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Volumn 4, Issue 3, 2000, Pages 397-411

Integrins as therapeutic targets

Author keywords

anti integrin therapy; antibody; cancer; cyclic peptides; inflammation; integrins; leukocytes; matrix metalloproteinase; multiple sclerosis; platelets; transplant rejection; vascular disease

Indexed keywords


EID: 0000755542     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.4.3.397     Document Type: Review
Times cited : (6)

References (125)
  • 1
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation and signaling in cell adhesion
    • Review of integrin structure and function
    • HYNES RO: Integrins: versatility, modulation and signaling in cell adhesion. Cell (1992) 69:11-25. Review of integrin structure and function.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 3
    • 0033206744 scopus 로고    scopus 로고
    • Integrin signaling in fibrosis and scleroderma
    • GARDNER HA: Integrin signaling in fibrosis and scleroderma. Curr. Rheum. Reports. (1999) 1:28-33.
    • (1999) Curr. Rheum. Reports. , vol.1 , pp. 28-33
    • Gardner, H.A.1
  • 4
    • 0030743346 scopus 로고    scopus 로고
    • The biological and clinical spectrum of Glanzmann's thrombasthenia: Implications of integrin alpha IIb beta 3 for its pathogenesis
    • KATO A: The biological and clinical spectrum of Glanzmann's thrombasthenia: implications of integrin alpha IIb beta 3 for its pathogenesis. Crit. Rev. Oncol. Hematol. (1997) 26:1-23.
    • (1997) Crit. Rev. Oncol. Hematol. , vol.26 , pp. 1-23
    • Kato, A.1
  • 6
    • 0032725055 scopus 로고    scopus 로고
    • Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia
    • HYNES RO, HODIVALA-DILKE KM: Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia. Thromb. Haemost. (1999) 82:481-485.
    • (1999) Thromb. Haemost. , vol.82 , pp. 481-485
    • Hynes, R.O.1    Hodivala-Dilke, K.M.2
  • 7
    • 0023083976 scopus 로고
    • Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1 and p150,95 glycoproteins
    • ANDERSON DC, SPRINGER TA: Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1 and p150,95 glycoproteins. Ann. Rev. Med. (1987) 38:175-194.
    • (1987) Ann. Rev. Med. , vol.38 , pp. 175-194
    • Anderson, D.C.1    Springer, T.A.2
  • 9
    • 0029775681 scopus 로고    scopus 로고
    • RGD and other recognition sequences for integrins
    • DOI 10.1146/annurev.cellbio.12.1.697
    • RUOSLAHTI E: RGD and other recognition sequences for integrins. Ann. Rev. Cell. Dev. Biol. (1996) 12:697-715. (Pubitemid 26422728)
    • (1996) Annual Review of Cell and Developmental Biology , vol.12 , pp. 697-715
    • Ruoslahti, E.1
  • 10
    • 0032168738 scopus 로고    scopus 로고
    • Integrin affinity modulation
    • DOI 10.1016/S0962-8924(98)01339-7, PII S0962892498013397
    • HUGHES PE, PFAFF M: Integrin affinity modulation. Trends Cell. Biol. (1998) 8:359-364. (Pubitemid 28398427)
    • (1998) Trends in Cell Biology , vol.8 , Issue.9 , pp. 359-364
    • Hughes, P.E.1    Pfaff, M.2
  • 11
    • 0029094814 scopus 로고
    • Thrombosis and the pharmacology of antithrombotic agents
    • HAINES ST, BUSSEY HI: Thrombosis and the pharmacology of antithrombotic agents. Ann. Pharmacother. (1995) 29:892-905.
