Opiate receptor-mediated mechanisms in the regulation of cerebral blood flow

Cerebrovascular and Brain Metabolism Reviews

Volumn 8, Issue 4, 1996, Pages 326-357

  Benyó, Zoltán ^a   Wahl, Michael ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Cerebral blood flow; Cerebral blood flow regulation; Opioids

Indexed keywords

OPIATE RECEPTOR;

BRAIN CIRCULATION; BRAIN LEVEL; HUMAN; PHYSIOLOGY; REVIEW;

BRAIN CHEMISTRY; CEREBROVASCULAR CIRCULATION; HUMANS; RECEPTORS, OPIOID;

EID: 0030346777     PISSN: 10408827     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (217)

1. Abbott NJ, Revest P. Control of brain endothelial permeability. Cerebrovasc Brain Metab Rev 1991;3:39-72.
2. Akil H, Watson SJ, Sullivan S, Barchas JD. Enkephalin-like material in normal human CSF: measurement and levels. Life Sci 1978;23:121-5.
3. Altura BT, Altura BM, Quirion R. Identification of benzomorphan-kappa opiate receptors in cerebral arteries which subserve relaxation. Br J Pharmacol 1984;82:459-66.
4. Altura BT, Quirion R, Pert CB, Altura BM. Phencyclidine ("angel dust") analogs and sigma opiate benzomorphans cause cerebral arterial spasm. Proc Natl Acad Sci USA 1983;80:865-9.
5. Armsread WM. Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs. Am J Physiol 1995;268:H226-32.
6. Armstead WM. Relationship between opioids and activation of phospholipase C and protein kinase C in brain injury induced pial artery vasoconstriction. Brain Res 1995;689:183-8.
7. Armstead WM. Role of vasopressin in altered pial artery responses to dynorphin and β-endorphin following brain injury. J Neurotrauma 1996;13:115-23.
8. 2-opioid eceptors to hypoxia-induced pial artery dilation in the newborn pig. J Cereb Blood Flow Metab 1995;15:539-46.
9. Armstead WM, Crofton JT, Share L, Mirro R, Zuckerman SL, Leffler CW. Influence of opioids on CSF vasopressin concentration in newborn pigs. Am J Physiol 1992;262:H862-7.
10. Armstead WM, Kurth CD. The role of opioids in newborn pig fluid percussion brain injury. Brain Res 1994;660:19-26.
11. Armstead WM, Mirro R, Busija DW, Desiderio DM, Leffler CW. Opioids in cerebrospinal fluid in hypotensive newborn pigs. Circ Res 1991;68:922-9.
12. Armstead WM, Mirro R, Busija DW, Leffler CW. Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets. J Cereb Blood Flow Metab 1991;11:380-7.
13. Armstead WM, Mirro R, Busija DW, Leffler CW. Prostanoids modulate opioid cerebrovascular responses in newborn pigs. J Pharmacol Exp Ther 1990;255:1083-9.
14. Armstead WM, Mirro R, Shibata M, Leffler CW. Prostanoids modulate opioid-induced increases in cerebrospinal fluid vasopressin concentration. Am J Physiol 1992;263:H1670-4.
15. Armstead WM, Mirro R, Zuckerman S, Busija DW, Leffler CW. The influence of opioids on local cerebral glucose utilization in the newborn pig. Brain Res 1992;571:97-102.
16. Armstead WM, Mirro R, Zuckerman SL, Leffler CW. Vasopressin modulates cerebrovascular responses to opioids in newborn pigs. J Pharmacol Exp Ther 1992;260:1107-12.
17. Artru AA, Steen PA, Michenfelder JD. Cerebral metabolic effects of naloxone administered with anesthetic and subanesthetic concentrations of halothane in the dog. Anesthesiology 1980;52:217-20.
18. Banks WA, Kastin AJ. Peptide transport systems for opiates across the blood-brain barrier. Am J Physiol 1990;259:E1-10.
19. Barjavel MJ, Bhargava HN. Effect of opioid receptor agonists on nitric oxide synthase activity in rat cerebral cortex homogenate. Neurosci Lett 1994;181:27-30.
20. Beckett AH, Casy AF. Synthetic analgesics: stereochemical considerations. J Pharm Pharmacol 1954;6:986-99.
21. 2 sensitivity of different brain regions. J Cereb Blood Flow Metab 1991;11:S272.
22. Benyó Z, Szabó C, Velkei MH, Bohus B, Wahl M, Sándor P. Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nitric oxide synthase activity. Peptides 1996;17:733-6.
