New enzyme lineages by subdomain shuffling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 17, 1998, Pages 9813-9818

  Hopfner, Karl Peter ^a   Kopetzki, Erhard ^b   Kreße, Georg Burkhard ^b   Bode, Wolfram ^a   Huber, Robert ^a   Engh, Richard A ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; SERINE PROTEINASE; TRYPSIN;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SEQUENCE; BINDING SITES; DNA PRIMERS; ENZYMES; EVOLUTION, MOLECULAR; FACTOR XA; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; TRYPSIN;

EID: 0032544073     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.17.9813     Document Type: Article

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