Nitric oxide synthase inhibition and cerebrovascular regulation

Journal of Cerebral Blood Flow and Metabolism

Volumn 14, Issue 2, 1994, Pages 175-192

  Iadecola, Costantino ^a   Pelligrino, Dale A ^b   Moskowitz, Michael A ^c   Lassen, Niels A ^d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Cerebral blood flow; Cerebral ischemia; Functional activation; Hypercapnia; Hypoxia; Vasodilation

Indexed keywords

ARGININE; ARGININE METHYL ESTER; ENDOTHELIUM DERIVED RELAXING FACTOR; N(G) METHYLARGININE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

AUTOREGULATION; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN ISCHEMIA; BRAIN PERFUSION; HUMAN; HYPERCAPNIA; HYPOXIA; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; TOPICAL DRUG ADMINISTRATION; VASODILATATION;

EID: 0028153878     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.1994.25     Document Type: Review

References (155)

1. Adachi K, Kennedy C, Wang F, Takahashi S, Melzer P, Sokoloff L (1993) Effect of nitric oxide synthase inhibitors on increases in local cerebral blood flow induced by whisker stroking. J Cereb Blood Flow Metab Suppl 13:S152
2. Adachi T, Inanami O, Sato A (1992) Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats. Neurosci Lett 1939:201-204
3. Alafaci C, Tomasello F, Jansen I, You J, Edvinsson L (1993) The effect of L-NMMA, a specific inhibitor of endothelium-dependent relaxation, on vasodilatory responses in rat cerebral arteries. J Cereb Blood Flow Metab Suppl 13:S172
4. 2 reactivity of cerebral vessels? J Cereb Blood Flow Metab Suppl 13:S137
5. Archer S (1993) Measurement of nitric oxide in biological models. FASEB J 7:349-360
6. Archer SL, Hampl V (1992) NG-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise. Biochem Biophys Res Commun 188:590-596
7. Ashwal S, Cole DJ, Osborne TN, Pearce WJ (1993) Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model. J Neurosurg Anesth 5:241-249
8. Beckman JS (1991) The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J Dev Physiol 15: 53-59
9. Beckman JS, Conger K, Chen J (1993) Inhibition of nitric oxide synthesis reduces increased cerebral blood flow following bicuculline-induced seizures in rats. J Cereb Blood Flow Metab Suppl 13:S161
10. Berger C, von Kummer R, Gerlach L, Stingele R, Haag P (1993) Role of nitric oxide in local cerebral blood flow under hypoxic conditions. In: Proceedings of the "International Symposium on Cerebral Blood Vessels '93," Zao, Japan, May
11. Bogle RG, Moncada S, Pearson JD, Mann GE (1992) Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter. Br J Pharmacol 105:768-770
12. Bredt DS, Snyder SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033
13. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770
14. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351:714-718
15. Buchanan JE, Phillis JW (1993) The role of nitric oxide in the regulation of cerebral blood flow. Brain Res 610:248-255
16. Buisson A, Plotkine M, Boulu RG (1992) The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal ischemia. Br J Pharmacol 106:766-767
17. Buisson A, Margaill I, Verrecchia C, Callebert J, Guillou J, Plotkine M, Boulu RG (1993) Deleterious and protective modulatory role of nitric oxide during focal cerebral ischaemia. J Cereb Blood Flow Metab Suppl 13:S166
18. Busija DW, Leffler CW, Wagerle LC (1990) Mono-L-arginine-containing compounds dilate piglet pial arterioles via an endothelium-derived relaxing factor-like substance. Circ Res 67:1374-1380
19. Buxton IL, Cheek DJ, Eckman D, Westfall DP, Sanders KM, Keef KD (1993) NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res 72:387-395
20. Cosentino F, Sill JC, Katusic ZS (1993) Endothelial L-arginine pathway and relaxations to vasopressin in canine basilar artery. Am J Physiol 264:H413-H418
