Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model

International journal of radiation oncology, biology, physics

Volumn 54, Issue 3, 2002, Pages 873-885

  Freytag, Svend O ^a   Paielli, Dell ^a   Wing, Mark ^a   Rogulski, Ken ^a   Brown, Steve ^a   Kolozsvary, Andy ^a   Seely, John ^b   Barton, Ken ^a   Dragovic, Alek ^a   Kim, Jae Ho ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ANIMAL; ARTICLE; C57BL MOUSE; CELL CULTURE; CYTOPATHOGENIC EFFECT; EVALUATION; GENE THERAPY; MALE; METHODOLOGY; MOUSE; MOUSE MUTANT; MULTIMODALITY CANCER THERAPY; PHYSIOLOGY; PROSTATE TUMOR; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; COMBINED MODALITY THERAPY; CYTOPATHOGENIC EFFECT, VIRAL; GENE THERAPY; MALE; MICE; MICE, INBRED C57BL; MICE, SCID; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

EID: 0010349948     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)03005-5     Document Type: Article

References (35)

1. J. Oesterling Z. Fuks C. Lee H. Scher V.T. DeVita S. Hellman S.A. Rosenberg Cancer Principles and practice of oncology 1997 JB Lippincott Philadelphia 1322 1386
2. R.A. Stephenson C.R. Smart G.P. Mineau B.C. James D.T. Janerich R.L. Dibble The fall of incidence of prostate cancer Cancer 77 1995 1342 1348
3. S.L. Parker T. Tong S. Bolden P.A. Wingo Cancer statistics, 1997 A Cancer Journal for Clinicians 47 1997 5 27
4. C.N. Coleman C. Beard R. Gelman P. Kantoff Rate of relapse following treatment for localized prostate cancer A critical analysis of retrospective reports Int J Radiat Oncol Biol Phys 28 1993 303 313
5. G. Zagars A. Pollack A. von Eschenbach Prognostic factors for clinically localized prostate carcinoma Analysis of 938 patients irradiated in the PSA era Cancer 79 1997 1370 1380
6. Z. Fuks S.A. Leibel K.E. Wallner The effect of local control on metastatic dissemination in carcinoma of the prostate Long-term results in patients treated with I-125 implantation Int J Radiat Oncol Biol Phys 21 1991 537 542
7. G. Hanks K. Martz J. Diamond The effect of dose on local control of prostate cancer Int J Radiat Oncol Biol Phys 15 1998 1299 1305
8. W. Smit P. Helle W. Van Putten Late radiation damage in prostate cancer patients treated by high dose external radiotherapy in relation to rectal dose Int J Radiat Oncol Biol Phys 18 1990 23 29
9. S.O. Freytag K.R. Rogulski D.L. Paielli J.D. Gilbert J.H. Kim A novel three-pronged approach to selectively kill cancer cells Concomitant viral, double suicide gene, and radiotherapy Hum Gene Ther 9 1998 1323 1333
10. K.R. Rogulski M. Wing D.L. Paielli J.D. Gilbert J.H. Kim S.O. Freytag Double suicide gene therapy augments the therapeutic efficacy of an oncolytic adenovirus through enhanced cytotoxicity and radiosensitization Hum Gene Ther 11 2000 67 76
11. J.H. Kim S.H. Kim S.L. Brown S.O. Freytag Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene Cancer Res 54 1994 6053 6056
12. J.H. Kim S.H. Kim A. Kolozsvary S.L. Brown O.B. Kim S.O. Freytag Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents Int J Radiat Oncol Biol Phys 33 1995 861 868
13. M. Khil J.H. Kim C.A. Mullen S.H. Kim S.O. Freytag Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene Clin Cancer Res 2 1995 53 57
14. K.R. Rogulski J.H. Kim S.H. Kim S.O. Freytag Glioma cells transduced with an E. coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity Hum Gene Ther 8 1997 73 85