23. Bernton EW, Long JB, Holaday JW. Opioids and neuropeptides: mechanisms in circulatory shock. Fed Proc 1985;44:290-9.
24. Bilfinger TV, Kushnerik V. The use of morphine in surgery: an overview. Adv Neuroimmunol 1994;4:133-44.
25. Bill A, Linder J. Sympathetic control of cerebral blood flow in acute arterial hypertension. Acta Physiol Scand 1976;96:114-21.
26. Blum K, Gaskill H, DeLallo L, Briggs AH, Hall W. Methionine enkephalin as a possible neuromodulator of regional cerebral blood flow. Experientia 1985;41:932-3.
27. Boisvert D. In vivo effect of nifedipine and naloxone on primate cerebral arterioles. J Cereb Blood Flow Metab 1983;3:S552-3.
28. Bradbury AF, Smyth DG, Snell CR, Birdsall NJM, Hulme EC. C fragment of lipotropin has a high affinity for brain opiate receptors. Nature 1976;260:793-5.
29. Brandt L, Andersson KE, Hindfelt B, Ljunggren B, Pickard JD. Are the vascular effects of naloxone attributable to the preservatives methyl- and propylparaben? J Cereb Blood Flow Metab 1983;3:395-8.
30. Brownstein MJ. A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci USA 1993;90:5391-3.
31. Bryan RM Jr. Cerebral blood flow and energy metabolism during stress. Am J Physiol 1990;259:H269-80.
32. Buchweitz E, Grandison L, Weiss HR. Effect of morphine on regional cerebral oxygen consumption and supply. Brain Res 1984;291:301-8.
33. Bunegin L, Albin MS, Ernst PS, Garcia C. Cerebrovascular responses to sufentanil citrate (SC) in primates with and without intracranial hypertension. J Neurosurg Anesthesiol 1989;1:138-9.
34. Carlsson C, Smith DS, Keykhah MM, Englebach I, Harp JR. The effects of high-dose fentanyl on cerebral circulation and metabolism in rats. Anesthesiology 1982;57:375-80.
35. Childers SR. Opioid receptor-coupled second messenger systems. Life Sci 1991;48:1991-2003.
36. Churchill L, Bausback HH, Gerritsen ME, Ward PE. Metabolism of opioid peptides by cerebral microvascular aminopeptidase M. Biochim Biophys Acta 1987;923:35-41.
37. Cornford EM, Braun LD, Crane PD, Oldendorf WH. Blood-brain barrier restriction of peptides and the low uptake of enkephalins. Endocrinology 1978;103:1297-303.
38. Cox BM. Endogenous opioid peptides: a guide to structures and terminology. Life Sci 1982;31:1645-58.
39. Crone C. The permeability of brain capillaries to non-electrolytes. Acta Physiol Scand 1965;64:407-17.
40. Davson H. A comparative study of the aqueous humour and cerebrospinal fluid in the rabbit. J Physiol (Lond) 1955;129:111-33.
41. DeGiulio PA, Roth RA, Mishra OP, Delivoria-Papadopoulos M, Wagerle LC. Effect of indomethacin on the regulation of cerebral blood flow during respiratory alkalosis in newborn piglets. Pediatr Res 1989;26:593-7.
42. Deli M, Bajenaru L, Maderspach K, Joó F. Kappa-opioid receptors in cultured cerebral endothelial cells. Neurochem Int 1992;21:C3.
43. Deliconstantinos G, Villiotou V Stavrides JC. Met-enkephalin receptor-mediated increase of membrane fluidity modulates nitric oxide (NO) and cGMP production in rat brain synaptosomes. Neurochem Res 1995;20:217-24.
44. Devine JO, Armstead WM. The role of nitric oxide in opioid-induced pial artery vasodilation. Brain Res 1995;675:257-63.
45. Dietrich HH, Dacey RG Jr. Effects of extravascular acidification and extravascular alkalinization on constriction and depolarization in rat cerebral arterioles in vitro. J Neurosurg 1994;81:437-42.
46. Dora E, Hines K, Kunos G, McLaughlin AC. Significance of an opiate mechanism in the adjustment of cerebrocortical oxygen consumption and blood flow during hypercapnic stress. Brain Res 1992;573:293-8.
47. Dunn AJ, Hurd RW. Regional glucose metabolism in mouse brain following ACTH peptides and naloxone. Pharmacol Biochem Behav 1982;17:37-41.
48. Edvinsson L, Owman C, Siesjö B. Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow. Brain Res 1976;117:519-23.
49. Ermisch A, Rühle H-J, Landgraf R, Hess J. Blood-brain barrier and peptides. J Cereb Blood Flow Metab 1985;5:350-7.
50. Erspamer V, Melchiorri P, Falconieri-Erspamer G. et al. Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc Natl Acad Sci USA 1989;86:5188-92.
51. 5]enkephalin on regional blood flow and vascular resistance in rabbits. Eur J Pharmacol 1987;137:25-31.