21. Dalkara T, Morikawa E, Moskowitz MA, Panahian N (1993) L-Arginine infusion induces functional recovery in a rat model of cerebral ischemia. Soc Neurosci Abstr 191 (part 1):849
22. Dauphin F, Lacombe P, Sercombe R, Hamel E, Seylaz J (1991) Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms. Brain Res 553:75-83
23. Dawson DA, Kusumoto K, Graham DI, McCulloch J, Macrae IM (1992) Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischemia. Neurosci Lett 142:151-154
24. Dawson VL, Dawson TM, Hartley DA, Uhl GR, Snyder SH (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661
25. Deal D, Colonna D, Busija D (1993) Nitric oxide (NO) promotes pial arteriolar dilation during cortical spreading depression (CSD) in anesthetized rabbits. FASEB J 7:A337 (abstr)
26. DeWitt DS, Prough DS, Colonna DM, Deal DD, Vines SM (1992) Nitric oxide inhibitors decrease cerebral blood flow but do not affect pressure autoregulation in rats. J Neurosurg Anesth 4:A303 (abstr)
27. DeWitt DS, Prough DS, Deal DD, Vines SM (1993) The nitric oxide synthase inhibitor L-NAME does not prevent cerebral vasodilation to hemodilution in rats. J Cereb Blood Flow Metab Suppl 13:S136
28. Dirnagl U, Lindauer U, Villringer A (1993a) Role of nitric oxide in the coupling of cerebral blood flow to neural activation in rats. Neurosci Lett 149:43-46
29. Dirnagl U, Lindauer U, Villringer A (1993b) Nitric oxide synthase blockade enhances vasomotion in the cerebral microcirculation of anesthetized rats. Microvasc Res 45:318-323
30. Duckrow RB (1993) A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Res 618:190-195
31. Dwyer MA, Bredt DS, Snyder SH (1991) Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem Biophys Res Commun 176:1136-1141
32. Edvinsson L, MacKenzie ET, McCulloch J (1993) Cerebral Blood Flow and Metabolism. New York, Raven Press
33. Fabricius M, Lauritzen M (1994) Examination of sources for nitric oxide modulating the hypercapnic rise of cerebral blood flow in rats. Am J Physiol (in press)
34. Faraci FM (1990) Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol 259:H1216-H1221
35. Faraci FM (1991) Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation. Am J Physiol 261:H1038-H1042
36. Faraci FM (1993) Regulation of the cerebral circulation by endothelium. Pharmacol Ther 56:1-22
37. Faraci FM, Breese KR (1993) Nitric oxide mediates vasodilation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res 72:476-480
38. Faraci FM, Breese KR, Heistad DD (1994) Nitric oxide contributes to dilatation of cerebral arterioles during seizures. Am J Physiol (in press)
39. Faraci FM, Breze K, Heistad DD (1994) Cerebral vasodilatation during hypercapnia: Role of nitric oxide and glibenclamide sensitive K+ channels. Exper Biol 94, Anaheim, CA (abst)
40. Forstermann U, Gorsky LD, Pollock JS, Schmidt HH, Heller M, Murad F (1990) Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochem Biophys Res Commun 168:727-732
41. Fujii K, Heistad DD, Faraci FM (1990) Vasomotion of basilar arteries in vivo. Am J Physiol 258:H1829-H1834
42. 2 tensions. Am J Physiol 258:H1049-H1054
43. Gally JA, Montague PR, Reeke GNJ, Edelman GM (1990) The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system. Proc Natl Acad Sci USA 87:3547-3551
44. Gaw AJ, Bevan JA (1993) Flow-induced relaxation of the rabbit middle cerebral artery is composed of both endothelium-dependent and -independent components. Stroke 24:105-110
45. Goadsby PJ, Hoskin KL (1993) Simultaneous continuous studies of flow and metabolism in hypercapnia, autoregulation and dynamic metabolic coupling. J Cereb Blood Flow Metab Suppl 13:S776
46. Goadsby PJ, Kaube H, Hoskin KL (1992) Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Res 595: 167-170
47. Gonzalez C, Estrada C (1991) Nitric oxide mediates the neurogenic vasodilation of bovine cerebral arteries. J Cereb Blood Flow Metab 11:366-370
