Effects of indomethacin upon cerebral hemodynamics of newborn pigs

Pediatric Research

Volumn 19, Issue 11, 1985, Pages 1160-1164

  Leffler, Charles W ^a   Busija, David W ^a   Fletcher, Anthony M ^a   Beasley, Donathan G ^a   Hessler, Jack R ^a   Green, Robert S ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDOMETACIN; PROSTAGLANDIN E2; THROMBOXANE B2;

ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; ARTERIAL GAS; BLOOD AND HEMOPOIETIC SYSTEM; BLOOD BRAIN BARRIER; BLOOD FLOW; BRAIN BLOOD FLOW; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFICACY; HEART; HEART OUTPUT; HYPERCAPNIA; HYPEREMIA; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; NERVOUS SYSTEM; NEWBORN; NONHUMAN; PERIPHERAL VASCULAR SYSTEM; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; BLOOD-BRAIN BARRIER; CEREBROVASCULAR CIRCULATION; HEMODYNAMIC PROCESSES; HYPERCAPNIA; HYPEREMIA; INDOMETHACIN; PROSTAGLANDINS; SWINE;

EID: 0022227209     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/00006450-198511000-00009     Document Type: Article

References (43)

1. Crockard HA, Iannotti F, Ladds, G 1982 Cerebrovascular effects of prostaglandin inhibitors in the gerbil. J Cereb Blood Flow Metab 2:67-72
2. Pickard JD, MacKenzie ET 1973 Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide. Nature New Biol 245:187-118
3. Sakabe T, Siesjo BK 1979 The effect of indomethacin on the blood flow metabolism couple in the brain under normal, hypercapnic and hypoxic conditions. Acta Physiol Scand 107:283-284
4. Busija DW 1983 Role of prostaglandins in the response of the cerebral circulation to carbon dioxide in awake rabbits. J Cereb Blood Flow Metab 3:376-380
5. Busija DW, Heistad DD 1983 Effects of indomethacin on cerebral blood flow during hypercapnia in cats. Am J Physiol 244:H519-H524
6. Jackson EK, Gerkens JF, Zimmerman JB, Uderman HD, Oates JA, Workman RJ, Branch RA 1983 Prostaglandin biosynthesis does not participate in hypercapnia-induced cerebral vasodilation in the dog. J Pharmacol Exp Ther 226:486-492
7. Wei EP, Ellis EF, Kontos HA 1980 Role of prostaglandins in pial arteriolar response to C02 and hypoxia. Am J Physiol 238:H226-H230
8. Friedman WF, Hirschklau MJ, Printz MP, Pitlick PT, Kirkpatrick SE 1976 Pharmacologic closure of the patent ductus arteriosus in the premature infant. N Engl J Med 295:526-529
9. Green RS, Leffler CW 1984 Hypoxia stimulates prostacyclin synthesis by neonatal lungs. Pediar Res 18:832-835
10. Heymann MA, Rudolph AM 1976 Effect of acetylsalicylic acid on the ductus arteriosus and circulation in fetal lambs in utero. Circ Res 38:418-422
11. Heymann MA, Rudolph AM, Silverman NA 1976 Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 295:530-533
12. Leffler CW, Hessler JR, Green RS 1984 The onset of breathing at birth stimulates pulmonary vascular prostacyclin synthesis. Pediatr Res 18:938-942
13. Leffler CW, Tyler TL, Cassin S 1978 Effect of indomethacin on pulmonary vascular response to ventilation of fetal goats. Am J Physiol 234:H346-H351
14. Matson JR, Stokes JB, Robillard JE 1981 Effects of inhibition of prostaglandin synthesis on fetal renal function. Kidney Int 20:621-627
15. Millard RW, Baig H, Vatner SF 1979 Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero. Circ Res 45:12-179
16. Cifuentes RF, OUey PM, Balfe JW, Radde IC, Soldin SJ 1979 Indomethacin and renal function in premature infants with persistent patent ductus arteriosus. J Pediatr 95:583-587
17. Friedman WF, Kirkpatrick SE 1980 Effects of prostaglandins, thromboxanes and inhibitors of their synthesis on renal and gastrointestinal function in the newborn period. Sem Perinatol 4:143-156
18. Gersony WH, Peckham GJ, Ellison RI, Miettinen DS, Nadas AS 1983 Effects of indomethacin in premature infants with patent ductus arteriosus: Results of a national collaborative study. J Pediatr 102:895-906
