Apoptosis in cancer therapy: Crossing the threshold

Cell

Volumn 78, Issue 4, 1994, Pages 539-542

  Fisher, David E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER THERAPY; CELL DEATH; CELL TRANSFORMATION; DRUG RESISTANCE; GENE INDUCTION; GENETIC TRANSFORMATION; ONCOGENE; PRIORITY JOURNAL; SHORT SURVEY; TARGET CELL;

APOPTOSIS; GENES, P53; HUMAN; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 0028025563     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90518-5     Document Type: Short Survey

References (30)

1. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
2. Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations
3. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
4. Thymocyte apoptosis induced by p53-dependent and independent pathways
5. Drug-target interactions: only the first step in the commitment to a programmed cell death?
6. Activation of programmed cell death by anticancer agents: cisplatin as a model system.
7. Induction of apoptosis in fibroblasts by c-myc protein
8. Clinical Implications of the p53 Tumor-Suppressor Gene
9. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
10. No germlineTP53 mutations detected in familial and bilateral testicular cancer
11. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
12. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
13. Bcl-2: a repressor of lymphocyte death
14. p53, guardian of the genome
15. p53 mutations increase resistance to ionizing radiation.
16. The p53 tumour suppressor gene
17. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
18. p53 is required for radiation-induced apoptosis in mouse thymocytes
19. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
20. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
21. p21 inhibits cyclin shock
22. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.
23. p53-Dependent apoptosis suppresses tumor growth and progression in vivo
24. Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing
25. p53 function and dysfunction
26. The biology of cell death in tumours.
27. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
28. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6