48. Gotoh F, Fukuuchi Y, Amano T, Tanaka K, Uematsu D, Suzuki N, Kavamura J, Yamawaki T, Itoh N, Obara K (1987) Role of endothelium in responses of pial vessels to change in blood pressure and to carbon dioxide in cats. J Cereb Blood Flow Metab 7:S275
49. Gustafsson H, Mulvany MJ, Nilsson H (1993) Rhythmic contractions of isolated small arteries from rat: influence of the endothelium. Acta Physiol Scand 148:153-163
50. Hamberg LM, Huang Z, Hunter GJ, Caramia F, Moskowitz MA, Rosen BR (1993) Time effects of L-arginine on cerebral hemodynamics and ischemic volume during acute focal ischemia demonstrated by dynamic MRI. 12th Annual Scientific Meeting, Society for Magnetic Resonance in Medicine (abstr)
51. Harder DR (1987) Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium. Circ Res 60:102-107
52. Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR (1990) Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochem Biophys Res Commun 167:1037-1043
53. Heistad D, Kontos H (1983) Cerebral circulation. In: Handbook of Physiology: The Cardiovascular System (Abboud F, Shephard J, eds), Bethesda, MD, American Physiological Society, pp 137-182
54. Hudetz AG, Roman RJ, Harder DR (1992) Spontaneous flow oscillations in the cerebral cortex during acute changes in mean arterial pressure. J Cereb Blood Flow Metab 12:491-499
55. Iadecola C (1992a) Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia? Proc Natl Acad Sci USA 89:3913-3916
56. Iadecola C (1992b) Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus. Am J Physiol 263:R1156-R1161
57. Iadecola C (1993) Regulation of the cerebral microcirculation during neural activity: Is nitric oxide the missing link? Trends Neurosci 16:206-214
58. Iadecola C, Ebner T (1993) Focal elevations in local blood flow elicited by microstimulation of the parallel fiber system of the cerebellar cortex. J Cereb Blood Flow Metab Suppl 13:S122
59. Iadecola C, Xu X (1994) Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism. Am J Physiol (in press)
60. Iadecola C, Zhang F (1994) Nitric oxide-dependent and independent components of cerebrovasodilation elicited by hypercapnia. Am J Physiol (in press)
61. Iadecola C, Arneric S, Baker H, Tucker L, Reis D (1987) Role of local neurons in the cerebrocortical vasodilation elicited from cerebellum. Am J Physiol 252 (Regul Integral Comp Physiol 21):R1082-R1091
62. Iadecola C, Beitz AJ, Renno W, Xu X, Mayer B, Zhang F (1993a) Nitric oxide synthase-containing neural processes on large cerebral arteries and cerebral microvessels. Brain Res 606:148-155
63. Iadecola C, Zhang F, Xu X (1993b) Role of nitric oxide synthase-containing vascular nerves in cerebovasodilation elicited from cerebellum. Am J Physiol 264:R738-R746
64. Ichord RN, Helfaer MA, Kirsch JR, Wilson D, Traystman RJ (1994) Nitric oxide synthase inhibition attenuates hypoglycemic cerebral hyperemia in piglets. Am J Physiol (in press)
65. Irikura K, Rosenblatt S, Kontos HA, Moskowitz MA (1993) The effect of nitric oxide synthase (NOS) inhibition on pial arterial dilation produced by somatosensory stimulation and hypercapnia. J Cereb Blood Flow Metab Suppl 13:S132
66. Irikura K, Maynard KI, Moskowitz MA (1994) Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissae stimulation. J Cereb Blood Flow Metab 14:45-48
67. Iwamoto J, Yang SP, Yoshinaga M, Krasney E, Krasney J (1992a) N omega-nitro-L-argmine influences cerebral metabolism in awake sheep. J Appl Physiol 73:2233-2240
68. Iwamoto J, Yoshinaga M, Yang SP, Krasney E, Krasney J (1992b) Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep. J Appl Physiol 73:2226-2232
69. Kader A, Solomon RA, Trifiletti RR (1993) Nitric oxide production during focal cerebral ischemia. Stroke 24:4 (abstr)
