Myelin-associated glycoprotein in myelin and expressed by Schwann cells inhibits axonal regeneration and branching

Molecular and Cellular Neurosciences

Volumn 12, Issue 1-2, 1998, Pages 79-91

  Shen, Ying Jing ^a   DeBellard, Maria Elena ^a   Salzer, James L ^b   Roder, John ^c   Filbin, Marie T ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; DOWN REGULATION; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SCHWANN CELL;

EID: 0004788427     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1998.0700     Document Type: Article

References (44)

1. Bartsch, U., Kirchhoff, F., and Schachner, M. (1989). Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J. Comp. Neurol. 284: 451-462.
2. Bartsch, L., Bandtlow, C. E., Schnell, L., Bartsch, S., Spillmann, A. A., Rubin, B. P., Hillenbrand, R., Montag, D., Schwab, M. E., and Schachner, M. (1995). Lack of evidence that the myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. Neuron 15: 1375-1381.
3. Brown, M. C., Perry, V. H., Lunn, E. R., Gordon, S., and Heumann, R. (1991). Macrophage dependence of peripheral sensory nerve regeneration: Possible involvement of nerve growth. Neuron 6: 359-370.
4. Brown, M. C., Lunn, E. R., and Perry, V. H. (1992). Consequences of slow Wallerian degeneration for regenerating motor and sensory axons. J. Neurobiol. 23: 521-536
5. Carbonetto, S., Evans, D., and Cochart, P. (1987). Nerve fiber growth in culture in tissue substrates from central and peripheral nervous system. J. Neurosci. 7: 610-620.
6. Caroni, P., and Schwab, M. E. (1988a). Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1: 85-96.
7. Caroni, P., and Schwab, M. E. (1988b). Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J. Cell Biol. 106: 1281-1288.
8. Caroni, P., and Schwab, M. E. (1989). Codistribution of neurite growth inhibitors and oligodendrocytes in rat CNS: Appearance follows nerve fiber growth and preceded myelination. Dev. Biol. 136: 287-295.
9. Colamarino, S. A., and Tessier-Lavigne, M. (1995). The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81: 621-629.
10. Culotti, J. G., and Kolodkin, A. L. (1996). Functions of netrins and semaphorins in axon guidance. Curr. Opin. Neurobiol. 6: 81-88.
11. David, S., Braun, P. E., Jackson, D. L., Kottis V, and McKerracher L (1995) Laminin overrides the inhibitory effects of peripheral nervous system and central nervous system myelin-derived inhibitors of neurite outgrowth. J Neurosci. Res. 42: 594-602.
12. DeBellard, M. E., Tang, S., Mukhopadhyay, G., Shen, Y., and Filbin, M. T. (1996). Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein. Mol. Cell. Neurosci. 7: 89-101.
13. Drescher, U., Kremoser, C., Handwerker, C., Loschinger, J., Noda, M., and Bonhoeffer, F. (1995). In vitro guidance of retinal cell axons by RAGS, a 25 kD tectal protein related to ligands of eph receptor tyrosine kinases. Cell 82: 359-370.
14. Doherty, P., Fruns, M., Seaton, P., Dickson, G., Barton, C. H., Sears, T. A., and Walsh, F. S. (1990). A threshold effect of the major isoforms of N CAM on neurite outgrowth. Nature 343: 464-466.
15. Fawcett, J. W., and Keynes, R. J (1990). Peripheral nerve regeneration. Annu. Rev. Neurosci. 13: 43-60.
16. Filbin, M. T. (1995). Myelin-associated glycoprotein: A role in myelination and in the inhibition of axonal regeneration? Curr. Opin. Neurobiol 5: 588-595.
17. Filbin, M. T. (1996). The muddle with MAG. Mol. Cell. Neurosci. 8: 84-92.
18. Johnson, P. W., Abramow-Newerly, W., Seilheimer, B., Sadoul, R., Tropak, M. B., Arquint, M., Dunn, R. J., Schachner, M., and Roder, J. C. (1989). Recombinant myelin associated glycoprotein confers neural adhesion and neurite outgrowth function. Neuron 3: 377-385.
19. Johnson, A. R. (1993). Contact inhibition in the failure of mammalian CNS axonal regeneration. BioEssays 15: 807-813.
20. Kapfhammer, J. P., and Schwab, M. E. (1994). Inverse patterns of myelination and GAP-43 expression in the adult CNS: Neurite growth inhibitors as regulators of neuronal plasticity? J. Comp. Neurol. 340: 94-206.
21. Kelm, S., Pelz, A., Schauer, R., Filbin, M. T., Tang, S., de Bellard, M.-E., Schnaar, R. L., Mahoney, J. A., Hartnell, A., Bradfield, P., and Crocker, P. R. (1994). Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. Curr. Biol. 4: 965-972.