19. Laptook AK, Stonestreet BS, Oh W 1983 The effect of carotid artery ligation on brain blood flow in newborn piglets. Brain Res 276:51-59
20. Leffler CW, Hessler JR, Green RS 1982 Surgery increases fetal plasma prostacyclin. Prostaglandins 24:387-396
21. Bedard MP, Kotagal UR, KJeinman LI 1983 Acute cardiovascular effects of indomethacin in anesthetized newborn dogs. Dev Pharmacol Ther 6:179-186
22. Ment LR, Stewart WB, Duncan CC 1984 Beagle puppy model of intraventricular hemorrhage: ethamsylate studies. Prostaglandins 27:245-256
23. Ment LR, Stewart WB, Duncan CC, Scott DT, Lambrecht R 1983 Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow. J Neurosurg 58:857-862
24. Kaapa P, Viinikka L, Ylikorkala O 1982 Plasma prostaglandin from birth to adolescence. Arch Dis Child 57:459-461
25. Fischer S, Scherer B, Weber PC 1982 Prostacyclin metabolites, in urine of adults and neonates, studied by gas chromatography and mass spectrometry and radioimmunoassay. Biochem Biophys Acta 710:493-501
26. Leffler CW, Hessler JR 1979 Pulmonary and systemic vascular effects of exogenous prostaglandin I2 in fetal lambs. Eur J Pharmacol 54:37-42
27. Leffler CW, Hessler JR 1981 Perinatal pulmonary prostaglandin production. Am J Physiol 241:H756-H759
28. Leffler CW, Hessler JR, Terragno NA 1980 Ventilation-induced release ofprostaglandin-like material from fetal lungs. Am J Physiol 238:H282-H286
29. Bensen DA, Lister G, Heymann MA, Rudolph A 1977 Effects of indomethacin on renal function in newborn lambs. Circulation 56:192(abstr)
30. Robillard JE, Weitzman RE, Burmeister L, Smith FS 1981 Developmental aspects of the renal response to hypoxemia in the lamb fetus. Circ Res 48:128-138
31. Chapnic BM, Paustian PW, Klainer E, Joiner PD, Hyman AL, Kadowitz PJ 1972 Influence of prostaglandins E, A and F on vasoconstrictor responses to norepinephrine, renal nerve stimulation and angiotensin in the feline kidney. J Pharmacol Exp Ther 196:44-52
32. Hedqvist P 1976 Prostaglandin action on transmitter release of adrenergic neuroeffector junctions. Adv Prostagl Thrombox Res 1:357-363
33. Kadowitz PJ, Sweet CS, Brody MJ 1971 Blockade of adrenergic vasoconstrictor responses in the dog by prostaglandins E, and A,. J Pharmacol Exp Ther 179:563-572
34. Malik KU, McGiff JC 1975 Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney. Circ Res 36:599-609
35. Wilson DA, O’Niell JT Said SI, Traystman JR 1981 Vasoactive intestinal polypeptide and the canine cerebral circulation. Circ Res 48:138-148
36. Weser U, Sellinger KH, Lengfelder E, Werner W, Strahle J 1980 Structure of Cu2 (Indomethacin) and the reaction with superoxide in aprotic systems. Biochim Biophys Acta 631:232-245
37. Kontos HA, Wei EP, Povlishock JT, Christman CW 1984 Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats. Circ Res 55:295-303
38. Burch RM, Wise WC, Halushka PV 1983 Prostaglandin-independent inhibition of calcium transport by nonsteroidal anti-inflammatory drugs: differential effects of carboxylic acids and piroxican. J Pharmacol Exp Therap 227:84-91
39. Northover BJ 1977 Indomethacin—a calcium antagonist. Gen Pharmacol 8:293-296
40. Erman A, Schwartzman M, Raz A 1980 Indomethacin but not aspirin inhibits basal and stimulated lipolysis in rabbit kidney. Prostaglandins 20:689-702
41. Franson RC, Eisen D, Jesse R, Lanni C 1980 Inhibition of highly purified mammalian phospholipases A2 by non-steroidal anti-inflammatory agents. Modulation by calcium ions. Biochem J 186:633-636
42. Kaplan L, Weiss J, Elsbach P 1978 Low concentrations of indomethacin inhibit phospholipase A2 of rabbit polymorphonuclear leukocytes. Proc Natl Acad Sci (USA) 75:2955-2958
43. Kantor HS, Hampton M 1978 Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase. Nature 276:841-842