    • (1995) Ann. Pharmacother. , vol.29 , pp. 892-905
    • Haines, S.T.1    Bussey, H.I.2
  • 12
    • 0030804833 scopus 로고    scopus 로고
    • 3 and platelet function
    • DU X, GINSBERG MH: Integrin alpha IIb beta 3 and platelet function. Thromb. Haemost. (1997) 78:96-100. (Pubitemid 27289223)
    • (1997) Thrombosis and Haemostasis , vol.78 , Issue.1 , pp. 96-100
    • Du, X.1    Ginsberg, M.H.2
  • 14
    • 0028246974 scopus 로고
    • Platelet adhesion to collagen and endothelial cell matrix under flow conditions is not dependent on platelet glycoprotein IV
    • SAELMAN EU, KEHREL B, HESE KM et al.: Platelet adhesion to collagen and endothelial cell matrix under flow conditions is not dependent on platelet glycoprotein IV. Blood (1994) 83:3240-3244. (Pubitemid 24158469)
    • (1994) Blood , vol.83 , Issue.11 , pp. 3240-3244
    • Saelman, E.U.M.1    Kehrel, B.2    Hese, K.M.3    De Groot, P.G.4    Sixma, J.J.5    Nieuwenhuis, H.K.6
  • 15
    • 0022353697 scopus 로고
    • Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
    • DOI 10.1038/318470a0
    • NIEUWENHUIS HK, AKKERMAN JW, HOUDIJK WT, SIXMA JJ: Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nature (1985) 318:470-472. (Pubitemid 16195848)
    • (1985) Nature , vol.318 , Issue.6045 , pp. 470-472
    • Nieuwenhuis, H.K.1    Akkerman, J.W.N.2    Houdijk, W.P.M.3    Sixma, J.J.4
  • 18
    • 0039552136 scopus 로고    scopus 로고
    • 'RKKH' peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain
    • PENTIKAINEN O, HOFFERN AM, IVASKA J et al.: 'RKKH' peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain. J. Biol. Chem. (1999) 274:31493-31505.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31493-31505
    • Pentikainen, O.1    Hoffern, A.M.2    Ivaska, J.3
  • 21
    • 0032523064 scopus 로고    scopus 로고
    • Integrin signaling: The platelet paradigm
    • SHATTIL SJ, KASHIWAGI H, PAMPORI N: Integrin signaling: the platelet paradigm. Blood (1998) 91:2645-2657. (Pubitemid 28227512)
    • (1998) Blood , vol.91 , Issue.8 , pp. 2645-2657
    • Shattil, S.J.1    Kashiwagi, H.2    Pampori, N.3
  • 22
    • 0033573790 scopus 로고    scopus 로고
    • Platelet GPIIb-IIIa blockers
    • DOI 10.1016/S0140-6736(98)11086-3
    • TOPOL EJ, BYZOVA TV, PLOW EF: Platelet GPIIb-IIIa blockers [see comments]. Lancet (1999) 353:227-231. (Pubitemid 29088046)
    • (1999) Lancet , vol.353 , Issue.9148 , pp. 227-231
    • Topol, E.J.1    Byzova, T.V.2    Plow, E.F.3
  • 23
    • 0028609229 scopus 로고
    • Abciximab (c7E3 Fab) A review of its pharmacology and therapeutic potential in ischaemic heart disease
    • FAULDS D, SORKIN EM: Abciximab (c7E3 Fab). A review of its pharmacology and therapeutic potential in ischaemic heart disease. Drugs (1994) 48:583-598.
    • (1994) Drugs , vol.48 , pp. 583-598
    • Faulds, D.1    Sorkin, E.M.2
  • 24
    • 0030863733 scopus 로고    scopus 로고
    • Clinical pharmacology of eptifibatide
    • DOI 10.1016/S0002-9149(97)00572-9, PII S0002914997005729
    • PHILLIPS DR, SCARBOROUGH RM: Clinical pharmacology of eptifibatide. Am. J. Cardiol. (1997) 80:11B-20B. (Pubitemid 27369147)
    • (1997) American Journal of Cardiology , vol.80 , Issue.A4
    • Phillips, D.R.1    Scarborough, R.M.2
  • 26
    • 0031007286 scopus 로고    scopus 로고
    • Antiplatelet therapy with glycoprotein IIb/IIIa receptor inhibitors and other novel agents
    • SCHAFER AI: Antiplatelet therapy with glycoprotein IIb/IIIa receptor inhibitors and other novel agents. Tex Heart Inst. J. (1997) 24:90-96. (Pubitemid 27273124)
    • (1997) Texas Heart Institute Journal , vol.24 , Issue.2 , pp. 90-96
    • Schafer, A.I.1
  • 28
    • 0033152575 scopus 로고    scopus 로고
    • GPIIbIIIa inhibitors as adjunctive therapy in acute myocardial infarction
    • DOI 10.1016/S0167-5273(99)00046-7, PII S0167527399000467
    • SALAME M, VERHEYE S, MORE R, KING SB, 3RD, CHRONOS N: GPIIbIIIa inhibitors as adjunctive therapy in acute myocardial infarction. Int. J. Cardiol. (1999) 69:231-236. (Pubitemid 29254098)
    • (1999) International Journal of Cardiology , vol.69 , Issue.3 , pp. 231-236
    • Salame, M.1    Verheye, S.2    More, R.3    King III, S.B.4    Chronos, N.5
  • 29
    • 0032751350 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa receptor antagonists in Non-ST elevation acute coronary syndromes and percutaneous revascularisation. A review of trial reports
    • DOI 10.2165/00003495-199958040-00003
    • KONG DF, CALIFF RM: Glycoprotein IIb/IIIa receptor antagonists in non-ST elevation acute coronary syndromes and percutaneous revascularisation: a review of trial reports. Drugs (1999) 58:609-620. (Pubitemid 29520508)
    • (1999) Drugs , vol.58 , Issue.4 , pp. 609-620
    • Kong, D.F.1    Califf, R.M.2
  • 31
    • 0032709788 scopus 로고    scopus 로고
    • Newer antiplatelet agents in acute coronary syndromes
    • WHITE HD: Newer antiplatelet agents in acute coronary syndromes. Am. Heart J. (1999) 138:S570-576.
