Zha H. Reed JC: R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J Cell Biol 1995:129: 1103-1114.
122. Gulbins E. Coggeshall KM. Brenner B. Schlottmann K. Linder-kamp O, Lang F: Fas-induccd apoptosis is mediated by activation of a Ras and Rac-protein regulated signaling pathway. J Biol Chem 1996; in press.
123. Nobes C. Hall A: Regulation and function of the Rho subfamily of small GTPascs. Curr Opin Genet Dev 1994:4:77-81.
124. Qiu RG. Chen J. McCormick F. Symons M: A role for Rho in Ras transformation. Proc Natl Acad Sci USA 1995;92:11781-11785.
125. Chant J, Stowers L: GTPase cascades choreographing cellular behavior: movement, morphogenesis. And more. Cell 1995:81:1 -4.
126. Adler V. Pincus M. Brandt-Rauf PW. Ronai Z: Complexes of p21Ras with Jun N-terminal kinase and Jun proteins. Proe Natl Acad Sci USA 1995:92:10585-10589.
127. Hockcnbcrry ON, Oltvai ZN. Yin XM. Milliman CL. Korsmeyer SJ: Bcl2 functions in an antoxidant pathway to prevent apoptosis. Cell 1993:75:241.
128. Bultke TM. Sandstrom PA: Redox regulation of programmed cell death in lymphocytes. Immunol Today 1994:15:7-10.
129. Kane DJ. Sarafian TA. Anton R. Hahn H. Butler Gralla E. Selvcr-stonc VJ. Ord T. Bredcscn DE: Bcl2-inhibition of neural death decreased generation of reactive oxygen species. Science 1993:262: 1274-1277.
130. Chiba T. Takahashi S. Sato N. Ishii S. Kikuchi K: Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur J Immunol 1996,26:1164-1169.
131. Urn HD. Orcnstein JM. Wahl SM: Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway. J Immunol 1996:156:3469-3477.
132. Hug H. Enari M. Nagata S: No requirement of reactive oxygen intermediates in Fas-mediated apoptosis. FEBS Lett 1994:351:311-313.
133. Clement MV. Stamenkovic 1: Superoxide anion is a natural inhibitor of Fas-mediated cell death. EM BO J 1996:15:216-225.
134. Jacobson MD. Raff M: Programmed cell death and Bcl-2 protection in very low oxygen. Nature 1995:374:814-816.
135. Oshimi Y. Miyazaki S: Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level. J Immunol 1995:154:599-609.
136. Rovere P. Clementi E. Ferrari M. Hcltai S. Sciorati C. Sabbadini MG. Rugarli C. Manfrcdi AA: CD95 Engagement releases calcium from intracellular stores of long term activated, apoptosis-prone gd T cells. J Immunol 1996: 156:4631-4637.
137. Gottlieb RA. Nordberg J. Sko-wronski E. Babior BM: Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci USA 1996:93:654-658.
138. Meiscnholder GW. Martin SJ. Green DR. Nordberg J. Babior BM. Gottlieb RA: Events in apoptosis: Acidification is downstream of protease activation and Bcl-2 protection. J Biol Chem 1996:271: 16260-16262.
139. Hawkins CJ. Vaux DL: Analysisof the role of bcl-2 in apoptosis. Immunol Rev 1994;142:127-139.
140. Hockcnberv DM: bcl-2 in cancer, development and apoptosis (review). J Cell Sci 1994:18(suppl): 51-55.
141. Itoh N. Tsujimoto Y, Nagata S: Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol 1993: 151:621-627.
142. Memon SA. Moreno MB. Petrak D. Zacharchuk CM: Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J Immunol 1995; 155:4644-4652.
143. Strasscr A. Harris AW. Huang DC. Krammer PH. Cory S: Bcl-2 and Fas/Apo-1 regulate distinct pathways to lymphocyte apoptosis. EMBOJ 1995:14:6136-6147.
144. Chiu VK. Walsh CM, Liu CC. Reed JC. Clark WR: Bcl-2 blocks dcgranulation but not fas-based cell-mediated cytotoxicity. J Immunol 1995:154:2023-2032.
145. Rodriguez I. Matsuura K. Khatib K. Reed JC. Nagata S. Vassalli P: A bcl-2 transgene expressed in hépatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med 1996:1996:1031-1036.
146. Lacronique V. Mignon A. Fabre M. Violett B. Rouquet N. Molina T. Porteau A. Henroin A. Bousca-ry D. Varlet P. Joulin V, Kahn A: Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nature Med 1996:2:80-86.
147. Schrôter M. Lowin B. Borner C. Tschopp J: Regulation of the Fas-(Apo-l/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2. Eur J Immunol 1995:25:3509-3513.
148. Armstrong RC. Aja T. Xiang J. Gaur S. Krebs J. Hoang K. Bai X, Korsmcyer SJ. Karancwsky DS. Fritz LC. Tomasclli K: Fas-in-duced activation of the cell death related protease CPP32 is inhibited by bcl-2 and by ICE family protease inhibitors. J Biol Chem 1996: 271:16850-16855.
149. Chinnaiyan AM. Orth K. O'Rourke K. Duan H. Poirier GG. Dixit VM: Molecular ordering of the cell death pathway. J Biol Chem 1996:271:4573-4576.