Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

Journal of Neurochemistry

Volumn 49, Issue 1, 1987, Pages 310-315

  Zloković, Berislav V ^a   Lipovac, Milo N ^a   Begley, David J ^a   Davson, Hugh ^a   Rakić, Ljubiša ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Blood brain barrier; Guinea pig; Leu enkephalin; Perfused brain; Transfer constant

Indexed keywords

ENKEPHALIN; LEUCINE ENKEPHALIN; LEUCINE ENKEPHALIN H 3; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL CELL; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; CENTRAL NERVOUS SYSTEM; GUINEA PIG; NONHUMAN; PERIPHERAL VASCULAR SYSTEM; PHARMACOKINETICS; PRIORITY JOURNAL;

BACITRACIN; BLOOD-BRAIN BARRIER; BRAIN; CAUDATE NUCLEUS; ENKEPHALIN, LEUCINE; FEMALE; HIPPOCAMPUS; KINETICS; MALE; NALOXONE; PARIETAL LOBE; TYROSINE;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0023220909     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1987.tb03431.x     Document Type: Article

References (37)

1. 3H‐Tyr]‐leucine enkephalin from rabbit cerebrospinal fluid
2. Neuropeptides and the blood‐brain barrier
3. Transport of α‐aminoisobutyric acid across brain capillary and cellular membranes
4. Blood‐brain barrier restriction of peptides and the low uptake of enkephalins
5. The permeability of brain capillaries to nonelectrolytes
6. The blood‐brain barrier
7. Ventriculo‐cisternal perfusion of twelve amino acids in the rabbit
8. Distinct subtypes of the opioid receptor with allosteric interactions in brain membranes.
9. Characterization of opioid receptor subtypes in solution.
10. High and low affinity transport of D‐gJucose from blood to brain
11. Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogues in vivo: a re‐examination
12. Enkephalins
13. Encephalinases
14. Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates
15. An aminopeptidase from bovine brain which catalyses the hydrolysis of enkephalin
16. Biogenesis, release and inactivation of enkephalins and endorphins
17. Significance and function of neuropeptides in cerebrospinal fluid
18. CNS actions of various hypothalamic‐pituitary peptides in animals and man
19. Blood‐brain barrier, half time disappearance, and brain distribution for labeled enkephalin and a potent analog.
20. Enkephalin and a potent analog facilitate maze performance after intraperitoneal administration in rats.
21. CNS effects of peripherally administered peptides
22. Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with receptors
23. Adenohypophysial hormones in the CSF
24. Endogenous opioid receptors: multiple agonists and receptors
25. Lower limits of cerebrovascular permeability to non‐electrolytes in the conscious rat
26. Brain uptake of radiolabelled amino acids, amines and hexoses after arterial injection
27. Amino acid assignment to one of three blood‐brain barrier carriers
28. Enkephalins and the blood‐brain barrier: studies of binding and degradation in isolated brain microvessels
29. Classification of opioid receptors
30. Graphical evaluation of blood to brain transfer constants from multiple time uptake data
31. Neuropharmacological actions of enkephalin after systemic administration
32. Entry of opioid peptides into the central nervous system
33. Blood‐brain barrier permeability to dipeptides and their constituent amino acids
34. 5‐enkephalin and their N‐terminal amino acid (tyrosine)
35. Measurement of solute transport across the blood‐brain barrier in the perfused guinea pig brain: method and application to N‐methyl‐α‐aminoisobutyric acid