Entropy-controlled asymmetric synthesis. How differential activation entropy is induced in chiral tethered reactions

Organic Letters

Volumn 3, Issue 1, 2001, Pages 37-40

  Sugimura, Takashi ^a   Hagiya, Kazutake ^a   Sato, Yasuhiro ^a   Tei, Takahiro ^a   Tai, Akira ^a   Okuyama, Tadashi ^a  

^a UNIVERSITY OF HYOGO   (Japan)

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EID: 0001773523     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol006741m     Document Type: Article

References (35)

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12. 3).
13. Structures of the minor products were not identified in all reactions. Values of the de of the major products were determined by GLC with achiral and chiral columns after treatments of the reaction mixtures with lithium aluminum hydride and acetic anhydride/pyridine. Reference samples were prepared through epimerization of the isolated major products followed by the above conversion. The selectivities shown in Table 1 might be underestimated because of intermolecular reactions. See the Supporting Information for the experimental details.
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