52. + channels and nitric oxide. Stroke 1994;25:1679-83.
53. Faraci FM, Brian JE Jr. Nitric oxide and the cerebral circulation. Stroke 1994;25:692-703.
54. Fowler CJ, Fraser GL. μ-, δ-, κ-opioid receptors and their subtypes. A critical review with emphasis on radioligand binding experiments. Neurochem Int 1994;24:401-26.
55. Freeman J, Ingvar DH. Effects of fentanyl on cerebral cortical blood flow and EEG in the cat. Acta Anaesthesiol Scand 1967;11:381-91.
56. Frost JJ, Dannals RF, Duelfer T, et al. In vivo studies of opiate receptors. Ann Neurol 1984;15:S85-92.
57. Fuller SA, Stein EA. Effects of heroin and naloxone on cerebral blood flow in the conscious rat. Pharmacol Biochem Behav 1991;40:339-44.
58. Furui T, Kageyama N, Haga T, Ichiyama A, Fukushima M. Radioreceptor assay of methionine-enkephalinlike substance in human cerebrospinal fluid. Pain 1980;9:63-72.
59. Can EA, Duckles SP Comparison of the pre-junctional effect of opioids in two blood vessels of the rabbit. Eur J Pharmacol 1988;158:21-8.
60. Geary WA, Woolen GF. Similar functional anatomy of spontaneous and precipitated morphine withdrawal. Brain Res 1985;334:183-6.
61. Golanov EV, Reis DJ. Oxygen-sensitive neurons of the rostral ventrolateral medulla (RVL) mediate hypoxic cerebrocortical vasodilation. J Cereb Blood Flow Metab 1995;15:S508.
62. Goldstein A, Barrett RW, James IF, et al. Morphine and other opiates from the beef brain and adrenal. Proc Natl Acad Sci USA 1985;82:5203-7.
63. Goldstein A, Fischli W, Lowney LI, Hunkapiller M, Hood L. Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. Proc Natl Acad Sci USA 1981;78:7219-23.
64. Grandison L, Buchweitz E, Weiss HR. Effect of naltrexone on regional brain oxygen consumption in the cat. Brain Res 1982;233:369-79.
65. Haffmans J, Heiligers J, Dzoljic MR, Saxena PR. Regional cerebral blood flow during enkephalin-induced seizures in the rat. Neuropharmacology 1986;25:361-5.
66. Hamel E, Edvinsson L, MacKenzie ET. Heterogenous vasomotor responses of anatomically distinct feline cerebral arteries. Br J Pharmacol 1988;94:423-36.
67. Hanko JH, Hardebo JE. Enkephalin-induced dilatation of pial arteries in vitro probably mediated by opiate receptors. Eur J Pharmacol 1978;51:295-7.
68. Hanley DF, Struble R, Wilson C, Kirsch J, Wilson D, Traystman RJ. VIP and leucine enkephalin in the canine pituitary. Fed Proc 1987;46:1070.
69. Hardebo JE, Suzuki N, Owman C. Dynorphin B is present in sensory and parasympathetic nerves innervating pial arteries. J Auton Nerv Syst 1994;47:171-6.
70. Harder DR, Madden JA. Cellular mechanisms of opiate receptor stimulation in cat middle cerebral artery. Eur J Pharmacol 1984;102:411-6.
71. Heistad DD, Marcus ML, eds. Cerebral blood flow, effect of nerves and neurotransmitters. New York: Elsevier North Holland, 1982.
72. Heistad DD, Marcus ML, Gross PM. Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey. Am J Physiol 1978;235:H544-52.
73. Hoehner PJ, Whitson T, Kirsch JR, Traystman RJ. Effect of intracarotid and intraventricular morphine on regional cerebral blood flow and metabolism in pentobarbital-anesthetized dogs. Anesth Analg 1993;76:266-73.
74. Hoffman WE, Cunningham F, James MK, Baughman VL, Albrecht RF. Effects of remifentanil, a new short-acting opioid, on cerebral blood flow, brain electrical activity, and intracranial pressure in dogs anesthetized with isoflurane and nitrous oxide. Anesthesiology 1993;79:107-13.
75. Hoffman WE, Werner C, Segil LJ, Edelman G, Miletich DJ. The effects of fentanyl with nitrous oxide on cerebral blood flow and autoregulation. J Neurosurg Anesthesiol 1990;2:226.
76. Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 1975;258:577-9.
77. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 1994;14:175-92.
78. Iadecola C, Zhang F. Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. Am J Physiol 1994;266:R546-52.
79. Iuvone T, Capasso A, D'Acquisto F, Carnuccio R. Opioids inhibit the induction of nitric oxide synthase in J774 macrophages. Biochem Biophys Res Commun 1995;212:975-80.
