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Volumn 1, Issue 4, 2000, Pages 303-309

Bone Cancer Pain: From Mechanism to Model to Therapy

Author keywords

Astrocyte Hypertrophy; Bone; C fos Protein; Dynorphin; Osteolysis; Osteoprotegerin; Persistent Pain

Indexed keywords


EID: 0001374046     PISSN: 15262375     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-4637.2000.00047.x     Document Type: Article
Times cited : (85)

References (69)
  • 1
    • 0025771939 scopus 로고
    • Pain causes in 200 patients referred to a multidisciplinary cancer pain clinic
    • Banning A, Sjogren P, Henriksen H. Pain causes in 200 patients referred to a multidisciplinary cancer pain clinic. Pain 1991;45:45-8.
    • (1991) Pain , vol.45 , pp. 45-48
    • Banning, A.1    Sjogren, P.2    Henriksen, H.3
  • 2
    • 0032078278 scopus 로고    scopus 로고
    • A randomised phase II study of oral pamidronate for the treatment of bone metastases from breast cancer
    • Coleman RE, Houston S, Purohit OP, Rubens RD, Kandra A, Ford J. A randomised phase II study of oral pamidronate for the treatment of bone metastases from breast cancer. Eur J Cancer 1998;34: 820-4.
    • (1998) Eur J Cancer , vol.34 , pp. 820-824
    • Coleman, R.E.1    Houston, S.2    Purohit, O.P.3    Rubens, R.D.4    Kandra, A.5    Ford, J.6
  • 3
    • 0031756228 scopus 로고    scopus 로고
    • How can we improve the treatment of bone metastases further?
    • Coleman RE. How can we improve the treatment of bone metastases further? Curr Opinion Oncol 1998;10(suppl 1):S7-13.
    • (1998) Curr Opinion Oncol , vol.10 , pp. S7-13
    • Coleman, R.E.1
  • 4
    • 0023137823 scopus 로고
    • The clinical course of bone metastases from breast cancer
    • Coleman RE, Rubens RD. The clinical course of bone metastases from breast cancer. Br J Cancer 1987;55:61-6.
    • (1987) Br J Cancer , vol.55 , pp. 61-66
    • Coleman, R.E.1    Rubens, R.D.2
  • 6
    • 0030838804 scopus 로고    scopus 로고
    • Bisphosphonates and breast carcinoma
    • Lipton A. Bisphosphonates and breast carcinoma. Cancer 1997;80(suppl 8):1668-73.
    • (1997) Cancer , vol.80 , pp. 1668-1673
    • Lipton, A.1
  • 7
    • 0032406920 scopus 로고    scopus 로고
    • The role of bisphosphonates in the treatment of painful metastatic bone disease: A review of phase III trials
    • Fulfaro F, Casuccio A, Ticozzi C, Ripamonti C. The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials. Pain 1998;78:157-69.
    • (1998) Pain , vol.78 , pp. 157-169
    • Fulfaro, F.1    Casuccio, A.2    Ticozzi, C.3    Ripamonti, C.4
  • 8
    • 0032454825 scopus 로고    scopus 로고
    • Breakthrough pain in cancer patients: Pathophysiology and treatment
    • Mercadante S and Arcuri E. Breakthrough pain in cancer patients: pathophysiology and treatment. Cancer Treat Rev 1998;24:425-32.
    • (1998) Cancer Treat Rev , vol.24 , pp. 425-432
    • Mercadante, S.1    Arcuri, E.2
  • 9
    • 0031056437 scopus 로고    scopus 로고
    • Malignant bone pain: Pathophysiology and treatment
    • Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain 1997;69:1-18.
    • (1997) Pain , vol.69 , pp. 1-18
    • Mercadante, S.1
  • 10
    • 0032899247 scopus 로고    scopus 로고
    • Breakthrough pain: Characteristics and impact in patients with cancer pain
    • Portenoy RK, Payne D, Jacobsen P. Breakthrough pain: characteristics and impact in patients with cancer pain. Pain 1999;81:129-34.