70. Kastrup J, Bulow J, Lassen NA (1989) Vasomotion in human skin before and after local heating recorded by laser-Dop-pler flowmetry. Int J Microcirc Clin Exp 8:205-215
71. Katusic ZS, Shepherd JT, Vanhoutte PM (1987) Endothelium-dependent contraction to stretch in canine basilar arteries. Am J Physiol 252:H671-H673
72. Kim P, Franco L, Sasaki T, Kirino T, Takakura K, Nonomura Y (1993) Observation of myogenic rhythmic contractions of brain intraparenchymal arterioles and responsiveness to nitric oxide. J Cereb Blood Flow Metab Suppl 13:S151
73. Koenig HM, Pelligrino DA, Albrecht RF (1993a) Halothane vasodilatation and nitric oxide in rat pial vessels. J Neurosurg Anesth 5:264-271
74. Koenig HM, Pelligrino DA, Albrecht RF, Sharp A (1993b) Isoflurane: role of nitric oxide in rat pial vessel dilation. Anesth Analg 76:5190 (abstr)
75. Kovach AG, Szabo C, Benyo Z, Csaki C, Greenberg JH, Reivich M (1992) Effects of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat. J Physiol (Lond) 449:183-196
76. Kovach AGB, Balla I, Lohinai Z, Vass Z, Reivich M (1993) Effects of Ng-Nitro-L-arginine on rCBF and cerebrovascular reactivity in the cat. J Cereb Blood Flow Metab Suppl 13:S134
77. Kozniewska E, Oseka M, Stys T (1992) Effects of endothelium-derived nitric oxide on cerebral circulation during normoxia and hypoxia in the rat. J Cereb Blood Flow Metab 12:311-317
78. Kuluz JW, Prado RJ, Schlein CL, Watson BD (1993) The effect of nitric oxide synthase inhibition on infarct volume following reversible focal cerebral ischemia in conscious rats. Stroke 24:2023-2029
79. Kurosawa M, Sato A, Sato Y (1989) Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats. Neurosci Lett 98:45-50
80. Lassen NA (1964) Autoregulation of cerebral blood flow. Circ Res 14/15(Suppl 1):201-204
81. Lassen NA (1968) Brain extracellular pH: the main factor controlling cerebral blood flow. Scand J Clin Lab Invest 22:247-251
82. Lee TJ, Sarwinski SJ (1991) Nitric oxidergic neurogenic vasodilation in the porcine basilar artery. Blood Vessels 28:407-412
83. Lipton SA, Choi Y-B, Pan Z-H, Lei SZ, Vincent Chen H-S, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364:626-632
84. Malinski T, Bailey F, Zhang ZG, Chopp M (1993) Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 13:355-358
85. Marshall JJ, Wei EP, Kontos HA (1988) Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide. Am J Physiol (Heart Circ Physiol 24) 255:H847-H854
86. Mayhan WG (1992) Endothelium-dependent responses of cerebral arterioles to adenosine 5′-diphosphate. J Vasc Res 29: 353-358
87. Maynard KI, Rosenblatt S, Boccalini P, Moskowitz MA (1993) Nitric oxide synthase inhibition attenuates postocclusive cerebral hyperemia. J Cereb Blood Flow Metab Suppl 13:S37
88. McPherson RW, Kirsch JR, Moore LE, Traystman RJ (1993) Nω-Nitro-L-arginine methyl ester prevents cerebral hyperemia by inhalation anesthetics in dogs. Anesth Analg 77:891-897
89. McPherson RW, Koehler RC, Traystman RJ (1994) Hypoxia, α2-adrenergic and nitric oxide dependent interactions on canine cerebral blood flow. Am J Physiol (in press)
90. Mollace V, Bagetta G, Nistico G (1991) Evidence that L-arginine possesses proconvulsant effects mediated through nitric oxide. NeuroReport 2:269-272
91. Moncada S (1992) The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand 145:201-227
92. Moncada S, Lekieffre D, Arvin B, Meldrum B (1992) Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions. NeuroReport 3:530-532
93. Moore LE, Kirsch JR, Helfaer MA, Tobin JR, McPherson RW, Traystman RJ (1994) Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs. Anesthesiology (in press)
94. Morii S, Ngai AC, Ko KR, Winn HR (1987) Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. Am J Physiol 253:H165-H175
95. Morikawa E, Huang A, Moskowitz MA (1992a) L-Arginine decreases infarct size caused by middle cerebral arterial occlusion in SHR. Am J Physiol 263:H1632-H1635