80. Jobes DR, Kennell E, Bitner R, Swenson E, Wollman H. Effects of morphine-nitrous oxide anesthesia on cerebral autoregulation. Anesthesiology 1975;42:30-4.
81. Jobes DR, Kennell EM, Bush GL, et al. Cerebral blood flow and metabolism during morphine-nitrous oxide anesthesia in man. Anesthesiology 1977;47:16-8.
82. Kapadia SE, de Lanerolle NC. Immunohistochemical and electron microscopic demonstration of vascular innervation in the mammalian brainstem. Brain Res 1984;292:33-9.
83. Kastin AJ, Nissen C, Schally AV, Coy DH. Blood-brain barrier, half-time disappearance, and brain distribution for labeled enkephalin and a potent analog. Brain Res Bull 1976;1:583-9.
84. Keykhah MM, Smith DS, Carlsson C, Safo Y, Englebach I, Harp JR. Influence of sufentanil on cerebral metabolism and circulation in the rat. Anesthesiology 1985;63:274-7.
85. Kirsch JR, Hanley DF, Wilson DA, Traystman RJ. Effect of centrally administered encephalinamides on regional cerebral blood flow in the dog. J Cereb Blood Flow Metab 1988;8:385-94.
86. Kitazono T, Faraci FM, Taguchi H, Heistad DD. Role of potassium channels in cerebral blood vessels. Stroke 1995;26:1713-23.
87. Klein RL, Duncan RW, Selva TJ, Kong JY, Thureson Klein AK. Neuronal and adrenal enkephalins and catecholamines in response to acute CNS ischemia and reserpine in pig. J Auton Nerv Syst 1990;30:37-62.
88. Knapp RJ, Malatynska E, Collins N, et al. Molecular biology and pharmacology of cloned opioid receptors. FASEB J 1995;9:516-25.
89. Knoll J. Neuronal peptide (enkephalin) receptors in the ear artery of the rabbit. Eur J Pharmacol 1976;39:403-7.
90. 5)-enkephalinamide and naloxone on pial vessels in cats. J Cereb Blood Flow Metab 1985;5:34-9.
91. Komjáti K, Harvich-Velkei M, Tóth J, Dallos, G, Nyáry I, Sándor P. Endogenous opioid mechanisms in hypothalamic blood flow autoregulation during haemorrhagic hypotension and angiotensin-induced acute hypertension in cats. Acta Physiol Scand 1996;157:53-61.
92. Komjati K, Sandor P, Reivich M. Effect of NOS blockade, opiate receptor blockade and their combination on steady state regional cerebral blood flow. J Cereb Blood Flow Metab 1995;15:S470.
93. 2-responsiveness. FASEB J 1995;9:A348.
94. Kong JY, Thureson Klein AK, Klein RL. Are NPY and enkephalins costored in the same noradrenergic neurons and vesicles? Peptides 1990;11:565-75.
95. 2, and bicarbonate on pial vessels. Stroke 1977;8:358-60.
96. Koskinen LO. Naloxone and TRH affect regional blood flows in the anesthetized rabbit. Peptides 1991;12:1273-7.
97. Koskinen LO, Bill A. Regional cerebral, ocular and peripheral vascular effects of naloxone and morphine in unanesthetized rabbits. Acta Physiol Scand 1983;119:235-41.
98. Kovách AGB, Szabó C, Faragó M, et al. Nitric oxide and global cerebral ischemia. In: Krieglstein J, Oberpichler-Schwenk H, eds. Pharmacology of cerebral ischemia. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH, 1992:395-408.
99. Krystal JH, Woods SW, Levesque M, Heninger C, Heninger GR. The effects of carbon dioxide inhalation on plasma MHPG, plasma hormones, respiratory rate and behavior in the rhesus monkey. Life Sci 1989;45:1657-63.
100. Ksoll E, Parsons AA, Mackert JRL, Schilling L, Wahl M. Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery. Naunyn Schmiedebergs Arch Pharmacol 1991;343:377-83.
101. Kuschinsky W, Wahl M. Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol Rev 1978;58:656-89.
102. Kuschinsky W, Wahl M, Bosse O, Thurau K. Perivascular potassium and pH as determinants of local pial arterial diameter in cats. A microapplication study. Circ Res 1972;31:240-7.
103. Lassen NA. Control of cerebral circulation in health and disease. Circ Res 1974;34:749-60.
104. Law WR, Ritzmann RF, Lee JM, Kapin MA, Ferguson JL. The effects of acute and chronic morphine on regional distribution of cardiac output in brain. Experientia 1985;41:78-80.