    • (1999) Pain , vol.81 , pp. 129-134
    • Portenoy, R.K.1    Payne, D.2    Jacobsen, P.3
  • 11
    • 0032421144 scopus 로고    scopus 로고
    • Practice guidelines for cancer pain therapy. Issues pertinent to the revision of national guidelines
    • Payne R. Practice guidelines for cancer pain therapy. Issues pertinent to the revision of national guidelines. Oncology 1998;12:169-75.
    • (1998) Oncology , vol.12 , pp. 169-175
    • Payne, R.1
  • 12
    • 0030753267 scopus 로고    scopus 로고
    • Mechanisms and management of bone pain
    • Payne R. Mechanisms and management of bone pain. Cancer 1997;80(suppl 8):1608-13.
    • (1997) Cancer , vol.80 , pp. 1608-1613
    • Payne, R.1
  • 13
    • 0033573528 scopus 로고    scopus 로고
    • Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain
    • Schwei MJ, Honore P, Rogers SD, et al. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci 1999;19:10886-97.
    • (1999) J Neurosci , vol.19 , pp. 10886-10897
    • Schwei, M.J.1    Honore, P.2    Rogers, S.D.3
  • 14
    • 0024532374 scopus 로고
    • Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord
    • Nahin RL, Hylden JLK, Iadarola MJ, Dubner R. Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord. Neurosci Lett 1989;96:247-52.
    • (1989) Neurosci Lett , vol.96 , pp. 247-252
    • Nahin, R.L.1    Hylden, J.L.K.2    Iadarola, M.J.3    Dubner, R.4
  • 15
    • 0025853449 scopus 로고
    • Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons
    • Noguchi K, Kowalski K, Traub R, Solodkin A, Iadarola MJ, Ruda MA. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons. Mol Brain Res 1991;10:227-33.
    • (1991) Mol Brain Res , vol.10 , pp. 227-233
    • Noguchi, K.1    Kowalski, K.2    Traub, R.3    Solodkin, A.4    Iadarola, M.J.5    Ruda, M.A.6
  • 16
    • 0030879183 scopus 로고    scopus 로고
    • Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors
    • Laughlin TM, Vanderah TW, Lashbrook J, et al. Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors. Pain 1997;72:253-60.
    • (1997) Pain , vol.72 , pp. 253-260
    • Laughlin, T.M.1    Vanderah, T.W.2    Lashbrook, J.3
  • 17
    • 0024268743 scopus 로고
    • Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding
    • Iadarola MJ, Brady LS, Draisci G, Dubner R. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain 1988;35:313-26.
    • (1988) Pain , vol.35 , pp. 313-326
    • Iadarola, M.J.1    Brady, L.S.2    Draisci, G.3    Dubner, R.4
  • 18
    • 0026539501 scopus 로고
    • Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia
    • Hylden JL, Noguchi K, Ruda MA. Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia. J Neurosci 1992; 12:1716-25.
    • (1992) J Neurosci , vol.12 , pp. 1716-1725
    • Hylden, J.L.1    Noguchi, K.2    Ruda, M.A.3
  • 19
    • 0024385766 scopus 로고
    • Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord
    • Draisci G, Iadarola MJ. Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Brain Res Mol Brain Res 1989;6:31-7.
    • (1989) Brain Res Mol Brain Res , vol.6 , pp. 31-37
    • Draisci, G.1    Iadarola, M.J.2
  • 20
    • 0026018284 scopus 로고
    • Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation
    • Draisci G, Kajander KC, Dubner R, Bennett GJ, Iadarola MJ. Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation. Brain Res 1991;560:186-92.