    • (1999) Am. Heart J. , vol.138
    • White, H.D.1
  • 32
    • 0032477682 scopus 로고    scopus 로고
    • Oral platelet glycoprotein IIb/IIIa receptor antagonists: The present challenge is safety
    • VORCHHEIMER DA, FUSTER V: Oral platelet glycoprotein IIb/IIIa receptor antagonists: the present challenge is safety [editorial; comment]. Circulation (1998) 97:312-314. (Pubitemid 28074329)
    • (1998) Circulation , vol.97 , Issue.4 , pp. 312-314
    • Vorchheimer, D.A.1    Fuster, V.2
  • 35
    • 0031092633 scopus 로고    scopus 로고
    • + T Cells
    • PICARELLA D, HURLBUT P, ROTTMAN J, SHI X, BUTCHER E, RINGLER DJ: Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of SCID mice reconstituted with CD45RBhigh CD4+ T cells. J. Immunol. (1997) 158:2099-2106. (Pubitemid 127469991)
    • (1997) Journal of Immunology , vol.158 , Issue.5 , pp. 2099-2106
    • Picarella, D.1    Hurlbut, P.2    Rottman, J.3    Shi, X.4    Butcher, E.5    Ringler, D.J.6
  • 37
    • 0029991362 scopus 로고    scopus 로고
    • 1 integrins
    • DOI 10.1038/380171a0
    • HIRSCH E, IGLESIAS A, POTOCNIK AJ, HARTMANN U, FASSLER R: Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins. Nature (1996) 380:171-175. (Pubitemid 26085885)
    • (1996) Nature , vol.380 , Issue.6570 , pp. 171-175
    • Hirsch, E.1    Iglesias, A.2    Potocnik, A.J.3    Hartmann, U.4    Fassler, R.5
  • 38
    • 0030604540 scopus 로고    scopus 로고
    • Differential requirements for α4 integrins during fetal and adult hematopoiesis
    • DOI 10.1016/S0092-8674(00)81301-X
    • ARROYO AG, YANG JT, RAYBURN H, HYNES RO: Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell (1996) 85:997-1008. (Pubitemid 26231167)
    • (1996) Cell , vol.85 , Issue.7 , pp. 997-1008
    • Arroyo, A.G.1    Yang, J.T.2    Rayburn, H.3    Hynes, R.O.4
  • 41
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • DOI 10.1016/0092-8674(94)90337-9
    • SPRINGER TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell (1994) 76:301-314. (Pubitemid 24046692)
    • (1994) Cell , vol.76 , Issue.2 , pp. 301-314
    • Springer, T.A.1
  • 42
    • 0026579147 scopus 로고
    • Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1
    • ISOBE M, YAGITA H, OKUMURA K, IHARA A: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science (1992) 255:1125-1127.
    • (1992) Science , vol.255 , pp. 1125-1127
    • Isobe, M.1    Yagita, H.2    Okumura, K.3    Ihara, A.4
  • 44
    • 0029870339 scopus 로고    scopus 로고
    • Integrin activation by R-ras
    • DOI 10.1016/S0092-8674(00)81082-X
    • ZHANG Z, VUORI K, WANG H, REED JC, RUOSLAHTI E: Integrin activation by R-ras. Cell (1996) 85:61-69. (Pubitemid 26116807)
    • (1996) Cell , vol.85 , Issue.1 , pp. 61-69
    • Zhang, Z.1    Vuori, K.2    Wang, H.-G.3    Reed, J.C.4    Ruoslahti, E.5
  • 45
    • 0030909050 scopus 로고    scopus 로고
    • Suppression of integrin activation: A novel function of a Ras/Raf- initiated MAP kinase pathway
    • DOI 10.1016/S0092-8674(00)81892-9
    • HUGES PE, RENSHAW MW, PFAFF M et al.: Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell (1997) 88:521-530. (Pubitemid 27154417)
    • (1997) Cell , vol.88 , Issue.4 , pp. 521-530
    • Hughes, P.E.1    Renshaw, M.W.2    Pfaff, M.3    Forsyth, J.4    Keivens, V.M.5    Schwartz, M.A.6    Ginsberg, M.H.7
  • 46
    • 0028786294 scopus 로고
    • Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix
    • WU C, KEIVENS VM, O'TOOLE TE, MCDONALD JA, GINSBERG MH: Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell (1995) 83:715-724.
    • (1995) Cell , vol.83 , pp. 715-724
    • C, W.U.1    Keivens, V.M.2    O'Toole, T.E.3    McDonald, J.A.4    Ginsberg, M.H.5
  • 48
    • 0028790773 scopus 로고
    • Mononuclear leukocytes invade rabbit arterial intima during thickening formation via CD18-and VLA-4-dependent mechanisms and stimulate smooth muscle migration
    • KLING D, FINGERLE J, HARLAN JM, LOBB RR, LANG F: Mononuclear leukocytes invade rabbit arterial intima during thickening formation via CD18-and VLA-4-dependent mechanisms and stimulate smooth muscle migration. Circ. Res. (1995) 77:1121-1128.