96. Morikawa E, Rosenblatt S, Moskowitz MA (1992b) L-Arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. Br J Pharmacol 107:905-907
97. Morikawa E, Huang Z, Rosenblatt S, Yoshida T, Moskowitz MA (1994) Therapeutic potential of L-arginine, a precursor of nitric oxide, in focal ischemia. In: The human brain circulation (J Bevan, eds.), Harbor Basin Conference, Vermont, in press
98. Morita-Tsuzuki Y, Hardebo JE, Bouskela E (1993) Inhibition of nitric oxide synthase attenuates the cerebral blood flow response to stimulation of postganglionic parasympathetic nerves in the rats. J Cereb Blood Flow Metab 13:993-997
99. Murphy S, Simmons ML, Agullo L, Garcia A, Feinstein DL, Galea E, Reis DJ, Minc-Golomb D, Schwartz JP (1993) Synthesis of nitric oxide in CNS glial cells. Trends Neurosci 16:323-328
100. Nagafuji T, Matsui T, Koide T, Asano T (1992) Blockade of nitric oxide formation by N omega-nitro-L-arginine mitigates ischemic brain edema and subsequent cerebral infarction in rats. Neurosci Lett 147:159-162
101. Nakai M, Iadecola C, Ruggiero D, Tucker L, Reis D (1983) Electrical stimulation of cerebellar fastigial nucleus increases cerebrocortical blood flow without change in local metabolism: evidence for an intrinsic system in brain for primary vasodilation. Brain Res 260:35-49
102. Nathan C (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J 6:3051-3064
103. Ngai AC, Meno JR, Winn HR (1993) Effects of nitric oxide synthase inhibition on the pial dilator responses to hypercarbia and somatosensory stimulation. J Cereb Blood Flow Metab Suppl 13:S135
104. ω-nitro-L-arginine methyl ester attenuates caudate injury during focal ischemia in cats. J Cereb Blood Flow Metab Suppl 13:S154
105. Niwa K, Lindauer U, Villringer A, Dirnagl U (1993) Blockade of nitric oxide synthesis in rats strongly attenuates the CBF response to extracellular acidosis. J Cereb Blood Flow Metab 13:535-539
106. Northington FJ, Matherne GP, Berne RM (1992) Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation. Proc Natl Acad Sci USA 89:6649-6652
107. Nowicki JP, Duval D, Poignet H, Scatton B (1991) Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur J Pharmacol 204:339-340
108. Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH (1993) Possible origin and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. J Cereb Blood Flow Metab 13:70-79
109. Palmer R, Ashton D, Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664-666
110. Paulson OB, Strandgaard S, Edvinsson L (1990) Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2:161-192
111. Pearce WJ, Reynier-Rebuffel A-M, Lee J, Aubineau P, Ignarro L, Seylaz J (1990) Effect of methylene blue on hypoxic cerebral vasodilatation in the rabbit. J Pharmacol Exp Ther 254:616-625
112. Pelligrino DA, Koenig H, Albrecht RF (1993a) Nitric oxide synthesis and regional cerebral blood flow responses to hypercapnia and hypoxia in the rat. J Cereb Blood Flow Metab 13:80-87
113. Pellegrino DA, Koenig HM, Albrecht RF (1993b) The role of nitric oxide (NO) in cerebral arteriolar relaxation during hypoxia in the rat. Anesthesiology 79:A757
114. Peterson DA, Peterson DC, Archer S, Weir EK (1992) The non specificity of specific nitric oxide synthase inhibitors. Biochem Biophys Res Commun 187:797-801
115. Prado R, Watson B, Wester P (1993) Effects of nitric oxide synthase inhibition on cerebral blood flow following bilateral carotid occlusion and recirculation in the rat. J Cereb Blood Flow Metab 13:720-723
116. Raszkiewicz JL, Linville DG, Kerwin JFJ, Wagenaar F, Arneric SP (1992) Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation. J Neurosci Res 33:129-135
117. Raty SR, Bryan RM (1993) Measurement of cerebral blood flow during hypoglycemia in the rat using laser-Doppler: Effects of nitric oxide inhibition. Anesthesiology 79:A760.