105. Leffler CW, Busija DW, Fletcher AM, Beasley DG, Hessler JR, Green RS. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Pediatr Res 1985;19:1160-4.
106. Li CH, Chung D. Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands. Proc Natl Acad Sci USA 1976;73:1145-8.
107. Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW. Endogenous opioid peptides: multiple agonists and receptors. Nature 1977;267:495-9.
108. Lu GP, Gibson JA, Frost EAM, Goldiner PL. Effects of alfentanil vs. sufentanil on brain microcirculation. J Neurosurg Anesthesiol 1989;1:165-6.
109. Lui F, Zhang C, Gelb AW. The cerebral vasoactive effects of fentanyl, sufentanil and alfentanil. J Neurosurg Anesthesiol 1990;2:221.
110. MacKenzie ET, McGeorge AP, Graham DI, Fitch W, Edvinsson L, Harper AM. Effects of increasing arterial pressure on cerebral blood flow in the baboon: influence of the sympathetic nervous system. Pflugers Arch 1979;378:189-95.
111. Madden A, Kalbfleisch JH, Harder DR. Distribution of excitatory junction potential amplitude in cat cerebral arteries: examination of its quantal nature and modulation by opiates. J Cell Physiol 1987;131:262-6.
112. Makman MH. Morphine receptors in immunocytes and neurons. Adv Neuroimmunol 1994;4:69-82.
113. Marson L, Kiritsy-Roy JA, Van Loon GR. μ-Opioid peptide modulation of cardiovascular and sympathoadrenal responses to stress. Am J Physiol 1990;257:R901-8.
114. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 1976;197:517-32.
115. Matsumiya N, Dohi S. Effects of intravenous or subarachnoid morphine on cerebral and spinal cord hemodynamics and antagonism with naloxone in dogs. Anesthesiology 1983;59:175-81.
116. Mayer N, Weinstabl C, Podreka I, Spiss CK. Sufentanil does not increase cerebral blood flow in healthy human volunteers. Anesthesiology 1990;73:240-3.
117. McCall ML, Taylor HW. The effects of morphine sulfate on cerebral circulation and metabolism in normal and toxemic pregnant women. Am J Obstet Gynecol 1952;64:1131-6.
118. McPherson RW, Traystman RJ. Fentanyl and cerebral vascular responsivity in dogs. Anesthesiology 1984;60:180-6.
119. 1 receptor. Nature 1995;377:532-5.
120. Michenfelder JD, Theye RA. Effects of fentanyl, droperidol, and innovar on canine cerebral metabolism and blood flow. Br J Anaesth 1971;43:630-6.
121. Milde LN, Milde JH, Gallagher WJ. Cerebral effects of fentanyl in dogs. Br J Anaesth 1989;63:710-5.
122. Milde LN, Milde JH, Gallagher WJ. Effects of sufentanil on cerebral circulation and metabolism in dogs. Anesth Analg 1990;70:138-46.
123. Miller RL, Forsyth RP, Melmon KL. Morphine-induced redistribution of cardiac output in the unanesthetized monkey. Pharmacology 1972;7:138-48.
124. Mollereau C, Parmentier M, Mailleux P, et al. ORL1, a novel member of the opioid receptor family. FEBS Lett 1994;341:33-8.
125. Monitto CL, Kurth CD. The effect of fentanyl, sufentanil, and alfentanil on cerebral arterioles in piglets. Anesth Analg 1993;76:985-9.
126. Morris ME, Millar RA. Blood pH/plasma catecholamine relationships: respiratory acidosis. Br J Anaesth 1962;34:672-81.
127. Moskowitz MA, Brezina LR, Kuo C. Dynorphin B-containing perivascular axons and sensory neurotransmitter mechanisms in brain blood vessels. Cephalalgia 1986;6:81-6.
128. Moskowitz MA, Saito K, Brezina L, Dickson J. Nerve fibers surrounding intracranial and extracranial vessels from human and other species contain dynorphin-like immunoreactivity. Neuroscience 1987;23:731-7.
129. Motavkin PA, Lomakin AV. Localization of leuencephalin in the cerebral stem of animals and man. Arkh Anat Gistol Embriol 1990;99:49-54.
130. Moyer JH, Pontius R, Morris G, Hershberger R. Effect of morphine and n-allylnormorphine on cerebral hemodynamics and oxygen metabolism. Circulation 1957;15:379-84.
131. Murr R, Berger S, Schürer L, Peter K, Baethmann A. Influence of isoflurane, fentanyl, thiopental, and α-chloralose on formation of brain edema resulting from a focal cryogenic lesion. Anesth Analg 1995;80:1108-15.
132. Naughton N, Hoffman WE, Larscheid P, Cook JM, Albrecht RF, Miletich DJ. A benzodiazepine antagonist inhibits the cerebral metabolic and respiratory depressant effects of fentanyl. Life Sci 1985;36:2239-45.
