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Honkanen RE, Caplan FR, Baker KK, Baldwin CL, Bobzin SC, Bolis CM, Cabrera GM, Johnson LA, Jung JH, Larsen LK, Levine IA, Moore RE, Nelson CS, Patterson GML, Tschappal KD, Tuang GD, Boynton AL, Arment AR, An J, Carmichael WW, Rodland KD, Magun BE, Lewin RA: Protein phosphatase inhibitory activity in extracts of cultured blue-green algae (cyanophyta). JPhycol'(1995) 31:478-486. This is a good example of a large well managed screening program that lead to the discovery of compounds such as the cryptophycins.
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Caplan FR, Baker KK, Baldwin CL, Bobzin SC, Bolis CM, Cabrera GM, Johnson LA, Jung JH, Larsen LK, Levine IA, Moore RE, Nelson CS, Patterson GML, Tschappal KD, Tuang GD, Boynton AL, Arment AR, An J, Carmichael WW, Rodland KD, Magun BE, Lewin RA: Protein Phosphatase Inhibitory Activity in Extracts of Cultured Blue-green Algae (Cyanophyta).
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Ohtani I, Patterson GML, Moore RE, Corbett TH: Total Structures of Cryptophycins, Potent Antitumor Depsipeptides. J Am Chem Ste(1994) 116:4729-4737. the Initial Paper Reporting the Discovery of the
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Corbett TH, Valeriote FA, Demchik L, Lowichik N, Polin L, Panchapon Discovery of cryptophycin-1 and BCN-183577: Examples of strategies and problems in detection of antitumor activity in mice. Invest New Drugs (1997) 15:207-218. This publication indicates how the activity of the cryptophycins might have been missed if only one method of administration had been investigated.
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Valeriote FA, Demchik L, Lowichik N, Polin L, Panchapon Discovery of Cryptophycin-1 and BCN-183577: Examples of Strategies and Problems in Detection of Antitumor Activity in Mice. Invest New Drugs (1997) 15:207-218. This Publication Indicates How the Activity of the Cryptophycins Might Have Been Missed if only One Method of Administration Had Been
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Proteau PJ, Nagle DG, Hamel E, Blokhin A, Slate DL: Structure of Curacin-A, A Novel Antimitotic, Antiproliferative, and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya Majuscula. J Orff Chem (1994) 59:1243-45. the Initial Publication Reporting the Discovery Ofcuracin
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