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This auxiliary is now commercially available from Aldrich Chemical Company (Cat. no. 49,470-4 & 49,469-0). For its synthesis, see Sibi, M. P.; Deshpande, P. K.; La Loggia, A. J.; Christensen, J. W. Tetrahedron Lett. 1995, 36, 8961.
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A variety of procedures can be employed for the acylation of 1 with simple acids as well as acids containing sensitive functional groups
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A variety of procedures can be employed for the acylation of 1 with simple acids as well as acids containing sensitive functional groups.
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Enolate allylation of 3-(1-oxopropyl)-4-(methylethyl)-2-oxazolidinone gave a 98:2 mixture of the allylated product (reference 8).
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45
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The higher selectivity for aryl-containing auxiliaries indicates that some π stacking may be operating in these systems
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The higher selectivity for aryl-containing auxiliaries indicates that some π stacking may be operating in these systems.
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47
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