133. Nishimura J, Endo Y, Kimura F. Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone. Stroke 1992;23:1325-9.
134. North RA. Opioid receptor types and membrane ion channels. Trends Neurosci 1986;9:114-7.
135. Nyberg F, Terenius L. Endorphins in human cerebrospinal fluid. Life Sci 1982;31:1737-40.
136. Olsen GD, Hohimer AR, Mathis MD. Cerebral blood flow and metabolism during morphine-induced stimulation of breathing movements in fetal lambs. Life Sci 1983;33:751-4.
137. Pardridge WM, Mietus LJ. Enkephalin and blood-brain barrier: studies of binding and degradation in isolated brain microvessels. Endocrinology 1981;109:1138-43.
138. Parsons AA, Ksoll E, Mackert JRL, Schilling L, Wahl M. Comparison of cromakalim-induced relaxation of potassium precontracted rabbit, cat, and rat isolated cerebral arteries. Naunyn Schmiedebergs Arch Pharmacol 1991;343:384-92.
139. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 1990;2:161-92.
140. Peroutka SJ, Moskowitz MA, Reinhard JF, Snyder SH. Neurotransmitter receptor binding in bovine cerebral microvessels. Science 1980;208:610-2.
141. Pert CB, Snyder SH. Opiate receptor: demonstration in nervous tissue. Science 1973;179:1011-4.
142. Phillis JW. Cerebral vascular responses to hypoxia, hyper- and hypocapnia and hypotension. In: Phillis JW, ed. The regulation of cerebral blood flow. Boca Raton: CRC Press, 1993:249-65.
143. Phillis JW, DeLong RE, Towner JK. Naloxone enhances cerebral reactive hyperemia in the rat. Neurosurgery 1985;17:596-9.
144. Pickard JD. Role of prostaglandins and arachidonic acid derivatives in the coupling of cerebral blood flow to cerebral metabolism. J Cereb Blood Flow Metab 1981;1:361-84.
145. Pickel VM, Chan J. Met5-enkephalin is localized within axon terminals in the subfornical organ: vascular contacts and interactions with neurons containing gamma-aminobutyric acid. J Neurosci Res 1994;37:735-49.
146. Rapoport SI, Klee WA, Pettigrew KD, Ohno K. Entry of opioid peptides into the central nervous system. Science 1980;207:84-6.
147. Recio L, Marin J, Reviriego J, Salaices M, Lopez Rico M. Effect of morphine on the cat middle cerebral artery. Brain Res 1986;376:262-7.
148. Reid JM, Paterson DJ, Ashcroft FM, Bergel DH. The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anaesthetized rat. Pflugers Arch 1993;425:362-4.
149. Reinscheid RK, Nothacker H-P, Bourson A, et al. Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science 1995;270:792-4.
150. Reisine T, Pasternak G. Opioid analgesics and antagonists. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Oilman A, eds. The pharmacological basis of therapeutics. New York: McGraw-Hill, 1996:521-55.
151. 2 and cerebral hemodynamics. Am J Physiol 1964;206:25-35.
152. Rhee HM, Eulie P, Laughlin H. Effects of methionine enkephalin (met-enkephalin) on regional blood flow and vascular resistance: radioactive microsphere techniques. Adv Exp Med Biol 1988;222:665-74.
153. Safo Y, Keykhah M, Smith DS, et al. High doses of narcotics and narcotic antagonists alter cerebral blood flow in the rat. J Cereb Blood Flow Metab 1983;3:S538-9.
154. Safo Y, Young ML, Smith DS, et al. Effects of fentanyl on local cerebral blood flow in the rat. Acta Anaesthesiol Scand 1985;29:594-8.
155. Saito Y, Maruyama K, Saido TC, Kawashima S. N23K, a gene transiently up-regulated during neural differ-
156. entiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Biochem Biophys Res Commun 1995;217:539-45.
157. Sakurada O, Sokoloff L, Jacquet YF. Local cerebral glucose utilization following injection of β-endorphin into periaqueductal gray matter in the rat. Brain Res 1978;153:403-7.
158. Sandor P, Cox-van Put J, deJong W, deWied D. Continuous measurement of cerebral blood volume in rats with the photoelectric technique: effect of morphine and naloxone. Life Sci 1986;39:1657-65.
159. Sandor P, de Jong W, Barna I, Wiegant V, de Wied D. Disturbed hypothalamic blood flow autoregulation in the rat following hypophysectomy: a role of pituitary β-endorphin? Brain Res 1990;512:102-6.
160. Sándor P, de Jong W, de Wied D. Endorphinergic mechanisms in cerebral blood flow autoregulation. Brain Res 1986;386:122-9.