    • (1995) Circ. Res. , vol.77 , pp. 1121-1128
    • Kling, D.1    Fingerle, J.2    Harlan, J.M.3    Lobb, R.R.4    Lang, F.5
  • 50
    • 0026605385 scopus 로고
    • Roles of beta 2 integrins of rat neutrophils in complement-and oxygen radical-mediated acute inflammatory injury
    • MULLIGAN MS, VARANI J, WARREN JS et al.: Roles of beta 2 integrins of rat neutrophils in complement-and oxygen radical-mediated acute inflammatory injury. J. Immunol. (1992) 148:1847-1857.
    • (1992) J. Immunol. , vol.148 , pp. 1847-1857
    • Mulligan, M.S.1    Varani, J.2    Warren, J.S.3
  • 51
    • 0028310665 scopus 로고
    • Integrins, ICAMs and selectins: Role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites
    • KISHIMOTO TK, ROTHLEIN R: Integrins, ICAMs and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites. Adv. Pharmacol. (1994) 25:117-169.
    • (1994) Adv. Pharmacol. , vol.25 , pp. 117-169
    • Kishimoto, T.K.1    Rothlein, R.2
  • 52
    • 0028813617 scopus 로고
    • Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury
    • MULLIGAN MS, VAPORCIYAN AA, WARNER RL et al.: Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury. J. Immunol. (1995) 154:1350-1363.
    • (1995) J. Immunol. , vol.154 , pp. 1350-1363
    • Mulligan, M.S.1    Vaporciyan, A.A.2    Warner, R.L.3
  • 53
    • 0026329185 scopus 로고
    • A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits
    • discussion, 219-220
    • SHARAR SR, WINN RK, MURRY CE, HARLAN JM, RICE CL: A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits. Surgery (1991) 110:213-219; discussion 219-220.
    • (1991) Surgery , vol.110 , pp. 213-219
    • Sharar, S.R.1    Winn, R.K.2    Murry, C.E.3    Harlan, J.M.4    Rice, C.L.5
  • 54
    • 0025806503 scopus 로고
    • Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis
    • MILESKI WJ, WINN RK, HARLAN JM, RICE CL: Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis. Surgery (1991) 109:497-501.
    • (1991) Surgery , vol.109 , pp. 497-501
    • Mileski, W.J.1    Winn, R.K.2    Harlan, J.M.3    Rice, C.L.4
  • 57
    • 0028177035 scopus 로고
    • Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep
    • ABRAHAM WM, SIELCZAK MW, AHMED A et al.: Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J. Clin. Invest. (1994) 93:776-787.
    • (1994) J. Clin. Invest. , vol.93 , pp. 776-787
    • Abraham, W.M.1    Sielczak, M.W.2    Ahmed, A.3
  • 58
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • YEDNOCK TA, CANNON C, FRITZ LC et al.: Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature (1992) 356:63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3
  • 59
    • 0028220264 scopus 로고
    • The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between α4-integrins and vascular cell adhesion molecule-1
    • BARON JL, REICH EP, VISINTIN I, JANEWAY CA, JR.: The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. J. Clin. Invest. (1994) 93:1700-1708. (Pubitemid 24116411)
    • (1994) Journal of Clinical Investigation , vol.93 , Issue.4 , pp. 1700-1708
    • Baron, J.L.1    Reich, E.-P.2    Visintin, I.3    Janeway Jr., C.A.4
  • 60
    • 0027512121 scopus 로고
    • Monoclonal antibodies to the integrin α-4 subunit inhibit the murine contact hypersensitivity response
    • CHISHOLM PL, WILLIAMS CA, LOBB RR: Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response. Eur. J. Immunol. (1993) 23:682-688. (Pubitemid 23095104)
    • (1993) European Journal of Immunology , vol.23 , Issue.3 , pp. 682-688
    • Chisholm, P.L.1    Williams, C.A.2    Lobb, R.R.3
  • 61
    • 0033596831 scopus 로고    scopus 로고
    • A safety and pharmacokinetic study of intravenous natalizumab in patients with MS
    • SHEREMATA WA, VOLLMER TL, STONE LA, WILLMERHULME AJ, KOLLER M: A safety and pharmacokinetic study of intravenous natalizumab in patients with MS. Neurology (1999) 52:1072-1074. (Pubitemid 29161624)
    • (1999) Neurology , vol.52 , Issue.5 , pp. 1072-1074
    • Sheremata, W.A.1    Vollmer, T.L.2    Stone, L.A.3    Willmer-Hulme, A.J.4    Koller, M.5
  • 63
    • 0032135083 scopus 로고    scopus 로고
    • Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents
    • LIN KC, CASTRO AC: Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. Curr. Opin. Chem. Biol. (1998) 2:453-457. (Pubitemid 128645697)
    • (1998) Current Opinion in Chemical Biology , vol.2 , Issue.4 , pp. 453-457
    • Lin, K.-C.1    Castro, A.C.2
  • 64
    • 0025777183 scopus 로고
    • The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine
    • KOMORIYA A, GREEN LJ, MERVIC M et al.: The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced Type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J. Biol. Chem. (1991) 266:15075-15079. (Pubitemid 21907620)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.23 , pp. 15075-15079
    • Komoriya, A.1    Green, L.J.2    Mervic, M.3    Yamada, S.S.4    Yamada, K.M.5    Humphries, M.J.6
  • 65
    • 0029046132 scopus 로고
    • The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): A cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction
    • WANG JH, PEPINSKY RB, STEHLE T et al.: The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction. Proc. Natl. Acad. Sci. USA (1995) 92:5714-5718.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5714-5718
    • Wang, J.H.1    Pepinsky, R.B.2    Stehle, T.3
  • 66
    • 0026531015 scopus 로고
    • Activation-dependent recognition by hematopoietic cells of the LDV sequence in the v region of fibronectin
    • WAYNER EA, KOVACH NL: Activation-dependent recognition by hematopoietic cells of the LDV sequence in the V region of fibronectin. J. Cell Biol. (1992) 116:489-497.
