Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: An in vitro study

BMC Cancer

Volumn 1, Issue , 2001, Pages

  Kuranaga, Noritsugu ^a   Shinomiya, Nariyoshi ^a   Mochizuki, Hidetaka ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; FLUOROURACIL; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; TELOMERASE; CARRIER PROTEIN; DNA BINDING PROTEIN; TEP1 PROTEIN, HUMAN;

ANEUPLOIDY; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER SURVIVAL; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA DETERMINATION; DRUG EXPOSURE; ENZYME ACTIVITY; GENE EXPRESSION; HISTOGRAM; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS RATE; MOLECULAR CLONING; MONITORING; MULTIDRUG RESISTANCE; TELOMERE; ADENOCARCINOMA; BIOSYNTHESIS; CELL CLONE; CELL CULTURE; CELL DIVISION; CHEMISTRY; COLON TUMOR; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVATION; GENE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; UPREGULATION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; CELL DIVISION; CISPLATIN; CLONE CELLS; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FLUOROURACIL; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MDR; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; TELOMERASE; TELOMERE; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0009350704     PISSN: 14712407     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2407-1-10     Document Type: Article

References (27)

1. Goldstein LJ, Galski H, Fojo A, Willingham M, Lai SL, Gazdar A, Pirker R, Green A, Crist W, Brodeur GM: Expression of a multidrug resistance gene in human cancers J Natl Cancer Inst 1989, 81:116-124
2. Roninson IB: Molecular mechanism of multidrug resistance in tumor cells Clin Physiol Biochem 1987, 5:140-151
3. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line Science 1992, 258:1650-1654
4. Eijdems EW, De Haas M, Coco-Martin JM, Ottenheim CP, Zaman GJ, Dauwerse HG, Breuning MH, Twentyman PR, Borst P, Baas F: Mechanisms of MRP over-expression in four human lung-cancer cell lines and analysis of the MRP amplicon Int J Cancer 1995, 60:676-684
5. Schoenlein PV, Shen DW, Barrett JT, Pastan I, Gottesman MM: Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells Mol Biol Cell 1992, 3:507-520
6. Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl G: Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells Cancer Res 1991, 51:6273-6279
7. Ishikawa F: Telomere crisis, the driving force in cancer cell evolution Biochem Biophys Res Commun 1997, 230:1-6
8. Urquidi V, Tarin D, Goodison S: Role of telomerase in cell senescence and oncogenesis Annu Rev Med 2000, 51:65-79
9. Kiyozuka Y, Yamamoto D, Yang J, Uemura Y, Senzaki H, Adachi S, Tsubura A: Correlation of chemosensitivity to anticancer drugs and telomere length, telomerase activity and telomerase RNA expression in human ovarian cancer cells Anticancer Res 2000, 20:203-212
10. Oulton R, Harrington L: Telomeres, telomerase, and cancer: life on the edge of genomic stability Curr Opin Oncol 2000, 12:74-81
11. Hahn WC, Stewart SA, Brooks MW, York SG, Baton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA: Inhibition Med 1999, 5:1164-1170
12. Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, Hirschowitz EA, Crystal R, Weichselbaum R, Kufe DW, et al: In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine Hum Gene Ther 1996, 7:713-720
13. Husain A, Yan XJ, Resales N, Aghajanian C, Schwartz GK, Spriggs DR: UCN-01 in ovary cancer cells: effective as a single agent and in combination with cis-diamminedichloroplatinum (II) independent of p53 status Clin Cancer Res 1997, 3:2089-2097
14. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity EMBO J 1992, 11:1921-1929
15. Engelhardt M, Ozkaynak MF, Drullinsky P, Sandoval C, Tugal O, Jayabose S, Moore MA: Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy Leukemia 1998, 12:13-24
16. Okusa Y, Shinomiya N, Ichikura T, Mochizuki H: Correlation between telomerase activity and DNA ploidy in gastric cancer Oncology 1998, 55:258-264
17. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer Science 1994, 266:2011-2015
18. Abe Y, Nakamura M, Ota E, Ozeki Y, Tamai S, Inoue H, Ueyama Y, Ogata T, Tamaoki N: Expression of the multidrug resistance gene (MDR1) in non-small cell lung cancer Jpn J Cancer Res 1994, 85:536-541
19. Narasaki F, Matsuo I, Ikuno N, Fukuda M, Soda H, Oka M: Multidrug resistance-associated protein (MRP) gene expression in human lung cancer Anticancer Res 1996, 16:2079-2082
20. Rapi S, Caldini A, Fanelli A, Berti P, Lisi E, Anichini E, Caligiani R, Sbernini F, Taddei G, Amorosi A, et al: Flow cytometric measurement of DNA content in human solid tumors: a comparison with cytogenetics Cytometry 1996, 26:192-197
21. Engelhardt M, Drullinsky P, Guillem J, Moore MA: Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer Clin Cancer Res 1997, 3:1931-1941
22. Bryan TM, Reddel RR: Telomere dynamics and telomerase activity in in vitro immortalised human cells Eur J Cancer 1997, 33:767-773
23. Aragona M, Maisano R, Panetta S, Giudice A, Morelli M, La Torre I, La Torre F: Telomere length maintenance in aging and carcinogenesis Int J Oncol 2000, 17:981-989
24. Savre-Train I, Gollahon LS, Holt SE: Clonal heterogeneity in telomerase activity and telomere length in tumor-derived cell lines Proc Soc Exp Biol Med 2000, 223:379-388
25. Ishibashi T, Lippard SJ: Telomere loss in cells treated with cisplatin Proc Natl Acad Sci USA 1998, 95:4219-4223
26. Terashima M, Takiyama I, Uesugi N, Sasaki N, Takagane A, Hayakawa Y, Abe K, Araya M, Nishizuka S, Shimooki O, et al: Telomerase assay as a possible predictor of the response to anticancer chemotherapy Anticancer Res 2000, 20:293-297
27. Ishikawa T, Kamiyama M, Hisatomi H, Ichikawa Y, Momiyama N, Hamaguchi Y, Hasegawa S, Narita T, Shimada H: Telomerase enzyme activity and RNA expression in adriamycin-resistant human breast carcinoma MCF-7 cells Cancer Lett 1999, 141:187-194