    • (1991) Brain Res , vol.560 , pp. 186-192
    • Draisci, G.1    Kajander, K.C.2    Dubner, R.3    Bennett, G.J.4    Iadarola, M.J.5
  • 21
    • 0038094464 scopus 로고
    • In situ hybridization histochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model peripheral inflammation and hyperalgesia
    • Ruda MA, Iadarola MJ, Cohen LV, Young WSI. In situ hybridization histochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model peripheral inflammation and hyperalgesia. Proc Natl Acad Sci USA 1988;85:622-26.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 622-626
    • Ruda, M.A.1    Iadarola, M.J.2    Cohen, L.V.3    Young, W.S.I.4
  • 22
    • 17344385566 scopus 로고    scopus 로고
    • Single intrathecal injections of dynorphin A or desTyr-dynorphins produce long-lasting allodynia in rats; Blockade by MK-801 but not naloxone
    • Vanderah TW, Laughlin T, Lashbrook JM, et al. Single intrathecal injections of dynorphin A or desTyr-dynorphins produce long-lasting allodynia in rats; Blockade by MK-801 but not naloxone. Pain 1996;68:275-81.
    • (1996) Pain , vol.68 , pp. 275-281
    • Vanderah, T.W.1    Laughlin, T.2    Lashbrook, J.M.3
  • 23
    • 0030973073 scopus 로고    scopus 로고
    • Antinociceptive Effects of Rb101, a Complete Inhibitor of Enkephalin-Catabolizing Enzymes, Are Enhanced by a Cholecystokinin Type B Receptor Antagonist, As Revealed by Noxiously Evoked Spinal C-Fos Expression in Rats
    • Honore P, Buritova J, Fourniezaluski MC, Roques BP, Besson JM. Antinociceptive Effects of Rb101, a Complete Inhibitor of Enkephalin-Catabolizing Enzymes, Are Enhanced By a Cholecystokinin Type B Receptor Antagonist, As Revealed By Noxiously Evoked Spinal C-Fos Expression in Rats. J Pharmacol Exp Ther 1997;281:208-17.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 208-217
    • Honore, P.1    Buritova, J.2    Fourniezaluski, M.C.3    Roques, B.P.4    Besson, J.M.5
  • 24
    • 0031924143 scopus 로고    scopus 로고
    • Up 202-56, an Adenosine Analogue, Selectively Acts Via A(1) Receptors to Significantly Decrease Noxiously-Evoked Spinal C-Fos Protein Expression
    • Honore P, Buritova J, Chapman V, Besson JM. Up 202-56, an Adenosine Analogue, Selectively Acts Via A(1) Receptors to Significantly Decrease Noxiously-Evoked Spinal C-Fos Protein Expression. Pain 1998;75:281-93.
    • (1998) Pain , vol.75 , pp. 281-293
    • Honore, P.1    Buritova, J.2    Chapman, V.3    Besson, J.M.4
  • 25
    • 0030441130 scopus 로고    scopus 로고
    • To what extent do spinal interactions between an alpha-2 adrenoceptor agonist and a mu opioid agonist influence noxiously evoked c-Fos expression in the rat? A pharmacological study
    • Honore P, Chapman V, Buritova J, Besson JM. To what extent do spinal interactions between an alpha-2 adrenoceptor agonist and a mu opioid agonist influence noxiously evoked c-Fos expression in the rat? A pharmacological study. J Pharmacol Exp Ther 1996;278:393-403.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 393-403
    • Honore, P.1    Chapman, V.2    Buritova, J.3    Besson, J.M.4
  • 26
    • 0028178395 scopus 로고
    • Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation
    • Abbadie C, Honore P, Fournie-Zaluski MC, Roques BP, Besson JM. Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation. Eur J Pharmacol 1994;258:215-27.
    • (1994) Eur J Pharmacol , vol.258 , pp. 215-227
    • Abbadie, C.1    Honore, P.2    Fournie-Zaluski, M.C.3    Roques, B.P.4    Besson, J.M.5
  • 27
    • 0029080690 scopus 로고
    • The contribution of NMDA receptor activation to spinal c-Fos expression in a model of inflammatory pain
    • Chapman V, Honore P, Buritova J, Besson JM. The contribution of NMDA receptor activation to spinal c-Fos expression in a model of inflammatory pain. Br J Pharmacol 1995;116:1628-34.