    • (1992) J. Cell Biol. , vol.116 , pp. 489-497
    • Wayner, E.A.1    Kovach, N.L.2
  • 67
    • 0028900673 scopus 로고
    • Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)
    • KAMATA T, PUZON W, TAKADA Y: Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29). Biochem. J. (1995) 305:945-951.
    • (1995) Biochem. J. , vol.305 , pp. 945-951
    • Kamata, T.1    Puzon, W.2    Takada, Y.3
  • 68
    • 0026691731 scopus 로고
    • Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin
    • IIDA J, SKUBITZ AP, FURCHT LT, WAYNER EA, MCCARTHY JB: Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J. Cell. Biol. (1992) 118:431-444.
    • (1992) J. Cell. Biol. , vol.118 , pp. 431-444
    • Iida, J.1    Skubitz, A.P.2    Furcht, L.T.3    Wayner, E.A.4    McCarthy, J.B.5
  • 69
    • 0029079296 scopus 로고
    • Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts
    • MOLOSSI S, ELICES M, ARRHENIUS T et al.: Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. J. Clin. Invest. (1995) 95:2601-2610.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2601-2610
    • Molossi, S.1    Elices, M.2    Arrhenius, T.3
  • 72
    • 0030916713 scopus 로고    scopus 로고
    • Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface
    • DOI 10.1038/387312a0
    • CASANOVAS JM, SPRINGER TA, LIU JH, HARRSON SC, WANG JH: Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. Nature (1997) 387:312-315. (Pubitemid 27220770)
    • (1997) Nature , vol.387 , Issue.6630 , pp. 312-315
    • Casasnovas, J.M.1    Springer, T.A.2    Liu, J.-H.3    Harrison, S.C.4    Wang, J.-H.5
  • 74
    • 0344334075 scopus 로고    scopus 로고
    • Adhesion molecules in inflammatory diseases
    • DOI 10.2165/00003495-199856060-00003
    • GONZALEZ-AMARO R, DIAZ-GONZALES F, SANCHEZMADRID F: Adhesion molecules in inflammatory diseases. Drugs (1998) 56:977-988. (Pubitemid 29010217)
    • (1998) Drugs , vol.56 , Issue.6 , pp. 977-988
    • Gonzalez-Amaro, R.1    Diaz-Gonzalez, F.2    Sanchez-Madrid, F.3
  • 77
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • DOI 10.1016/0092-8674(94)90187-2
    • FIDLER IJ, ELLIS LM: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell (1994) 79:185-188. (Pubitemid 24324908)
    • (1994) Cell , vol.79 , Issue.2 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 78
    • 0025994605 scopus 로고
    • First steps of tumor-related angiogenesis
    • PAKU S, PAWELETZ N: First steps of tumor-related angiogenesis. Lab. Invest. (1991) 65:334-346.
    • (1991) Lab. Invest. , vol.65 , pp. 334-346
    • Paku, S.1    Paweletz, N.2
  • 79
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • RISAU W: Mechanisms of angiogenesis. Nature (1997) 386:671-674. (Pubitemid 27193480)
    • (1997) Nature , vol.386 , Issue.6626 , pp. 671-674
    • Risau, W.1
  • 80
    • 1842407860 scopus 로고    scopus 로고
    • Vascular development: Cellular and molecular regulation
    • BECK LJ, D'AMORE PA: Vascular development: cellular and molecular regulation. FASEB J. (1997) 11:365-373. (Pubitemid 27193941)
    • (1997) FASEB Journal , vol.11 , Issue.5 , pp. 365-373
    • Beck Jr., L.1    D'Amore, P.A.2
  • 81
    • 0029021904 scopus 로고
    • Endothelial receptor tyrosine kinases involved in angiogenesis
    • MUSTONEN T, ALITAL K: Endothelial receptor tyrosine kinases involved in angiogenesis. J. Cell. Biol. (1995) 129:895-898.
    • (1995) J. Cell. Biol. , vol.129 , pp. 895-898
    • Mustonen, T.1    Alital, K.2
  • 82
    • 0030448814 scopus 로고    scopus 로고
    • Blood vessel formation: What is its molecular basis?