22. Keynes, R. J., and Cook, G. M. W. (1995). Repulsive and inhibitory signals. Curr. Opin. Neurobiol. 5: 75-82.
23. Li, M., Shibata, A., Li, C., Braun, P. E., McKerracher, L., Roder, J., Kater, S. B., and David, S. (1996). Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J. Neurosci. Res. 46: 404-414.
24. Luo, Y., Raible, D., and Raper, J. A. (1993). Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75: 217-227.
25. Martini, R., and Schachner, M. (1988), Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM and MAG) in regenerating adult mouse sciatic nerve. J. Cell Biol. 106: 1735-1746.
26. McKerracher, L., David, S., Jackson, D. L., Kottis, V., Dunn, R. J., and Braun, P. E. (1994). Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite outgrowth. Neuron 13: 805-811.
27. Mukhopadhyay, G., Doherty, P., Walsh, F. S., Crocker, P. R., and Filbin, M. T. (1994). A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13: 757-767.
28. Nakamoto, M., Cheng, H. J., Friedman, G. C., McLaughlin, T., Hansen, M., Yoon, C. H., O'Leary, D. M., and Flanagan, J. G. (1996). Topographically specific effects of elf-1 on retinal axon guidance in vitro and retinal mapping in vivo. Cell 86: 755-766.
29. Norton, W. T., and Poduslo, S. E. (1973). Myelination in rat brain: Method of myelin isolation. J. Neurochem. 21: 749-757.
30. Owens, G. C., Boyd, C. J., Bunge, R. P., and Salzer, J. L. (1990). Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by myelinating Schwann cells. J. Cell Biol. 111: 1171-1182.
31. Porter, S. L., Glaser, L., and Bunge, R. P. (1987). Release of autocrine growth factor by primary and immortalized Schwann cells. Proc Natl Acad Sci USA 83: 7768-7771.
32. Savio, T., and Schwab, M. E. (1989), Rat CNS white matter, but not gray matter, is non-permissive for neuronal cell adhesion and fiber outgrowth. J. Neurosci. 9: 1126-1133.
33. Schafer, M., Fruttiger, M., Montag, D., Schachner, M., and Martini, R. (1996). Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth in C57BL/Wld mice. Neuron 16: 1107-1113.
34. Scherer, S. S., and Salzer, J. L. (1996). Axon-Schwann cell interactions during peripheral nerve degeneration and regeneration. In Glial Cell Development: Basic Principles and Clinical Relevance (K. R. Jessen, and W. D. Richardson, Eds.), pp. 165-185. BIOS Scientific, Oxford.
35. Schnell, L., and Schwab, M. E. (1990). Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343: 269-272.
36. Schwab, M. E., and Caroni, P. (1988). Oligodendrocytes and CNS myelin are non-permissive substrates for neurite outgrowth and fibroblast spreading in vitro. J. Neurosci. 8: 2381-2391.
37. Schwab, M. E., Kapfhammer, J. P., and Bandtlow, C. E. (1993). Inhibitors of neurite growth. Annu. Rev. Neurosci. 16: 565-596.
38. Schwegler, G., Schwab, M. E., and Kapfhammer, J. P. (1995). Increased collateral sprouting of primary afferents in the myelin-free spinal cord. J. Neurosci. 15: 2756-2767.
39. Tessier-Lavigne, M., and Goodman, C. S. (1996). The molecular biology of axonal guidance. Science 274: 1123-1133.
40. Tang, S., Shen, Y., Mukhopadhyay, G., DeBellard, M. E., Crocker, P., and Filbin, M. T. (1997a). Myelin-associated glycoprotein, MAG, recognizes neurons via two epitopes, a sialic acid binding site at Arg118 and a distinct neurite inhibition epitope. J. Cell Biol. 138: 1355-1366.
41. Tang, S., Woodhall, R. W., Shen, Y. J., DeBellard, M. E., Saffell, J. L., Doherty, P., Walsh, F. S., and Filbin, M. T. (1997b). Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol. Cell. Neurosci. 9: 333-346.
42. Tuttle, R., Schlagger, B. L., Braisted, J., and O'Leary, D. M. (1995). Maturation-dependent upregulation of growth-promoting molecules in developing cortical plate controls thalmic and cortical neurite growth. J. Neurosci. 15: 3039-3052.
43. Walter, J., Henke-Fahle, S., and Bonhoeffer, F. (1987). Avoidance of posterior tectal membranes by temporal axons. Development 101: 909-913.
44. Wang, H. U., and Anderson, D. J. (1997). Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18: 383-396.