Androgenic maintenance of the rat erectile response via a non-nitric- oxide-dependent pathway

Journal of Andrology

Volumn 18, Issue 6, 1997, Pages 588-594

  Reilly, Christopher M ^a   Lewis, Ronald W ^a   Stopper, Vivienne S ^a   Mills, Thomas M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

cGMP; Penile erection; Phosphodiesterase 5; Testosterone

Indexed keywords

ANDROGEN; CYCLIC GMP; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NEUROTRANSMITTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE INHIBITOR; TESTOSTERONE; ZAPRINAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CASTRATION; CONTROLLED STUDY; GANGLION; HORMONE ACTION; HYPOTHESIS; MALE; NERVE STIMULATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL;

ANDROGENS; ANIMALS; ANTI-INFECTIVE AGENTS, URINARY; ANTINEOPLASTIC AGENTS, HORMONAL; BLOOD PRESSURE; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME INHIBITORS; GANGLIA; MALE; METHYLENE BLUE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROARGININE; PENILE ERECTION; PENIS; PHOSPHODIESTERASE INHIBITORS; PURINONES; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; TIME FACTORS;

EID: 0031406114     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Alaranta S, Uusitalo H, Hautamaki AM, Klinge E. Calcitonin gene-related peptide: immunohistochemical localization in, and effects on, the bovine penile artery. Int J Impot Res 1991;3:49-59.
2. Boolell M, Allan MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingel C. Sildenfil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996;8:47-52.
3. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science 1992;257: 401-403.
4. Burnett AL, Ricker DD, Chamness SL, Maguire MP, Crone JK, Bredt DS, Snyder SH, Chang TS. Localization of nitric oxide synthase in the reproductive organs of the male rat. Biol Reprod 1995;52:1-7.
5. Carrillo Y, Fernandez E, Dail WG, Walton G. Distribution and origin of neuropeptide Y-immunoreactive fibers in the penis of the rat. Cell Tissue Res 1991;264:127-132.
6. Chamness SL, Ricker DD, Crone JK, Dembeck CL, Maguire MP, Burnett AL, Chang TS. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil Steril 1995;63:1101-1107.
7. Garcia-Pascual A, Persson K, Holmquist F, Andersson KE. Endothelin-1-induced phosphoinositide hydrolysis and contraction in isolated rabbit detrusor and urethral smooth muscle. Gen Pharmacol 1993;24: 131-138.
8. Gozes I, Fridkin M. A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model. J Clin Invest 1992;90:810-814.
9. Hanawa A. Roles of prostaglandin on rabbit vesicourethral smooth muscle contraction. Jpn J Urol 1991;82:1256-1264.
10. Holmquist F, Fridstrand M, Hedlund H, Andersson KE. Actions of 3-morpholinosydnonimin (SIN-1) on rabbit isolated penile erectile tissue. J Urol 1993;150:1310-1315.
11. Holmquist F, Hedlund H, Andersson KE. L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated corpus cavernosum. Acta Physiol Scand 1991;141:441-442.
12. Holmquist F, Kirkeby HJ, Larsson B, Forman A, Alm P, Andersson KE. Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit. J Pharmacol Exp Ther 1992;261:795-802.
13. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of neuronal nitric oxide synthase gene. Cell 1993;75:1273-1286.
14. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990;170:843-850.
15. Kawada T, Takaharu I, Sasage H, Kato K, Imai S. Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit. Gen Pharmacol 1994;25:1361-1373.
16. Kawano M, Sugita O, Inagaki S, Furuyama T, Takagi H. Neuropeptide Y innervation in the spinal nucleus of bulbocavernosus of the rat. Neurosci Lett 1993;152:158-160.
17. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest 1991;88: 112-118.
18. 1 on corpus cavernosum smooth muscle of arteriogenically and diabetically impotent men. Eur Urol 1994;26:35-39.
19. Lugg JA, Rajfer J, Gonzalez-Cadivid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide mediated penile erection in the rat. Endocrinology 1995;136:1495-1501.
20. Lugnier C, Komas N. Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP: role in vasodilation. Eur Heart J (Suppl I) 1993;14:141-148.
21. Martinez-Pineiro L, Trigo-Rocha F, Hsu GL, von Heyden B, Lue TF, Tanagho EA. Cyclic guanosine monophosphate mediates penile erection in the rat. Eur Urol 1993;24:492-499.
22. Mayer B, Brunner F, Schmidt K. Novel actions of methylene blue. Eur Heart J (Suppl I) 1993;14:22-26.
23. Meiner MH, Abney TO. The direct effect of 17b-estradiol on LH-stimulated testosterone production in hypophysectomized rats. J Steroid Biochem 1980;13:203-210.
24. Mills TM, Reilly CM, Lewis RW. Androgens and penile erection: a review. J Androl 1996a;17:633-638.
25. Mills TM, Stopper VS, Reilly CM. Sites of androgenic regulation of cavernosal blood pressure during penile erection in the rat. Int J Impot Res 1996b;8:29-34.
26. Mills TM, Stopper VS, Wiedmeier VT. Effects of castration and androgen replacement on the hemodynamics of penile erection in the rat. Biol Reprod 1994;51:234-238.
27. Mills TM, Wiedmeier VT, Stopper VS. Androgen maintenance of erectile function in the rat penis. Biol Reprod 1992;46:342-348.
28. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, Dawson TM, Snyder SH. Behavioral abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 1995;378:383-386.
29. Penson DF, Ng C, Cai L, Rajfer J, Gonzalez-Cadavid NF. Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biol Reprod 1996;55:567-574.
30. Persson K, Garcia-Pascual A, Holmquist F, Andersson KE. Endothelin-1-induced contractions of isolated pig detrusor and vesical arterial smooth muscle: calcium dependence and phosphoinositide hydrolysis. Gen Pharmacol 1992;23:445-453.
31. Pickard RS, Powell PH, Zar MA. The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle. Br J Pharmacol 1991;104:755-759.
32. Pollock DM, Polakowski JS, Divish BJ, Opgenorth TJ. Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition. Hypertension 1993;21:660-666.
33. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to non-adrenergic, noncholinergic neurotransmission. N Engl J Med 1992; 326:90-94.
34. Reilly CM, Zamorano P, Stopper VS, Mills TM. Androgenic regulation of NO availability in rat penile erection. J Androl 1997;18:110-115.
35. Shenfeld O, Hanani J, Shalhav A, Vardi Y, Goldwasser B. Papaverine-phentolamine and prostaglandin E1 versus papaverine-phentolamine alone for intracorporeal injection therapy: a clinical double-blind study. J Urol 1995;154:1017-1019.
36. Stief CG, Benard F, Bosch RJ, Aboseif SR, Lue TF, Tanagho EA. A possible role for calcitonin-gene-related peptide in the regulation of the smooth muscle tone of the bladder and penis. J Urol 1990;143: 392-397.
37. Trigo-Rocha F, Aronson WJ, Hohenfellner M, Ignarro LJ, Rajfer J, Lue TF. Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Am J Physiol 1993;204:H419-H422.
38. Trigo-Rocha F, Hsu GL, Donatucci CF, Martinez-Pineiro L, Lue TF, Tanagho EA. Intracellular mechanism of penile erection in monkeys. Neurourol Urodyn 1994;13:71-80.
39. Wang R, Higuera TR, Sikka SC, Minkes RK, Bellan JA, Kadowitz PJ, Domer FR, Hellstrom WJ. Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside. Urol Res 1993;21:75-78.
40. Zvara P, Sioufi R, Schipper H, Begin L, Brock G. Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. Int J Impot Res 1995;7:209-219.