    • DOI 10.1016/S0092-8674(00)81810-3
    • FOLKMAN J, D'AMORE PA: Blood vessel formation: what is its molecular basis? Cell (1996) 87:1153-1155. (Pubitemid 27010098)
    • (1996) Cell , vol.87 , Issue.7 , pp. 1153-1155
    • Folkman, J.1    D'Amore, P.A.2
  • 87
    • 0033578910 scopus 로고    scopus 로고
    • Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
    • O'REILLY MS, PIRIE-SHEPHERD S, LANE WS, FOLKMAN J: Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science (1999) 285:1926-1928.
    • (1999) Science , vol.285 , pp. 1926-1928
    • O'Reilly, M.S.1    Pirie-Shepherd, S.2    Lane, W.S.3    Folkman, J.4
  • 88
    • 0030484702 scopus 로고    scopus 로고
    • Role of integrins in angiogenesis
    • BROOKS PC: Role of integrins in angiogenesis. Eur. J. Cancer. (1996) 32A:2423-2429.
    • (1996) Eur. J. Cancer. , vol.32 A , pp. 2423-2429
    • Brooks, P.C.1
  • 90
    • 0033134622 scopus 로고    scopus 로고
    • Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
    • STETLER-STEVENSON WG: Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. J. Clin. Invest. (1999) 103:1237-1241. (Pubitemid 29218293)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.9 , pp. 1237-1241
    • Stetler-Stevenson, W.G.1
  • 91
    • 0027982162 scopus 로고
    • Integrins as dynamic regulators of vascular function
    • LUSCINSKAS FW, LAWLER J: Integrins as dynamic regulators of vascular function. FASEB J. (1994) 8:929-938. (Pubitemid 24286856)
    • (1994) FASEB Journal , vol.8 , Issue.12 , pp. 929-938
    • Luscinskas, F.W.1    Lawler, J.2
  • 92
    • 0030117714 scopus 로고    scopus 로고
    • Cellular adhesion molecules. Newly identified mediators of angiogenesis
    • POLVERINI PJ: Cellular adhesion molecules. Newly identified mediators of angiogenesis. Am. J. Pathol. (1996) 148:1023-1029.
    • (1996) Am. J. Pathol. , vol.148 , pp. 1023-1029
    • Polverini, P.J.1
  • 93
    • 84907113049 scopus 로고
    • The integrin alpha v beta 3: Angiogenesis and apoptosis
    • VARNER JA, BROOKS PC, CHERESH DA: The integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes. Commun. (1995) 3:367-374.
    • (1995) Cell Adhes. Commun. , vol.3 , pp. 367-374
    • Varner, J.A.1    Brooks, P.C.2    Cheresh, D.A.3
  • 94
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • BROOKS PC, CLARK RA, CHERESH DA: Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science (1994) 264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 96
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins
    • BADER BL, RAYBURN H, CROWLEY D, HYNES RO: Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all alpha v integrins. Cell (1998) 95:507-519. (Pubitemid 28533307)
    • (1998) Cell , vol.95 , Issue.4 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 98
    • 0031459892 scopus 로고    scopus 로고
    • Angiogenesis promoted by vascular endothelial growth factor: Regulation through alpha1beta1 and alpha2beta1 integrins
    • SENGER DR, CLAFFEY KP, BENES JE et al.: Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc. Natl. Acad. Sci. USA (1997) 94:13612-13617.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13612-13617
    • Senger, D.R.1    Claffey, K.P.2    Benes, J.E.3
  • 100
    • 0027513593 scopus 로고
    • Integrin β1- and β3-mediated endothelial cell migration is triggered through distinct signaling mechanisms
    • LEAVESLEY DI, SCHWARTZ MA, ROSENFELD M, CHERESH DA: Integrin beta 1-and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J. Cell. Biol. (1993) 121:163-170. (Pubitemid 23097372)
    • (1993) Journal of Cell Biology , vol.121 , Issue.1 , pp. 163-170
    • Leavesley, D.I.1    Schwartz, M.A.2    Rosenfeld, M.3    Cheresh, D.A.4
  • 101
    • 0027399032 scopus 로고
    • Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation
    • DOI 10.1002/jcb.240510213
    • DAVIS CM, DANEHOWER SC, LAURENZA A, MOLONY JL: Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation. J. Cell. Biochem. (1993) 51:206-218. (Pubitemid 23058578)
    • (1993) Journal of Cellular Biochemistry , vol.51 , Issue.2 , pp. 206-218
    • Davis, D.M.1    Danehower, S.C.2    Laurenza, A.3    Molony, J.L.4
  • 102
    • 0027371908 scopus 로고
    • 5 integrin-deficient mice
    • YANG JT, RAYBURN H, HYNES RO: Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development (1993) 119:1093-1105. (Pubitemid 23358579)
    • (1993) Development , vol.119 , Issue.4 , pp. 1093-1105