15. S.H. Kim J.H. Kim A. Kolozsvary S.L. Brown S.O. Freytag Preferential radiosensitization of 9L glioma cells transduced with HSV-TK gene by acyclovir J Neurooncol 33 1997 189 194
16. K.R. Rogulski K. Zhang A. Kolozsvary J.H. Kim S.O. Freytag Pronounced anti-tumor effects and tumor radiosensitization of double suicide gene therapy Clin Cancer Res 3 1997 2081 2088
17. M. Gable J.H. Kim A. Kolozsvary M. Khil S.O. Freytag Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. Coli cytosine deaminase (CD) gene Int J Radiat Oncol Biol Phys 41 1997 883 887
18. J.H. Kim A. Kolozsvary K.R. Rogulski M. Khil S.O. Freytag Double suicide fusion gene A selective radiosensitization of 9L glioma in rat brain Cancer J Scient Am 4 1998 364 369
19. S.O. Freytag M. Khil H. Stricker 2002. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer Cancer Res 62 2002 4968 4976
20. Y. Xie J.D. Gilbert J.H. Kim S.O. Freytag Efficacy of adenovirus-mediated CD/5-FC and HSV-1 TK/GCV suicide gene therapies concomitant with p53 gene therapy Clin Cancer Res 5 1999 4224 4232
21. A. Alfieri E. Hahn An in situ method for estimating cell survival in a solid tumor Cancer Res 38 1978 3006 3011
22. N. Sato M. Gleave N. Bruchovsky P. Rennie E. Beraldi L. Sillivan A metastatic and androgen-sensitive human prostate cancer model using intraprostatic inoculation of LNCaP cells in SCID mice Cancer Res 57 1997 1584 1589
23. F. Ellis Dose, time and fractionation A clinical hypothesis Clin Radiol 20 1969 1 7
24. D.L. Paielli M. Wing K.R. Rogulski Evaluation of the biodistribution, toxicity, and potential of germ line transmission of a replication-competent human adenovirus following intraprostatic administration in the mouse Molecular Ther 1 2000 263 274
25. K.R. Rogulski S.O. Freytag K. Zhang Anti-tumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy Cancer Res 60 2000 1193 1196
26. Y. Chen T. DeWeese J. Dilley CV706, a prostate cancer-specific adenovirus variant, in combination with radiotherapy produces synergistic antitumor efficacy without increasing toxicity Cancer Res 61 2001 5453 5460
27. D.S. Shewach T.M. Hahn E. Chang L.W. Hertel T.S. Lawrence Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells Cancer Res 54 1994 3218 3223
28. H. Ginsberg L. Moldawer P. Sehgal A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia Proc Natl Acad Sci U S A 88 1991 1651 1655
29. G. Prince D. Potter A. Jenson R. Horswood R. Chanock H. Ginsberg Pathogenesis of adenovirus type 5 pneumonia in Cotton rats ( Sigmodon hispidus ) J Virol 67 1993 101 111
30. Y. Yang E. Hildegund J. Wilson MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses Immunity 1 1994 433 442
31. Y. Yang Z. Xiang H. Ertl J. Wilson Upregulation of class I histocompatibility complex antigens by interferon γ is necessary for T-cell-mediated elimination of recombinant adenoviruses-infected hepatocytes in vivo Proc Natl Acad Sci U S A 92 1995 7257 7261
32. D. Hallahan D. Spriggs M. Beckett D. Kufe R. Weichselbaum Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation Proc Natl Acad Sci U S A 86 1989 10104 10107
33. C. Chiang W. McBride Radiation enhances tumor necrosis factor alpha production by murine brain cells Brain Res 566 1991 265 269
34. R. Syljuasen A. Belldegrun C. Tsao H. Withers W. McBride Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection Radiat Res 148 1997 443 448
35. J. Hong C. Chiang C. Tsao P. Lin W. McBride C. Wu Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation Int J Radiat Biol 75 1999 1421 1427