β-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain

Journal of Immunology

Volumn 152, Issue 10, 1994, Pages 5050-5059

  Jiang, Haixiang ^a,b   Burdick, Debra ^a   Glabe, Charles G ^a   Cotman, Carl W ^a   Tenner, Andrea J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; COLLAGEN; COMPLEMENT COMPONENT C1Q;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CELL INTERACTION; COMPLEMENT FIXATION; COMPLEMENT SYSTEM; DRUG ACTIVATION; HUMAN; HUMAN CELL; MACROMOLECULE; PRIORITY JOURNAL; PROTEIN DOMAIN; SENILE PLAQUE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; BINDING SITES; COLLAGEN; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 0028178458     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Miller, D. L., I. A. Papyannopoulos, J. Styles, S. Bobin, Y. Lin, K. Biemann, and K. Iqbal. 1993. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits in Alzheimer's disease. Arch. Biochem. Biophys. 301:41.
2. Roher, A. E., J. D. Lowenson, S. Clarke, C. Wolkow, R. Wang, R. J. Cotter, I. M. Reardon, H. A. Zurcher-Neely, R. L. Heinrikson, M. J. Ball, and B. D. Greenberg. 1993. Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J. Biol. Chem. 268:3072.
3. Kang, J., H. G. Lemaire, A. Unterbeck, J. M. Salbaum, C. L. Masters, K. H. Grzeschik, G. Multhaup, K. Beyreuther, and B. Muller-Hill. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733.
4. Pike, C. J., D. Burdick, A. J. Walencewicz, C. G. Glabe, and C. W. Cotman. 1993. Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13:1676.
5. Mattson, M. P., B. Cheng, D. Davis, K. Bryant, I. Lieberburg, and R. E. Rydel. 1992. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:376.
6. Nitsch, R. M., J. K. Blusztajn, A. G. Pittas, B. E. Slack, J. H. Growdon, and R. J. Wurtman. 1992. Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci. USA 89:1671.
7. Koh, J. Y., L. L. Yang, and C. W. Cotman. 1990. β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533:315.
8. Eikelenboom, P., and F. C. Stam. 1982. Immunoglobulins and complement factors in senile plaques. Acta Neuropathol. 57:239.
9. Berkenbosch, F., J. Biewenga, M. Brouns, J. M. Rozemuller, P. Strijbos, and A. M. van Dam. 1992. Cytokines and inflammatory proteins in Alzheimer's disease. Res. Immunol. 143:657.
10. McRae, A., and A. Dahlstrom. 1992. Cerebrospinal fluid antibodies: an indicator for immune responses in Alzheimer's disease. Res. Immunol. 143:663.
11. Eikelenboom, P., J. M. Rozemuller, G. Kraal, F. C. Stam, P. A. McBride, M. E. Bruce, and H. Fraser. 1991. Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process. Virchows Archiv B Cell Pathol. 60:329.
12. Ishii, T., and S. Haga. 1984. Immuno-electron-microscopic localization of complement in amyloid fibrils of senile plaques. Acta Neuropathol. 63:296.
13. Rogers, J., N. R. Cooper, S. Webster, J. Schultz, P. L. McGeer, S. D. Styren, W. H. Civin, L. Brachova, B. Bradt, P. Ward, and I. Lieberburg. 1992. Complement activation by β-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 89:10016.
14. McGeer, P. L., H. Akiyama, S. Itagaki, and E. G. McGeer. 1989. Immune system response in Alzheimer's disease. Can. J. Neurol. Sci. 16:516.
15. Johnson, S. A., M. Lampert-Etchells, G. M. Pasinetti, I. Rozovsky, and C. Finch. 1992. Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiol. Aging 13:641.
16. Levi-Strauss, M., and M. Mallat. 1987. Primary cultures of murine astrocytes produce C3 and Factor B, two components of the alternative pathway of complement activation. J. Immunol. 139:2361.
17. Haga, S., K. Ikeda, M. Sato, and T. Ishii. 1993. Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res. 601:88.
18. Reid, K. B. M., J. Gagnon, and J. Frampton. 1982. Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement. Biochem. J. 203:559.
19. Porter, R. R., and K. B. M. Reid. 1978. The biochemistry of complement. Nature 275:699.
20. Cooper, N. R. 1985. The classical complement pathway: activation and regulation of the first complement component. Adv. Immunol. 37:151.
21. Jiang, H., F. A. Robey, and H. Gewurz. 1992. Localization of sites through which CRP binds and activates complement to residues 14-26 and 76-92 of the human C1q A chain. J. Exp. Med. 175:1373.
22. Jiang, H., B. Cooper, F. A. Robey, and H. Gewurz. 1992. DNA binds and activates complement via a specific sequence on the human C1q A chain. J. Biol. Chem. 267:25597.
23. Ying, S.-C, A. T. Gewurz, H. Jiang, and H. Gewurz. 1993. Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q. J. Immunol. 150:169.
24. Tenner, A. J., P. H. Lesavre, and N. R. Cooper. 1981. Purification and radiolabeling of human C1q. J. Immunol. 127:648.
25. Young, K. R., J. L. Ambrus, Jr., A. Malbran, A. S. Fauci, and A. J. Tenner. 1991. Complement subcomponent C1q stimulates immunoglobulin production by human B lymphocytes. J. Immunol. 146:3356.