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 103
    • 0031813032 scopus 로고    scopus 로고
    • Recent insights into the role of integrins in cancer metastasis
    • DOI 10.1007/s000180050182
    • CLEZARDIN P: Recent insights into the role of integrins in cancer metastasis. Cell. Mol. Life Sci. (1998) 54:541-548. (Pubitemid 28325627)
    • (1998) Cellular and Molecular Life Sciences , vol.54 , Issue.6 , pp. 541-548
    • Clezardin, P.1
  • 104
    • 0032709474 scopus 로고    scopus 로고
    • Physiological roles of matrix metalloproteinases: Implications for tumor growth and metastasis
    • DOI 10.1139/cjpp-77-7-465
    • FORGET MA, DESROSIERS RR, BELIVEAU R: Physiological roles of matrix metalloproteinases: implications for tumor growth and metastasis. Can. J. Physiol. Pharmacol. (1999) 77:465-480. (Pubitemid 29500892)
    • (1999) Canadian Journal of Physiology and Pharmacology , vol.77 , Issue.7 , pp. 465-480
    • Forget, M.-A.1    Desrosiers, R.R.2    Beliveau, R.3
  • 105
    • 0033593335 scopus 로고    scopus 로고
    • Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase
    • RAVANTI L, HEINO J, LOPEZ-OTIN C, KAHIRI VM: Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase. J. Biol. Chem. (1999) 274:2446-2455.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2446-2455
    • Ravanti, L.1    Heino, J.2    Lopez-Otin, C.3    Kahiri, V.M.4
  • 106
    • 0028979348 scopus 로고
    • Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression
    • RIIKONEN T, WESTMARCK J, KOIVISTO L, BROBERG A, KAHARI VM, HEINO J: Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression. J. Biol. Chem. (1995) 270:13548-13552.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13548-13552
    • Riikonen, T.1    Westmarck, J.2    Koivisto, L.3    Broberg, A.4    Kahari, V.M.5    Heino, J.6
  • 107
    • 0031593365 scopus 로고    scopus 로고
    • Alpha2beta1 integrin signaling via the mitogen activated protein kinase pathway modulates retinoic acid-dependent tumor cell invasion and transcriptional downregulation of matrix metalloproteinase 9 activity
    • VO HP, LEE MK, CROWE DL: alpha2beta1 integrin signaling via the mitogen activated protein kinase pathway modulates retinoic acid-dependent tumor cell invasion and transcriptional downregulation of matrix metalloproteinase 9 activity. Int. J. Oncol. (1998) 13:1127-1134.
    • (1998) Int. J. Oncol. , vol.13 , pp. 1127-1134
    • Hp, V.O.1    Lee, M.K.2    Crowe, D.L.3
  • 108
    • 0024335963 scopus 로고
    • Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
    • WERB Z, TREMBLE PM, BEHRENDTSEN O, CROWLEY E, DAMSKY CH: Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell. Biol. (1989) 109:877-889. (Pubitemid 19197045)
    • (1989) Journal of Cell Biology , vol.109 , Issue.2 , pp. 877-889
    • Werb, Z.1    Tremble, P.M.2    Behrendtsen, O.3    Crowley, E.4    Damsky, C.H.5
  • 109
    • 0032883939 scopus 로고    scopus 로고
    • Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways
    • ESPARZA J, VILARDELL C, CALVO J et al.: Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways. Blood (1999) 94:2754-2766. (Pubitemid 29477304)
    • (1999) Blood , vol.94 , Issue.8 , pp. 2754-2766
    • Esparza, J.1    Vilardell, C.2    Calvo, J.3    Juan, M.4    Vives, J.5    Urbano-Marquez, A.6    Yague, J.7    Cid, M.C.8
  • 111
    • 0029932456 scopus 로고    scopus 로고
    • Modulation of matrix metalloprotease-2 and invasion in human glioma cells by α3β1 integrin
    • DOI 10.1016/0304-3835(96)04215-2
    • CHINTALA SK, SAWAYA R, GOKASLAN ZL, RAO JS: Modulation of matrix metalloprotease-2 and invasion in human glioma cells by alpha 3 beta 1 integrin. Cancer Lett. (1996) 103:201-208. (Pubitemid 26147699)
    • (1996) Cancer Letters , vol.103 , Issue.2 , pp. 201-208
    • Chintala, S.K.1    Sawaya, R.2    Gokaslan, Z.L.3    Rao, J.S.4
  • 112
    • 0032515913 scopus 로고    scopus 로고
    • 1 integrin- mediated signal transduction events: Implications for a collagen structural modulation mechanism of tumor cell invasion
    • DOI 10.1021/bi972958l
    • LAUER JL, GENDRON CM, FIELDS GB: Effect of ligand conformation on melanoma cell alpha3beta1 integrin-mediated signal transduction events: implications for a collagen structural modulation mechanism of tumor cell invasion. Biochemistry (1998) 37:5279-5287. (Pubitemid 28176529)
    • (1998) Biochemistry , vol.37 , Issue.15 , pp. 5279-5287
