Polyaromatic scavenger reagents (PAHSR): A new methodology for rapid purification in solution-phase combinatorial synthesis

Organic Letters

Volumn 2, Issue 13, 2000, Pages 1807-1809

  Warmus, Joseph S ^a   Da Silva, Marianne I ^a,b  

^a PFIZER INC   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000204199     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol005822f     Document Type: Article

References (30)

1. Fukase, K. Yuki Gosei Kagaku Kyokaishi 1997, 55, 474-479.
2. Fruechtel, J. S.; Jung, G. Angew. Chem., Int. Ed. Engl. 1996, 35, 17-42.
3. Lam, K. S. Anti-Cancer Drug Des. 1997, 12, 145-167.
4. Storer, R. Drug Discovery Today 1996, 1, 248-254.
5. Ferritto, R.; Seneci, P. Drugs Future 1998, 23, 643-654.
6. (a) Wentworth, P. Trends Biotechnol. 1999, 17, 448-452.
7. (b) Perrier, H. l. n.; Labelle, M. J. Org. Chem. 1999, 64, 2110-2113.
8. (a) Curran, D. P. Med. Res. Rev. 1999, 19, 432-438.
9. (b) Studer, A.; Hadida, S.; Ferritto, R.; Kim, S.-Y.; Jeger, P.; Wipf, P.; Curran, D. P. Science 1997, 275, 823-826.
10. Curran, D. P.; Hadida, S. J. Am. Chem. Soc. 1996, 118, 2531-2532.
11. Siegel, M. G.; Hahn, P. J.; Dressman, B. A.; Fritz, J. E.; Grunwell, J. R.; Kaldor, S. W. Tetrahedron Lett. 1997, 38, 3357-3360.
12. Kibbey, C. E. Lab. Rob. Autom. 1997, 9, 309-321.
13. Goetzinger, W. K.; Kyranos, J. N. In PCT Int. Appl. (Arqule, Inc., USA) Wo, 1999; Vol. G01N030-34, p 36 pp.
14. Zeng, L.; Kassel, D. B. Anal. Chem. 1998, 70, 4380-4388.
15. Booth, R. J.; Hodges, J. C. J. Am. Chem. Soc. 1997, 119, 4882-4886.
16. Kaldor, S. W.; Siegel, M. G.; Fritz, J. E.; Dressman, B. A.; Hahn, P. J. Tetrahedron Lett. 1996, 37, 7193-7196.
17. (a) Flynn, D. L. Med. Res. Rev. 1999, 19, 408-431.
18. (b) Weidner, J. J.; Parlow, J. J.; Flynn, D. L. Tetrahedron Lett. 1999, 40, 239-242.
19. (c) Starkey, G. W.; Parlow, J. J.; Flynn, D. L. Bioorg. Med. Chem. Lett. 1998, 8, 2385-2390.
20. Flynn D. L.; Crich, J. Z.; Devraj, R. V.; Hockerman, S. L.; Parlow, J. J.; South M. S.; Woodard, S. J. Am. Chem. Soc. 1997, 119, 4874-4881.
21. Flynn, D. L.; Devraj, R. V.; Parlow, J. J. Curr. Opin. Drug Discovery Dev. 1998, 1, 41-50.
22. Parlow, J. J.; Devraj, R. V.; South, M. S. Curr. Opin. Chem. Biol. 1999, 3, 320-336.
23. Calbiochem-Novabiochem, 800 228-9622.
24. Rana, S.; White, P.; Bradley, M. Tetrahedron Lett. 1999, 40, 8137-8140.
25. Ramage, R.; Swenson, H. R.; Shaw, K. T. Tetrahedron Lett. 1998, 39, 8715-8718
26. Brown, A. R.; Irving, S. L.; Ramage, R.; Raphy, G. Tetrahedron 1995, 51, 11815-30.
27. Brown, A. R.; Irving, S. L.; Ramage, R. Tetrahedron Lett. 1993, 34, 7129-32.
28. Hay, A. M.; Hobbs-Dewitt, S.; MacDonald, A. A.; Ramage, R. Synthesis 1999, 11, 1979-1985.
29. Adamczyk, M.; Fishpaugh, J. R.; Heuser, K. J. Org. Prep. Proced. Int. 1998, 30, 339-348.
30. 3) δ 8.15 (d, 1H, J = 9.1 Hz), 7.97(m, 8H), 4.2 (s, 2H), 2.67 (t, 2H, J = 5.9 Hz), 2.55 (t, 2H, 5.9 Hz); MS (CI) M(+1) 486; melting point of the HCl salt, 157°C.