Thrombopoietin, a direct stimulator of viability and multilineage growth of primitive bone marrow progenitor cells

Stem Cells

Volumn 14, Issue SUPPL. 1, 1996, Pages 173-180

  Jacobsen, Sten Eirik W ^a   Borge, Ole J ^a   Ramsfjell, Veslemøy ^a   Cui, Li ^a   Cardier, José E ^a   Veiby, Ole P ^a   Murphy Jr , Martin J ^a   Lok, Si ^b  

^a Cancer Prevention Institute Dayton   (United States)

^b ZYMOGENETICS INC   (United States)

Author keywords

Apoptosis; flt3 ligand; Kit ligand; Murine; Proliferation; Stem cells; Thrombopoietin

Indexed keywords

FLT3 LIGAND PROTEIN; INTERLEUKIN 3; MEMBRANE PROTEIN; STEM CELL FACTOR; THROMBOPOIETIN;

ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; BONE MARROW CELL; CELL DIVISION; CELL SURVIVAL; HEMATOPOIETIC STEM CELL; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW; THROMBOCYTE;

ANIMALS; APOPTOSIS; BLOOD PLATELETS; BONE MARROW CELLS; CELL DIVISION; CELL SURVIVAL; HEMATOPOIETIC STEM CELLS; INTERLEUKIN-3; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; STEM CELL FACTOR; THROMBOPOIETIN;

EID: 0030307591     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.5530140722     Document Type: Article

References (57)