26. Reid, K. B. M. 1976. Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent C1q of the first component of human complement. Biochem. J. 155:5.
27. Siegel, R. C., and V. N. Schumaker. 1983. Measurement of the association constants of the complexes formed between intact C1q or pepsin-treated C1q stalks and the unactivated or activated C1r2C1s2 tetramers. Mol. Immunol. 20:53.
28. Reid, K. B. M., R. B. Sim, and A. P. Faiers. 1977. Inhibition of the reconstitution of the haemolytic activity of the first component of human complement by a pepsin-derived fragment of subcomponent C1q. Biochem. J. 161:239.
29. Sellar, G. C., D. J. Blake, and K. B. M. Reid. 1991. Characterization and organization of the genes encoding the A-, B-, and C-chains of human complement subcomponent C1q. Biochem. J. 274:481.
30. Glabe, C. G. 1990. Semiautomatic synthesis of large peptides with a continuous flow instrument using FMOC-amino acid chemistry. Technique 2:138.
31. Burdick, D., B. Soreghan, M. Kwon, J. Kosmoski, M. Knauer, A. Henschen, J. Yates, C. Cotman, and C. Glabe. 1992. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267:546.
32. Mayer, M. M. 1961. Complement and complement fixation. In Experimental Immunochemistry, 2nd ed. E. A. Kabat and M. M. Mayer, eds. Thomas, Springfield, IL, p. 133.
33. Jiang, H., Y. B. Kim, and H. Gewurz. 1994. Endotoxin activates the classical complement pathway via residues 14-26 of the C1q A chain, and peptide 14-26 inhibits this activation. J. Clin. Invest. In press.
34. Eikelenboom, P., C. E. Hack, J. M. Rozemuller, and F. C. Stam. 1989. Complement activation in amyloid plaques in Alzheimer's dementia. Virchows Arch. B Cell Pathol. 56:259.
35. Tomski, S. J., and R. M. Murphy. 1992. Kinetics of aggregation of synthetic β-amyloid peptide. Arch. Biochem. Biophys. 294:630.
36. Barrow, C. J., A. Yasuda, P. T. Kenny, and M. G. Zagorski. 1992. Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease: analysis of circular dichroism spectra. J. Mol. Biol. 225:1075.
37. Jarrett, J. T., E. P. Berger, and P. T. J. Lansbury. 1993. The carboxyl terminus of the β-amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693.
38. Kowall, N. W., A. C. McKee, B. A. Yankner, and M. F. Beal. 1992. In vivo neurotoxicity of β-amyloid [β(1-40)] and the β(25-35) fragment. Neurobiol. Aging 13:537.
39. Frank, M. M., and L. F. Fries. 1991. The role of complement in inflammation and phagocytosis. Immunol. Today 12:322.
40. Weisman, H. F., T. Bartow, M. K. Leppo, Jr. H. C. Marsh, G. R. Carson, M. F. Concino, M. P. Boyle, K. H. Roux, M. L. Weisfeldt, and D. T. Fearon. 1990. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249:146.
41. Perry, V. H., and S. Gordon. 1991. Macrophages and the nervous system. Int. Rev. Cytol. 125:203.
42. Lee, S. C., W. Liu, D. W. Dickson, C. F. Brosnan, and J. W. Berman. 1993. Cytokine production by human fetal microglia and astrocytes. J. Immunol. 150:2659.
43. Perry, V. H., P.-B. Andersson, and S. Gordon. 1993. Macrophages and inflammation in the central nervous system. Trends Neurosci. 16:268.
44. Schnabel, J. 1993. New Alzheimer's therapy suggested. Science 260: 1719.
45. Folkerd, E. J., B. Gardner, and N. C. Hughes-Jones. 1980. The relationship between the binding ability and the rate of activation of the complement component C1. Immunology 41:179.
46. Cooper, N. R., F. C. Jensen, Jr., R. M. Welsh, and M. B. A. Oldstone. 1976. Lysis of RNA tumor viruses by human serum: direct antibody-independent triggering of the classical complement pathway. J. Exp. Med. 144:970.
47. Cooper, N. R., and D. C. Morrison. 1978. Binding and activation of the first component of human complement by the lipid A region of lipopolysaccharides. J. Immunol. 120:1862.
48. Zohair, A., S. Chesne, R. H. Wade, and M. G. Colomb. 1989. Interaction between complement subcomponent C1q and bacterial lipopolysaccharides. Biochem. J. 257:865.
49. Tenner, A. J., R. J. Ziccardi, and N. R. Cooper. 1984. Antibody-independent C1 activation by -Escherichia coli. J. Immunol. 133: 886.
50. Kovacsovics, T., J. Tschopp, A. Kress, and H. Isliker. 1985. Antibody-independent activation of C1, the first component of complement, by cardiolipin. J. Immunol. 135:2695.
51. Kagiyama, A., H. E. Savage, L. H. Michael, G. Hanson, M. L. Entman, and R. D. Rossen. 1988. Molecular basis of complement activation in ischemic myocardium: identification of specific molecules of mitochondrial origin that bind human C1q and fix complement. Circulation Res. 64:607.
52. Bristow, C. L., and R. Boackle. 1986. Evidence for the binding of human serum amyloid P component to C1q and Fab. Mol. Immunol. 23:1045.