118. Regidor J, Edvinsson L, Divac I (1993) NOS neurones lie near branchings of cortical arteriolae. NeuroReport 4:112-114
119. Rigaud AS, Pinard E, Charbonne R, Heron A, Seylaz J (1993) Crucial role of NO in the increase in cerebral blood flow during seizures. J Cereb Blood Flow Metab Suppl 13:S167
120. Rosenblum WI (1992) Endothelium-derived relaxing factor in brain blood vessels is not nitric oxide. Stroke 23:1527-1532
121. Rosenblum WI, Nishimura H, Nelson GH (1990) Endothelium-dependent L-Arg and L-NMMA-sensitive mechanisms regulate tone of brain microvessels. Am J Physiol 259:H1396-H1401
122. Rosenblum WI, Nelson GH, Shimizu T (1992) L-Arginine suffusion restores response to acetylcholine in brain arterioles with damaged endothelium. Am J Physiol 262:H961-H964
123. Saito S, Wilson DA, Hanley DF, Traystman RJ (1993) Nitric oxide modulates cerebral blood vessel tone and depresses cerebrovascular resistance changes to carbon dioxide in anesthetized dog. J Cereb Blood Flow Metab Suppl 13:S153
124. Sakuma I, Stuehr DJ, Gross SS, Nathan C, Levi R (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc Natl Acad Sci USA 85:8664-8667
125. 2 responsiveness of the cerebral and spinal cord vessels in the cat. J Cereb Blood Flow Metab 14:49-58
126. Sato S, Tominaga T, Ohnishi T, Ohnishi ST (1993) EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat. Biochim Biophys Acta 1181:195-197
127. Schmidt HH, Warner TD, Murad F (1992) Double-edged role of endogenous nitric oxide [letter]. Lancet 339:986
128. Seylaz J, Kara H, Pinard E, Mraovitch S, MacKenzie ET, Edvinsson L (1989) Cerebrovascular effects of stimulation and ablation of the sphenopalatine ganglion. J Cereb Blood Flow Metab 9(Suppl 1):S33
129. Snyder SH (1992) Nitric oxide: first in a new class of neurotransmitters. Science 257:494-496
130. Sokoloff L, Kennedy C, Adachi K, Wang S, Takahashi S, Melzer P (1992) Effects of inhibition of nitric oxide synthase on resting cerebral blood flow and on changes induced by hypercapnia or local functional activity. In: Pharmacology of Cerebral Ischemia (Krieglstein J, Oberpichler-Schwenk H, eds), Stuttgart, Wissenschaftliche Verlagsgesellschaft, pp. 371-381
131. Stamler JS, Singel DJ, Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898-1902
132. Stuehr DJ, Griffith OW (1992) Mammalian nitric oxide synthase. Adv Enzymol Relat Areas Mol Biol 65:287-346
133. Suzuki N, Fukuuchi Y, Koto A, Naganuma Y, Isozumi K, Matsuoka S, Gotoh J, Shimizu T (1993) Cerebrovascular NADPH Diaphorase-containing nerve fibers in the rat. J Cereb Blood Flow Metab Suppl 13:S115
134. Tanaka K, Gotoh F, Gomi S, Takashima S, Mihara B, Shirai T, Nogawa S, Nagata E (1991) Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat. Neurosci Lett 127:129-132
135. Tanaka K, Fukuuchi Y, Gomi S, Mihara B, Shirai T, Nogawa S, Nozaki H, Nagata E (1993) Inhibition of nitric oxide synthesis impairs autoregulation of local cerebral blood flow in the rat. Neuroreport 4:267-270
136. Thomas G, Ramwell PW (1992) Interaction of non-arginine compounds with the endothelium-derived relaxing factor inhibitor, NG-monomethyl L-arginine. J Pharmacol Exp Ther 260: 676-679