    • (1995) Br J Pharmacol , vol.116 , pp. 1628-1634
    • Chapman, V.1    Honore, P.2    Buritova, J.3    Besson, J.M.4
  • 28
    • 0029074099 scopus 로고
    • Cholecystokinin B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat
    • Chapman V, Honore P, Buritova J, Besson JM. Cholecystokinin B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat. Neuroscience 1995;67:731-9.
    • (1995) Neuroscience , vol.67 , pp. 731-739
    • Chapman, V.1    Honore, P.2    Buritova, J.3    Besson, J.M.4
  • 29
    • 0023277535 scopus 로고
    • Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
    • Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 1987;328:632-4.
    • (1987) Nature , vol.328 , pp. 632-634
    • Hunt, S.P.1    Pini, A.2    Evan, G.3
  • 30
    • 0028579556 scopus 로고
    • Proto-oncogenes: Basic concepts and stimulation induced changes in the spinal cord
    • Munglani R, Hunt SP. Proto-oncogenes: basic concepts and stimulation induced changes in the spinal cord. Prog Brain Res 1995;104:283-98.
    • (1995) Prog Brain Res , vol.104 , pp. 283-298
    • Munglani, R.1    Hunt, S.P.2
  • 31
    • 0033104153 scopus 로고    scopus 로고
    • Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in rat
    • Doyle CA, Hunt SP. Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: a c-Fos study in rat. Neuroscience 1999;89: 17-28.
    • (1999) Neuroscience , vol.89 , pp. 17-28
    • Doyle, C.A.1    Hunt, S.P.2
  • 32
    • 0028999848 scopus 로고
    • Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation
    • Mantyh PW, Demaster E, Malhotra A, et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 1995;268:1629-32.
    • (1995) Science , vol.268 , pp. 1629-1632
    • Mantyh, P.W.1    Demaster, E.2    Malhotra, A.3
  • 33
    • 0030764290 scopus 로고    scopus 로고
    • Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
    • see comments
    • Mantyh PW, Rogers SD, Honore P, et al. Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor [see comments]. Science 1997;278:275-9.
    • (1997) Science , vol.278 , pp. 275-279
    • Mantyh, P.W.1    Rogers, S.D.2    Honore, P.3
  • 34
    • 0032978019 scopus 로고    scopus 로고
    • Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury
    • Allen BJ, Li J, Menning PM, et al. Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury. J Neurophysiol 1999;81:1379-90.
    • (1999) J Neurophysiol , vol.81 , pp. 1379-1390
    • Allen, B.J.1    Li, J.2    Menning, P.M.3
  • 35
    • 0033197997 scopus 로고    scopus 로고
    • Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states
    • Honore P, Menning PM, Rogers SD, et al. Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states. J Neurosci 1999;19:7670-8.
    • (1999) J Neurosci , vol.19 , pp. 7670-7678
    • Honore, P.1    Menning, P.M.2    Rogers, S.D.3
  • 36
    • 0030798999 scopus 로고    scopus 로고
    • Inflammation Increases the Distribution of Dorsal Horn Neurons That Internalize the Neurokinin-1 Receptor in Response to Noxious and Non-Noxious Stimulation
    • Abbadie C, Trafton J, Liu HT, Mantyh PW, Basbaum AI. Inflammation Increases the Distribution of Dorsal Horn Neurons That Internalize the Neurokinin-1 Receptor in Response to Noxious and Non-Noxious Stimulation. J Neurosci 1997;17:8049-60.
    • (1997) J Neurosci , vol.17 , pp. 8049-8060
    • Abbadie, C.1    Trafton, J.2    Liu, H.T.3    Mantyh, P.W.4    Basbaum, A.I.5
  • 37
    • 0028899642 scopus 로고
    • Reduction of carrageenin oedema and the associated c-Fos expression in the rat lumbar spinal cord by nitric oxide synthase inhibitor
    • Honore P, Chapman V, Buritova J, Besson JM. Reduction of carrageenin oedema and the associated c-Fos expression in the rat lumbar spinal cord by nitric oxide synthase inhibitor. Br J Pharmacol 1995;114:77-84.
