Asymmetric total synthesis of (+)-tolterodine, a new muscarinic receptor antagonist, via copper-assisted asymmetric conjugate addition of aryl Grignard reagents to 3-phenyl-prop-2-enoyl-oxazolidinones

Journal of Organic Chemistry

Volumn 63, Issue 22, 1998, Pages 8067-8070

  Andersson, Pher G ^a,b   Schink, Hans E ^a,b   Österlund, Krister ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b Pharmacia & Upjohn AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC RECEPTOR BLOCKING AGENT; REAGENT; TOLTERODINE;

ARTICLE; BLADDER MUCOSA; CHIRALITY; COMPETITIVE INHIBITION; CONJUGATION; DRUG SYNTHESIS; HYDROGENATION; LIGAND BINDING; METAL BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; URINE INCONTINENCE;

EID: 0032582756     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo981259r     Document Type: Article

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