161. Sándor P, Demchenko IT, Morgalyov YN, Moskalenko YE, Kovách AG. Cerebral blood flow and tissue pO2 changes following local met-enkephalin administration in awake, freely moving cats. Acta Physiol Hung 1983;61:155-61.
162. 5)-enkephalinamide, and naloxone on cortical blood flow and cerebral blood volume in experimental brain ischemia in anesthetized cats. J Cereb Blood Flow Metab 1986;6:553-8.
163. 2-responsiveness. FASEB J 1995;9:A348.
164. 2-sensitivity of the cerebral and spinal cord vessels following general opiate receptor blockade by naloxone. J Endocrinol Invest 1991;14(suppl 4):231.
165. Sasaki T, Kassell NF, Turner DM, Coester HC. Comparison of the effect of naloxone on cerebral versus mesenteric arterial smooth muscle in feline and primate species. Stroke 1984;15:1025-8.
166. Sasaki T, Kassell NF, Turner DM, Maixner W, Torner JC, Coester HC. Effects of naloxone on canine cerebral vascular smooth muscle. J Cereb Blood Flow Metab 1984;4:166-72.
167. Sawynok J, Pinsky C, LaBella FS. Minireview on the specificity of naloxone as an opiate antagonist. Life Sci 1979;25:1621-32.
168. Schadt JC, Ludbrook J. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. Am J Physiol 1991;260:H305-18.
169. Schilling L, Parsons AA, Wahl M. Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat. J Neurosurg 1995;83:123-8.
170. + activity in the cortical subarachnoidal space of cats. Pflügers Arch 1977;372:103-7.
171. Schulz R, Faase E, Wüster M, Herz A. Selective receptors for β-endorphin on the rat vas deferens. Life Sci 1979;24:843-50.
172. + channels. Am J Physiol 1995;269:H997-1002.
173. Shigeno T, Teasdale GM, Kirkham D, Mendelow D, Graham DI, McCulloch J. Effect of naloxone on cerebral glucose metabolism in normal rats and rats with focal cerebral ischaemia. J Cereb Blood Flow Metab 1983;3:S528-9.
174. 3H]-etorphine to rat-brain homogenate. Proc Natl Acad Sci USA 1973;70:1947-9.
175. Solhonne B, Gros C, Pollard H, Schwartz J-C. Major localization of aminopeptidase M in rat brain microvessels. Neuroscience 1987;22:225-32.
176. Stefano GB, Scharrer B. Endogenous morphine and related opiates, a new class of chemical messengers. Adv Neuroimmunol 1994;4:57-67.
177. Sun PY, Zhang AZ. Dynorphin receptor in the blood vessel. Neuropeptides 1985;5:595-8.
178. Takeshita H, Michenfelder JD, Theye RA. The effects of morphine and N-allylnormorphine on canine cerebral metabolism and circulation. Anesthesiology 1972;37:605-12.
179. Terenius L. Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of rat cerebral cortex. Acta Pharmacol Toxicol (Copenh) 1973;32:317-20.
180. Thompson SE, Audus KL. Leucine-enkephalin metabolism in brain microvessel endothelial cells. Peptides 1994;15:109-16.
181. Thorogood MC, Armstead WM. Influence of brain injury on opioid-induced pial artery vasodilation. Am J Physiol 1995;269:H1776-83.
182. Thureson-Klein A, Kong JY, Klein RL. Enkephalin and neuropeptide Y in large cerebral arteries of the pig after ischemia and reserpine. Blood Vessels 1989;26:177-84.
183. Tian R, Vogel P, Lassen NA, Mulvany MJ, Andreasen F, Aalkjaer C. Role of extracellular and intracellular acidosis for hypercapnia-induced inhibition of tension of isolated rat cerebral arteries. Circ Res 1995;76:269-75.
184. Trajnor JR, Elliott J. δ-Opioid receptor subtypes and cross-talk with μ-receptors. Trends Pharmacol Sci 1993;14:84-5.
185. Trindle MR, Dodson BA, Rampil IJ. Effects of fentanyl versus sufentanil in equianesthetic doses on middle cerebral artery blood flow velocity. Anesthesiology 1993;78:454-60.
186. Trusk TC, Stein EA. Effect of intravenous heroin and naloxone on regional cerebral blood flow in the conscious rat. Brain Res 1987;406:238-45.
187. Turcani P, Gotoh F, Ishihara N, et al. Dual effect of naloxone on blood platelet aggregation and cerebral blood flow in gerbils. Thromb Res 1986;44:817-28.
188. Turner DM, Kassell NF, Sasaki T, Comair YG, Beck DO, Boarini DJ. High dose naloxone produces cerebral vasodilation. Neurosurgery 1984;15:192-7.