    • (1995) Br J Pharmacol , vol.114 , pp. 77-84
    • Honore, P.1    Chapman, V.2    Buritova, J.3    Besson, J.M.4
  • 38
    • 0346458909 scopus 로고
    • Noxious stimulus-evoked Fos-like immunoreactivity in spinoparabrachial neurons in lamina I is not affected by morphine
    • Jasmin L, Wang H, Tarczy-Hornoch K, Levine JD, Basbaum AI. Noxious stimulus-evoked Fos-like immunoreactivity in spinoparabrachial neurons in lamina I is not affected by morphine. IASP-7th World Congress on Pain; 1993:606.
    • (1993) IASP-7th World Congress on Pain , pp. 606
    • Jasmin, L.1    Wang, H.2    Tarczy-Hornoch, K.3    Levine, J.D.4    Basbaum, A.I.5
  • 39
    • 0002417922 scopus 로고
    • Immediate-early genes and pain: What's all the "Fos" about?
    • Basbaum AI. Immediate-early genes and pain: What's all the "Fos" about? APSJ 1994;3:49-52.
    • (1994) APSJ , vol.3 , pp. 49-52
    • Basbaum, A.I.1
  • 40
    • 0027499092 scopus 로고
    • C-fos expression in rat lumbar spinal cord following peripheral stimulation in adjuvant-induced arthrtis and in normal rats
    • Abbadie C, Besson JM. C-fos expression in rat lumbar spinal cord following peripheral stimulation in adjuvant-induced arthrtis and in normal rats. Brain Res 1993;607:195-204.
    • (1993) Brain Res , vol.607 , pp. 195-204
    • Abbadie, C.1    Besson, J.M.2
  • 41
    • 0031941807 scopus 로고    scopus 로고
    • Pamidronate. A review of its use in the management of osteolytic bone metastases, tumor-induced hypercalcaemia and Paget's disease of bone
    • Coukell AJ, Markham A. Pamidronate. A review of its use in the management of osteolytic bone metastases, tumor-induced hypercalcaemia and Paget's disease of bone. Drugs Aging 1998;12:149-68.
    • (1998) Drugs Aging , vol.12 , pp. 149-168
    • Coukell, A.J.1    Markham, A.2
  • 42
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy GR. Mechanisms of bone metastasis. Cancer 1997;80(suppl 8):1546-56.
    • (1997) Cancer , vol.80 , pp. 1546-1556
    • Mundy, G.R.1
  • 43
    • 0030844752 scopus 로고    scopus 로고
    • Bisphosphonates in prostate carcinoma
    • Adami S. Bisphosphonates in prostate carcinoma. Cancer 1997;80(suppl 8):1674-9.
    • (1997) Cancer , vol.80 , pp. 1674-1679
    • Adami, S.1
  • 44
    • 0029939932 scopus 로고    scopus 로고
    • Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts
    • Clohisy DR, Ogilvie CM, Carpenter RJ, Ramnaraine ML. Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts. J Orthop Res 1996;14:2-6.
    • (1996) J Orthop Res , vol.14 , pp. 2-6
    • Clohisy, D.R.1    Ogilvie, C.M.2    Carpenter, R.J.3    Ramnaraine, M.L.4
  • 45
    • 0030152757 scopus 로고    scopus 로고
    • Human breast cancer induces osteoclast activation and increases the number of osteoclasts at sites of tumor osteolysis
    • Clohisy DR, Palkert D, Ramnaraine ML, Pekurovsky I, Oursler MJ. Human breast cancer induces osteoclast activation and increases the number of osteoclasts at sites of tumor osteolysis. J Orthop Res 1996;14:396-402.