    • Lauer, J.L.1    Gendron, C.M.2    Fields, G.B.3
  • 113
    • 0032587548 scopus 로고    scopus 로고
    • α1 and α2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression
    • LOCHTER A, NAVRE M, WERB Z, BISSELL MJ: alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression. Mol. Biol. Cell. (1999) 10:271-282. (Pubitemid 29156472)
    • (1999) Molecular Biology of the Cell , vol.10 , Issue.2 , pp. 271-282
    • Lochter, A.1    Navre, M.2    Werb, Z.3    Bissell, M.J.4
  • 114
    • 0032572410 scopus 로고    scopus 로고
    • Integrin α1β1 mediates a unique collagen-dependent proliferation pathway in vivo
    • DOI 10.1083/jcb.142.2.587
    • POZZI A, WARY KK, GIANCOTTI FG, GARDNER HA: Integrin alpha1beta1 mediates a unique collagendependent proliferation pathway in vivo. J. Cell. Biol. (1998) 142:587-594. (Pubitemid 28361562)
    • (1998) Journal of Cell Biology , vol.142 , Issue.2 , pp. 587-594
    • Pozzi, A.1    Wary, K.K.2    Giancotti, F.G.3    Gardner, H.A.4
  • 115
    • 0033035808 scopus 로고    scopus 로고
    • Absence of integrin α1β1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis
    • GARDNER H, BROBERG A, POZZI A, LAATO M, HEINO J: Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis. J. Cell. Sci. (1999) 112:263-272. (Pubitemid 29080649)
    • (1999) Journal of Cell Science , vol.112 , Issue.3 , pp. 263-272
    • Gardner, H.1    Broberg, A.2    Pozzi, A.3    Laato, M.4    Heino, J.5
  • 116
    • 0031678829 scopus 로고    scopus 로고
    • Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma
    • DOI 10.1002/(SICI)1096-9896(199809)186:1<51::AID-PATH131>3.0.CO;2-P
    • VAISANEN A, KALLIONEN M, TASKINEN PJ, TURPEENNIEMI-HUJANEN T: Prognostic value of MMP-2 immunoreactive protein (72 kD Type IV collagenase) in primary skin melanoma. J. Pathol. (1998) 186:51-58. (Pubitemid 28407488)
    • (1998) Journal of Pathology , vol.186 , Issue.1 , pp. 51-58
    • Vaisanen, A.1    Kallioinen, M.2    Taskinen, P.J.3    Turpeenniemi-Hujanen, T.4
  • 119
    • 0010712792 scopus 로고    scopus 로고
    • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
    • DOI 10.1016/S0092-8674(00)80931-9
    • BROOKS PC, SILETTI S, VON SCHALSCHA TL, FRIEDLANDER M, CHERESCH DA: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell (1998) 92:391-400. (Pubitemid 28093016)
    • (1998) Cell , vol.92 , Issue.3 , pp. 391-400
    • Brooks, P.C.1    Silletti, S.2    Von Schalscha, T.L.3    Friedlander, M.4    Cheresh, D.A.5
  • 120
    • 0032612382 scopus 로고    scopus 로고
    • New drugs on the horizon: Matrix metalloproteinase inhibitors
    • ROTHENBERG ML, NELSON AR, HANDE KR: New drugs on the horizon: matrix metalloproteinase inhibitors. Stem Cells (1999) 17:237-240.
    • (1999) Stem Cells , vol.17 , pp. 237-240
    • Rothenberg, M.L.1    Nelson, A.R.2    Hande, K.R.3
  • 121
    • 0028346025 scopus 로고
    • Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
    • BERNHARD EJ, GRUBER SB, MUSCHEL RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci. USA (1994) 91:4293-4297. (Pubitemid 24143419)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.10 , pp. 4293-4297
    • Bernhard, E.J.1    Gruber, S.B.2    Muschel, R.J.3
  • 122
    • 0028950493 scopus 로고
    • The effect of E1A transfection on MMP-9 expression and metastatic potential
    • BERNHARD EJ, HAGNER B, WONG C LUBENSKI I, MUSCHEL RJ: The effect of E1A transfection on MMP-9 expression and metastatic potential. Int. J. Cancer (1995) 60:718-724.
    • (1995) Int. J. Cancer , vol.60 , pp. 718-724
    • Bernhard, E.J.1    Hagner, B.2    Wong Lubenski C, I.3    Muschel, R.J.4
  • 123
    • 0028955056 scopus 로고
    • Suppression of matrilysin inhibits colon cancer cell invasion in vitro
    • YAMAMOTO H, ITOH F, HINODA Y, IMAI K: Suppression of matrilysin inhibits colon cancer cell invasion in vitro. Int. J. Cancer (1995) 61:218-222.
    • (1995) Int. J. Cancer , vol.61 , pp. 218-222
    • Yamamoto, H.1    Itoh, F.2    Hinoda, Y.3    Imai, K.4
  • 125
    • 0030717692 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions
    • GOMEZ DE, ALONSO DF, YOSHIJI H, THORGEIRSSON UP: Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur. J. Cell. Biol. (1997) 74:111-122. (Pubitemid 27455388)
    • (1997) European Journal of Cell Biology , vol.74 , Issue.2 , pp. 111-122
    • Gomez, D.E.1    Alonso, D.F.2    Yoshiji, H.3    Thorgeirsson, U.P.4


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