1. Spangrude GJ, Smith L, Uchida N et al. Mouse hematopoietic stem cells. Blood 1991;78:1395-1402.
2. Metcalf D. Hematopoietic regulators: redundancy or subtlety. Blood 1993;82:3515-3523.
3. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993;81:2844-2853.
4. Lyman SD. Biology of flt3 ligand and receptor. Int J Hematol 1995;62:63-73.
5. Jacobsen SEW, Okkenhaug C, Myklebust J et al. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. J Exp Med 1995;181:1357-1363.
6. Moore MAS. Clinical implications of positive and negative hematopoietic stem cell regulators. Blood 1991;78:1-19.
7. Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 1994;91:11104-11108.
8. Sohma Y, Akahori H, Seki N et al. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 1994;353:57-61.
9. Bartley TD, Bogenberger J, Hunt P et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994;77:1117-1124.
10. Lok S, Kaushansky K, Holly RD et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994;369:565-568.
11. de Sauvage FJ, Hass PE, Spencer SD et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994;369:533-538.
12. Wendling F, Maraskovsky E, Debili N et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994;369:571-574.
13. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995;86:419-431.
14. Gurney AL, Carver-Moore K, de Sauvage FJ et al. Thrombocytopenia in c-mpl-deficient mice. Science 1994;265:1445-1447.
15. Kaushansky K, Lok S, Holly RD et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994;369:568-571.
16. Broudy VC, Lin NL, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995;85:1719-1726.
17. Debili N, Wendling F, Katz A et al. The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 1995;86:2516-2525.
18. Methia N, Louache F, Vainchenker W et al. Oligodeoxynucleotides antisense to the protooncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993;82:1395-1401.
19. Zeigler FC, de Sauvage F, Widmer HR et al. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994;84:4045-4052.
20. Berardi AC, Wang A, Levine JD et al. Functional isolation and characterization of human hematopoietic stem cells. Science 1995;267:104-108.
21. Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988;241:58-62.
22. Li CL, Johnson GR. Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization. Blood 1995;85:1472-1479.
23. Heimfeld S, Hudak S, Weissman IL et al. The in vitro response of phenotypically defined mouse stem cells and myeloerythroid progenitors to single or multiple growth factors. Proc Natl Acad Sci USA 1991;88:9902-9906.
24. Uchida N, Fleming WH, Alpern EJ et al. Heterogeneity of hematopoietic stem cells. Curr Opin Immunol 1993;5:177-184.
25. + hemopoietic stem cells. J Exp Med 1992;175:1443-1447.
26. Randall TD, Lund FE, Howard MC et al. Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood 1996;87:4057-4067.
27. Trevisan M, Iscove NN. Phenotypic analysis of murine long-term hematopoietic reconstituting cells quantitated competitively in vivo and comparison with more advanced colony-forming progeny. J Exp Med 1995;181:93-103.
28. Borge OJ, Ramsfjell V, Veiby OP et al. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood 1996 (in press).
29. Ramsfjell V, Borge OJ, Veiby OP et al. Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. Blood 1996 (in press).
30. Jacobsen FW, Stokke T, Jacobsen SE. Transforming growth factor-β potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells. Blood 1995;86:2957-2966.
31. Veiby OP, Lyman SD, Jacobsen SEW. Combined signaling through IL-7 receptor and flt3 but not c-kit potently and selectively promotes B cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. Blood 1996;88:1256-1265.
32. Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA 1992;89:1502-1506.
33. Li CL, Johnson GR. Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells. Blood 1994;84:408-414.
34. Katayama N, Clark SC, Ogawa M. Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors. Blood 1993;81:610-616.
35. Rasko JE, Metcalf D, Rossner MT et al. The flt3/flk-2 ligand: receptor distribution and action on murine haematopoietic cell survival and proliferation. Leukemia 1995;9:2058-2066.
36. Jacobsen FW, Veiby OP, Stokke T et al. TNF-α bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro. J Immunol 1996;157:1193-1199.
37. Sawada K, Krantz SB, Kans JS et al. Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin. J Clin Invest 1987;80:357-366.
38. Youssoufian H, Longmore G, Neumann D et al. Structure, function, and activation of the erythropoietin receptor. Blood 1993;81:2223-2236.
39. Bodine D, Crosier P, Clark SC. Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture. Blood 1991;78:914-920.
40. Itoh Y, Ikebuchi K, Hirashima K. Interleukin-3 and granulocyte colony-stimulating factor as survival factors in murine hemopoietic stem cells in vitro. Int J Hematol 1992;55:139-145.
41. 0 and entry into the cell cycle of primitive human hemopoietic progenitors. Proc Natl Acad Sci USA 1992;89:4013-4017.
42. Sasaki H, Hirabayashi Y, Inoue T et al. Promotion of survival and proliferation by interleukin 3, kit-ligand and erythropoietin on early and late appearing spleen colony forming units in culture. STEM CELLS 1993;11:555-561.
43. Keller JR, Ortiz M, Ruscetti FW. Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division. Blood 1995;86:1757-1764.
44. Wineman JP, Nishikawa S, Muller-Sieburg CE. Maintenance of high levels of pluripotent hematopoietic stem cells in vitro: effect of stromal cells and c-kit. Blood 1993;81:365-372.
45. Zeigler FC, Bennett BD, Jordan CT et al. Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells. Blood 1994;84:2422-2430.
46. Brandt JE, Bhalla K, Hoffman R. Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells. Blood 1994;83:1507-1514.
47. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993;53:1945-1951.
48. Ku H, Yonemura Y, Kaushansky K et al. Thrombopoietin, the ligand for the MPL receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996;87:4544-4551.
49. Sitnicka E, Lin N, Priestley GV et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996;87:4998-5005.
50. Kaushansky K, Broudy VC, Grossmann A et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 1995;96:1683-1687.
51. Kobayashi M, Laver JH, Kato T et al. Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood 1995;86:2494-2499.
52. -) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med 1996;183:2551-2558.
53. de Sauvage FJ, Carver-Moore K, Luoh S et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996;183:651-656.
54. Warren SA, Roberts AW, Nicola NA et al. Deficiencies in progentior cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 1996;87:2162-2170.
55. Hokom MM, Lacey D, Kinstler OB et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 1995;86:4486-4492.
56. Farese AM, Hunt P, Granb LB et al. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasias. J Clin Invest 1996;97:2145-2151.
57. Veiby OP, Jacobsen FW, Cui L et al. The Flt3 ligand promotes survival of primitive hematopoietic progenitor cells with myeloid as well as B-lymphoid potenetial: suppression of apoptosis and counteraction by TNF-α and TGF-β. J Immunol 1996 (in press).