    • (1996) J Orthop Res , vol.14 , pp. 396-402
    • Clohisy, D.R.1    Palkert, D.2    Ramnaraine, M.L.3    Pekurovsky, I.4    Oursler, M.J.5
  • 47
    • 0028157337 scopus 로고
    • Messenger plasticity in primary sensory neurons following axotomy and its functional implications
    • see comments
    • Hokfelt T, Zhang X, Wiesenfeld-Hallin Z. Messenger plasticity in primary sensory neurons following axotomy and its functional implications [see comments]. Trends Neurosci 1994;17:22-30.
    • (1994) Trends Neurosci , vol.17 , pp. 22-30
    • Hokfelt, T.1    Zhang, X.2    Wiesenfeld-Hallin, Z.3
  • 48
    • 0024855163 scopus 로고
    • Pain modulation: Opiates and chronic pain
    • Fields, HL. Pain modulation: opiates and chronic pain. NIDA Res Monogr 1989;95:92-101.
    • (1989) NIDA Res Monogr , vol.95 , pp. 92-101
    • Fields, H.L.1
  • 49
    • 0034130227 scopus 로고    scopus 로고
    • Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons
    • Honore P, Rogers SD, Schwei MJ, et al. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience 2000;98:585-98.
    • (2000) Neuroscience , vol.98 , pp. 585-598
    • Honore, P.1    Rogers, S.D.2    Schwei, M.J.3
  • 50
    • 0034105966 scopus 로고    scopus 로고
    • Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neuro-chemical reorganization of the spinal cord
    • Honore P, Luger NM, Sabino MA, et al. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neuro-chemical reorganization of the spinal cord. Nat Med 2000;6:521-8.
    • (2000) Nat Med , vol.6 , pp. 521-528
    • Honore, P.1    Luger, N.M.2    Sabino, M.A.3
  • 51
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397:315-23.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 52
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin - A Novel Secreted Protein Involved in the Regulation of Bone Density
    • Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin - a Novel Secreted Protein Involved in the Regulation of Bone Density. Cell 1997;892: 309-19.
    • (1997) Cell , vol.892 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 53
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;932:165-76.
    • (1998) Cell , vol.932 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 54
    • 0000314105 scopus 로고    scopus 로고
    • Comparison of the inhibitory effects of osteoprotegerin and of APD on PTHrP-mediated hypercalcemia and bone remodeling
    • Kostenuik PJ, Morony S, Capparelli C, Lacey DL, Dunstan CR. Comparison of the inhibitory effects of osteoprotegerin and of APD on PTHrP-mediated hypercalcemia and bone remodeling. J Bone Miner Res 1999;14:S166.
    • (1999) J Bone Miner Res , vol.14 , pp. S166
    • Kostenuik, P.J.1    Morony, S.2    Capparelli, C.3    Lacey, D.L.4    Dunstan, C.R.5
  • 55
    • 0002801861 scopus 로고
    • Mechanism of mineral solubilization and matrix degradation in osteoclastic bone resorption
    • Rifkin BR, Gay CV, eds. Ann Arbor: CRC
    • Delaisse J-M, Vaes G. Mechanism of mineral solubilization and matrix degradation in osteoclastic bone resorption. In: Rifkin BR, Gay CV, eds. Biology and Physiology of the Osteoclast. Ann Arbor: CRC; 1992:289-314.
    • (1992) Biology and Physiology of the Osteoclast , pp. 289-314
    • Delaisse, J.-M.1    Vaes, G.2
  • 56
    • 0032550139 scopus 로고    scopus 로고
    • An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats
    • Olson TH, Riedl MS, Vulchanova L, Ortiz-Gonzalez XR, Elde R. An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats. Neuroreport 1998;9:1109-13.
    • (1998) Neuroreport , vol.9 , pp. 1109-1113
    • Olson, T.H.1    Riedl, M.S.2    Vulchanova, L.3    Ortiz-Gonzalez, X.R.4    Elde, R.5
  • 57
    • 0030770623 scopus 로고    scopus 로고
    • Tumour Necrosis Factor-Alpha Induces Ectopic Activity in Nociceptive Primary Afferent Fibres
    • Sorkin LS, Xiao WH, Wagner R, Myers RR. Tumour Necrosis Factor-Alpha Induces Ectopic Activity in Nociceptive Primary Afferent Fibres. Neuroscience 1997;81:255-62.
