Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth along myelin in C57BL/WId(s) mice

Neuron

Volumn 16, Issue 6, 1996, Pages 1107-1113

  Schäfer, Marcel ^a   Fruttiger, Marcus ^a   Montag, Dirk ^a   Schachner, Melitta ^a   Martini, Rudolf ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEMYELINATION; MOUSE; MYELIN SHEATH; NERVE CRUSH; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL;

EID: 0030175624     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80137-3     Document Type: Article

References (31)

1. Acheson, A., Barker, P.A., Alderson, R.F., Miller, F.D., and Murphy, R. (1991). Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF. Neuron 7, 265-275.
2. Bandtlow, C.E., Heumann, R., Schwab, M.E., and Thoenen, H. (1987). Cellular localization of nerve growth factor synthesis by in situ hybridization. EMBO J. 6, 891-899.
3. Bartsch, U., Bandtlow, C.E., Schnell, L., Bartsch, S., Spillmann, A.A., Rubin, B.P., Hillenbrand, R., Montag, D., Schwab, M.E., and Schachner, M. (1995a). Lack of evidence that the myelin-associated glycoprotein (MAG) is a major inhibitor of axonal regeneration in the CNS. Neuron 15, 1375-1382.
4. Bartsch, U., Montag, D., Bartsch, S., and Schachner, M. (1995b). Multiply myelinated axons in optic nerve of mice deficient for the myelin-associated glycoprotein. Glia 14, 115-122.
5. Bedi, K.S., Winter, J., Berry, M., and Cohen, J. (1992). Adult rat dorsal root ganglion neurons extend neurites on predegenerated but not on normal peripheral nerves in vitro. Eur. J. Neurosci. 4, 193-200.
6. Brown, M.C., Lunn, E.R., and Perry, V.H. (1991a). Poor growth of mammalian motor and sensory axons into intact proximal nerve stumps. Eur. J. Neurosci. 3, 1366-1369.
7. Brown, M.C., Perry, V.H., Lunn, E.R., Gordon, S., and Heumann, R. (1991b). Macrophage dependence of peripheral nerve regeneration: possible involvement of nerve growth factor. Neuron 6, 359-370.
8. David, S., Braun, P.E., Kottis, V., and McKerracher, L. (1995). Laminin overrides the inhibitory effects of peripheral nervous system and central nervous system myelin-derived inhibitors of neurite growth. J. Neurosci. Res. 42, 594-602.
9. Fawcett, J.W., and Keynes, R.J. (1990). Peripheral nerve regeneration. Annu. Rev. Neurosci. 13, 43-60.
10. s mice: possible implications for axonal regeneration. J. Neurocytol. 24, 1-14.
11. Fruttiger, M., Montag, D., Schachner, M., and Martini, R. (1995b). Crucial role for the myelin-associated glycoprotein for the maintenance of axon-myelin integrity. Eur. J. Neurosci. 7, 511-515.
12. Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V.M.K., and Persson, H. (1993). Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. Biochem. Biophys. Res. Commun. 194, 1317-1322.
13. Giese, K.P., Martini, R., Lemke, G., Soriano, P., and Schachner, M. (1992). Mouse PO gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell 71, 565-576.
14. Hall, S.M. (1993). Observations on the progress of Wallerian degeneration in transected peripheral nerves of C57BL/Wld mice in the presence of recruited macrophages. J. Neurocytol. 22, 480-490.
15. Heumann, R., Lindholm, D., Bandtlow, C., Meyer, M., Radeke, M.J., Misko, T.P., Shooter, E., and Thoenen, H. (1987). Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proc. Natl. Acad. Sci. USA 84, 8735-8739.
16. Johnson, P.W., Abramow-Newerly, W., Seilheimer, B., Sadoul, R., Tropak, M.B., Arquint, M., Dunn, R.J., Schachner, M., and Roder, J.C. (1989). Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function. Neuron 3, 377-385.
17. Kühn, R., Schwenk, F., Aguet, M., and Rajewsky, K. (1995). Inducible gene targeting in mice. Science 269, 1427-1429.
18. Martini, R. (1994). Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves. J. Neurocytol. 23, 1-28.
19. Martini, R., and Schachner, M. (1986). Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J. Cell Biol. 103, 2439-2448.
20. Martini, R., Schachner, M., and Faissner, A. (1990). Enhanced expression of the extracellular matrix molecule J1/tenascin in the regenerating adult mouse sciatic nerve. J. Neurocytol. 19, 601-616.
21. McKerracher, L., David, S., Jackson, D.L., Kottis, V., Dunn, R.J., and Braun, P.E. (1994). Identification of myelin-associated glycoprotein as a mayor myelin-derived inhibitor of neurite growth. Neuron 13, 805-811.
22. Meyer, M., Matsuoka, I., Wetmore, C., Olson, L., and Thoenen, H. (1992). Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119, 45-54.
23. Montag, D., Giese, K.P., Bartsch, U., Martini, R., Lang, Y., Blüthmann, H., Karthigasan, J., Kirschner, D.A., Wintergerst, E.S., Nave, K.-A., Zielasek, J., Toyka, K.V., Lipp, H.-P., and Schachner, M. (1994). Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron 13, 229-246.
24. Mukhopadhyay, G., Doherty, P., Walsh, F.S., Crocker, P.R., and Filbin, M.T. (1994). A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757-767.
25. Perry, V.H., Lunn, E.R., Brown, M.C., Cahusac, S., and Gordon, S. (1990). Evidence that the rate of Wallerian degeneration is controlled by a single autosomal dominant gene. Eur. J. Neurosci. 2, 408-413.
26. Raivich, G., Hellweg, R., and Kreutzberg, G.W. (1991). NGF receptor-mediated reduction in axonal NGF uptake and retrograde transport following sciatic nerve injury and during regeneration. Neuron 7, 151-164.
27. Schachner, M., Taylor, J., Bartsch, U., and Pesheva, P. (1994). The perplexing multifunctionality of janusin, a tenascin-related molecule. Persp. Dev. Neurobiol. 2, 33-41.
28. Scherer, S.S., and Easter, S.S. (1984). Degenerative and regenerative changes in the trochlear nerve of goldfish. J. Neurocytol. 13, 519-565.
29. Schwab, M.E., Kapfhammer, J.P., and Bandtlow, C.E. (1993). Inhibitors of neurite growth. Annu. Rev. Neurosci. 16, 565-595.
30. Zhang, Y., Campbell, G., Andersen, P.N., Martini, R., Schachner, M., and Lieberman, A.R. (1995a). Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts I. Neural cell adhesion molecules. J. Comp. Neurol. 361, 193-209.
31. Zhang, Y., Campbell, G., Andersen, P.N., Martini, R., Schachner, M., and Lieberman, A.R. (1995b). Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts II. Tenascin-C. J. Comp. Neurol. 361, 210-224.