189. Turner DM, Kassell NF, Sasaki T, Comair YG, Beck DO, Klein SL. Cerebral and systemic vascular effects of naloxone in pentobarbital-anesthetized normal dogs. Neurosurgery 1984;14:276-82.
190. Turner DM, Kassell NF, Sasaki T, Comair YG, Boarini DJ, Beck DO. Effects of naloxone on cerebral blood flow and metabolism in isoflurane/nitrous oxide-anesthetized dogs. Neurosurgery 1984;14:688-96.
191. Uddman R, Edvinsson L. Neuropeptides in the cerebral circulation. Cerebrovasc Brain Metab Rev 1989;1:230-52.
192. Upton R, Grant C, Ludbrook G. An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep. J Cereb Blood Flow Metab 1994;14:680-8.
193. 2 response in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways. Circ Res 1988;62:1019-26.
194. Wahl M. Effects of enkephalins, morphine, and naloxone on pial arteries during perivascular microapplication. J Cereb Blood Flow Metab 1985;5:451-7.
195. Wahl M. Local chemical, neural, and humoral regulation of cerebrovascular resistance vessels. J Cardiovasc Pharmacol 1985;7:S36-46.
196. Wahl M. The effects of pinacidil and tolbutamide in feline pial arteries in situ. Pflügers Arch 1989;415:250-2.
197. Wahl M, Deetjen P, Thurau K, Ingvar DH, Lassen NA. Micropuncture evaluation of the importance of perivascular pH for the arteriolar diameter on the brain surface. Pflügers Arch 1970;316:152-63.
198. + activities for the adjustment of pial arterial diameter during changes of arterial blood pressure in cats. Pflügers Arch 1979;382:203-8.
199. Wahl M, Parsons AA, Schilling L. Dilating effect of perivascularly applied potassium channel openers cromakalim and pinacidil in rat and cat pial arteries in situ. Cardiovasc Res 1994;28:1803-7.
200. Wahl M, Schilling L. Regulation of cerebral blood flow - a brief review. Acta Neurochir 1993;59:3-10.
201. G-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats. Brain Res 1994;641:257-64.
202. Wang Q-P, Nakai Y. Immunoelectron microscopy of β-endorphinergic synaptic innervation of nitric oxide synthase immunoreactive neurons in the dorsal raphe nucleus. Brain Res 1995;684:185-93.
203. Waters A, Harder DR. Electromechanical coupling in rat basilar artery in response to morphine. Neurosurgery 1983;13:676-80.
204. Watson S, Girdlestone D. Receptor and ion channel nomenclature supplement. Trends Pharmacol Sci 1996;17:S51-2.
205. Wei EP, Kontos HA. Cerebrovascular flow regulation by adenosine. In: Phillis JW, ed. The regulation of cerebral blood flow. Boca Raton: CRC Press, 1993:281-95.
206. Werner C, Hoffman WE, Baughman VL, Albrecht RF, Schulte am Esch J. Effects of sufentanil on cerebral blood flow, cerebral blood flow velocity, and metabolism in dogs. Anesth Analg 1991;72:177-81.
207. West GA, Leppla DC, Simard JM. Effects of external pH on ionic currents in smooth muscle cells from the basilar artery of the guinea pig. Circ Res 1992;71:201-9.
208. Wilderman MJ, Armstead WM. Relationship between nitric oxide and opioids in hypoxia-induced pial artery vasodilation. Am J Physiol 1996;270:H869-74.
209. Wüster M, Schulz R, Herz A. Specificity of opioids towards the μ-, δ- and ε-opiate receptors. Neurosci Lett 1979;15:193-8.
210. Yaster M, Koehler RC, Traystman RJ. Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs. Anesthesiology 1987;66:524-30.
211. Yaster M, Koehler RC, Traystman RJ. Interaction of fentanyl and pentobarbital on peripheral and cerebral hemodynamics in newborn lambs. Anesthesiology 1989;70:461-9.
212. Young ML, Smith DS, Greenberg J, Reivich M, Harp JR. Effects of sufentanil on regional cerebral glucose utilization in rats. Anesthesiology 1984;61:564-8.
213. Young WL, Prohovnik I, Correll JW, et al. A comparison of the cerebral hemodynamic effects of sufentanil and isoflurane in humans undergoing carotid endarterectomy. Anesthesiology 1989;71:863-9.
214. 5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res 1985;336:125-32.
215. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem 1987;49:310-5.
216. Zlokovic BV, Mackic JB, Djuricic B, Davson H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J Neurochem 1989;53:1333-40.
217. Zlokovic BV, Segal MB, Davson H, Mitrovic DM. Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regul Pept 1988;20:33-44.