    • (1997) Neuroscience , vol.81 , pp. 255-262
    • Sorkin, L.S.1    Xiao, W.H.2    Wagner, R.3    Myers, R.R.4
  • 58
    • 0033061315 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-joints
    • Tonussi CR, Ferreira SH. Tumour necrosis factor-alpha mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-joints. Pain. 1999;82: 81-7.
    • (1999) Pain , vol.82 , pp. 81-87
    • Tonussi, C.R.1    Ferreira, S.H.2
  • 61
    • 0025727850 scopus 로고
    • Distribution of CGRP-, VIP-, DβH-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat
    • Hill EL, Elde R. Distribution of CGRP-, VIP-, DβH-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell Tissue Res 1991; 264:469-80.
    • (1991) Cell Tissue Res , vol.264 , pp. 469-480
    • Hill, E.L.1    Elde, R.2
  • 62
    • 0029840243 scopus 로고    scopus 로고
    • Noradrenergic and peptidergic innervation of the mouse femur bone marrow
    • Tabarowski Z, Gibson-Berry K, Felten SY. Noradrenergic and peptidergic innervation of the mouse femur bone marrow. Acta Histochem 1996;98:453-7.
    • (1996) Acta Histochem , vol.98 , pp. 453-457
    • Tabarowski, Z.1    Gibson-Berry, K.2    Felten, S.Y.3
  • 63
    • 0027239493 scopus 로고
    • Hypercalcemia of cancer: An update
    • Goni MH, Tolis G. Hypercalcemia of cancer: an update. Anticancer Res 1993;13:1155-60.
    • (1993) Anticancer Res , vol.13 , pp. 1155-1160
    • Goni, M.H.1    Tolis, G.2
  • 64
    • 0028670898 scopus 로고
    • Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6
    • Suzuki K, Yamada S. Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6. Bone Miner 1994;273:219-33.
    • (1994) Bone Miner , vol.273 , pp. 219-233
    • Suzuki, K.1    Yamada, S.2
  • 66
    • 0028982492 scopus 로고
    • Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia
    • Safieh-Garabedian B, Poole S, Allchorne A, Winter J, Woolf CJ. Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol 1995;115:1265-75.
    • (1995) Br J Pharmacol , vol.115 , pp. 1265-1275
    • Safieh-Garabedian, B.1    Poole, S.2    Allchorne, A.3    Winter, J.4    Woolf, C.J.5
  • 67
    • 0030913028 scopus 로고    scopus 로고
    • Cytokines, nerve growth factor and inflammatory hyperalgesia: The contribution of tumour necrosis factor alpha
    • Woolf CJ, Allchorne A, Safieh-Garabedian B, Poole S. Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha. Br J Pharmacol 1997; 121:417-24.
    • (1997) Br J Pharmacol , vol.121 , pp. 417-424
    • Woolf, C.J.1    Allchorne, A.2    Safieh-Garabedian, B.3    Poole, S.4
  • 68
    • 0032514131 scopus 로고    scopus 로고
    • Behavioral signs of acute pain produced by application of endothelin-1 to rat sciatic nerve
    • Davar G, Hans G, Fareed MU, Sinnott C, Strichartz G. Behavioral signs of acute pain produced by application of endothelin-1 to rat sciatic nerve. Neuroreport 1998;9:2279-83.
    • (1998) Neuroreport , vol.9 , pp. 2279-2283
    • Davar, G.1    Hans, G.2    Fareed, M.U.3    Sinnott, C.4    Strichartz, G.5
  • 69
    • 0031737709 scopus 로고    scopus 로고
    • Recent advances in the pharmacology of nerve-injury pain
    • Hans G, Davar G. Recent advances in the pharmacology of nerve-injury pain. Neurol Clin 1998;16: 951-66.
    • (1998) Neurol Clin , vol.16 , pp. 951-966
    • Hans, G.1    Davar, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.