137. Toda N, Okamura T (1990) Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle. Biochem Biophys Res Commun 170:308-313
138. Toda N, Okamura T (1991) Role of nitric oxide in neurally induced cerebroarterial relaxation. J Pharmacol Exp Ther 258: 1027-1032
139. Toda N, Ayajiki K, Enokibori M, Okamura T (1993) Monkey cerebral arterial relaxation caused by hypercapnic acidosis and hypertonic bicarbonate. Am J Physiol 265:H929-H933
140. Trifiletti RR (1992) Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat. Eur J Pharmacol 218:197-198
141. Wahl M, Parsons AA, Schilling L, Kaumann AJ (1993) Reduction of pial arterial dilatation during cortical spreading depression by local application of an inhibitor of nitric oxide synthesis. J Cereb Blood Flow Metab Suppl 13:S177
142. Wang Q, Paulson OB, Lassen NA (1992a) Is autoregulation of cerebral blood flow in rats influenced by nitro-L-arginine, a blocker of the synthesis of nitric oxide. Acta Physiol Scand 145:297-298
143. Wang Q, Paulson OB, Lassen NA (1992b) Effect of nitric oxide blockade by NG-nitro-L-arginine on cerebral blood flow response to changes in carbon dioxide tension. J Cereb Blood Flow Metab 12:935-946
144. Wang Q, Kjaer T, Jorgensen MB, Paulson OB, Lassen NA, Diemer NH, Lou HC (1993a) Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats. Neurol Res 15:33-36
145. Wang Q, You JP, Jansen I, Edvinsson L, Paulson OB, Lassen NA (1993b) Mechanisms underlying effect of nitric oxide inhibition on hypercapnic vasodilation in isolated basilar arteries from rats. J Cereb Blood Flow Metab Suppl 13:S170
146. Wang Q, Paulson OB, Lassen NA (1993c) Indomethacin abolishes cerebral blood flow increases in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia. J Cereb Blood Flow Metab 13:724-727
147. Wang Q, Pelligrino DA, Koenig HM (1993d) The role of endothelium in rat pial arteriolar dilatory responses in vivo. Soc Neurosci Abstr 19 (part 1):1219
148. 2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine. Hypertension 16:162-169
149. Wei EP, Kukreja R, Kontos HA (1992) Effects in cats of inhibition of nitric oxide synthesis on cerebral vasodilation and endothelium-derived relaxing factor from acetylcholine. Stroke 23:1623-1628
150. Weissman BA, Kadar T, Brandeis R, Shapira S (1992) NG-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils. Neurosci Lett 146:139-142
151. Wilson DA, Hanley DF, Traystman RJ (1993) Neurally derived nitric oxide sets basal neurohypophyseal blood vessel tone. J Cereb Blood Flow Metab Suppl 13:S133
152. Xu X, Zhang F, Hu J, El-Fakahany EE, Iadecola C (1993) Long-lasting inhibition of brain nitric oxide synthesis by systemic administration of nitro-L-arginine methyl ester. Soc Neurosci Abstr 19 (part 1):1385
153. Yamamoto S, Golanov EV, Berger SB, Reis DJ (1992) Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J Cereb Blood Flow Metab 12:717-726
154. Zhang F, Iadecola C (1993) Nitroprusside improves blood flow and reduces brain damage after focal ischemia. NeuroReport 4:559-562
155. Zhang F, White JG, Iadecola C (1994) Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 14:217-226