Intravenous β-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nihic oxide synthase activity

Peptides

Volumn 17, Issue 4, 1996, Pages 733-736

  Benyó, Zoltán ^a,b   Szabó, Csaba ^a,c   Velkei, Mária H ^a   Bohus, Béla ^d   Wahl, Michael ^b   Sándor, Péter ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b UNIVERSITY OF MUNICH   (Germany)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Endorphin; Cerebral blood flow autoregulation; Hypertension; Hypothalamus; N(G) Nitro L arginine methyl ester (L NAME); Nitric oxide synthase blockade; Rat

Indexed keywords

BETA ENDORPHIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; HYPERTENSION; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029934085     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(96)00065-4     Document Type: Article

References (23)

1. 1. Armstead, W. M.; Leffler, C. W. Neurohumoral regulation of the cerebral circulation. Proc. Soc. Exp. Biol. Med. 199:149-157; 1992.
2. 2. Armstead, W. M. Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs. Am. J. Physiol. 268:H226-H232; 1995.
3. 3. Arnal, J.-F.; Warin, L.; Michel J.-B. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 90:647-652; 1992.
4. 4. Aukland, K.; Bower, B. F.; Berliner R. W. Measurement of local blood flow with hydrogen gas, Circ. Res. 14:164-187; 1964.
5. 5. Benyó, Z.; Szabó, C.; Stuiver, B. T.; Bohus, B.; Sándor, P. Hypothalamic blood flow remains unaltered following chronic nitric oxide synthase blockade in rats. Neurosci. Lett. 198:127-130; 1995.
6. 6. Böger, R. H.; Bode-Böger, S. M.; Gerecke, U.; Frölich, J. C. Long term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats. Cardiovasc. Res. 28:494-499; 1994.
7. 7. Churchill, L.; Bausback, H. H.; Gerritsen, M. E.; Ward, P. E. Metabolism of opioid peptides by cerebral microvascular aminopeptidase M. Biochim. Biophys. Acta 923:35-41; 1987.
8. 8. Devine, J. O.; Armstead, W. M. The role of nitric oxide in opioid-induced pial artery vasodilation. Brain Res. 675:257-263; 1995.
9. 9. Guillemin, R.; Vargo, T.; Rossier, J.; et al. β-Endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197:1367-1369; 1977
10. 10. Hirsch, M. D.; Millington, W. R. Endoproteolytic conversion of β-endorphin-1-31 to β-endorphin-1-27 potentiates its central cardioregulatory activity, Brain Res. 550:61-68; 1991.
11. 11. Komjati, K.; Sandor, P.; Reivich, M. Effect of NOS blockade, opiate receptor blockade and their combination on steady state regional cerebral blood flow. J. Cereb. Blood Flow Metab. 15:S470;1995.
12. 12. Kovách, A. G. B.; Szabó, C.; Faragó, M.; et al. Nitric oxide and global cerebral ischemia. In: Krieglstein, J.; Oberpichler-Schwenk, H., eds. Pharmacology of cerebral ischemia. Stuttgart: Wissenschaftliche Verlagsgeseflschaft mbH; 1992:395-408.
13. 13. Lemaire, I.; Tseng, R.; Lemaire, S. Systemic administration of β-endorphin: Potent hypotensive effect involving a serotonergic pathway. Proc. Natl. Acad. Sci. USA 75:6240-6242; 1978.
14. 14. Oliver, C.; Mical, R. S.; Porter, J. C. Hypothalamic-pituitary vasculature: Evidence for retrograde blood flow in the pituitary stalk. Endocrinology 101:598-604; 1977.
15. 15. Page, R. B. Pituitary blood flow. Am. J. Physiol. 243:E427-E442; 1982.
16. 16. Pellegrino, L. J.; Pellegrino, S. A.; Cusham, A. A stereotaxic atlas of the rat brain. New York: Plenum; 1979.
17. 17. Rapoport, S. I.; Klee, W. A.; Pettigrew, K. D.; Ohno, K. Entry of opioid peptides into the central nervous system. Science 207:84-86; 1980.
18. 18. Sándor, P.; De Jong, W.; De Wied, D. Endorphinergic mechanisms in cerebral blood flow autoregulation. Brain Res. 386:122-129; 1986.
19. 19. Sándor, P.; De Jong, W.; Barna, I.; Wiegant, V.; De Wied, D. Disturbed hypothalamic blood flow autoregutation in the rat following hypophysectomy: A role of pituitary β-endorphin? Brain Res. 512:102-106; 1990.
20. 2-responsiveness. FASEB J. 9:A348; 1995.
21. 21. Schadt, J. C.; Ludbrook, J. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. Am. J. Physiol. 260:H305-H318; 1991.
22. 22. Sitsen, J. M. A.; Van Ree, J. M.; De Jong, W. Cardiovascular and respiratory effects of β-endorphin in anesthetized and conscious rats. J. Cardiovasc. Pharmacol. 4:883-888; 1982.
23. 23. Solhonne, B.; Gros, C.; Pollard, H.; Schwanz, J-C. Major localization of aminopeptidase M in rat brain microvessels. Neuroscience 22:225-232; 1987.